Treatment with istradefylline for postural abnormalities in Parkinson's disease.
AB Abstract INTRODUCTION: In the current edition, Fujioka and colleagues report on four Japanese patients with Parkinson disease (PD) and severe postural abnormalities treated with istradefylline (adenosine A2A receptor antagonist); further, dopamine agonists were with- drawn. Three patients experienced significant improvements of postural abnormalities. CLINICAL REFLECTIONS: Postural abnormalities in PD include camptocormia, antecollis, lateral trunk flexion, and scoliosis. They may be very pronounced and significantly reduce quality of life. The therapy of postural deformities in PD is currently disappoint...
Source: Neurologia i Neurochirurgia Polska - September 1, 2019 Category: Neurology Authors: Deutschländer AB Tags: Neurol Neurochir Pol Source Type: research

Direct oral anticoagulants in the treatment of cerebral venous sinus thrombosis: a single institution's experience.
CONCLUSIONS AND CLINICAL IMPLICATIONS: DOACs could be an alternative to VKA in CVST patients. PMID: 31454061 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 27, 2019 Category: Neurology Authors: Rusin G, Wypasek E, Papuga-Szela E, Zuk J, Undas A Tags: Neurol Neurochir Pol Source Type: research

A new therapeutic strategy with istradefylline for postural deformities in Parkinson's disease.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Postural deformities caused by dopamine agonists generally improve less than two weeks after dopamine agonist withdrawal. Given the response time in the present study, the response was unlikely to be caused solely by dopamine agonist withdrawal. Istradefylline can be a potential therapeutic option; however, appropriate selection of patients for treatment with istradefylline is warranted. PMID: 31441493 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Fujioka S, Yoshida R, Nose K, Hayashi Y, Mishima T, Fukae J, Kitano K, Kikuchi H, Tsuboi Y Tags: Neurol Neurochir Pol Source Type: research

Epidemiological analysis of hospitalisations due to recurrent stroke in the Silesian Province, Poland, between 2009 and 2015.
Abstract BACKGROUND AND AIM: There is a lack of recent epidemiological studies on recurrent stroke (RS) in Poland. The aim of this study was to analyse all hospitalisations related to RS in Silesia - an industrial region covering 12% of the Polish population. MATERIAL AND METHODS: We carried out statistical analysis of data contained in stroke questionnaires transferred to the Polish National Health Fund by hospitals in Silesia, Poland, between 2009 and 2015. RESULTS: In the analysed period, the number of RS hospitalisations in Silesia was 18,063 (22.2% of all acute strokes). The percentage of RS signifi...
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Łabuz-Roszak B, Skrzypek M, Starostka-Tatar A, Lasek-Bal A, Gąsior M, Gierlotka M Tags: Neurol Neurochir Pol Source Type: research

Multiple sclerosis: oral health, behaviours and limitations of daily oral hygiene - a questionnaire study.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Dry mouth and bleeding from gums are more frequent in patients with longer lasting and more advanced types of MS. Daily oral hygiene and oral health self-control is limited in patients with MS, mainly due to motor deficits, balance problems and pain, and this becomes worse with disease duration. To minimise the burden of the disease, patients with MS require better education and improvement in their awareness regarding proper oral health control, such as the use of electric toothbrushes. In addition, patients with chronic and progressive disability from multiple sclerosis may benefit ...
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Łabuz-Roszak B, Niewiadomska E, Starostka-Tatar A, Kubicka-Bączyk K, Krzystanek E, Arkuszewski M, Tyrpień-Golder K, Rybus-Kalinowska B, Pierzchała B, Pierzchała K Tags: Neurol Neurochir Pol Source Type: research

Altered functional brain imaging in migraine patients: BOLD preliminary study in migraine with and without aura.
CONCLUSIONS: Results of our preliminary study suggest that migraine with aura and migraine without aura might be separate disorders, and this requires further investigation. PMID: 31441496 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Kreczmański P, Wolak T, Lewandowska M, Domitrz I Tags: Neurol Neurochir Pol Source Type: research

