Stereotypies in adults: a systematic review.
Abstract Stereotypies are abnormal involuntary non-goal-directed movement patterns or vocalisations which repeat continuously in the same fashion over a period of time and on multiple occasions and are typically distractible. Stereotypies are common in both children and adults, but they are extensively reviewed only in children. There are very few studies, mainly in the form of case reports and case series, focusing on stereotypies occurring in adults as part of different neurological disorders. In adults, stereotypies can be both physiological and pathological. Common physiological stereotypies in adults are leg ...
Source: Neurologia i Neurochirurgia Polska - July 24, 2020 Category: Neurology Authors: Shukla T, Pandey S Tags: Neurol Neurochir Pol Source Type: research

Hyperekplexia: a surprise diagnosis.
, Yüksel D PMID: 32706098 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 24, 2020 Category: Neurology Authors: Yayıcı Köken Ö, Toptaş Dedeoğlu Ö, Aksoy A, Yüksel D Tags: Neurol Neurochir Pol Source Type: research

Effectiveness and safety of ICA stenting in conjunction with mechanical thrombectomy (antegrade approach) in acute ischaemic stroke patients due to tandem occlusion.
CONCLUSIONS AND CLINICAL IMPLICATIONS: We conclude that an antegrade approach is a feasible and effective method for treating acute TO stroke, giving the patient the chance to regain his or her full independence in everyday life, with low overall complication and final mortality rates. PMID: 32700307 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 23, 2020 Category: Neurology Authors: Sojka M, Szmygin M, Pyra K, Tarkowski P, Luchowski P, Wojczal J, Drelich-Zbroja A, Jargiełło T Tags: Neurol Neurochir Pol Source Type: research

Significant fall in stroke admissions in the Malopolska Voivodeship of Poland during the COVID-19 pandemic.
PMID: 32700757 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 23, 2020 Category: Neurology Authors: Słowik A, Nowak R, Popiela T Tags: Neurol Neurochir Pol Source Type: research

Treatment and management of migraine in neurological ambulatory practice in Poland by indicating therapy with monoclonal anti-CGRP antibodies.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Migraine is underdiagnosed and undertreated in Poland. Understanding of the diagnostic criteria for migraine among neurologists is insufficient. Most neurologists in Poland see patients in whom anti-CGRP/R-targeting treatment is indicated. PMID: 32687594 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 20, 2020 Category: Neurology Authors: Domitrz I, Lipa A, Rożniecki J, Stępień A, Kozubski W Tags: Neurol Neurochir Pol Source Type: research

Spinocerebellar ataxia type 6 family with phenotypic overlap with Multiple System Atrophy.
CONCLUSIONS AND CLINICAL IMPLICATIONS: While MSA and SCA may have similar presentations during early disease stages, the presence of both conditions on the list of differential diagnoses can be a diagnostic dilemma. Further analysis will aid in developing a biomarker to distinguish between the two conditions and guide proper management. PMID: 32687595 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 20, 2020 Category: Neurology Authors: Hanna Al-Shaikh R, Wernick AI, Strongosky AJ, Soto-Beasley AI, van Gerpen JA, Cheshire WP, Uitti RJ, Ross OA, Wszolek ZK Tags: Neurol Neurochir Pol Source Type: research

DBS patient with diagnosed Non-Hodgkin's Lymphoma: is radiation therapy safe?
PMID: 32677029 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 17, 2020 Category: Neurology Authors: Milanowski Ł, Grassle AL, Uitti RJ Tags: Neurol Neurochir Pol Source Type: research

Neurological manifestations of SARS-CoV-2 - a systemic review.
DISCUSSION: Data regarding neurological manifestations of SARS-CoV-2 is scarce and mostly inconsistent. There are however identifiable trends which might provide a basis for future research. There is strong evidence that this novel coronavirus may be neuroinvasive and could cause a wide array of neurological symptoms and complications. Cerebrospinal fluid testing may shed more light on the occurrence of SARS-CoV-2 in the central nervous system. Clarification of the respiratory failure mechanisms requires post mortem examinations and brain tissue analysis, and further research is of the utmost importance. However, we strong...
Source: Neurologia i Neurochirurgia Polska - July 15, 2020 Category: Neurology Authors: Słyk S, Domitrz I Tags: Neurol Neurochir Pol Source Type: research

