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Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

A high burden of ischemic stroke in regions of Eastern/Central Europe is largely due to modifiable risk factors.
Abstract Incidence and mortality of ischemic stroke in Croatia is significantly higher than in many other developed European countries. Here, we aimed to evaluate underlying conditions of this unacceptably high ischemic stroke burden. An observational prospective cohort study of ) first-ever ischemic stroke patients identified in a population-based incidence study (N=751) (study 1, S1) and a concurrent case-control trial (215 patients, 125 controls, S2) were conducted in the country of Varazdin from 2007-2010. Atrial fibrillation (AF) was common (36.1% in S1, 40.9% in S2) and mostly (>50%) unrecognized before t...
Source: Current Neurovascular Research - July 30, 2015 Category: Neurology Authors: Pikija S, Trkulja V, Malojcic B, Mutzenbach JS, Sellner J Tags: Curr Neurovasc Res Source Type: research

Stroke in HIV-infected African Americans: a retrospective cohort study
Abstract The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of African Americans with HIV infection and new-onset stroke admitted at the Johns Hopkins Hospitals (2000–2012). Multivariate linear regression was used to examine the association between potential predictors and odds of an unfavorable outcome, defined as a higher modified Rankin Scale (mRS) score on hospital discharge. African Americans comprised 105/125 (84 %) of HIV-inf...
Source: Journal of NeuroVirology - July 9, 2015 Category: Neurology Source Type: research

Statins and subarachnoid hemorrhage in Medicare patients with unruptured cerebral aneurysms
ConclusionsStatin use by patients with unruptured cerebral aneurysms was not associated with subarachnoid hemorrhage risk. Given the prior animal experimental studies demonstrating a protective effect, further prospective studies are needed to investigate the potential relationship.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Kimon Bekelis, Jeremy Smith, Weiping Zhou, Todd A. MacKenzie, David W. Roberts, Jonathan Skinner, Nancy E. Morden Tags: Research Source Type: research

Infratentorial Microbleeds: Another Sign of Microangiopathy in Migraine Brief Reports
Conclusions— Migraine, notably without aura, is associated with infratentorial CMBs at older age. CMBs and infarcts co-occur more often in migraine than in controls. This supports the hypothesis of small-vessel involvement in migraine pathophysiology.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Arkink, E. B., Terwindt, G. M., de Craen, A. J. M., Konishi, J., van der Grond, J., van Buchem, M. A., Ferrari, M. D., Kruit, M. C., on behalf of the PROSPER Study Group Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke Brief Reports Source Type: research

Clinical Reasoning: A 66-year-old man with recurrent multi-territory infarcts
A 66-year-old man was referred to our center for evaluation of recurrent infarcts in multiple vascular territories over the preceding 6 months (figure 1). The patient first presented with a 3-month, stuttering course of transient neurologic deficits, including right arm and leg hemiparesis, expressive aphasia, and right homonymous hemianopia. He was initially evaluated at a community Stroke Prevention Clinic. His medical history was significant for several classic vascular risk factors: coronary artery disease requiring a coronary artery bypass graft, dyslipidemia for which he was taking atorvastatin 20 mg daily, and obstr...
Source: Neurology - June 8, 2015 Category: Neurology Authors: Kouzmitcheva, E., Steriade, C., Prica, A., Hazrati, L.-N., Mandell, D. M. Tags: All Cerebrovascular disease/Stroke, All Education RESIDENT AND FELLOW SECTION Source Type: research

Statin therapy and the risk of intracerebral haemorrhage: a nationwide observational study
ConclusionsIn this matched case‐controlled study, statin therapy was associated with a decreased risk of incident intracerebral haemorrhage. Future studies on risk of stroke with statin therapy after intracerebral haemorrhage are needed.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Signild Åsberg, Marie Eriksson Tags: Research Source Type: research

Racial/Ethnic Variation in Carotid Artery Revascularization Utilization and Outcomes: Analysis From the National Cardiovascular Data Registry Clinical Sciences
Conclusion— During the study period, utilization of CAS and CEA was highest among non-Hispanic whites. There was a trend toward increased CAS utilization over time among non-Hispanic whites and other groups, and a trend toward increased CEA utilization among Hispanics and blacks. In-hospital major adverse cardiac and cerebrovascular events remained comparable between groups, whereas 30-day major adverse cardiac and cerebrovascular events were significantly higher in blacks.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Wayangankar, S. A., Kennedy, K. F., Aronow, H. D., Rundback, J., Tafur, A., Drachman, D., Patel, B., Sivaram, C. A., Latif, F. Tags: Carotid Stenosis, Carotid endarterectomy, Angioplasty and Stenting Clinical Sciences Source Type: research