Acute bacterial meningitis and stroke.
Abstract INTRODUCTION: Acute bacterial meningitis remains a common disease, especially in developing countries. Although advances over the last century have improved mortality and morbidity, the neurological adverse effects remain high. Specifically, acute ischaemic stroke is a serious comorbidity that represents both disease severity and poor prognosis. This review presents the clinical connection between meningitis and stroke, and discusses the neuroinflammatory components that have direct ties between these diseases. STATE OF THE ART: Ischaemic stroke is the direct result of the inflammatory response produ...
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Siegel J Tags: Neurol Neurochir Pol Source Type: research

The symptoms asymmetry of drug-induced parkinsonism is not related to nigrostriatal cell degeneration: a SPECT-DaTSCAN study.
CONCLUSIONS: Our results have not confirmed the presence of a presynaptic nigrostriatal deficit which could be related to asymmetry of DIP. The factors responsible for the asymmetry of DIP symptoms should be sought in the postsynaptic part of the nigrostriatal dopaminergic system. PMID: 31441498 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 23, 2019 Category: Neurology Authors: Gajos A, Dąbrowski J, Bieńkiewicz M, Płachcińska A, Kuśmierek J, Bogucki A Tags: Neurol Neurochir Pol Source Type: research

Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review.
CONCLUSION: BoNT-A therapy is a safe and effective method of treating trigeminal neuralgia. PMID: 31397877 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 9, 2019 Category: Neurology Authors: Ostrowski H, Roszak J, Komisarek O Tags: Neurol Neurochir Pol Source Type: research

Risk factors predicting a higher grade of subarachnoid haemorrhage in small ruptured intracranial aneurysm ( < 5 mm).
Risk factors predicting a higher grade of subarachnoid haemorrhage in small ruptured intracranial aneurysm (
Source: Neurologia i Neurochirurgia Polska - August 9, 2019 Category: Neurology Authors: Tai J, Liu J, Lv J, Huibin K, Hou Z, Yang J, Zhang H, Huang Q Tags: Neurol Neurochir Pol Source Type: research

Clinical value of 99Tcm-MIBI gated myocardial perfusion imaging in evaluating sarcoglycanopathy.
CONCLUSIONS: 99Tcm-MIBI G-MPI can objectively show impaired myocardium in patients with sarcoglycanopathy. Therefore, this method is helpful for early diagnosis and follow-up of myocardial damage. PMID: 31343070 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 25, 2019 Category: Neurology Authors: Fu P, Wei LG, Hu J, Gao JQ, Jing JM, Liu XM, Huang JM Tags: Neurol Neurochir Pol Source Type: research

Assessment of the relationship between platelet reactivity, vascular risk factors and gender in cerebral ischaemia patients.
CONCLUSIONS: There are no differences between platelet reactivity and the incidence of aspirin resistance in patients with stroke and TIA. Male gender and smoking are associated with greater reactivity of platelets and more frequent occurrence of acetylsalicylic acid resistance in patients with cerebral ischaemia. CLINICAL IMPLICATIONS: Dual antiplatelet therapy or clopidogrel treatment should be considered in smoking males with cerebral ischaemia due to the high risk of aspirin inefficiency. PMID: 31343071 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 25, 2019 Category: Neurology Authors: Wiśniewski A, Sikora J, Filipska K, Kozera G Tags: Neurol Neurochir Pol Source Type: research

Prevention of epilepsy in humans - truth or myth? The experience from Sturge-Weber syndrome and Tuberous Sclerosis Complex.
We present the results of preventive antiepileptic treatment in children with Sturge-Weber syndrome and Tuberous Sclerosis Complex as examples of the possible prevention of epilepsy and epilepsy-associated cognitive impairment in children. PMID: 31166003 [PubMed - indexed for MEDLINE] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 11, 2019 Category: Neurology Authors: Słowińska M, Golec W, Jóźwiak S Tags: Neurol Neurochir Pol Source Type: research

Electrodiagnostics: MUNE and MUNIX as methods of estimating the number of motor units - biomarkers in lower motor neurone disease.
Abstract Routine quantitative electromyography is used for the assessment of the presence of lower motor neurone involvement and its consequences, including primary denervation and compensatory reinnervation of muscle fibres. However, it is not useful for the assessment of the motor unit number reserve. The need for a valid biomarker to evaluate lower motor neurone disease progression in such diseases as amyotrophic lateral sclerosis, and for use in clinical trials, has led to a number of studies of the methods that allow assessment of the number of motor units. In this review, motor unit number estimation (MUNE) ...
Source: Neurologia i Neurochirurgia Polska - June 17, 2019 Category: Neurology Authors: Gaweł M Tags: Neurol Neurochir Pol Source Type: research