Validation of the Polish version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
CONCLUSIONS AND CLINICAL IMPLICATIONS: The Polish version of the MDS-UPDRS meets the requirements to be designated as the Official Polish Version of the MDS-UPDRS, and is available on the MDS web page. We strongly recommend using the MDS-UPDRS instead of the UPDRS for research purposes and in everyday clinical practice. PMID: 32639019 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 8, 2020 Category: Neurology Authors: Siuda J, Boczarska-Jedynak M, Budrewicz S, Figura M, Fiszer U, Gajos A, Gorzkowska A, Koziorowska-Gawron E, Koziorowski D, Krygowska-Wajs A, Rudzińska-Bar M, Sławek J, Ren X, Luo S, Martinez-Martin P, Stebbins G, Goetz CG, Opala G, Bogucki A, Dulski J, Tags: Neurol Neurochir Pol Source Type: research

The editors of Neurologia i Neurochirurgia Polska (the Polish Journal of Neurology and Neurosurgery) announce new editorial features.
PMID: 32602933 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - July 2, 2020 Category: Neurology Authors: Wszolek ZK, Sławek J, Stolarczyk Ł Tags: Neurol Neurochir Pol Source Type: research

Botulinum toxin for cervical dystonia: addressing treatment failure and improving outcomes.
Abstract INTRODUCTION: Cervical dystonia is a form of focal dystonia characterised by tilting and turning of the head and neck. This can cause significant disability in affected patients. Botulinum toxin injections are the mainstay of therapy. However, approximately 30% of patients discontinue treatment. CLINICAL REFLECTIONS: Tyślerowicz et al. have provided a comprehensive review of the factors contributing to treatment failure. Such factors include appropriate identification of dystonia patterns, accurate injection of muscles, and addressing non-motor features of cervical dystonia. CLINICAL IMPLICATIO...
Source: Neurologia i Neurochirurgia Polska - July 2, 2020 Category: Neurology Authors: Pena AB Tags: Neurol Neurochir Pol Source Type: research

Response to "Does amantadine have a protective effect against COVID-19?"
Response to "Does amantadine have a protective effect against COVID-19?" Neurol Neurochir Pol. 2020 Jun 25;: Authors: Tipton PW, Wszolek ZK PMID: 32583401 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 25, 2020 Category: Neurology Authors: Tipton PW, Wszolek ZK Tags: Neurol Neurochir Pol Source Type: research

Advancing gene therapies, methods, and technologies for Parkinson's Disease and other neurological disorders.
Abstract INTRODUCTION: Vector-based intracerebral gene therapies are being used to treat specific neurodegenerative conditions such as Parkinson's Disease (PD). This review presents a basis for central nervous system (CNS) gene therapy treatments of neurodegenerative diseases such as PD, as well as the need for novel skill sets and health delivery strategies within the clinical neurosciences (neurology and neurosurgery) to meet future demand for such therapies. STATE OF THE ART: Preclinical vector-based gene therapy approaches have been translated into clinical trials for PD and other neurodegenerative condit...
Source: Neurologia i Neurochirurgia Polska - June 18, 2020 Category: Neurology Authors: Fiandaca MS, Lonser RR, Elder JB, Ząbek M, Bankiewicz KS Tags: Neurol Neurochir Pol Source Type: research

Cardiac autonomic modulation in drug-resistant epilepsy patients after vagus nerve stimulation therapy.
CONCLUSIONS: Our results indicate that VNS appears not to alter the cardiac autonomic function after three months of neurostimulation. HRV analysis is a useful tool for evaluating cardiac autonomic modulation in epilepsy patients during VNS therapy. CLINICAL IMPLICATIONS: Patients with decreased HRV should be periodically monitored. Cardiac changes in patients with epilepsy are important because of the additional risk of arrhythmias mediated through the autonomic dysfunction. PMID: 32557527 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 18, 2020 Category: Neurology Authors: Constantinescu V, Matei D, Constantinescu I, Cuciureanu DI Tags: Neurol Neurochir Pol Source Type: research

