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Specialty: Neurology
Therapy: Statin Therapy

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Total 360 results found since Jan 2013.

Atorvastatin Treatment and Carotid Plaque Morphology in First-ever Atherosclerotic Transient Ischemic Attack/Stroke: A Case–Control Study
A relationship between echolucency of carotid plaques and the consequent risk of ipsilateral ischemic stroke has been observed. An aggressive lipid-lowering therapy may increase the echogenicity of carotid plaque in patients with elevated low-density lipoprotein cholesterol levels. The aim of this study is to prospectively evaluate the long-term effect of high-dose atorvastatin on carotid plaque morphology in patients with first-ever transient ischemic attack or stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2014 Category: Neurology Authors: Pasquale Marchione, Claudio Vento, Manuela Morreale, Chiara Izzo, Andrea Maugeri, Federica Manuppella, Tommaso Romeo, Patrizia Giacomini Source Type: research

Subsequent Vascular Events after Ischemic Stroke: The Japan Statin Treatment Against Recurrent Stroke—Longitudinal
We undertook a multicenter cohort observational study to investigate the frequency and type of subsequent vascular events after an ischemic stroke and to compare the rates of vascular events between patients with and without hyperlipidemia.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2014 Category: Neurology Authors: Eiichi Nomura, Akifumi Suzuki, Isao Inoue, Jyoji Nakagawara, Kazuo Takahashi, Tetsuya Takahashi, Yasuhiro Manabe, Chiaki Yokota, Kazunori Okada, Tetsuhiro Nishihara, Yasumasa Yamamoto, Koichi Noda, Shinichi Takahashi, Setsuro Ibayashi, Makoto Takagi, Kazu Source Type: research

The Effects of Previous Statin Treatment on Plasma Matrix Metalloproteinase-9 Level in Chinese Stroke Patients Undergoing Thrombolysis
It is unclear whether previous statin therapy influences the prognosis, hemorrhagic transformation, and plasma matrix metalloproteinases (MMP)-9 levels in Chinese stroke patients receiving intravenous thrombolysis. We conduct a prospective cohort study of 193 patients treated with intravenous thrombolysis. All the enrolled patients were divided into 2 groups (the control group and the statin group), according to the previous history of statin use. The plasma MMP-9 levels were detected before and at 6 hours, 12 hours, 24 hours, and 72 hours after intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2014 Category: Neurology Authors: Hong-Dong Zhao, Ying-Dong Zhang Source Type: research

Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis Clinical Sciences
Conclusions— Our findings indicate a higher risk of sICH and PH after intravenous thrombolysis when multiple CMBs are present, with a graded relationship to increasing baseline CMB number.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Dannenberg, S., Scheitz, J. F., Rozanski, M., Erdur, H., Brunecker, P., Werring, D. J., Fiebach, J. B., Nolte, C. H. Tags: Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis Clinical Sciences Source Type: research

Effect of High-Dose Atorvastatin on Renal Function in Subjects With Stroke or Transient Ischemic Attack in the SPARCL Trial Clinical Sciences
Conclusions— This post hoc analysis suggests that atorvastatin treatment may improve renal function in patients with prior stroke or transient ischemic attack with and without chronic kidney disease, and that atorvastatin treatment may prevent eGFR decline in patients with stroke and diabetes mellitus. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00147602.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Amarenco, P., Callahan, A., Campese, V. M., Goldstein, L. B., Hennerici, M. G., Messig, M., Sillesen, H., Welch, K. M. A., Wilson, D. J., Zivin, J. A. Tags: Lipids, Secondary prevention, Cerebrovascular disease/stroke Clinical Sciences Source Type: research

Demographic and Clinical Predictors of Leptomeningeal Collaterals in Stroke Patients
Background: Leptomeningeal collaterals improve outcome after stroke, including reduction of hemorrhagic complications after thrombolytic or endovascular therapy, smaller infarct size, and reduction in symptoms at follow-up evaluation. The purpose of this study was to determine the demographic and clinical variables that are associated with a greater degree of cerebral collaterals.Methods: Clinical data of patients presenting with M1 occlusions of the middle cerebral artery (MCA) and associated computed tomography angiography studies after admission from 3 separate institutions were retrospectively compiled (n = 82). Occl...
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Nitin Malik, Qinghua Hou, Achala Vagal, James Patrie, Wenjun Xin, Patrik Michel, Ashraf Eskandari, Tudor Jovin, Max Wintermark Tags: Original Articles Source Type: research

Endovascular treatment of critical basilar stenosis with a Solitaire ® stent device: a first experience in our centre.
CONCLUSIONS. As far as we know, this is the first case of critical stenosis of the basilar artery being treated by placement of a Solitaire® stent to be reported in the literature. PMID: 25030071 [PubMed - in process]
Source: Revista de Neurologia - July 19, 2014 Category: Neurology Authors: Mulero P, Cortijo-Garcia E, Ruiz-Pinero M, Perez-Fernandez S, Arenillas-Lara JF, Martinez-Galdamez M Tags: Rev Neurol Source Type: research