Autoimmune response in lung cancer patients with neurological paraneoplastic syndromes.
CONCLUSIONS: FasL expression in PBMCs is up-regulated in lung cancer patients. The interplay between granzyme B and FasL may be involved in the development of PNS at the level of the peripheral and the central nervous systems in different manners. Gender is associated with PBMC expression of granzyme B and perforin in lung cancer patients. CLINICAL IMPLICATIONS: The novel findings that we report broaden the current knowledge on PNS pathomechanism, with aspects that have not been previously explored. Our findings provide a rationale for further exploration of the granzyme B/FasL pathway with regards to its potential di...
Source: Neurologia i Neurochirurgia Polska - June 12, 2019 Category: Neurology Authors: Michalak S, Piorunek T, Zaborowski M, Rybacka-Mossakowska J, Stefens-Stawna P, Kalinowska-Łyszczarz A, Kozubski W, Batura-Gabryel H Tags: Neurol Neurochir Pol Source Type: research

Molecular biomarkers for neuromuscular disorders - challenges and future perspectives.
Abstract There is an ever-growing need for molecular biomarkers in assessing clinical course and diagnosing neuromuscular disorders, as well as in monitoring drug therapy. With the development of high throughput techniques, there has been an acceleration in the discovery of potential biomarkers. It is quite easy to find potential candidates, but difficult to validate them and translate into a clinical setting. Neuromuscular diseases (NMD) are a major challenge in terms of finding potential molecular biomarkers, mainly because of their heterogeneous aetiology and variability in phenotype, their as yet incompletely ...
Source: Neurologia i Neurochirurgia Polska - June 10, 2019 Category: Neurology Authors: Mroczek M, Machoń L, Filipczyńska I Tags: Neurol Neurochir Pol Source Type: research

Multiparametric MRI in differentiating solitary brain metastasis from high-grade glioma: diagnostic value of the combined use of diffusion-weighted imaging, dynamic susceptibility contrast imaging, and magnetic resonance spectroscopy parameters.
CONCLUSIONS: The combination of peritumoural region ADCmin, rCBV, and Cho/NAA parameters can help in differentiating SBM from HGG, with a diagnostic accuracy of 97%. PMID: 31180131 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 10, 2019 Category: Neurology Authors: Aslan K, Gunbey HP, Tomak L, Incesu L Tags: Neurol Neurochir Pol Source Type: research

Prevention of epilepsy in humans - mirage or possibility? The experience from Sturge-Weber syndrome and Tuberous Sclerosis Complex.
We present the results of preventive antiepileptic treatment in children with Sturge-Weber syndrome and Tuberous Sclerosis Complex as examples of the possible prevention of epilepsy and epilepsy-associated cognitive impairment in children. PMID: 31166003 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 5, 2019 Category: Neurology Authors: Słowińska M, Golec W, Jóźwiak S Tags: Neurol Neurochir Pol Source Type: research

Seasonal variations in the occurrence of transient global amnesia (TGA).
CONCLUSIONS: Our findings suggest that there is a relationship between the season of the year and the probability of TGA. PMID: 31162624 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 4, 2019 Category: Neurology Authors: Chojdak-Łukasiewicz J, Dziadkowiak E, Noga L, Wieczorek M, Paradowski B Tags: Neurol Neurochir Pol Source Type: research

Assessment of relationship between C-reactive protein to albumin ratio and 90-day mortality in patients with acute ischaemic stroke.
l;rk Ö Abstract AIM AND CLINICAL RATIONALE FOR THE STUDY: It is now known that inflammation is involved i n the pathophysiology of acute ischaemic stroke (AIS). It has been proven that CRP and albumin alone are useful in predicting a prognosis for stroke patients. A combination of these two parameters, namely the ratio of CRP to albumin (CAR), is believed to be a more accurate indicator of inflammatory status than CRP or albumin alone, and may be more valuable than either of them separately in predicting the prognosis of ıschaemic stroke patients. However, the role of CAR as a predictor of mortality in patie...
Source: Neurologia i Neurochirurgia Polska - May 30, 2019 Category: Neurology Authors: Kocatürk M, Kocatürk Ö Tags: Neurol Neurochir Pol Source Type: research