Safety and tolerability of therapeutic plasma exchange in autoimmune neurological diseases - a retrospective single-centre analysis.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Our study proves that the use of plasmapheresis conducted by filtration in the treatment of autoimmune neurological diseases is safe and well tolerated. PMID: 32557528 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 18, 2020 Category: Neurology Authors: Gala-Błądzińska A, Mazur K, Dębiec A, Gargasz K, Bartosik-Psujek H Tags: Neurol Neurochir Pol Source Type: research

Pentosidine, advanced glycation end product, in acute ischaemic stroke patients with and without atrial rhythm disturbances.
CONCLUSIONS AND CLINICAL IMPLICATIONS: A higher serum level of pentosidine was observed in AIS patients without atrial fibrillation compared to the healthy volunteers. According to the results of the present study, no difference between these patients in the selected risk factors of atherosclerosis were observed. Further studies are needed to identify a reliable marker of AF that would bring added value to the standard diagnostic workup after acute ischaemic stroke. PMID: 32510570 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 8, 2020 Category: Neurology Authors: Leńska-Mieciek M, Korczak-Kowalska G, Bocian K, Fiszer U Tags: Neurol Neurochir Pol Source Type: research

Does amantadine have a protective effect against COVID-19?
rra A PMID: 32495926 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - June 4, 2020 Category: Neurology Authors: Cortés Borra A Tags: Neurol Neurochir Pol Source Type: research

Sex-related differences among ischaemic stroke patients treated with intravenous thrombolysis in Poland.
Abstract AIM OF STUDY: We investigated sex differences i n i schaemic s troke p atients t reated w ith i ntravenous a lteplase. CLINICAL RATIONALE FOR STUDY: We suggest that it is necessary to improve care for women with atrial fibrillation. Our data suggests that closer evaluation of treatment for ischaemic stroke in men and women is needed, preferably in the form of a prospective study. MATERIALS AND METHODS: This was a multicentre analysis of 1,830 ischaemic stroke patients treated with alteplase from 2004 to 2012. Data was prospectively collected in the Safe Implementation of Treatments in Stroke (SI...
Source: Neurologia i Neurochirurgia Polska - May 29, 2020 Category: Neurology Authors: Wiszniewska M, Fryze W, Wiśniewska A, Karliński M, Sobolewski P, Krzykowski G, Członkowska A Tags: Neurol Neurochir Pol Source Type: research

Biomarkers in Multiple Sclerosis: a review of diagnostic and prognostic factors.
This article summarises current knowledge on the use of new prognostic factors such as neurofilament light chain, chitinase 3-like 1 and 2, heat shock proteins, and tubulins in MS. FUTURE DIRECTIONS: Despite numerous studies on the use of biomarkers in the diagnosis of MS, more extensive research is needed to determine the clinical usefulness of these molecules and to develop diagnostic tests applicable in everyday practice. This in turn may result in earlier MS detection, faster implementation of treatment, and better therapeutic effects. PMID: 32462652 [PubMed - as supplied by publisher] (Source: Neurologia i N...
Source: Neurologia i Neurochirurgia Polska - May 28, 2020 Category: Neurology Authors: Sapko K, Jamroz-Wiśniewska A, Marciniec M, Kulczyński M, Szczepańska-Szerej A, Rejdak K Tags: Neurol Neurochir Pol Source Type: research

Late onset multiple sclerosis - multiparametric MRI characteristics.
Abstract INTRODUCTION: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) with heterogenic character. Typical age of onset is between 20 and 35 years. Clinically definite multiple sclerosis (CDMS) can occur also in patients older than 50 years. This type of MS is called Late Onset Multiple Sclerosis (LOMS). Until now, the differences in clinical course, type of first symptoms, and prognosis of LOMS have not been well established. Also the MRI characteristics of patients with LOMS have not been determined. Neither conventional nor nonconventional MRI features are known to be typi...
Source: Neurologia i Neurochirurgia Polska - May 5, 2020 Category: Neurology Authors: Jasek Ł, Śmigielski J, Siger M Tags: Neurol Neurochir Pol Source Type: research

