Medication Adherence and Stroke Prevention: What Real World Data Tells Us.
Authors: Hsieh CY Abstract Medication adherence, by definition,(2) is "the extent to which a patient acts in accordance with the prescribed interval and dose of a dosing regimen." Poor medication adherence can interfere with the ability to treat many diseases, leading to greater complications and a lower quality of life.(3) In this issue of Acta Neurologica Taiwanica, Chen et al.(4) presented the inverse association between adherence of antithrombotic agents and poor outcomes after a first-ever ischemic stroke. The findings were consistent with Sung, et al.(5) that medication nonadherence are prevalent in...
Source: Acta Neurologica Taiwanica - February 7, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Potential Mechanism and Pathways in Cerebral Ischemia- Reperfusion Injury: Therapeutic GLANCE.
Authors: Amini F, Zayeri ZD, Nejad KH Abstract Abtract Cerebral ischemia-reperfusion injury is a progressive disease that results in the lack of oxygen and nutrients needed for cellular metabolism in neurons due to blood flow disorders. The pathogenesis of this disease is different; however, it has been shown that the onset of inflammation interacts with I/R through the production of active oxygen species and increases the apoptosis of the neural cells. Therefore, different signaling pathways interfere with the induction of inflammation and the production of active oxygen species. Therefore, the common point of the...
Source: Acta Neurologica Taiwanica - February 7, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Low Persistence of Antithrombotic Agents is Associated with Poor Outcomes after First-ever Acute Ischemic Stroke.
This study investigated the time-trend persistence with antithrombotic agents (AT) and assessed the impact of AT persistence on outcome events and adverse events (AE) within two years after first-ever acute ischemic stroke (IS). METHODS: Using Taiwan's National Health Insurance claims dataset, 7,341 IS subjects hospitalized between 2001 and 2005 with AT prescribed at discharge and survived at least 3 months were followed up for 2 years. Time-trends of AT usage were analyzed. Medication persistence was assessed as the proportion of days covered (PDC) for filled prescription, and categorized into low, intermediate and hi...
Source: Acta Neurologica Taiwanica - February 7, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Recurrent Epistaxis of Unknown Origin: the Role of Imaging.
We report two cases of patients who presented to the Emergency Room (ER) with a history of recurrent epistaxis. Conservative treatment was provided to both patients and the most common causes of bleeding were excluded. Patients underwent radiological examinations that revealed the presence of an Intracavernous Carotid Artery Aneurysm (ICAA) extending into the sphenoid sinus through the erosion of postero-lateral bony wall. Aneurysms rupture caused massive nasal bleeding. The purpose of our case report is to illustrate as a very common symptom like epistaxis, in a small number of cases can be underestimated: rare and severe...
Source: Acta Neurologica Taiwanica - February 7, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Orofacial Pain and Menstrually Related Migraine.
CONCLUSION: A thorough history and examination, as well as an understanding of migraine headaches, is necessary to differentiate odontogenic pain and migraine headaches. Key Words: menstrually related migraine, orofacial pain, ICHD-3, headache. PMID: 32026457 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 7, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Auditory Brainstem Response in Patients with Tinnitus Associated with Vitamin B12 Deficiency.
CONCLUSION: These results support that ABR findings can be influenced in vitamin B12 deficiency patients having tinnitus. More detailed studies are needed in tinnitus associated with vitamin B12 deficient patients. Key words: Auditory brainstem response, Tinnitus, Vitamin B12 deficiency, Neurophysiology, Low amplitude. PMID: 32002975 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Association of Paraoxonse1 (PON1) Genotypes with the Activity of PON1 in Patients with Parkinson's Disease.
CONCLUSION: In the current study, we reported associations between PON1 polymorphisms (55, 192) and enzyme activities in Parkinson's disease as there was a significant reduction in PON1 levels in patients with Parkinson compared with healthy. Taken together, paraoxonase enzyme in subjects with different genotypes could be a potential biomarker for determining the severity and prognosis of Parkinson. However, more studies are needed to clarify its clinical values. Key words: Parkinson's disease; paraoxonase1; Polymorphism. PMID: 32002976 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

High Resistance Index in the Feeding Arteries of Indirect Carotidcavernous Fistulae: A Diagnostic Pitfall.
