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Specialty: Neurology
Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

The influence of statin withdrawal and adherence on stroke outcomes
ConclusionThe suboptimal use of statins is associated with significantly worse clinical outcomes in stroke patients.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

Statin Effects in Atrial Fibrillation-Related Stroke: A Systematic Review and Meta-Analysis
Conclusions: Statin therapy for AF-related stroke may reduce all-cause mortality and improve functional outcomes. Randomized controlled studies are warranted to confirm the effects of statins on the outcomes of AF-related stroke.
Source: Frontiers in Neurology - October 9, 2020 Category: Neurology Source Type: research

Prestroke statin use enhances collateralization in acute ischemic stroke patients.
CONCLUSIONS: Our findings suggest that prestroke statin use was associated with good leptomeningeal collaterals and clinical outcomes in acute ischemic stroke (AIS) patients presenting with occlusion of the middle cerebral artery. However, clinical studies should be conducted to verify this claim. PMID: 32925118 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - September 16, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Statins Use and Outcome of Acute Ischemic Stroke Patients after Systemic Thrombolysis
Conclusion: Our study does not show any significant association between risk of sICH and poor outcome after IVT for patients on prior statin therapy. We also did not find significant association between the risk of sICH and poor outcome after IVT and the intensity of the stain used.Cerebrovasc Dis
Source: Cerebrovascular Diseases - September 14, 2020 Category: Neurology Source Type: research

Statins in primary prevention of poststroke seizures and epilepsy: A systematic review.
CONCLUSIONS: Data from the literature suggest an association between statin use and a reduced risk of ASPSS after ischemic stroke and a reduced risk of PSE after ischemic and hemorrhagic stroke. Although the certainty of the evidence is low, these findings appear promising and worthy of further investigation. PMID: 32916580 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - September 7, 2020 Category: Neurology Authors: Nucera B, Rinaldi F, Nardone R, Lattanzi S, Brigo F Tags: Epilepsy Behav Source Type: research

Effects of statin therapy on outcomes of ischemic stroke: a real-world experience in Brazil
Conclusions: Statins play an important role in the treatment of ischemic stroke, preventing stroke recurrence and cardiovascular events, and improving functional performance.RESUMO Introdu ção: A terapia com estatinas tornou-se um dos avanços mais importantes na prevenção secundária do acidente vascular cerebral (AVC). Objetivo: Fornecer evidências de dados do mundo real para avaliar associações detalhadas entre a prevenção secundária do AVC e o uso de estatinas no Bras il. Métodos: Realizamos um estudo de coorte prospectivo, incluindo pacientes consecutivos com diagnóstico de AVC isquêmico. Os indivíduos f...
Source: Arquivos de Neuro-Psiquiatria - September 2, 2020 Category: Neurology Source Type: research

Effects of High Dose of Atorvastatin for Preventing Periprocedural Ischemic Brain Damage in Patients Undergoing Carotid Artery Stenting (PICAS) in China: A Randomized Controlled Clinical Trial
This study is the first to assess whether high-dose atorvastatin treatment is capable of reducing the incidence of perioperative cerebral ischemic injury in patients of Chinese ethnicity undergoing CAS. These results will offer evidence regarding which statin treatment regimens are more appropriate when treating Chinese patients undergoing CAS in an effort to minimize their risk of any perioperative cerebral ischemic injury.Trial Registration:ClinicalTrials.gov NCT03079115; registered March 14, 2017.
Source: Frontiers in Neurology - August 24, 2020 Category: Neurology Source Type: research

Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae
Intracranial hemorrhage (ICH) acutely and severely damages brain function.1,2 The prognosis of ICH is poor due to the drastic and rapid progression of its pathology, and the lack of effective treatments presents a significant unmet clinical need. Therefore, novel therapeutic agents for ICH have the potential to significantly improve clinical outcomes. The collagenase-induced rodent ICH model is the most commonly used experimental ICH model.3 However, detailed live imaging of hematoma development in rodent models is inherently limited, as rodents are opaque.
Source: Journal of Stroke and Cerebrovascular Diseases - August 13, 2020 Category: Neurology Authors: Shinsuke Nakamura, Yuichi Saito, Takumi Gouda, Takahiko Imai, Masamitsu Shimazawa, Yuhei Nishimura, Hideaki Hara Source Type: research