Message from the Editors of the Polish Journal of Neurology & Neurosurgery to our Reviewers.
Message from the Editors of the Polish Journal of Neurology & Neurosurgery to our Reviewers. Neurol Neurochir Pol. 2020;54(2):101-103 Authors: Sławek J, Wszolek ZK PMID: 32352151 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - May 1, 2020 Category: Neurology Authors: Sławek J, Wszolek ZK Tags: Neurol Neurochir Pol Source Type: research

Time matters greatly in acute stroke care.
Abstract Stroke is a leading cause of morbidity worldwide. 'Time is brain' is a slogan that characterises contemporary stroke care. Rapid evaluation of stroke begins with community education to better recognise the signs and symptoms of stroke, an organised system of care by first responders and the emergency department, prompt evaluation by the stroke team, and the timely administration of reperfusion including intravenous thrombolysis and endovascular thrombectomy (EVT). In their new study [1], Novak et al. have shown that a shorter time from stroke onset to groin puncture is associated with better recanalisatio...
Source: Neurologia i Neurochirurgia Polska - May 1, 2020 Category: Neurology Authors: Lin MP Tags: Neurol Neurochir Pol Source Type: research

What can Parkinson's disease teach us about COVID-19?
PMID: 32323862 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 23, 2020 Category: Neurology Authors: Tipton PW, Wszolek ZK Tags: Neurol Neurochir Pol Source Type: research

Telemedicine in neurosurgery during the novel coronavirus (COVID-19) pandemic.
PMID: 32319670 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 22, 2020 Category: Neurology Authors: Szmuda T, Ali S, Słoniewski P, Group NW Tags: Neurol Neurochir Pol Source Type: research

Fibrinogen concentrations in ischaemic stroke patients with metabolic disorders.
Abstract BACKGROUND: Hyperfibrinogenemia plays a crucial role in the coagulation cascade leading to the formation of clots. It is involved in the process of platelet aggregation, primary haemostasis, and leukocyte-endothelial cell interactions. The aim of our study was to assess the correlations between fibrinogen concentration and particular risk factors for vascular diseases and atherosclerotic changes in stroke patients. METHODS: The study group consisted with 94 patients with acute ischaemic stroke with normo- or hyperglycaemia and normoor hyperlipidemia. 21 healthy subjects served as a control group. Fib...
Source: Neurologia i Neurochirurgia Polska - April 15, 2020 Category: Neurology Authors: Pawelczyk M, Kaczorowska B, Baj Z Tags: Neurol Neurochir Pol Source Type: research

Radiation therapy in patients with implanted deep brain stimulation.
CONCLUSIONS: Since there are no clear safety guidelines for RT in DBS patients, it is important to document experience in this field. A combined approach involving multidisciplinary discussions between neurosurgeons, radiotherapists, clinical oncologists and neurologists is recommended. PMID: 32285432 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 14, 2020 Category: Neurology Authors: Schinwelski MJ, Dulski J, Łuczak W, Libionka W, Mandat T, Sławek J Tags: Neurol Neurochir Pol Source Type: research

Smoking as a risk factor of onset and relapse of Multiple Sclerosis - a review.
Abstract INTRODUCTION AND OBJECTIVE: Multiple Sclerosis (MS) is a chronic demyelinating disease caused by damage to myelin in the brain and spinal cord. The cause of the disease is unclear, but it is probably correlated with dysregulation of the immunological system, as well as non-modifiable and modifiable risk factors. Unfortunately, there is no cure for MS. However, the course of the condition has been shown to be modifiable by treatment and various environmental factors. Cigarette smoking is one of the most common addictions around the world, and may be a key modifiable risk factor in MS. Here, we review data ...
Source: Neurologia i Neurochirurgia Polska - April 14, 2020 Category: Neurology Authors: Jasielski P, Piędel F, Rocka A, Petit V, Rejdak K Tags: Neurol Neurochir Pol Source Type: research

