Robots for stroke rehabilitation: not all that glitters is gold.
Authors: Morone G PMID: 31172933 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Visual-spatial training in patients with sub-acute stroke without neglect: a randomized, single-blind controlled trial.
Authors: Tramontano M, Dell'Uomo D, Cinnera AM, Luciani C, Di Lorenzo C, Marcotulli M, Vona F, Mercuro A, Abbruzzese S Abstract Many people who have suffered a stroke will experience sensorimotor impairments that disrupt their performance of motor skills, including balance and gait. Furthermore, stroke-induced brain damage can Result in visual disorders that may significantly impact performance of normal daily activities. The primary aim of this study was to investigate the effects, on balance, of visual-spatial training as an add-on intervention to conventional neurorehabilitation in patients with subacute stroke ...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Hearing and cognitive impairment: a functional evaluation of associative brain areas in patients affected by Alzheimer's disease.
We examined 131 diagnosed AD patients and a control group (CG) of 36 normal subjects. After a complete clinical investigation, focused on hearing function, all subjects underwent a brain FDG PET/CT. AD subjects vs CG showed reduced glucose consumption in BA 6,7,8,39, whereas we did not find differences in the primary auditory cortex. In AD, connectivity analyses showed a positive correlation of the primary auditory cortex with BA 6,8,21,31,39,40,42 and a negative correlation with BA 19, cerebellum and basal ganglia. Our findings suggest that neurological evaluation of patients with hearing loss might allow earlier (preclin...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The role of Personal KinetiGraph ™ fluctuator score in quantifying the progression of motor fluctuations in Parkinson's disease.
In conclusion, PKG FS can distinguish EF from TF, as well as dyskinetic from non-dyskinetic patients, but cannot discriminate subtler MF. PKG may provide objective MF measures for routine PD management and clinical trials. PMID: 31172936 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Evaluation of the psychometric properties of the Barthel Index in an Italian ischemic stroke population in the acute phase: a cross-sectional study.
This study demonstrates the psychometric properties of the IcaBI in an Italian stroke population, and therefore shows that the scale can be considered a valid and reliable assessment tool for measuring functional disability in Italian acute ischemic stroke survivors. PMID: 31172937 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Augmentative and alternative communication improves quality of life in the early stages of amyotrophic lateral sclerosis.
In conclusion, in this study we highlighted how early AAC-T in patients with ALS may be a valuable tool to demonstrate how specific strategies and low-technology aids can improve QoL of these patients and their caregivers, also decreasing stress and depression. PMID: 31172938 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Effectiveness of intensive neurorehabilitation in obese subacute stroke patients.
Authors: Ciancarelli I, Tonin P, Garo ML, Tozzi Ciancarelli MG Abstract The relationship between abdominal subcutaneous adipose tissue thickness (aSAT), body fat percentage (BFP), waist-to-hip ratio (WHR) and body mass index (BMI) and outcome measures of neurological deficit and functional recovery was evaluated in obese subacute stroke patients before and after neurorehabilitation. Decreased National Institutes of Health Stroke Scale (p = 0.0001) and modified Rankin Scale (mRS) (p= 0.002) scores, as well as increased Barthel Index (p= 0.0001) scores were detected after neurorehabilitation. Decreased BMI, aSAT, BFP...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

A novel neurocognitive rehabilitation tool in the recovery of hemiplegic hand grip after stroke: a case report.
Authors: Paolucci T, Capobianco SV, Vinciguerra SM, Cilli M, Villani C, Saraceni VM Abstract Stroke has significant physical, psychological and social consequences. Recent rehabilitation approaches suggest that cognitive exercises with dual-task (sensory-motor) exercises positively influence the recovery and function of the hemiplegic hand grip. The purpose of this study was to describe a rehabilitation protocol involving the use of a new neurocognitive tool called "UOVO" for hand grip recovery after stroke. A 58-year-old right-handed male patient in the chronic stage of stroke, presenting with left-sided...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Music and neurorehabilitation: Yes, we can!
Authors: Raglio A Abstract PMID: 30663962 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports.
Authors: Gómez-Ochoa SA, Espín-Chico BB, Pinilla-Monsalve GD, Kaas BM, Téllez-Mosquera LE Abstract Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome occurring predominantly in elderly females and in the setting of non-ketotic hyperglycemia (NKH). A systematic review was conducted in accordance with the PRISMA statement. Studies published between 1980 and 2018 that reported demographic, clinical, laboratory and imaging features from patients with HCB were screened. 136 studies describing 286 patients were included in the analysis. The patients included had a me...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Recovery of circadian melatonin rhythm after a melatonin holiday in daytime haemodialysis patients on long-term exogenous melatonin.