Use of statins for the secondary prevention of stroke: are we respecting the scientific evidences?
Background: Stroke accounts for approximately as 5.0% of disability-adjusted years of life and 10.0% of all deaths worldwide. Secondary stroke prevention in surviving individuals, which includes the use of statins, reduces atherothrombotic stroke recurrence, complications and mortality. The present study aimed to characterize the Brazilian population with stroke history and estimate the prevalence of statin use as secondary prevention.Methods: This is a population-based cross-sectional study conducted in Brazilian urban areas.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jo ão Paulo Vilela Rodrigues, Lucas Borges Pereira, Maria Olívia Barboza Zanetti, Andréia Turmina Fontanella, Nereida Kilza da Costa Lima, Sotero Serrate Mengue, Leonardo Régis Leira Pereira Source Type: research

Acute ischemic stroke management in Lebanon: obstacles and solutions.
This study assesses the current practices of physicians in Lebanon routinely involved in ischemic stroke (IS) management. We conducted a prospective observational study of patients hospitalized at 8 different Lebanese hospitals in the period August 1, 2015 to July 31, 2016, with a diagnosis of acute stroke. Baseline characteristics and data on diagnostic studies, as well as treatments received during hospitalization and at discharge, were collected and analyzed. Two hundred and three strokes/transient ischemic attacks (TIAs) were recorded but only 173 patients (85%) with ischemic events were included in the study. The pati...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Association between statin use and mortality risks during the acute phase of ischemic stroke in patients admitted to an intensive care unit
Conclusion: Statins and angiotensin converting enzyme inhibitors use during hospitalization were independently associated to a lower rate of all-cause mortality in the first 7 days of intensive care unit admission.Resumo O acidente vascular cerebral (AVC) isqu êmico é uma causa comum de morte. O papel das estatinas na prevenção secundária da fase crônica do AVC isquêmico foi estabelecido. No entanto, as evidências sobre a sua eficácia na fase aguda do AVC isquêmico são limitadas e contraditórias. Objetivo: Avaliar a associação entre o uso de estatinas e o risco de mortalidade durante a fase aguda do AVC isquÃ...
Source: Arquivos de Neuro-Psiquiatria - April 27, 2020 Category: Neurology Source Type: research

Factors associated with medication persistence among ischemic stroke patients: a systematic review.
Conclusions: Stroke patients' medication persistence decreases over time, and persistence on antiplatelets, anticoagulants, and statin was poor. Several factors were associated with medication persistence, and these factors should be considered in future secondary preventative strategies. PMID: 32321382 [PubMed - as supplied by publisher]
Source: Neurological Research - April 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Prevalence and predictors of statin utilization among patient populations at high vascular risk in Ghana
Inadequate implementation of evidence-based preventive measures for individuals at high risk of cardiovascular disease (CVD) will only worsen the current epidemic of CVDs in sub-Saharan Africa. We assessed rates and predictors of statin utilization among two high CVD risk patient populations, people with type 2 diabetes mellitus (T2DM) and those with stroke, encountered across five hospitals in Ghana.
Source: Journal of the Neurological Sciences - April 14, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

Medical Management for Secondary Stroke Prevention
This article reviews the evidence base and recommendations for medical management for secondary stroke prevention. RECENT FINDINGS Recent developments for secondary stroke prevention include evidence to support the use of short-term dual antiplatelet therapy after minor stroke and transient ischemic attack, direct oral anticoagulants for nonvalvular atrial fibrillation, reversal agents for direct oral anticoagulant–associated hemorrhage, and aspirin rather than presumptive anticoagulation with a direct oral anticoagulant for embolic stroke of undetermined source. SUMMARY Most strokes are preventable. The mainstays ...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Positive Influence of Stroke Health Manager on Risk Factors Control and Medication Adherence After Ischemic Stroke
Conclusions: Stroke health manager intervention improved the control of blood pressure, LDL-C, glucose levels and the persistence for secondary prevention medications 3 months after discharge.
Source: Frontiers in Neurology - March 10, 2020 Category: Neurology Source Type: research