Association between polymorphisms of a folate - homocysteine - methionine - SAM metabolising enzyme gene and multiple sclerosis in a Polish population.
CONCLUSIONS: It was found that, regardless of the presence of a specific allele, the gender of MS patients affects the age differences at the time of the clinical onset of the disease: in rs1801133 for the C allele and T, the average age was 35 for female and 29 for men (p = 0.0004; p = 0.034 respectively). Similarly for the second polymorphism rs1801131 for the A allele and C the average age was 35 for female and 29 for men (p = 0.001; p = 0.01 respectively). No significant allelic / genotypic frequency differences have been observed between the studied groups (c.677C> T, CT/TT p = 0.719, p = 0.262; c.1298A> C, AC/C...
Source: Neurologia i Neurochirurgia Polska - May 30, 2019 Category: Neurology Authors: Chorąży M, Wawrusiewicz-Kurylonek N, Gościk J, Posmyk R, Czarnowska A, Więsik M, Kapica-Topczewska K, Krętowski AJ, Kochanowicz J, Kułakowska A Tags: Neurol Neurochir Pol Source Type: research

Statement by a Working Group conceived by the Polish National Consultants in Cardiology and Neurology addressing the use of implantable cardiac monitors in patients after ischaemic embolic stroke of undetermined source.
Abstract INTRODUCTION: Stroke remains one of the main causes of death and the most common cause of long-term disability in adults. Embolic strokes of undetermined source (ESUS) amount to a significant proportion of all ischaemic strokes. Detection of atrial fibrillation (AF) in this group of patients would allow for a major therapeutic decision to switch from antiplatelets to oral anticoagulants and therefore significantly reduce the risk of recurrence. STATE OF THE ART: Current technology allows long-term continuous ECG monitoring with different systems, including implantable cardiac monitors (ICM). However,...
Source: Neurologia i Neurochirurgia Polska - May 30, 2019 Category: Neurology Authors: Farkowski MM, Karlinski MA, Kaźmierczak J, Kułakowski P, Mitkowski P, Ptaszyński P, Ryglewicz D, Sławek J, Słowik A, Sterliński M Tags: Neurol Neurochir Pol Source Type: research

Transthoracic echocardiography in the assessment of cardiogenic causes of ischaemic stroke.
CONCLUSIONS: 1. Transthoracic echocardiography performed routinely in all AIS patients affects the treatment in a very low percentage of cases. 2. The group that could benefit the most from TTE examination includes people without established indications for chronic anticoagulant therapy, in particular patients after myocardial infarction and people with additional clinical symptoms. 3. In patients with AIS, the diagnostic sensitivity of TTE in the detection of PFO is low. Young people with a cryptogenic ischaemic stroke should undergo a transoesophageal assessment. PMID: 31020990 [PubMed - indexed for MEDLINE] (Source...
Source: Neurologia i Neurochirurgia Polska - May 29, 2019 Category: Neurology Authors: Król W, Żarek A, Wilk A, Guzik W, Ziemska M, Konopka M, Franczuk-Gwiazda M, Kuch M, Braksator W Tags: Neurol Neurochir Pol Source Type: research

Brain abscess and pyocephalus: our experience with treatment.
CONCLUSIONS: Pyocephalus will continue to be a serious complication in the treatment of brain abscesses, although we were unable to determine its utility as a prognostic factor. Patients with this complication have elevated CRP levels on the day of operation. PMID: 31020989 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 25, 2019 Category: Neurology Authors: Večeřa Z, Krejčí O, Krejčí T, Krajča J, Kanta M, Lipina R Tags: Neurol Neurochir Pol Source Type: research

Transthoracic echocardiography in the assessment of cardiogenic causes of ischemic stroke.
CONCLUSIONS: 1. Transthoracic echocardiography performed routinely in all AIS patients affects the treatment in a very low percentage of cases. 2. The group that could benefit the most from TTE examination includes people without established indications for chronic anticoagulant therapy, in particular patients after myocardial infarction and people with additional clinical symptoms. 3. In patients with AIS, the diagnostic sensitivity of TTE in the detection of PFO is low. Young people with a cryptogenic ischaemic stroke should undergo a transoesophageal assessment. PMID: 31020990 [PubMed - as supplied by publisher] (S...
Source: Neurologia i Neurochirurgia Polska - April 25, 2019 Category: Neurology Authors: Król W, Żarek A, Wilk A, Guzik W, Ziemska M, Konopka M, Franczuk-Gwiazda M, Kuch M, Braksator W Tags: Neurol Neurochir Pol Source Type: research