Prestroke Statins, Progression of White Matter Hyperintensities, and Cognitive Decline in Stroke Patients with Confluent White Matter Hyperintensities
In this study, we investigated the hypothesis that prestroke statin use would reduce the progression of WMH and/or cognitive decline among stroke patients with confluent WMH. Patients (n = 100) were participants of the VITAmins To Prevent Stroke magnetic resonance imaging substudy. All patients had confluent WMH on magnetic resonance imaging at baseline. Eighty-one patients completed the 2-year follow-up. We assessed general cognition and executive function using the mini-mental state examination and Mattis dementia rating scale–initiation/perseveration subscale, respectively. We compared the change in volume of WMH ...
Source: Neurotherapeutics - July 1, 2014 Category: Neurology Source Type: research

Stroke in Patients With Aortic Stenosis: The Simvastatin and Ezetimibe in Aortic Stenosis Study Clinical Sciences
Conclusions— In patients with aortic stenosis not prescribed oral anticoagulation, atrial fibrillation, AVR with concomitant coronary artery bypass grafting, and CHA2DS2-VASc score were the major predictors of stroke. Incident stroke was strongly associated with mortality. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00092677.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Greve, A. M., Dalsgaard, M., Bang, C. N., Egstrup, K., Ray, S., Boman, K., Rossebo, A. B., Gohlke-Baerwolf, C., Devereux, R. B., Kober, L., Wachtell, K. Tags: Thrombosis risk factors, CV surgery: valvular disease, Acute Cerebral Infarction Clinical Sciences Source Type: research

Statins Improve Survival in Patients With Cardioembolic Stroke Brief Reports
Conclusions— Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Choi, J.-Y., Seo, W.-K., Kang, S. H., Jung, J.-M., Cho, K.-H., Yu, S., Oh, K. Tags: Cerebrovascular disease/stroke, Embolic stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology Comments and Opinions
Source: Stroke - May 27, 2014 Category: Neurology Authors: Eisa-Beygi, S., Wen, X.-Y., Macdonald, R. L. Tags: Cerebrovascular disease/stroke, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Intracerebral Hemorrhage Comments and Opinions Source Type: research

Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque
Conclusion: Serum LDL and total cholesterol were associated with acutely symptomatic carotid plaque FDG uptake, supporting experimental data suggesting lipids may promote plaque inflammation, mediating rupture and clinical events.
Source: Neurology - May 12, 2014 Category: Neurology Authors: Chroinin, D. N., Marnane, M., Akijian, L., Merwick, A., Fallon, E., Horgan, G., Dolan, E., Murphy, S., O'Rourke, K., O'Malley, K., O'Donohoe, M., McDonnell, C., Noone, I., Barry, M., Crowe, M., Kavanagh, E., O'Connell, M., Kelly, P. J. Tags: PET, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model
Abstract Finding an efficient neuroprotectant is of urgent need in the field of stroke research. The goal of this study was to test the effect of acute simvastatin administration after stroke in a rat embolic model and to explore its mechanism of action through brain proteomics. To that end, male Wistar rats were subjected to a Middle Cerebral Arteria Occlusion and simvastatin (20 mg/kg s.c) (n = 11) or vehicle (n = 9) were administered 15 min after. To evaluate the neuroprotective mechanisms of simvastatin, brain homogenates after 48 h were analyzed by two‐dimensional fluorescence Difference in Gel Electrophoresi...
Source: Journal of Neurochemistry - April 30, 2014 Category: Neurology Authors: Mireia Campos‐Martorell, Nelida Salvador, Marta Monge, Francesc Canals, Lidia García‐Bonilla, Mar Hernández‐Guillamon, María Irene Ayuso, Pilar Chacón, Anna Rosell, Alberto Alcazar, Joan Montaner Tags: Original Article Source Type: research

Incidence, Trends, and Predictors of Ischemic Stroke 30 Days After an Acute Myocardial Infarction Clinical Sciences
Conclusions— The incidence of ischemic stroke within 30 days of an AMI has decreased during the period 1998 to 2008. This decrease is associated with increased use of acetylsalicylic acid, P2Y12 inhibitors, statins, and percutaneous coronary intervention.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Kajermo, U., Ulvenstam, A., Modica, A., Jernberg, T., Mooe, T. Tags: Risk Factors, Acute myocardial infarction, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients Clinical Sciences
Conclusions— The presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy. Specific therapeutic interventions should now be trialed to address this residual risk.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Sirimarco, G., Labreuche, J., Bruckert, E., Goldstein, L. B., Fox, K. M., Rothwell, P. M., Amarenco, P., on behalf of the PERFORM and SPARCL Investigators and Committees, Bousser, Chamorro, Ford, Fox, Fisher, Hennerici, Mattle, Rothwell, Callahan, Goldste Tags: Acute Cerebral Infarction, Primary and Secondary Stroke Prevention, Other Stroke Treatment - Medical, Transient Ischemic Attacks Clinical Sciences Source Type: research