Authors: Lin WT, Chen BA Abstract Carotid-cavernous fistulae (CCFs) are classified into the direct and indirect types, which can be attributed to trauma, atherosclerosis, hypertension, diabetes mellitus, pregnant or postmenopausal status(1). Cerebral angiography is the gold standard for the diagnosis of CCFs. Doppler ultrasound, which typically reveals increased blood flow velocity and decreased resistance index (RI) in the feeding arteries, can assist in the diagnosis(2-3). We herein report a case of indirect CCF presenting with high RI in the feeding arteries, which is mainly attributed to the generalized atheros...
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Ictal-Interictal Comparison of FDG-PET Findings in Sporadic Hemiplegic Migraine.
CONCLUSION: These findings reveal an increase in metabolism in the motor cortex during general cortical dysfunction in the frontal and occipital cortices in SHM. Key words: FDG-PET, hemiplegic migraine, migraine, positron emission tomography, SISCOM. PMID: 32002978 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Acute Ischemic Stroke.
Authors: Rossi UG, Ierardi AM, Cariati M Abstract A 77-year-old woman with a history of hypertension developed acute onset of aphasia and right hemiplegia and hemisensory loss. She was urgently referred to emergency department. Cerebral multidetector computed tomographic angiography (MD-CTA) revealed an acute ischemic stroke due to the occlusion of the left middle cerebral artery (Figure 1). Since the symptoms started three hours previously, the patient was candidate for mechanical thrombectomy. The patient then performed a selective digital subtraction angiography (DSA) of the left internal carotid artery that con...
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Cannabis and Neuropsychiatric Disorders: An Updated Review.
Authors: Chayasirisobhon S Abstract Cannabis plant has the scientific name called Cannabis sativa L. Cannabis plant has many species, but there are three main species including Cannabis sativa, Cannabis indica and Cannabis ruderalis. Over 70 compounds isolated from cannabis species are called cannabinoids (CBN). Cannabinoids produce over 100 naturally occurring chemicals. The most abundant chemicals are delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD). THC is psychotropic chemical that makes people feel "high" while CBD is nonpsychotropic chemical. However, cannabinoid chemicals are not found only...
Source: Acta Neurologica Taiwanica - December 25, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Cerebellar PACNS in an Elderly Patient Present as a Tumor-Like Mass Lesion: A case Report.
CONCLUSION: Due to variations in clinical presentation and nonspecific findings on imaging studies, PACNS is not easily diagnosed, especially in the aged population. PACNS should be considered as one of the differential diagnoses of any CNS dysfunction. PACNS is also an exclusionary diagnosis, so although brain biopsy is limited for its low sensitivity, its application is still important to exclude the possibility of other diseases. Although there have been reports of fulminant cases, PACNS can be treated successfully with immunosuppressant as maintaining therapy. PMID: 31867705 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 25, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Adult onset MELAS Syndrome Presenting as A Mimic of Herpes Simplex Encephalitis.
CONCLUSION: The clinical presentation and imaging studies of MELAS in adults are variable and may mimic those of HSE. Antiviral therapy should be administered until the diagnosis of MELAS is definitive. Infection and metformin may have also precipitated MELAS manifestation in this patient. Clinicians should avoid potential mitochondrial-toxic drugs in these patients. PMID: 31867706 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 25, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

A Case of Fabry Disease Presenting with Young Stroke and Fever.
Authors: Wu LC, Chiang CT, Lee KF Abstract Although it is known that Fabry disease should be included in the differential diagnosis of young stroke and fever of unknown origin, it has not been reported in the literature of stroke with fever as the presentation of Fabry disease. This is relevant because stroke with fever may misguide the differential diagnosis. Here we present a young stroke patient with fever. DWI of brain MRI revealed acute multiple infarctions. Due to the fever, infectious and inflammatory origins such as infective endocarditis and autoimmune diseases were examined first. However, we could not id...
Source: Acta Neurologica Taiwanica - December 25, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Duplication of Intracavernous Internal Carotid Artery.
Authors: Rebella G, Castaldi A, Rossi UG Abstract ation. No significant past medical history except for pharmacologically controlled mild hypertension. During the neurological examination the patient appeared alert, oriented and showed no deficit of strength, sensitivity and coordination. An expressive temporary aphasia was confirmed and Transient Ischemic Attacks (TIA) was suspected. Cranial Computed Tomography Angiography (CTA) showed hypoplasia of left Internal Carotid Artery (ICA) with a focal duplication in the intracavernous segment (Figure 1, arrowhead). Circle of Willis appears to be regular, with the left ...
Source: Acta Neurologica Taiwanica - December 25, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

New insights of the fever following subarachnoid hemorrhage and introducing a new thermoregulator like structure in choroid plexuses; preliminary study.