Lipid Lowering for Primary Stroke Prevention in Elderly? Lipid Lowering for Primary Stroke Prevention in Elderly?
The use of statins or fibrates was associated with a one third lower risk for stroke in older adults without previous vascular disease in a new observational study. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - May 20, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Prevention of Stroke in Rheumatoid Arthritis
Opinion statement Recognizing that systemic inflammation is a major contributor to the increased risk of cardiovascular disease (CVD), including stroke, in rheumatoid arthritis (RA) serves as the basis for prevention strategies for cerebrovascular disease in RA. In addition to traditional cardiovascular risk factors, recognize that RA may be an independent risk factor for cerebrovascular accident (CVA). The risk of CVD should be assessed in each patient with RA, utilizing modified risk score calculators. Careful monitoring and control of systemic inflammation should be undertaken in conjunction with assessing eac...
Source: Current Treatment Options in Neurology - May 18, 2015 Category: Neurology Source Type: research

Combination of intracerebral haemorrhage and familial hypercholesterolemia in the acute hospital setting – a challenge for statin treatment?
It is estimated that worldwide, around 35 million people have familial hypercholesterolemia (FH). Thus, patients affected by the combination of FH and acute intracerebral hemorrhage (ICH) are not exceptional and neurologists should be prepared to encounter them. Despite a recent finding of beneficial association between statin use during hospitalization and improved outcomes, the increased risk of recurrent ICH in the long term may make clinicians avoid statins in patients with a history of ICH. However, discontinuing statins in patients with FH worsens cardiovascular outcomes and even increases all‐cause mortality. Acco...
Source: International Journal of Stroke - May 14, 2015 Category: Neurology Authors: Alpo Vuorio, Markku Kaste, Petri T. Kovanen Tags: Leading opinion Source Type: research

Fixed-Dose Combination Treatment After Stroke for Secondary Prevention in China: A National Community-Based Study Clinical Sciences
Conclusions— A huge number of stroke patients in China require preventive therapy and would be eligible for a polypill. This study indicates that it would be reasonable to consider and assess the value of a polypill strategy to improve secondary prevention of stroke in China.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Longde, W., Ling, Y., Yang, H., Yi, Z., Yongjun, W., Xunming, J., Xiaoyuan, N., Qiumin, Q., Li, H., Yuming, X., Mei, L., Jiayi, S., Jing, L., Dong, Z. Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Pravastatin acute neuroprotective effects depend on Blood brain barrier integrity in experimental cerebral ischemia.
Abstract Statins have since long been reported to exert acute neuroprotection in experimental stroke models. However, crucial questions still need to be addressed as far as the timing of their cerebral effects after intravascular administration and the role played by the blood brain barrier (BBB) crossing properties. We tested the effects of an hydrophilic statin (pravastatin, 100nM), which poorly crosses BBB under physiological conditions. Pravastatin was administered either 90min before or immediately after transient middle cerebral artery occlusion in the in vitro isolated guinea pig brain preparation. A multi-...
Source: Brain Research - April 23, 2015 Category: Neurology Authors: Carone D, Librizzi L, Cattalini A, Sala G, Conti E, Cuccione E, Versace A, Cai R, Monza L, de Curtis M, Ferraresea C, Beretta S Tags: Brain Res Source Type: research

Aggressive Statin Therapy (AST) and Brain Atrophy/Associated Leucoaraiosis: MRI 6 Years Observational Study (P1.045)
CONCLUSIONS: Apart from Leucoaraiosis and aging, prolonged AST is significantly associated with cerebral atrophy (NNH=5 in 6 yrs). Leucoaraiosis may aggravate. Nicardipine had a protective effect on Leucoaraiosis but not on AST induced atrophy.Disclosure: Dr. Devathasan has nothing to disclose. Dr. Senna has nothing to disclose. Dr. Dosado has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Devathasan, G., Senna, W., Dosado, L. Tags: Cerebrovascular Disease and Interventional Neurology: The Spectrum of Small Vessel Cerebrovascular Disease Source Type: research

Are patients with carotid stenosis receiving optimal medical therapy? (I2-1A)
Conclusion: Despite the presence of established large vessel atherosclerosis, a sizable proportion of patients reported that they were not receiving statin therapy or aspirin. Intensification of "real world" medical therapy will be important to reduce stroke rates and improve long-term survival.Disclosure: Dr. Koch has nothing to disclose. Dr. Chaturvedi has received personal compensation for activities with Genentech, Inc., Abbott Vascular, Boehringer-Ingelheim, WL Gore, and Merck. Dr. Chaturvedi has received personal compensation in an editorial capacity for NEJM Journal Watch Neurology. Dr. Romano has received personal ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Koch, S., Chaturvedi, S., Romano, J. Tags: Management of Asymptomatic Cerebrovascular Lesions Data Blitz Presentations Source Type: research

Value of Eye Movement Exam in Aiding Precise Localization in Stroke (P1.016)
We present an unusual presentation of midbrain stroke presenting with bilateral ptosis in an African American male with vascular risk factors and concurrent use of bevacizumab. This case illustrates how detailed knowledge of anatomy and detailed neurologic exam remain valuable tools for localizing and diagnosing subtle presentations of common neurologic disease. Case description: A 69 year-old African American man with vascular risk factors including hypertension, hyperlipidemia and poorly controlled diabetes experienced sudden onset horizontal diplopia associated with fatigue. The patient presented to the Emergency Depart...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Khandker, N., Schmerler, D., Mahajan, S., Serra, A., Strbian, D. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research