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Specialty: Neurology
Therapy: Statin Therapy
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Total 360 results found since Jan 2013.
Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA.
Source: Stroke - November 27, 2017 Category: Neurology Authors: David Gaist, Larry B. Goldstein, Lucia Cea Soriano, Luis Alberto Garcia Rodriguez Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited
In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used.Neurosignals 2017;25:54 –73
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research
Risk factors, vascular lesion distribution, outcome and recurrence of strokes due to intracranial atherosclerosis: One year data from Hyderabad stroke registry
Conclusion: Risk factors, distribution of vascular lesions and high recurrence of stroke due to ICAS in this study is similar to that reported from other Asian countries. Aggressive medical management and risk factor control remains the best strategy for preventing recurrence.
Source: Annals of Indian Academy of Neurology - October 25, 2017 Category: Neurology Authors: Raghu Ram Subhash Kaul Suvarna Alladi Jabeen S Afshan T Surya Prabha Abhijeet Kohat Swetha Tandra Jyotsna Y Rani Source Type: research
Statins for Neuroprotection After Acute Ischemic Stroke Editorial
Source: Stroke - October 23, 2017 Category: Neurology Authors: Peter Kelly, Shyam Prabhakaran Tags: Ischemic Stroke, Neuroprotectants Editorials Source Type: research
One-Year Outcomes After Minor Stroke or High-Risk Transient Ischemic Attack Clinical Sciences
Conclusions—Contemporary secondary stroke prevention strategies based on thorough diagnostic evaluation may contribute to the low subsequent vascular event rates observed in real-world clinical practice in Korea.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, M Tags: Quality and Outcomes, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02549846.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takashi Daimon, Ryuzo Takashima, Kazuhiro Kimura, Takeshi Morimoto, on behalf of ASSORT Trial Investigator* Tags: Clinical Studies, Lipids and Cholesterol, Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited
In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used.Neurosignals 2017;25:54 –73
Source: Neurosignals - October 17, 2017 Category: Neurology Source Type: research
Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited.
In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used.
PMID: 29041003 [PubMed - as supplied by publisher]
Source: Neuro-Signals - October 17, 2017 Category: Neurology Authors: Lang UE, Walter M Tags: Neurosignals Source Type: research
Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke Clinical Sciences
Conclusions—After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo Tags: Secondary Prevention, Compliance/Adherence, Ischemic Stroke Original Contributions Source Type: research
Specific rescue by ortho ‐hydroxy atorvastatin of cortical GABAergic neurons from previous oxygen/glucose deprivation: role of pCREB
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 7, 2017 Category: Neurology Authors: Ver ónica Guirao, Octavi Martí‐Sistac, Nuria DeGregorio‐Rocasolano, Jovita Ponce, Antoni Dávalos, Teresa Gasull Tags: Original Article Source Type: research
The fate of asymptomatic severe carotid stenosis in the era of best medical therapy.
CONCLUSION: The most recent series of ACAS ≥70% and BMT had an overall stroke rate which is relatively low; however, the risk of developing symptoms is still relevant (3.4%/year).
PMID: 28816542 [PubMed - as supplied by publisher]
Source: Brain Injury - August 18, 2017 Category: Neurology Tags: Brain Inj Source Type: research
Treating Dyslipidemia for the Primary and Secondary Prevention of Stroke
Semin Neurol 2017; 37: 286-293 DOI: 10.1055/s-0037-1603511Stroke is associated with a heavy burden of mortality and disability, underscoring the importance of effective primary and secondary prevention measures. Dyslipidemia as a risk factor for ischemic stroke has long been disputed. Nevertheless, accumulating epidemiological evidence supports a role of lipid abnormalities in increasing ischemic stroke risk and representing a potential target for therapeutic interventions. 3-hydroxy-3-methyl-glutaryl- (HMG-) CoA reductase inhibitors (i.e., statins) are currently the mainstay of therapy for the management of hypercholester...
Source: Seminars in Neurology - July 31, 2017 Category: Neurology Authors: Barkas, Fotios Milionis, Haralampos Tags: Review Article Source Type: research
Use of Statins and Outcomes in Intracerebral Hemorrhage Patients Clinical Sciences
Conclusions—Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician’s view of a patient’s prognosis rather than a predictor of survival.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Fazeel M. Siddiqui, Carl D. Langefeld, Charles J. Moomaw, Mary E. Comeau, Padmini Sekar, Jonathan Rosand, Chelsea S. Kidwell, Sharyl Martini, Jennifer L. Osborne, Sonja Stutzman, Christiana Hall, Daniel Woo Tags: Intracranial Hemorrhage Original Contributions Source Type: research
Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting Clinical Sciences
Background and Purpose—Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) and high-dose statin (HDS) therapy, is recommended for patients with symptomatic intracranial atherosclerotic disease. However, limited data on the real-world application of this regimen exist. We hypothesized that recurrent stroke risk among patients treated with AMM is similar to the medical arm of the SAMMPRIS cohort.Methods—Using a prospective registry, we identified all patients adm...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Rajbeer S. Sangha, Andrew M. Naidech, Carlos Corado, Sameer A. Ansari, Shyam Prabhakaran Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Stenosis, Vascular Disease Original Contributions Source Type: research
Optimal Medical Management Reduces Risk of Disease Progression and Ischemic Events in Asymptomatic Carotid Stenosis Patients: A Long-Term Follow-Up Study
Conclusion: Intensive medical therapy in the patients with ACAS results in lower incidence of IS/TIA, CRV, and PSCS with a significant incremental beneficial effect.Cerebrovasc Dis 2017;44:150-159
Source: Cerebrovascular Diseases - July 7, 2017 Category: Neurology Source Type: research