Vitamin D as an immune modulator in multiple sclerosis.
Abstract Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system. The disease is characterised by inflammation with extensive immune infiltration, demyelination, axonal loss and damage of oligodendrocytes, presumably auto-immune in nature. The influence of environmental factors on the development and activity of MS has been known for a long time. Vitamin D and sun exposure are among the most important ones. Both serum vitamin D level and sun exposure independent of vitamin D production are correlated with epidemiological and clinical parameters of MS, and the ...
Source: Neurologia i Neurochirurgia Polska - March 27, 2019 Category: Neurology Authors: Bartosik-Psujek H, Psujek M Tags: Neurol Neurochir Pol Source Type: research

Absorbable sutures for the achievement of stable osteosynthesis in surgery for craniosynostosis.
CONCLUSION AND CLINICAL IMPLICATIONS: The exclusive application of absorbable suture material enables stable and cost-effective osteosynthesis in craniofacial surgery without altering the osteotomy design. PMID: 30855700 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Horn F, Kilipiris E, Pinzon J, Tsolakis I, Kabat M, Petrik M, Kuniakova D Tags: Neurol Neurochir Pol Source Type: research

Positron emission tomography neuroimaging in neurodegenerative diseases: Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
This article summarises the results of studies on the use of positron emission tomography (PET) in the diagnosis of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. It focuses on clinical-pathogenetic aspects of individual diseases, as well as disease-specific patterns relevant in differential diagnosis and in assessing the risk of disease development and prognosis. PMID: 30855701 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Barc K, Kuzma-Kozakiewicz M Tags: Neurol Neurochir Pol Source Type: research

Analysis of echocardiographic parameters of cardiac function in patients with acute stroke.
Abstract INTRODUCTION: Cardiologic diagnostics in stroke patients is designed to identify heart disease as a potential cause of stroke. The aim of this study was to evaluate the effect of low ejection fraction (EF) and left ventricular systolic/diastolic dysfunction (LVSD, LVDD) on the neurological state on the 1st day of stroke, as well as post-stroke functional status at 30 days after stroke. PATIENTS AND METHODS: For a prospective study, 162 stroke patients (mean age 74 years) were qualified. They were analysed according to neurological state on the 1st day of stroke, the results of transthoracic echocardi...
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Lasek-Bal A, Żak A, Pysz P, Puz P, Gąsior Z Tags: Neurol Neurochir Pol Source Type: research

Should non-movement specialists refer patients for SPECT-DaTSCAN?
CONCLUSIONS: Our presented results probably reflect t he l imited e xperience o f g eneral n eurologists i n t he e valuation o f parkinsonian syndromes and tremor. The use of SPECT-DaTSCAN by non-movement disorders specialists is associated with a significant risk of overuse of this tool. To minimise this risk, the skills of general neurologists in diagnosing parkinsonian and tremor syndromes should be improved. Moreover, patients should be provided with access to movement disorders specialists. PMID: 30855703 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Gajos A, Dąbrowski J, Bieńkiewicz M, Płachcińska A, Kuśmierek J, Bogucki A Tags: Neurol Neurochir Pol Source Type: research

Early predictors of injectable disease modifying drugs suboptimal response based on clinical and radiological data assessment in Polish Multiple Sclerosis patients.
Abstract BACKGROUND: Prospective database studies can provide useful information regarding 'real-world' outcomes and drug efficacy. OBJECTIVE: To determine the early predictors of suboptimal treatment responses at two and three years under injectable Disease Modifying Therapy (DMT). METHODS: This was a multi-centre prospective database study. Adult patients who started injectable DMTs between January 2008 and June 2013 were included. The follow-up continued until July 2014. Suboptimal treatment responses were defined as: the presence of clinical relapse and/or Expanded Disability Status Score (EDSS) prog...
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Wawrzyniak S, Koziarska D, Kułakowska A, Bartosik-Psujek H, Adamczyk-Sowa M Tags: Neurol Neurochir Pol Source Type: research