Authors: Sparla S, Koch B, Bosma R, Nagtegaal E Abstract The effects of exogenous melatonin on sleep diminish after its long-term use in haemodialysis patients. Our aim was to determine whether melatonin levels accumulate after chronic (at least three months) use of exogenous melatonin, 5 mg daily, and whether discontinuation of this treatment improves endogenous melatonin production and improves the circadian sleep-wake rhythm. In this case series, stable haemodialysis patients discontinued their chronic exogenous melatonin usage for seven days and melatonin concentrations in saliva were analysed. The primary endp...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Multiple sclerosis and non-dystrophic myotonias: do they share a common pathophysiology?
Authors: Portaro S, Naro A, Russo M, Bramanti P, Lauria P, D'Aleo G, La Rosa G, Bramanti A, Calabrò RS Abstract Some patients with multiple sclerosis (MS) complain of symptoms, such as myokymia, myotonia, spasms, and stiffness, which have been demonstrated to be due to a concurrent non-dystrophic myotonia, i.e. myotonia congenita or paramyotonia congenita. Beyond the known casual association between MS and non-dystrophic myotonia, a channelopathy representing a primary trait of MS rather than an epiphenomenon of demyelization (i.e., an acquired channelopathy) may exist. Indeed, the finding of MS patients wit...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

From paper to informatics: the Post Soft Care-App, an easy-to-use and fast tool to help therapists identify unmet needs in stroke patients.
Authors: De Bartolo D, Morone G, Lupo A, Aloise F, Baricich A, Di Francesco D, Calderone C, Cisari C, Verdecchia G, Sandrini G, Pistarini C, Antonucci G, Smania N, Paolucci S, Iosa M Abstract Even after rehabilitation, post stroke patients remain disabled. The Post Stroke Checklist (PSC) was developed to highlight unmet needs of community-dwelling stroke patients. The present study set out to validate Post Soft Care-App, designed to administer the PSC using smartphones and tablets, in order to monitor unmet needs in chronic patients. Fifty-three patients and fifteen physiotherapists were enrolled. The therapists ad...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Automated mechanical peripheral stimulation and postural control in subjects with Parkinson's disease and freezing of gait: a randomized controlled trial.
This study aimed to investigate the effects of AMPS on postural control in individuals with PD and FOG. Thirty-three subjects participated in this randomized controlled trial. Participants were allocated to two groups: AMPS and AMPS SHAM. Subjects underwent eight sessions of real (AMPS) or placebo AMPS (AMPS SHAM) once every three/four days. Postural control was assessed by means of posturography before the first and after the eighth session of treatment. We did not find positive effects of AMPS on center of pressure parameters. Thus, it seems that AMPS has no positive effect in terms of improving static postural control i...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations.
Authors: Aragona B, De Luca R, Piccolo A, Le Cause M, Destro M, Casella C, Filoni S, Calabrò RS Abstract Post-stroke apathy is considered to be one of the clinical consequences of lesions affecting the structures of the prefrontal cortex, basal ganglia, thalamus and limbic system. However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying etiology and comorbidities. A 62-year-old man, affected by hemorrhagic stroke in the left thalamus, presented with mood depression, anhedonia, hyporexia and marked apathy. The patient underwent clinical evaluation b...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

TIA patients with higher ABCD3-I scores are prone to a higher incidence of intracranial stenosis, unstable carotid plaques and multiple-vessel involvement.
Authors: Yu Q, Miao W, Han J Abstract The ABCD3-I criteria have proved to be effective for use in regular clinical practice to assist in transient ischemic attack (TIA) risk stratification and treatment. In this prospective study we aimed to explore the relationships between risk stratification and arterial stenosis location, carotid plaque morphology and vessel involvement in 90 TIA patients, stratifying risk by ABCD3-I scores. Clinical variables such as total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, homocysteine and high-sensitive C-reactive protein levels were reco...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Is there a correlation between urological and cardiovascular dysfunction in Parkinson's disease?
Authors: Brusa L, Rocchi C, Ponzo V, Stanzione P, Finazzi E, Attanasio A Abstract It is well established that non-motor symptoms are a core feature of Parkinson's disease (PD). A dysregulation of the autonomic nervous system seems to be present in PD, supporting the coexistence of urological and cardiovascular non-motor features. We evaluated whether bladder dysfunctions in patients with PD are linked to blood pressure dysregulation. Twenty-eight mild PD patients, previously submitted to a urodynamic evaluation, underwent 24-hour ambulatory blood pressure and heart rate monitoring to allow assessment of their circa...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Cross-cultural adaptation and validation in the Italian population of the wolf motor function test in patients with stroke.