CONCLUSIONS: We introduce a thermo regulator like structure, describe a new syndrome. In addition, it was noted thatwater-filled vesicles of CP are increased, brain temperature in nearly normal in the early phase of SAH due to likely irritation of vagal nerves. However in the late phase, mean number of water-filled vesicles numbers decreased in accordance with increased brain temperature with degenerative changes of the nodose ganglion. PMID: 31321759 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 21, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Klebsiella pneumoniae brain abscesses in an elderly patient without clinically evident neurological signs and symptoms.
CONCLUSION: Cranial MRI should be performed to identify the presence of brain abscesses in elderly patients with K. pneumoniae bloodstream infections but without clinically evident neurological signs or symptoms. Serial MRI studies are important to monitor the therapeutic course. PMID: 31321760 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 21, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Effects of surgical treatment for classical trigeminal neuralgia with concomitant persistent facial pain.
CONCLUSION: Microvascular decompression may be more effective than radiofrequency thermocoagulation for patients with classical trigeminal neuralgia with concomitant persistent facial pain. PMID: 31321761 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 21, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Cerebral microbleeds associated with critical illness.
Authors: Kuo KH, Yu YB, Lai TH PMID: 31321762 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 21, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Epilepsy versus Asthma Perceptions among Preschool Teachers in Taiwan-Past versus Present.
Authors: Chiou HH, Hsieh LP PMID: 31304570 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 17, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Renal Function Estimates and Dosing of Direct Oral Anticoagulants in Stroke Patients with Atrial Fibrillation: An Observational Study.
CONCLUSION: Although substituting eGFR for CrCl carries potential risks of DOAC overdosing in patients with AF, the effect might be offset by clinicians' predilection for lower dosage in this stroke cohort. PMID: 31304571 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 17, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Perceived Social Stigma in Patients with Multiple Sclerosis: A Study from Iran.
CONCLUSION: Recognition of the impacts of perceived stigma on various aspects of the patients' lives are necessary to find appropriate strategies to deal with stigma and its consequences. Training programs can improve the patients' skills for coping with stigma. Furthermore, programs aimed to upgrade public knowledge and reduce the negative attitudes toward the disease should be promoted. PMID: 30315555 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Subdural Hemorrhage in Patients with End-Stage Renal Disease Requiring Dialysis: A Single-Center Study.
CONCLUSION: Among ESRD patients with SDH, the 30-day mortality rates were similar between EHD and CPD groups. MAP change during dialysis might be an important modifiable risk factor for 30-day mortality, though the effect was not significant in multivariate analysis. Further prospective studies with larger sample size are warranted. PMID: 30315556 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Delayed Endovascular Thrombectomy in a Patient Suffering from Stroke in Progression after Intravenous Thrombolytic Therapy.
CONCLUSION: In LAO patients, directly proceeding EVT following IVT may not be hesitated. In addition, while LAO patients with incomplete IV-tPA treatment responses result in transient improvement of neurological symptoms but later reversed, EVT may be a potential rescue therapy in carefully selected patients. PMID: 30315557 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Recurrent Hypoglycemia-induced Hemiballism with Self-limited after Sleep - A Case Report.
CONCLUSION: We suppose that sleep modify the glucose counterregulatory responses with increased growth hormone, which salvage hypoglycemic status in our presented case. With this report, we would like to draw clinicians' attention to including the treatable hypoglycemia state in the differential diagnosis of episodic involuntary movements. PMID: 30315558 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Autologous Hematopoietic Stem Cell Transplantation for the Treatment of Neuromyelitis Optica in Singapore.
Authors: Hoay KY, Ratnagopal P PMID: 30315559 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Clinical Characteristics and Therapeutic Outcomes of Postneurosurgical Bacterial Meningitis in Elderly Patients over 65: A Hospital-based Study.
CONCLUSIONS: Elderly patients accounted for 30.9% of all cases of ABM, of whom 49.1% had postneurosurgical ABM. The clinical characteristics of the elderly patients with postneurosurgical ABM were non-specific, and cerebrospinal fluid studies were needed to confirm the diagnosis. The mortality rate of this group of patients was high, and septic shock was an important prognostic factor. The clinical and laboratory features and therapeutic outcomes were different between the elderly patients with postneurosurgical and spontaneous ABM. PMID: 30315560 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Quality of Life and Psychological Distress of Caregivers' of Stroke People.