Quantitative volumetric analysis of primary glioblastoma multiforme on MRI and 11C-methionine PET: initial study on five patients.
Abstract To investigate the discrepancy between 11C-methionine (MET) positron emission tomography (PET) and MRI results in primary glioblastoma multiforme (GBM) through three-dimensional (3D) volumetric analysis, we retrospectively analysed patients with primary GBM who underwent preoperative 3D MRI and MET PET and were operated between June 2016 and January 2017. Tumour delineation and volumetric analysis were conducted using MRIcron software. Tumour volumes defined by MRI (VMRI) were manually drawn slice by slice in axial and sagittal or coronal images of enhanced T1 sequence, while metabolic tumour volumes were...
Source: Neurologia i Neurochirurgia Polska - March 11, 2019 Category: Neurology Authors: Zhao J, Chen Z, Cai L, Yin S, Yang W, Wang Z Tags: Neurol Neurochir Pol Source Type: research

Health-Related Quality of life and medication adherence in elderly patients with epilepsy.
PMID: 30807640 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 26, 2019 Category: Neurology Authors: Hamedi-Shahraki S, Eshraghian MR, Yekaninejad MS, Nikoobakht M, Rasekhi A, Chen H, Pakpour A Tags: Neurol Neurochir Pol Source Type: research

Outcomes of traumatic brain injury: the prognostic accuracy of various scores and models.
CONCLUSION: All four prognostic models are applicable to eligible TBI patients in Colombia. The IMPACT model was shown to be more accurate than the other prognostic models, and had a higher sensitivity in predicting 6-month mortality and 6-month unfavourable outcomes in patients with TBI in a university hospital in Colombia. PMID: 30742300 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 11, 2019 Category: Neurology Authors: Charry JD, Navarro-Parra S, Solano J, Moscote-Salazar L Tags: Neurol Neurochir Pol Source Type: research

How does early decompressive craniectomy influence the intracranial volume relationship in traumatic brain injury (TBI) patients?
CONCLUSIONS: DC has limited effectiveness in patients aged over 70 years. In every patient with clamped basal cisterns, a skin incision enabling appropriate LDOC should be planned before surgery. DC should be as large as possible, and the limits of its dimensions should be the limits of anatomical safety. PMID: 30742301 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 11, 2019 Category: Neurology Authors: Jasielski P, Czernicki Z, Dąbrowski P, Koszewski W, Rojkowski R Tags: Neurol Neurochir Pol Source Type: research

Spatial distribution of white matter degenerative lesions and cognitive dysfunction in relapsing-remitting multiple sclerosis patients.
Abstract AIM: The aim of this study was to assess degenerative lesion localisation in the course of relapsing-remitting multiple sclerosis (RRMS) and to identify the association between localisation and the frequency of T1-hypointense lesions (black holes) with cognitive dysfunction. We also searched for neuroradiological predictors of cognitive dysfunction in patients. The clinical rationale for the study was previous research, and our own findings suggest that lesion localisation plays an important role in cognitive performance and neurological disability of MS patients. MATERIAL AND METHODS: Forty-two pati...
Source: Neurologia i Neurochirurgia Polska - February 11, 2019 Category: Neurology Authors: Nowaczyk N, Kalinowska-Łyszczarz A, Paprzycki W, Michalak S, Kaźmierski R, Pawlak MA Tags: Neurol Neurochir Pol Source Type: research

Trigone ventricular meningiomas - clinical characteristics, histopathology and results of surgical treatment.
hel A Abstract AIM OF THE STUDY: Intraventricular meningiomas (IVMs) are rare tumours accounting for 0.5-3.0% of all meningiomas. IVMs require different surgical approaches and preparation in deep brain areas. The aim of our study aim was to present the clinico-histopathological characteristics and treatment outcomes of trigone IVMs in a series of 15 patients. MATERIALS AND METHODS: Eight women and seven men (mean age 52) with 15 trigone IVMs were retrospectively analysed. Patients presented with headache (47%), psychoorganic syndrome (40%), hemianopsia (33%) or paresis (20%), including three (20%) patients w...
Source: Neurologia i Neurochirurgia Polska - January 10, 2019 Category: Neurology Authors: Leśniewski K, Kunert P, Matyja E, Czernicki T, Wójtowicz K, Wojciechowski J, Marchel A Tags: Neurol Neurochir Pol Source Type: research