The objective of this study was to translate and culturally adapt the WMFT for the Italian population (WMFT-IT) and examine its reliability and validity in Italian post-stroke adults with chronic hemiplegia or hemiparesis. The original scale was translated into Italian and culturally adapted in accordance with international guidelines. Its internal consistency and stability were examined using the Cronbach's alpha (α) coefficient and the intra-class correlation coefficient (ICC), respectively. Its concurrent validity was evaluated using the Pearson's correlation coefficient to compare the instrument with the Italian ...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The dawn of algometry: Paolo Mantegazza's research on pain.
Authors: Cani V Abstract By the 1860s, Paolo Mantegazza was a professor of general pathology at the University of Pavia, where he had graduated in medicine in 1854. There, he founded Italy's first laboratory of experimental pathology and did his first research on pain, the subject of various communications presented to the Istituto Lombardo in Milan. In 1880, Mantegazza published Physiology of Pain, one of the several "physiologies" (of pleasure, of love, of hatred, of woman) that he wrote during his career. In this book, a testament to his scientific versatility, experimental observations supplemented hi...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Errata corrige Functional Neurology 2018;33:2 Article: Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome?
Authors: Abstract PMID: 30457962 [PubMed] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Chronic stroke: an oxymoron or a challenge for rehabilitation?
Authors: Baricich A, Carda S Abstract PMID: 30457963 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Effects of a nutraceutical combination in patients with chronic lumbosacral radicular pain.
Authors: Geroin C, Tamburin S, Pagano G, Gandolfi M, Tinazzi M Abstract Drugs used for the treatment of chronic lumbosacral radicular pain (LRP) may have frequent adverse effects leading to medication withdrawal. The use of add-on nutraceuticals, which have no side effects, may therefore play a role in LRP treatment. We performed a six-week, single-center, open label prospective uncontrolled clinical study to evaluate the effect of a nutraceutical combination (Noxiall®) used as an add-on therapy in patients with chronic LRP. Fifteen patients were treated with Noxiall® twice a day for 10 consecutive days, fo...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.
Authors: Lupo A, Cinnera AM, Pucello A, Iosa M, Coiro P, Personeni S, Gimigliano F, Iolascon G, Paolucci S, Morone G Abstract Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute str...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

The required coefficient of friction in Parkinson's disease: people with freezing of gait.
Authors: Rozin Kleiner AF, Cubillos DM, Pinto C, Salazar AP, Marchese RR, Barros RML, Galli M, Pagnussat AS Abstract The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Non-pharmacological interventions for agitation/aggressive behaviour in patients with dementia: a randomized controlled crossover trial.
Authors: Dimitriou TD, Verykouki E, Papatriantafyllou J, Konsta A, Kazis D, Tsolaki M Abstract Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. This trial is a randomized controlled crossover trial conducted in Greece. The following measures were used: the Mini-Mental State Examination, Addenbrooke's Cognitive Examination Revised, Geriatric Depression Scale, Functiona...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats.
In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period. On day 15, pain tolerance was assessed through the tail flick test, and two days later the rats were investigated for anxiety in an elevated plus maze (EPM). Indices of oxidative stress (levels of malondialdehyde, glutathione, nitrite/nitrate and catalase activity in the VTA) were then studied in the animals. Malondialdehyde in the VTA was found to be reduced in the SI rats compared with...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.
Authors: Gatto RG, Mustafi SM, Amin MY, Mareci TH, Wu YC, Magin RL Abstract Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

An acute neurological complication of Crohn's disease.
Authors: Battista F, Tinella E, Colosimo C Abstract PMID: 30457970 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Shaping a pain-free future for cluster headache patients. The Declaration of Paris.
Authors: Rossi P, Bruce S, De Pascual MA, Muller H, Tyminski EK, De La Torre ER Abstract PMID: 30457971 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Shorter acute care hospital stay, longer stay in post-acute care facilities.
Authors: Formisano R, Contrada M, Aloisi M PMID: 29984682 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Understanding the pathophysiology of hyperglycemia-associated chorea-ballism: a systematic review of positron emission tomography findings.
Authors: Gómez Ochoa SA, Espín Chico BB Abstract Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported demographic, clinical, laboratory and imaging data from patients with HCB in whom a PET scan had been performed. Eleven patients were evaluated (women 82%, Asian origin 91%, mean age 71 years). The main findings were an increase in glucose me...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

A review of 500 patients with acute stroke admitted to the University Hospital of Saudi Arabia. Similarities and differences compared with the published literature.
