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Specialty: Neurology
Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

Statin use in spontaneous intracerebral hemorrhage: a systematic review and meta‐analysis
ConclusionsAlthough careful interpretation is necessary due to several study limitations, we have demonstrated that statin use in patients with intracerebral hemorrhage is likely associated with improved mortality and functional outcomes.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Jin‐Man Jung, Jeong‐Yoon Choi, Hyun Jung Kim, Woo‐Keun Seo Tags: Systematic Review Source Type: research

Life ‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena H änninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research

Statin treatment reduces the risk of poststroke seizures
Conclusions: Statin use, especially in the acute phase, may reduce the risk of poststroke early-onset seizures. In addition, statin treatment may prevent the progression of initial poststroke seizure-induced neurodegeneration into chronic epilepsy. Because of the observational nature of the study, more studies are needed to confirm the results. Classification of evidence: This study provides Class III evidence that in patients with a first-ever ischemic stroke, the early use of statins reduces the risk of early poststroke seizures.
Source: Neurology - August 24, 2015 Category: Neurology Authors: Guo, J., Guo, J., Li, J., Zhou, M., Qin, F., Zhang, S., Wu, B., He, L., Zhou, D. Tags: All Cerebrovascular disease/Stroke, Antiepileptic drugs ARTICLE Source Type: research

Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke Brief Reports
Conclusions— Statin pretreatment seems not to be associated with adverse outcomes in AIS patients treated with IVT. The effect of statin pretreatment on early functional outcomes in thrombolysed AIS patients deserves further investigation.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Tsivgoulis, G., Kadlecova, P., Kobayashi, A., Czlonkowska, A., Brozman, M., Švigelj, V., Csiba, L., Korv, J., Demarin, V., Vilionskis, A., Jatuzis, D., Katsanos, A. H., Rudolf, J., Krespi, Y., Mikulik, R. Tags: Thrombolysis Brief Reports Source Type: research

Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID? Clinical Sciences
Conclusions— After adjustment for confounding baseline characteristics, WASID patients had an almost 2-fold higher risk of the SAMMPRIS primary end point, which supports the hypothesis that the lower rate of the primary end point in the medical arm of SAMMPRIS compared with WASID patients was as a result of the aggressive medical management used in SAMMPRIS. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576693.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Chaturvedi, S., Turan, T. N., Lynn, M. J., Derdeyn, C. P., Fiorella, D., Janis, L. S., Chimowitz, M. I., for the SAMMPRIS Trial Investigators Tags: Risk Factors Clinical Sciences Source Type: research

Can statins prevent seizures after strokes?
People who have had strokes are at increased risk of developing seizures and epilepsy. In the article "Statin treatment reduces the risk of poststroke seizures," Guo and colleagues looked at whether treating patients who had recently had a stroke with a cholesterol-lowering "statin" medication might reduce the risk of developing seizures following the stroke.1
Source: Neurology - August 24, 2015 Category: Neurology Authors: Motika, P. V. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, All Epilepsy/Seizures PATIENT PAGES Source Type: research

Statins for poststroke seizures: The first antiepileptogenic agent?
Seizure following acute stroke occurs infrequently but represents a worrisome development. Worse, for a subset of patients, the acute monophasic neurologic condition—ischemia—can develop into a chronic active neurologic condition—epilepsy. In this issue of Neurology®, Guo et al.1 report that acute statin use reduces the risk of poststroke early-onset seizures and may also prevent the progression of initial poststroke seizures into chronic epilepsy.
Source: Neurology - August 24, 2015 Category: Neurology Authors: Siniscalchi, A., Mintzer, S. Tags: All Cerebrovascular disease/Stroke, Antiepileptic drugs EDITORIALS Source Type: research

Inpatient Statin Use Is Associated with Decreased Mortality of Acute Stroke Patients with Very Low Low-Density Lipoprotein Cholesterol
To investigate the potential benefits of inpatient statin therapy on mortality of acute stroke patients with very low admission low-density lipoprotein cholesterol (LDL-C) level (
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Bo Song, Yilong Wang, Xingquan Zhao, Liping Liu, Chunxue Wang, Anxin Wang, Wanliang Du, Yongjun Wang, Yuming Xu Source Type: research

Statins Reduced Seizures in Acute Post-Stroke Period
No abstract available
Source: Neurology Today - August 20, 2015 Category: Neurology Tags: Features Source Type: research

Letter by Huang regarding the article, “Statin use increases the risk of depressive disorder in stroke patients: A population-based study”
I read with interest the article by Kang et al. which evaluated the risk for depressive disorder (DD) among stroke patients with statin use [1]. In a retrospective cohort study including 11,218 Chinese patients who had a first-time acute hospitalization for stroke in Taiwan, the authors followed each study subject for a 1-year period, finding that regular statin use was positively associated with the occurrence of DD following stroke. Their findings seem interesting, but I would like to raise 2 concerns.
Source: Journal of the Neurological Sciences - August 14, 2015 Category: Neurology Authors: Jian Huang Tags: Letter to the editor Source Type: research

Letter by Huang regarding article, ''Statin use increases the risk of depressive disorder in stroke patients: a population-based study''
We read with interest the article by Kang et al which evaluated the risk for depressive disorder (DD) among stroke patients with statin use [1]. In a retrospective cohort study including 11,218 Chinese patients who had a first-time acute hospitalization for stroke in Taiwan, the authors followed each study subject for a 1-year period, finding that regular statin use was positively associated with the occurrence of DD following stroke. Their findings seem interesting, but I would like to raise 2 concerns.
Source: Journal of the Neurological Sciences - August 14, 2015 Category: Neurology Authors: Jian Huang Source Type: research

Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes
Conclusions: AIS are missed in patients with younger age with a lower cerebrovascular risk profile and may be masked by other acute conditions. Patients with chameleons present more often with milder strokes or coma, fewer focal signs and cerebellar strokes, and have higher disability and mortality rates at 12 months. These findings may be used to raise awareness in emergency departments to recognize and treat such patients appropriately.
Source: Neurology - August 10, 2015 Category: Neurology Authors: Richoz, B., Hugli, O., Dami, F., Carron, P.-N., Faouzi, M., Michel, P. Tags: Other cerebrovascular disease/ Stroke, Natural history studies (prognosis), Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Statins Reduce Post-Stroke Seizure RiskStatins Reduce Post-Stroke Seizure Risk
New study results suggest the potential for statins to prevent epilepsy in some patients. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - August 5, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Early statin use in ischemic stroke patients treated with recanalization therapy: retrospective observational study
Conclusion: Early statin use after recanalization therapy in ischemic stroke may improve the likelihood of a better functional outcome without increasing the risk of intracranial hemorrhage.
Source: BMC Neurology - July 30, 2015 Category: Neurology Authors: Jihoon KangNayoung KimTae ParkOh BangJi LeeJuneyoung LeeMoon-Ku HanSeong-Ho ParkPhilip GorelickHee-Joon Bae Source Type: research

Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study
Background: Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods: We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin...
Source: BMC Neurology - July 30, 2015 Category: Neurology Authors: Jay ChoiJi LeeTai ParkYong-Jin ChoJong-Moo ParkKyusik KangKyung LeeSoo-Joo LeeYoungchai KoJun LeeJoon-Tae KimKyung-Ho YuByung-Chul LeeJae-Kwan ChaDae-Hyun KimJuneyoung LeeDong-Eog KimMyung JangBeom KimMoon-Ku HanHee-Joon BaeKeun-Sik Hong Source Type: research