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Specialty: Neurology
Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

Utility of treatment with atorvastatin 40 mg plus ezetimibe 10 mg versus atorvastatin 80 mg in reducing the levels of LDL cholesterol in patients with ischaemic stroke or transient ischaemic attack.
CONCLUSIONS: Compared with atorvastatin 80 mg, atorvastatin 40 mg plus ezetimibe 10 mg increases the likelihood of achieving LDLc goals after ischaemic stroke or transient ischaemic attack. Both treatments were safe and well tolerated. PMID: 26916323 [PubMed - in process]
Source: Revista de Neurologia - February 27, 2016 Category: Neurology Authors: Palacio E, Viadero-Cervera R, Revilla M, Larrosa-Campo D, Acha-Salazar O, Novo-Robledo F, Oterino A Tags: Rev Neurol Source Type: research

Inflammatory Markers and Outcomes After Lacunar Stroke: Levels of Inflammatory Markers in Treatment of Stroke Study Clinical Sciences
Conclusions— Among recent lacunar stroke patients, IL-6 and TNF receptor concentrations predict risk of recurrent vascular events, and they are associated with the effect of antiplatelet therapies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Boehme, A. K., McClure, L. A., Zhang, Y., Luna, J. M., Del Brutto, O. H., Benavente, O. R., Elkind, M. S. V. Tags: Ischemic Stroke Clinical Sciences Source Type: research

The effect of decreasing statin's dosage on LDL-C levels after target levels achieved.
CONCLUSION: More patients had LDL-C level more than 100 mg/dL after dosage of statins decreased. We suggested that only for absolute contraindication or adverse effects of statins should we adjust LLT, it is better to maintain the dosage of statins after target level achieved. The impact of lipid profile changed after LLT adjustment on clinical outcomes needs further studied. PMID: 24030088 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Is it reasonable in strictly regulating the use of statins for treatment of patients with ischemic stroke and hyperlipidemia?
Authors: Peng GS PMID: 24030087 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Statins and Intracerebral Hemorrhage: Potential Mechanisms
In a recent publication, Tapia Pérez et al1 have argued, based on some of the previous meta-analyses, that the risk for statin-induced intracerebral hemorrhage (ICH) has been refuted. However, this is a premature and somewhat misleading conclusion, as whether high-dose statin therapy can elicit ICH remains to be a subject of contention among researchers and clinicians.2 In fact, according to the most recent guidelines by the American Stroke Association for the management of ICH, the question of whether statin therapy should be continued in patients remains elusive.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2015 Category: Neurology Authors: Shahram Eisa-Beygi, Suzan El-Rass Tags: Letter to the Editor Source Type: research

Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation-Related Stroke: A Population Study Clinical Sciences
Conclusions— AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Hayden, D. T., Hannon, N., Callaly, E., Ni Chroinin, D., Horgan, G., Kyne, L., Duggan, J., Dolan, E., O'Rourke, K., Williams, D., Murphy, S., Kelly, P. J. Tags: Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Effect of atorvastatin co ‐treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke
International Journal of Stroke,Volume 10, Issue 8, Page E90-E91, December 2015.
Source: International Journal of Stroke - November 18, 2015 Category: Neurology Source Type: research

Effect of atorvastatin co‐treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke
Source: International Journal of Stroke - November 18, 2015 Category: Neurology Authors: Atsushi Mizuma, Kazuyuki Iijima, Saori Kohara, Mie Shimizu, Ryoko Imazeki, Tsuyoshi Uesugi, Yoichi Ohnuki, Shunya Takizawa Tags: Letter to the editor Source Type: research

Effect of atorvastatin co ‐treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke
Source: International Journal of Stroke - November 17, 2015 Category: Neurology Authors: Atsushi Mizuma, Kazuyuki Iijima, Saori Kohara, Mie Shimizu, Ryoko Imazeki, Tsuyoshi Uesugi, Yoichi Ohnuki, Shunya Takizawa Tags: Letter to the editor Source Type: research

Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry.
This study investigated the effects of statins on the recovery of NA neuron circuitry and its function after transient focal cerebral ischemia (tFCI). Using the wheat germ agglutinin (WGA) transgene technique combined with the recombinant adenoviral vector system, NA-specific neuronal pathways were labeled, and were identified in the locus coeruleus (LC), where NA neurons originate. NA circuitry in the atorvastatin-treated group recovered faster than in the vehicle-treated group. The damaged NA circuitry was partly reorganized with the gradual recovery of autonomic dysfunction and neurobehavioral deficit. Newly proliferate...
Source: Neural Plasticity - October 11, 2015 Category: Neurology Authors: Cho KJ, Cheon SY, Kim GW Tags: Neural Plast Source Type: research

Potential role of statins in the intracerebral hemorrhage and subarachnoid hemorrhage.
Abstract Statins are used in primary and secondary prevention of cardiovascular episodes. Most of recent studies regard ischemic stroke. There are more emerging results of studies suggesting usefulness of these drugs in the other types of stroke e.g. intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). Searching for new methods of treatment is important, because both ICH and SAH lead to poor prognosis and severe psychomotor disability. The unquestionable role of inflammatory factors in the pathogenesis of these disorders justifies considering statin treatment. Previous results are contradictory, thus ...
Source: Neurologia i Neurochirurgia Polska - September 19, 2015 Category: Neurology Authors: Kotlęga D, Gołąb-Janowska M, Masztalewicz M, Ciećwież S, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

Meta-analysis of Statin Use for the Acute Therapy of Spontaneous Intracerebral Hemorrhage
Growing evidence demonstrates the neuroprotective effects of statins, and the risk to develop an intracerebral hemorrhage (ICH) using statins has been refuted. However, some controversy remains regarding their role in the acute phase after ICH onset. Therefore, we performed a systematic review to investigate this issue.
Source: Journal of Stroke and Cerebrovascular Diseases - September 16, 2015 Category: Neurology Authors: J. Humberto Tapia Pérez, O. Can Yildiz, Thomas Schneider, Christopher Nimsky Source Type: research

Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Life‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena Hänninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research