Cervical dystonia - improving the effectiveness of botulinum toxin therapy.
Abstract INTRODUCTION: Cervical dystonia is the most frequent form of focal dystonia. It is characterised by involuntary muscular contractions resulting in abnormal head/neck and shoulder movements and postures, which can be associated with tremor and pain. Local intramuscular injections of botulinum toxin type A (BoNT-A) is the treatment of choice, being both effective and well-tolerated. However, a considerable number (c. 30%) of patients discontinue this treatment. The aim of this review was to analyse the factors possibly responsible for treatment failures of cervical dystonia (CD), with special regard to the ...
Source: Neurologia i Neurochirurgia Polska - April 14, 2020 Category: Neurology Authors: Tyślerowicz M, Kiedrzyńska W, Adamkiewicz B, Jost WH, Sławek J Tags: Neurol Neurochir Pol Source Type: research

Vestibular migraine - an underdiagnosed cause of vertigo. Diagnosis and treatment.
Abstract INTRODUCTION: Migraine and vertigo are two common conditions. The main disorder connecting both these entities is vestibular migraine (VM). STATE OF THE ART: VM may affect 1-3% of the general population. It is a disabling disease of recurrent attacks of vestibular symptoms accompanied by migraine features which occur in patients with a current or previous history of migraine. The episodes can last minutes, hours or even days, and may occur without any concurrent headache, which can prompt misdiagnosis. VM often begins several years after a typical migraine, and the delay between onset of headache and...
Source: Neurologia i Neurochirurgia Polska - April 14, 2020 Category: Neurology Authors: Nowaczewska M Tags: Neurol Neurochir Pol Source Type: research

Symmetry and interhemispheric propagation of paediatric photoparoxysmal response.
CONCLUSIONS AND CLINICAL IMPLICATIONS: This study provides objective evidence of interhemispheric symmetry in paediatric PPR, which supports the link with generalised seizures. Interhemispheric propagation is facilitated in children with PS, and propagation is more likely in the occipital and temporal regions. PMID: 32266948 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 8, 2020 Category: Neurology Authors: Skadorwa T, Strzelecka J Tags: Neurol Neurochir Pol Source Type: research

Transcranial sonography changes in patients with Wilson's Disease during de-coppering therapy.
Abstract INTRODUCTION: Wilson's Disease (WD) is an inherited disorder of impaired hepatic copper metabolism that leads to copper accumulation in organs such as the liver and brain. Using transcranial sonography (TCS), we investigated brain changes in WD patients during de-coppering treatment. METHODS: Forty-one consecutive treatment-naïve WD patients were classified as having hepatic (WDh; n = 20) or neurological WD (WDn; n = 21) based on symptoms at diagnosis; all patients received either D-penicillamine or zinc sulfate and were observed for 24 months. TCS was performed at regular intervals from study e...
Source: Neurologia i Neurochirurgia Polska - April 7, 2020 Category: Neurology Authors: Skowrońska M, Litwin T, Kurkowska-Jastrzębska I, Członkowska A Tags: Neurol Neurochir Pol Source Type: research

Demographic and clinical profile of patients with multiple sclerosis diagnosed over the last 30 years according to different diagnostic criteria.
Abstract The aim of this study was to investigate the demographic and clinical characteristics of patients with multiple sclerosis (MS) diagnosed between 1986 and 2015. 333 patients with definite MS were divided into four subgroups according to the following diagnostic criteria: Group A) Poser (n = 145), Group B) McDonald 2000 (n = 66), Group C) McDonald 2005 (n = 62), and Group D) McDonald 2010 (n = 60). We investigated: 1) patient sex and age at diagnosis, 2) symptoms and number of relapses that prompted MS diagnosis, 3) time between first symptoms suggestive of MS and confirmed diagnosis, and 5) Expanded Disabi...
Source: Neurologia i Neurochirurgia Polska - April 3, 2020 Category: Neurology Authors: Przybek-Skrzypecka J, Małecka I, Członkowska A, Mirowska-Guzel DM Tags: Neurol Neurochir Pol Source Type: research

Clinical and genetic aspects of hereditary spastic paraplegia in patients from Turkey.
CONCLUSION: Our genetic studies confirmed that clinical analysis can be misleading when defining HSP subtypes. Genetic testing is an important tool for diagnosis and genetic counselling. However, in the majority of AR HSP cases, a genetic diagnosis is not possible. PMID: 32242913 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 3, 2020 Category: Neurology Authors: Akçakaya NH, Özeş Ak B, Gonzalez MA, Züchner S, Battaloğlu E, Parman Y Tags: Neurol Neurochir Pol Source Type: research