CONCLUSIONS: Caregivers of people with stroke experience mental disorders and burden negatively affecting their quality of life. Therefore, there is a need to implement strategies which should aim to the management of these problems for the welfare of both patients and their caregivers. PMID: 30315561 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

A Review of Infantile Vanishing White Matter Disease and A New Mutation.
Authors: Yavuz H PMID: 30315562 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Clinical and Electrophysiological Analysis of Chronic Eyelid Twitching.
CONCLUSION: Although CET has been considered as a benign, transient, somewhat physiological phenomenon, our study may suggest it can be a disease entity with minor facial nerve neuropathy. PMID: 30315563 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Electroencephalographic periodic discharges in Metronidazoleinduced encephalopathy: a case report.
Authors: Wang HH, Kwan SY PMID: 30315564 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - October 15, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Analysis of Clinical and Metabolic Profile of Acute Neuromuscular Weakness Related to Hypokalemia.
CONCLUSION: In half of the patients, secondary causes were identified. After IHP, the DHP emerged as second common cause in post monsoon season. SG had significantly lower serum potassium, recurrent attack and more time to improve. PMID: 29468618 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Outcome of Myasthenia gravis treated with high-dose prednisolone and azathioprine: A single centre ambispective study from India.
CONCLUSION: Aggressive therapy with prednisolone plus azathioprine induces remission in a high percentage of patients with generalized MG. PMID: 29468619 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Malnutrition in Acute Stroke Patients Stratified by Stroke Severity- A Hospital Based Study.
CONCLUSION: Nutritional status was poor in stroke patients across all stroke severities within weeks. Further longitudinal outcome studies to identify the poor outcome and the evolution of nutritional status are warranted. PMID: 29468620 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Fusarium Brain Abscess in a Patient with Diabetes Mellitus and Liver Cirrhosis.
CONCLUSION: CNS Fusarium infection should be considered when an immunocompromised patient presenting with fever, conscious change, cranial nerve palsies, and angioinvasion suggested by brain imaging. To properly manage the disease, early effective antifungal therapy and neurosurgical intervention are important. PMID: 29468621 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Diagnosis of Chronic Leptomeningitis by Using Meningeal Biopsy: A Case Report of Tuberculous Meningitis.
Authors: Huang LK, Lin CM, Chen CJ, Hu CJ PMID: 29468622 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Isolated Basilar Artery Dissection with Ischemic Stroke: Report of 4 Cases.
CONCLUSION: Isolated BAD may cause variable clinical manifestations and the outcome can be favorable. Application of different and advanced imaging studies with serial image follow-up are useful to confirm the diagnosis. PMID: 29468623 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - February 24, 2018 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Sporadic Nocturnal Frontal Lobe Epilepsy--Report on Two Cases and Review of the First Taiwanese Series of 10 Cases.
CONCLUSION: The two newly reported cases that were integrated into the first series of 10 Taiwanese patients with sporadic NFLE corresponds closely to previously reported sporadic and familial NFLE among Caucasian patients in Europe and North America. There was a high rate of sustained anticonvulsant treatment efficacy, particularly with carbamazepine, oxcarbamazepine, and topiramate. Also, 4 of the 10 patients had hypermotor manifestations (in part) of their NFLE (including one of the two newly reported cases), which are discussed in regards to the newly published entity of "Sleep-Related Hypermotor Epilepsy(1)."...
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Acute Onset of Parkinsonism an End-Stage Renal Disease Patient.
CONCLUSION: ODS may develop in patient with risk factors regardless of change in serum sodium concentration. Brain MRI could help in early detection of the demyelination. Secondary parkinsonism may occur as a rare manifestation of ODS. Supportive treatment, monitoring of vital signs and neurological deficits are warranted. Dopaminergic agent may be beneficial in symptomatic control. PMID: 29250757 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Refractory Facial Paralysis: A Case Report.
CONCLUSION: Salivary gland malignancy should be considered in patients with acute and subacute facial nerve paralysis, in addition to Bell's palsy. Brain imaging with contrast agents should be performed for differential diagnosis. PMID: 29250758 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Orbital Cellulitis Presenting as Giant Cell Arteritis: A Case Report.
CONCLUSION: Orbital cellulitis should be considered in patients with progressive headache over the unilateral temporal and periorbital areas, in addition to giant cell arteritis. Brain imaging with contrast should be performed for detecting occult orbital infection or other intracranial etiologies. PMID: 29250759 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Rapid Progression of Vertebral Artery Occlusion After Radiotherapy for Nasopharyngeal Carcinoma.