Delayed onset of Takotsubo syndrome after epileptic seizure.
r J PMID: 30620041 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 8, 2019 Category: Neurology Authors: Stöllberger C, Finsterer J Tags: Neurol Neurochir Pol Source Type: research

Electrophysiological and clinical assessment of dysautonomia in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP): a comparative study.
Abstract CLINICAL RATIONALE FOR THE STUDY: Autonomic nervous system (ANS) involvement in different parkinsonian syndromes has been frequently discussed. It is well established in multiple system atrophy (MSA), whereas it is less evident in progressive supranuclear palsy (PSP). AIMS OF THE STUDY: The aims were to assess the presence and pattern of ANS involvement in MSA and PSP using noninvasive tests i.e. the sympathetic skin response (SSR) test and the R-R interval variation (RRIV) test; to analyse the relationship between clinical and electrophysiological abnormalities in both disorders; and to assess wheth...
Source: Neurologia i Neurochirurgia Polska - January 8, 2019 Category: Neurology Authors: Nojszewska M, Potulska-Chromik A, Jamrozik Z, Janik P, Zakrzewska-Pniewska B Tags: Neurol Neurochir Pol Source Type: research

Familial occurrence of carpal tunnel syndrome.
The objective of this study was to investigate the incidence of familial carpal tunnel syndrome in patients admitted to the authors' institution for carpal tunnel release. Questionnaires completed by 120 patients: 92 women (77%) and 28 men (23%) at a mean age of 56 years at their baseline clinical examination were reviewed. Familial occurrence of the disease was noted in 21 patients (17%): 16 women and five men. Three family members were affected in three patients, two relatives in eight patients, and one relative in 10 patients, giving a total of 35 affected relatives. The patients' sisters (n = 16) were the most commonly...
Source: Neurologia i Neurochirurgia Polska - January 8, 2019 Category: Neurology Authors: Puchalski P, Szlosser Z, Yekaninejad MS, Zyluk A Tags: Neurol Neurochir Pol Source Type: research

A systematic review of Gamma-aminobutyric Acid Receptor Type B autoimmunity.
CONCLUSIONS: GABAB-R autoimmune disease is characterized by refractory seizures or status epilepticus and frequent association with small cell lung cancer. Additionally, a substantial minority of patients have non-inflammatory CSF. PMID: 30620044 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 8, 2019 Category: Neurology Authors: McKay JH, Dimberg EL, Lopez Chiriboga AS Tags: Neurol Neurochir Pol Source Type: research

Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in patients with chronic hyperventilation syndrome: results of a case-control study.
Abstract AIM: Chronic hyperventilation syndrome (CHVS) represents a frequent but poorly understood breathing pattern disorder. In a previous small pilot study, we reported a higher prevalence of right-to-left shunt (RLS) in CHVS patients than in healthy subjects. The aim of this study was to confirm previous results from this larger and matched case-control study and evaluate the prevalence and grade of RLS in patients with CHVS in whom organic and psychiatric causes were excluded. CLINICAL RATIONALE FOR THE STUDY: Determining other types of CHVS triggers not related to organic or psychiatric causes would be ...
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Staszewski J, Tomczykiewicz K, Piusińska-Macoch A, Stępień A Tags: Neurol Neurochir Pol Source Type: research

Stroke and TIA mimics in patients referred to a neurological emergency department by non-ambulance physicians, ambulance physicians and paramedics.
CONCLUSIONS: There seem to be no major differences in the structure, early diagnostic approach and management of ACE mimics between referrals from ambulance physicians and ambulance paramedics, which provides reassurance to the healthcare systems that rely solely on paramedics. Mimics referred by non-ambulance physicians appear different in structure and less resource consuming. PMID: 30614515 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Kozera-Strzelińska D, Karliński M, Rak G, Wojdacz M, Sienkiewicz-Jarosz H, Kurkowska-Jastrzębska I Tags: Neurol Neurochir Pol Source Type: research

Neurosurgical Cadaveric and In Vivo Large Animal Training Models for Cranial and Spinal Approaches and Techniques - Systematic Review of Current Literature.
CONCLUSIONS: Laboratory training models enhance surgical advancements of residents with the purpose of familiarization of certain neuroanatomical structures and to promote a better surgical dexterity. The accessibility of animal brains render the capacity of the surgeon to exercise techniques outside the operating field, thus optimizing their outcome in human surgical procedures. PMID: 30614516 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Morosanu CO, Nicolae L, Moldovan R, Farcasanu AS, Filip GA, Florian IS Tags: Neurol Neurochir Pol Source Type: research