Time from stroke onset to groin puncture affects rate of recanalisation after mechanical thrombectomy: a real-life single centre experience.
CONCLUSIONS AND CLINICAL IMPLICATIONS: We suggest that SO-GP time affects the rate of recanalisation in patients with MT. PMID: 32242914 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 3, 2020 Category: Neurology Authors: Nowak K, Derbisz J, Jagiełła J, Pułyk R, Popiela T, Słowik A Tags: Neurol Neurochir Pol Source Type: research

Sexual dysfunction in Huntington's Disease - a systematic review.
CONCLUSIONS: Sexual disorders in HD are common. This is a problem that is probably underestimated, both by patients/caregivers and physicians, who should focus more on these symptoms in order to improve patient quality of life. PMID: 32242915 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 3, 2020 Category: Neurology Authors: Szymuś K, Bystrzyński A, Kwaśniak-Butowska M, Konkel A, Leśnicka A, Nowacka M, Sławek J Tags: Neurol Neurochir Pol Source Type: research

Preferred muscles in cervical dystonia.
atu L Abstract The classification of abnormal posture and the assessment of the affected muscles in cervical dystonia (CD) have changed in recent years. To determine the frequency of injected muscles, we studied 306 patients with CD. The mean age was 55.5 ± 13.1 years (range 21-90), 67% were female. Splenius capitis was the most commonly injected muscle (83%), followed by sternocleidomastoid (79.1%), and trapezius muscles (58.5%). The three next most common were the levator scapulae, semispinalis capitis, and obliquus capitis inferior muscles. The study shows that the most commonly injected muscles have rem...
Source: Neurologia i Neurochirurgia Polska - March 30, 2020 Category: Neurology Authors: Jost WH, Biering-Sørensen B, Drużdż A, Kreisler A, Pandey S, Sławek J, Tatu L Tags: Neurol Neurochir Pol Source Type: research

Influence of levodopa on orthostatic hypotension in Parkinson's Disease.
CONCLUSION: Orthostatic hypotension frequently occurs in patients with PD, occasionally with serious consequences. LD has often been viewed as essentially causing this state. Our study did not confirm this supposition, but rather revealed merely a minor association in individual cases. PMID: 32219811 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 27, 2020 Category: Neurology Authors: Jost WH, Altmann C, Fiesel T, Becht B, Ringwald S, Hoppe T Tags: Neurol Neurochir Pol Source Type: research

Future challenges of spinal cord infarction treatment.
PMID: 32219812 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 27, 2020 Category: Neurology Authors: Jakubowicz-Lachowska D, Tarasiuk J, Kapica-Topczewska K, Mirończuk A, Kochanowicz J, Kułakowska A Tags: Neurol Neurochir Pol Source Type: research

Clinical and epidemiological characteristics of multiple sclerosis patients receiving disease-modifying treatment in Poland.
Abstract AIM OF STUDY: The aim of this study was to collect and analyse data on relapsing-remitting multiple sclerosis (RRMS) patients receiving disease-modifying therapies (DMTs) in Poland. MATERIAL AND METHODS: This observational, multicentre study with prospective data collection included RRMS patients receiving DMTs reimbursed by the National Health Fund (NFZ) in Poland, monitored by the Therapeutic Programme Monitoring System (SMPT). Demographic profiles, disability status, and treatment modalities were analysed. RESULTS: Data from 11,632 RRMS patients was collected (from 15,368 new prescriptions), ...
Source: Neurologia i Neurochirurgia Polska - March 27, 2020 Category: Neurology Authors: Kapica-Topczewska K, Collin F, Tarasiuk J, Chorąży M, Czarnowska A, Kwaśniewski M, Brola W, Bartosik-Psujek H, Adamczyk-Sowa M, Kochanowicz J, Kułakowska A Tags: Neurol Neurochir Pol Source Type: research

Polish Journal of Neurology and Neurosurgery (Neurologia i Neurochirurgia Polska) - a publication of increasing national and international stature.
PMID: 32115675 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - March 4, 2020 Category: Neurology Authors: Wszolek ZK, Sławek J Tags: Neurol Neurochir Pol Source Type: research