Authors: Chen TC, Tang SC, Jeng JS PMID: 29250760 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Medical Treatment Guidelines for Acute Migraine Attacks.
Authors: Hsu YC, Lin KC, Taiwan Headache Society TGSOTHS Abstract In 2015, the American Headache Society (AHS) amended the treatment guideline of acute migraine based on evidence-based medicine (EBM) that all triptans in any form of preparations, acetaminophen, and non-steroid anti-inflammation drugs-NSAID (aspirin, diclofenac, ibuprofen, naproxen), sumatriptan/naproxen, combined acetaminophen/aspirin/caffeine are considered effective (Level A). Previously effective drugs as prochlorperazine, and dihydroergotamine-DHE (excluded inhaled form) were downrated to probable effective (Level B). Taiwan Headache Society pu...
Source: Acta Neurologica Taiwanica - December 19, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Intravenous Alteplase for Acute Ischemic Stroke in Taiwan: Can We Expand the National Health Insurance's Reimbursement Criteria?
In conclusion, the non-reimbursement group in Su, et al(3). is a mixture of stroke patients with very heterogeneous characteristics. With the advances of imaging selection modalities and new hyperacute treatment options nowadays, they should no longer be considered as an identical group of patients. We strokologists, as an emerging subspecialists, should devote more in dedicated and individualized selection of stroke patients for appropriate early recanalization therapy to improve their outcomes. Conflict of Interest Disclosure: I received speaker fee from Boehringer Ingelheim for Actilyse® (http://grsp2013.innovarad.t...
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Safety and Effectiveness of Intravenous Thrombolysis for Acute Ischemic Stroke Outside the Coverage of National Health Insurance in Taiwan.
Conclusion: In stroke patients treated with intravenous thrombolysis according to the AHA/ASA guidelines, the outcomes were comparable between the reimbursement and non-reimbursement groups. PMID: 28752508 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

The Association of Apolipoprotein E Allele 4 Polymorphism with the Recovery of Sleep Disturbance after Mild Traumatic Brain Injury.
CONCLUSION: APOE4 is not associated with the recovery of sleep disturbance after mTBI. PMID: 28752509 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Comparison of LCModel and SAGE in Analysis of Brain Metabolite Concentrations-A study of Patients with Mild Cognitive Impairment.
CONCLUSION: Both methods were acceptable in estimating brain metabolite concentration ratios. However, LCModel was marginally more accurate than SAGE because of its full automation, basis set, and user independency. PMID: 28752510 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Wernicke's Encephalopathy after Bariatric Surgery with Atypical Magnetic Resonance Imaging: A Case Report.
Authors: Chen BA, Chen LC Abstract Wernicke's encephalopathy (WE) is a disease caused by thiamine deficiency related to alcoholism, hyperemesis, or thiamine malabsorption. The clinical manifestations of WE are mental change, ataxia, and ophthalmoplegia. The typical magnetic resonance imaging (MRI) findings of WE are symmetrical involvement of medial thalamus, periventricular region of the third ventricle, periaqueductal area, and mammillary body. The atypical MRI findings are more common in nonalcoholic WE. Since the increasing population of obesity and the preference of weight loss surgery, the risk of developing ...
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Medical Treatment Guidelines for Preventive Treatment of Migraine.
Authors: Huang TC, Lai TL, Taiwan Headache Society TGSOTHS Abstract The Treatment Guideline Subcommittee of the Taiwan Headache Society evaluated the medications currently used for migraine prevention in Taiwan. We assessed the results of new published drug trials, information from medical database and referred to the latest guidelines published. After comprehensive discussion, we proposed Taiwanese consensus about the preventive treatment for migraine including recommendation levels, strength of evidences, and related prescription information regarding dosage and adverse effects. This guideline is updated from ear...
Source: Acta Neurologica Taiwanica - July 30, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.
Authors: Chen CH, Joshi AU, Mochly-Rosen D Abstract Aldehydes-induced toxicity has been implicated in many neurodegenerative diseases. Exposure to reactive aldehydes from (1) alcohol and food metabolism; (2) environmental pollutants, including car, factory exhausts, smog, pesticides, herbicides; (3) metabolism of neurotransmitters, amino acids and (4) lipid peroxidation of biological membrane from excessive ROS, all contribute to 'aldehydic load' that has been linked to the pathology of neurodegenerative diseases. In particular, the α, β-unsaturated aldehydes derived from lipid peroxidation, 4-hydroxynon...
Source: Acta Neurologica Taiwanica - April 8, 2017 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research