No association between MRI changes in the lumbar spine and intensity of pain, quality of life, depressive and anxiety symptoms in patients with low back pain.
Abstract INTRODUCTION: The association between changes in magnetic resonance imaging (MRI) and clinical symptoms in patients with low back pain (LBP) is unclear. AIM: To evaluate the correlations between combined MRI findings of the lumbar spine (LS) and pain intensity, depressive and anxiety symptoms and quality of life in patients with LBP. MATERIAL AND METHODS: 200 subjects (93 men, 107 women; mean age 51.42±13.21) with LBP referred for MRI were enrolled in the study. All patients completed the Hospital Anxiety and Depression Scale (HADS), Quality of Life Scales (EQ-5D, EQ-VAS) and the Visual A...
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Babińska A, Wawrzynek W, Czech E, Skupiński J, Szczygieł J, Łabuz-Roszak B Tags: Neurol Neurochir Pol Source Type: research

Attitudes towards neurology among medical undergraduates.
Abstract Diseases of the nervous system are an important contributor to clinical and social problems. Therefore there is a need to provide undergraduates and postgraduates of medical faculties with adequate training in neurology. However, many shortcomings have been observed in this field, often associated with students' negative perception of neurology. The aim of this study was to explore attitudes towards neurology amongst undergraduates of the medical faculty at Wroclaw Medical University, and the reasons for these attitudes. As a qualitative component of the study, a focus group discussion was conducted with ...
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Pokryszko-Dragan A, Mottershead J, Aitken G Tags: Neurol Neurochir Pol Source Type: research

Successful subthalamic stimulation after failed gamma-knife thalamotomy in the treatment of tremor-dominant Parkinson's disease.
PMID: 30614519 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 7, 2019 Category: Neurology Authors: Sobstyl M, Konopka M, Aleksandrowicz M, Pasterski T, Ząbek M Tags: Neurol Neurochir Pol Source Type: research

Editorial Announcement - The Change of Publisher of the Polish Journal of Neurology and Neurosurgery (Neurologia i Neurochirurgia Polska).
PMID: 30553409 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - November 1, 2018 Category: Neurology Authors: Wszolek ZK, Sławek J, Siemiński M Tags: Neurol Neurochir Pol Source Type: research

Guidelines of the Polish Medical Society of radiology for the routinely used MRI protocol in patients with multiple sclerosis.
Abstract Magnetic resonance imaging is widely used in diagnosing multiple sclerosis as a basic method for detecting and monitoring the disease. INTRODUCTION: Polish Medical Society of Radiology presents the second version of the recommendations for the routinely conducted MRI in multiple sclerosis, which include new data and practical remarks for radiographers and radiologists. The recommended protocol aims to improve the imaging procedure and, most importantly, to standardize conducting MRI scans in all MRI departments. This is crucial for monitoring the patients with MS, which directly contributes to essential c...
Source: Neurologia i Neurochirurgia Polska - October 4, 2018 Category: Neurology Authors: Sąsiadek M, Katulska K, Majos A, Siger M, Hartel M, Kalinowska A, Walecki J Tags: Neurol Neurochir Pol Source Type: research

Isoprostanes as potential cerebral vasospasm biomarkers.
ute;lski DJ Abstract Despite enormous progress in medicine, symptomatic cerebral vasospasm (CVS), remains an unexplained clinical problem, which leaves both physicians and patients helpless and relying on chance, due to the lack of specific marker indicative of imminent danger as well as the lack of specific treatment. In our opinion CVS occurrence depends on dynamic disbalance between free radicals' formation (oxidative stress) and antioxidant activity. Isoprostanes are products of free-radical peroxidation of polyunsaturated fatty acids, and seem to mark a promising path for the research aiming to unravel its po...
Source: Neurologia i Neurochirurgia Polska - October 4, 2018 Category: Neurology Authors: Wiśniewski K, Jóźwik-Pruska J, Bieńkowski M, Bobeff EJ, Bryl M, Kałużna-Czaplińska J, Jaskólski DJ Tags: Neurol Neurochir Pol Source Type: research