Myoclonus-dystonia (DYT11, DYT-SGCE) - a channelopathy?
Abstract INTRODUCTION: Kaczyńska et al. reported a family with myoclonus-dystonia (M-D) caused by a truncating SGCE mutation, in which two members had epilepsy. Further, patients had mild psychiatric and developmental deficits. CLINICAL REFLECTIONS: Characteristic motor features of M-D include myoclonus, dystonia and tremor. A wide range of additional disease manifestations are known. A few patients with M-D have seizures. CLINICAL IMPLICATIONS: Altered neuronal excitability has been found in the pathogenesis of M-D. This may explain the partial effectiveness of antiepileptics and a lower seizure thresh...
Source: Neurologia i Neurochirurgia Polska - March 4, 2020 Category: Neurology Authors: Wictorin K, Puschmann A Tags: Neurol Neurochir Pol Source Type: research

Cerebrospinal meningitis: a global disease with regional variability?
Abstract INTRODUCTION: In this edition, Szymanski et al. present the results of their retrospective study of the clinical differences between patients with meningococcal meningitis and pneumococcal cerebrospinal meningitis at the Regional Specialistic Hospital in Wroclaw, Poland. CLINICAL REFLECTIONS: The authors found that compared to patients with N. meningitidis, patients with S. pneumoniae were older, more frequently had chronic comorbidities, and had higher rates of pneumonia, longer hospitalisations, and higher mortality. Patients with N. meningitidis had higher rates of haemorrhagic rash and DIC. ...
Source: Neurologia i Neurochirurgia Polska - March 4, 2020 Category: Neurology Authors: Siegel JL Tags: Neurol Neurochir Pol Source Type: research

Edward Flatau (1868-1932) - world-leading pioneer of neurology and neurosurgery.
Abstract Polish neurology and neurosurgery owe a very great deal to Edward Flatau. He was a pioneer of these disciplines in Poland whose influence extends worldwide, and we recently celebrated the 150th anniversary of his birth. Edward Flatau's grandson, an outstanding physicist who has been living in San Diego in the USA for many years, has published a book 'Edward Flatau and his comet: beginnings of Polish neurology'. Its promotion took place in the Flatau hometown of Płock in Poland. In 1894, Edward Flatau published his notable work: 'Atlas of the human brain and the trajectory of fibres', the result of arduou...
Source: Neurologia i Neurochirurgia Polska - February 26, 2020 Category: Neurology Authors: Konieczna S, Koziorowski D Tags: Neurol Neurochir Pol Source Type: research

Risk factors for death by acute ischaemic stroke in patients from West-Pomerania, Poland.
Abstract AIM AND CLINICAL RATIONALE FOR STUDY: In Poland, it is widely believed that the outlook for ischaemic stroke patients is gradually improving due to the development of a network of stroke wards and other dedicated hospital units throughout the country. However, a study by Shah et al., reporting a significant increase in mortality from ischaemic stroke in several European countries including Poland, contradicts this belief. Therefore, the aim of this study was to determine the risk factors for death in patients with recent ischaemic stroke among a population of patients from Western Pomerania, a region in n...
Source: Neurologia i Neurochirurgia Polska - February 26, 2020 Category: Neurology Authors: Wańkowicz P, Gołąb-Janowska M, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

Extent of anterior clinoidectomy for clipping of carotid-ophthalmic aneurysms predicted on three-dimensional computerised tomography angiography.
CONCLUSIONS: The predictive value of 3D-CTA on the extent of anterior clinoidectomy still remains unsatisfactory; it is limited by the individual variability of COA and its surrounding structures. CLINICAL IMPLICATIONS: Currently, the role of 3D-CTA planning is restricted to educational purposes only. PMID: 32101325 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - February 26, 2020 Category: Neurology Authors: Szmuda T, Słoniewski P, Ali S, Kamieniecki A, Dzierżanowski J Tags: Neurol Neurochir Pol Source Type: research

