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Specialty: Neurology
Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

The effect of statin use in acute ischemic stroke patients treated with thrombolytic therapy
This study investigated the effects of statins for the acute ischemic stroke patients after thrombolysis on the stroke outcome considering statin intensity and time window.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Jong-Moo Park, Tae Kyoung Kim, Eui Sung Jung, Kyusik Kang, Woung-Woo Lee, Jungju Lee, Ohyun Kwon, Byung-Kun Kim Source Type: research

Statin Adherence and the Risk of Stroke: A Dose-Response Meta-Analysis
ConclusionImproved adherence to statins was associated with a lower risk of stroke, particularly of IS.
Source: CNS Drugs - March 12, 2017 Category: Neurology Source Type: research

Early Statins No Better Than Later Start After Stroke Early Statins No Better Than Later Start After Stroke
No benefit was seen in early vs later statin treatment following stroke, according to a new trial; however, the mild severity of strokes and relatively low numbers are seen as key limitations.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - March 3, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Recurrent stroke in a patient with vitamin B12 deficiency and MTHFR mutation
We report an unusual case of recurrent stroke in a patient with vitamin B12 deficiency who was also homozygous for the methylene tetrahydrofolate reductase (MTHFR) gene mutation. The patient was a 35-year-old male vegetarian with no known medical history who initially presented with global aphasia, slurred speech, right facial weakness, and right-sided hemiplegia and was found to have a stroke (NIH Stroke Scale score of 25). At that time a CT scan of the head ruled out intracranial hemorrhage and a CT angiogram of the head and neck was done. The patient was found to have occlusion of the M1 segment of the left middle cereb...
Source: Neurology Clinical Practice - February 12, 2017 Category: Neurology Authors: Zacharia, G., Shani, D., Ortiz, R. A. Tags: Stroke in young adults, Stroke prevention, Hematologic, All Cerebrovascular disease/Stroke Case Source Type: research

Left ventricular wall motion abnormalities are associated with stroke recurrence
Conclusions: This study suggests that LVWMA, even when unassociated with high-risk cardioembolic sources, could be an independent predictor for stroke recurrence in patients with ischemic stroke.
Source: Neurology - February 5, 2017 Category: Neurology Authors: Choi, J.-Y., Cha, J., Jung, J.-M., Seo, W.-K., Oh, K., Cho, K.-H., Yu, S. Tags: Cardiac, Embolism, Infarction ARTICLE Source Type: research

Stroke Epidemiology and Risk Factor Management
This article reviews the current recommendations for the management of each of these modifiable risk factors. Recent Findings: It has been documented that some blood pressure medications may increase variability of blood pressure and ultimately increase the risk for stroke. Stroke prevention typically includes antiplatelet therapy (unless an indication for anticoagulation exists), so the most recent evidence supporting use of these drugs is reviewed. In addition, emerging risk factors, such as obstructive sleep apnea, electronic cigarettes, and elevated lipoprotein (a), are discussed. Summary: Overall, secondary stroke p...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Exercise for stroke prevention: The neglected prescription
For over a decade, clinicians have used multimodal pharmacologic therapy for optimal stroke prevention based in part on promising results from clinical trials demonstrating the value of blood pressure and cholesterol lowering for secondary stroke prevention. Patients are typically treated with a cocktail of medications, including antithrombotic agents, antihypertensives, and statins.1
Source: Neurology - January 22, 2017 Category: Neurology Authors: Chaturvedi, S., Nahab, F. Tags: Stroke prevention, Infarction EDITORIALS Source Type: research

Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36
AbstractWe previously found that hematoma worsens hydrocephalus after intraventricular hemorrhage (IVH) via increasing iron deposition and aggravating ependymal cilia injury; therefore, promoting hematoma absorption may be a promising strategy for IVH. Recently, some investigations imply that simvastatin has the ability of accelerating hematoma absorption. Thus, this study was designed to examine the efficacy of simvastatin for IVH in rats. Intracerebral hemorrhage with ventricular extension was induced in adult male Sprague –Dawley rats after autologous blood injection. Simvastatin or vehicle was administered orally at ...
Source: Translational Stroke Research - January 18, 2017 Category: Neurology Source Type: research