Recommendations for neurological, obstetrical and gynaecological care in women with multiple sclerosis: a statement by a working group convened by the Section of Multiple Sclerosis and Neuroimmunology of the Polish Neurological Society.
Abstract INTRODUCTION: Multiple sclerosis (MS) is the most common non-traumatic neurological cause of disability in young adults, affecting women 1-3 times more often than men. Several specific challenges arise from the fact that young women diagnosed with MS often have to make decisions related to treatment and family planning at the same time. These issues are connected with fertility, the impact of pregnancy on disease course, the choice of pregnancy timing, and the optimal mode of disease-modifying therapy in the context of a planned pregnancy, contraception, urological complaints, and sexual dysfunction. ...
Source: Neurologia i Neurochirurgia Polska - February 21, 2020 Category: Neurology Authors: Kalinowska A, Kułakowska A, Adamczyk-Sowa M, Czajkowski K, Kurowska K, Pietrzak B, Radziszewski P, Rejdak K, Bartosik-Psujek H Tags: Neurol Neurochir Pol Source Type: research

In search of Parkinson's disease biomarkers - is the answer in our mouths? A systematic review of the literature on salivary biomarkers of Parkinson's disease.
Abstract The identification of reliable biomarkers of Parkinson's disease (PD) is a pivotal step in the introduction of causal therapies. Saliva is a biofluid which may be involved in synuclein pathology in PD. We have reviewed current studies on salivary proteins and compounds in PD patients and healthy controls, and their potential application as biomarkers. A systematic literature search of the Pubmed and Scopus databases was performed. A total of 198 studies were screened, of which 20 were included in our qualitative analysis. We conclude that the oligomeric form of salivary alpha synuclein is higher in PD pat...
Source: Neurologia i Neurochirurgia Polska - January 31, 2020 Category: Neurology Authors: Figura M, Friedman A Tags: Neurol Neurochir Pol Source Type: research

Paediatric stroke - a review of current guidelines for diagnosis and treatment.
iak S Abstract Stroke, increasingly recognised in children in recent years, is an important cause of long-term morbidity and disability. It can be classified by the stroke type as either arterial ischaemic stroke (AIS), haemorrhagic stroke (HS), or cerebral sinovenous thrombosis (CSVT). Furthermore, perinatal and childhood stroke can be distinguished. A wide range of conditions associated with paediatric stroke has been identified, which differ significantly from those in adults. A paediatric stroke can also present with a variety of symptoms and signs, both specific and non-specific. Because of the diversity of t...
Source: Neurologia i Neurochirurgia Polska - January 27, 2020 Category: Neurology Authors: Oborska Z, Urban P, Wychowaniec K, Jóźwiak S Tags: Neurol Neurochir Pol Source Type: research

Effectiveness and safety of CyberKnife radiosurgery in treatment of trigeminalgia - experiences of Polish neurological and oncological centres.
CONCLUSIONS: CyberKnife radiotherapy is characterised by high efficacy in 80% of patients with trigeminalgia, minimal invasiveness, and subsiding mild side effects. Radioablation of nerve V root in patients with neuralgia allows us to entirely stop antiepileptic therapy or reduce its doses, which in turn reduces the risk of potential side effects. CyberKnife can be a therapeutic option in those patients who have been offered ineffective therapies, or treatments with limited efficacy, and/or in older patients with comorbidities. PMID: 31976542 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - January 24, 2020 Category: Neurology Authors: Bal W, Łabuz-Roszak B, Tarnawski R, Lasek-Bal A Tags: Neurol Neurochir Pol Source Type: research

Monoclonal antibodies - a revolutionary therapy in multiple sclerosis.
Abstract INTRODUCTION: Multiple sclerosis (MS) has an increasing incidence and affects a young s egment of t he population, having a major impact on patients and consequently on society. The multifactorial aetiology and pathogenesis of this disease are incompletely known at present, but autoimmune aggression has a documented mechanism. STATE OF THE ART: Since the 1990s, immunomodulatory drugs of high efficacy and a good safety profile have been launched. But the concept of NEDA (No Evidence of Disease Activity) remains the target to achieve. Thus, the new revolutionary class of monoclonal antibodies (moAbs) u...
Source: Neurologia i Neurochirurgia Polska - January 24, 2020 Category: Neurology Authors: Sirbu CA, Budisteanu M, Falup-Pecurariu C Tags: Neurol Neurochir Pol Source Type: research