The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study: Rationale and Trial Protocol
The preventive effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study aims to determine the effect of pravastatin on carotid IMT in Japanese patients with hyperlipidemia who developed noncardioembolic ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 20, 2016 Category: Neurology Authors: Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Naohisa Hosomi, Hideki Origasa, Kazuo Kitagawa, Shinichiro Uchiyama, Masatoshi Koga, Masayasu Matsumoto, J-STARS Investigators Source Type: research

Interaction of incidental microbleeds and prior use of antithrombotics with early hemorrhagic transformation: Causative or protective ?
Conclusion: Presence of incidental CMBs was not associated with increased risk for early HT of an ischemic stroke. Interestingly, the prior intake of antiplatelets was found to be protective against HT of ischemic stroke.
Source: Annals of Indian Academy of Neurology - November 21, 2016 Category: Neurology Authors: Konark Malhotra Monica Khunger Bichun Ouyang David S Liebeskind Yousef M Mohammad Source Type: research

Recurrent cryptogenic stroke in young adult linked to congenital left ventricular diverticulum
A 47-year-old man had an acute ischemic stroke (IS); brain MRI revealed multiple silent old IS (figure 1A). A comprehensive workup, including prolonged cardiac monitoring (cumulated duration of 25 days) and cardiac transthoracic/transesophageal echography, was negative. Eleven months later, despite statin and aspirin therapy, a new symptomatic embolic IS of undetermined source occurred (figure 1B). Cardiac MRI1 revealed a left apical dyskinetic saccular evagination (figure 2, A–C) consistent with a congenital left ventricular diverticulum confirmed on left ventriculography (figure 2D) and the presumed source of recur...
Source: Neurology - November 13, 2016 Category: Neurology Authors: Gaillard, N., Targosz, F., Bertrand, J. L., Sablot, D., Bensalah, Z. M. Tags: Stroke in young adults, Cardiac, Embolism, Infarction NEUROIMAGES Source Type: research

Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy
ConclusionsTaking statins prior to CEA did not seem to affect the risk of major perioperative ischemic events and death, most likely due to the extremely low overall incidence of perioperative complications. Recent reports have shown that the preoperative use of statins has a protective role after noncardiac vascular and cardiac surgery, attenuating the perioperative incidence of stroke, myocardial infarction, and death. Only few studies, however, have investigated on the benefit of statin use in patients undergoing carotid endarterectomy for severe carotid disease, reporting variable results. Findings from our study show...
Source: Brain and Behavior - September 30, 2016 Category: Neurology Authors: Enzo Ballotta, Antonio Toniato, Filippo Farina, Claudio Baracchini Tags: Original Research Source Type: research

U ‐curve relation between cholesterol and prior ischemic stroke
ConclusionOur hypothesis was falsified. The association between lower cholesterol levels and higher frequency of prior ischemic stroke in patients with cholesterol <5.5 mmol/L cannot be solely an effect of aggressive statin treatment in patients with prior ischemic stroke, as the association pertained also to patients who did not use statin. Previous studies on ischemic stroke patients have shown conflicting results concerning the association between cholesterol level and patient outcome. We hypothesized that acute ischemic stroke patients with increased cholesterol on admission more frequently had experienced prior i...
Source: Brain and Behavior - August 31, 2016 Category: Neurology Authors: Gerd Haga Bringeland, Aliona Nacu, Ulrike Waje ‐Andreassen, Lars Thomassen, Halvor Naess Tags: Original Research Source Type: research

Prescription of Guideline-Based Medical Therapies at Discharge After Carotid Artery Stenting and Endarterectomy: An NCDR Analysis Clinical Sciences
Conclusions— US antiplatelet agent and statin discharge prescription rates were suboptimal after both CAS and CEA and varied by revascularization modality, operating physician specialty, and hospital characteristics. Improved and more uniform utilization after these procedures will be critical to the success of comprehensive stroke risk reduction efforts.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Aronow, H. D., Kennedy, K. F., Wayangankar, S. A., Katzen, B. T., Schneider, P. A., Abou-Chebl, A., Rosenfield, K. A. Tags: Secondary Prevention, Cardiovascular Surgery, Stent, Cerebrovascular Disease/Stroke, Peripheral Vascular Disease Clinical Sciences Source Type: research

Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke
Source: Neurology - August 14, 2016 Category: Neurology Authors: Larry B., G., Tsivgoulis, G., Katsanos, A. H., Alexandrov, A. V. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research