Authors: Zafar A Abstract Published studies have shown differences in types and underlying mechanisms of stroke between different regions of the world. There is a lack of published literature describing the characteristics of acute stroke in Saudi Arabia. The aim of this study was to identify different types and associated risk factors among acute stroke patients in Saudi Arabia. In this descriptive study, records of 500 patients with acute stroke were included. Acute stroke was classified as ischemic stroke, intracerebral hemorrhage, cerebral venous sinus thrombosis or subarachnoid hemorrhage. The TOAST classifica...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Direction-specific cortical response immediately after moving tactile stimuli in female humans.
This study looked for a direction-specific cortical response immediately after application of moving tactile stimuli in healthy female humans. Four pairs of stimulus electrodes were placed over the left index finger pulp on the distal-proximal axis. Four times, once in every 40 ms interval, an electrical stimulus to the finger pulp was delivered through one of the four pairs of electrodes; each time the stimulus site changed in order to induce a sensation of tactile motion. The slope of the electroencephalographic trace, as recorded from electrodes placed over the CP, P4 and right hMT+/V5 in the period 150-200 ms after the...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Impact of epilepsy after severe brain injury on safe resumption of driving: two-year follow-up.
Authors: Saviola D, De Tanti A, Delsoldato S, Chiari M, Inzaghi MG, Baldari F Abstract Safe resumption of driving after a severe acquired brain injury (sABI) is a strongly felt need because driving is related to recovery of independence and social-occupational re-integration. The aim of this prospective observational cohort study was to determine whether epilepsy secondary to sABI is a significant factor for being declared fit to drive by the relevant government authorities in Italy. In the period 2006-2015 we recruited 187 patients with sABI, 30 of whom (16.4%) developed secondary epilepsy. The interval between th...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome?
Authors: Avesani R, Dambruoso F, Scandola M, Formisano R, De Tanti A, Ferro S, Smania N, Roncari L, Rossato E Abstract Recent studies on recovery of consciousness of subjects in a vegetative state (VS) admitted to rehabilitation units have focused mainly on the identification of prognostic factors, whereas few studies have focused on outcome. The aim of this study was to compare demographic and clinical data and report functional outcome of patients in a VS due to severe acquired brain injury (ABI) of different aetiologies. The study was a retrospective multicentre cohort study and involved 492 patients in a VS due...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Laterality in Parkinson's disease may predict motor and visual imagery abilities.
Authors: Lo Monaco MR, Laudisio A, Fusco D, Vetrano DL, Ricciardi D, Delle Donne V, Proietti F, Zuccalà G, Silveri MC Abstract Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Dispariti...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Development of a patient-centered questionnaire for post-stroke spasticity assessment: a reliability study.
Authors: Baricich A, Cosenza L, Sandrini G, Paolucci S, Morone G, Santamano A, Cinone N, Peri E, Picelli A, Invernizzi M, Ferrieri G Abstract In the emerging scenario of patient-centered medicine, it is becoming increasingly important to involve patients in the management of chronic diseases. The rehabilitation field currently has no assessment tool for evaluating the functional impact of post-stroke spasticity on activities of daily living. The aim of this study was to identify a tool to fill this gap. The "Spasticity Questionnaire in Real Life" (SPQR) was administered, twice, to 39 patients with poststr...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Musculoskeletal impairment and functional limitations in a patient affected by mutation in the laminin a-5 gene.
Authors: Liguori S, de Sire A, Moretti A, Sodano L, Sampaolo S, Gimigliano F, Iolascon G PMID: 29984690 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Mechanical thrombectomy for acute ischemic stroke: the therapeutic window is larger but still "time is brain ».
Mechanical thrombectomy for acute ischemic stroke: the therapeutic window is larger but still "time is brain». Funct Neurol. 2018 Jan/Mar;33(1):5-6 Authors: Zivelonghi C, Tamburin S PMID: 29633691 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal.
Authors: Ferrari A, Manca M, Tugnoli V, Alberto L Abstract Three different type A botulinum neurotoxins (BoNTAs) - onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA) - are currently marketed in Europe to treat several conditions. Differences between BoNTA preparations, which depend on their specific biotypes and manufacturing processes, lead to clinically relevant pharmacotherapeutic dissimilarities. All three available products are separately recognized and reviewed in American Academy of Neurology guidelines. The neurotoxin load/100U is likewise different among the different BoNTAs, with the result t...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Multicentre registry of brain-injured patients with disorder of consciousness: rationale and preliminary data.
Authors: Pascarella A, Fiorenza S, Masotta O, Tibollo V, Vella D, Nardone AM, Rossi M, Volanti P, Madonia F, Cstronovo G, De Cicco D, Guarnaschelli C, Achilli MP, Chiapparino C, Angelillo MT, Tommasi MA, Pisano F, Grioni G, Vezzadini G, Ferriero G, Salvaderi S, Bellazzi R, Estraneo A Abstract Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On t...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Apathy in Parkinson's disease: differences between caregiver's report and self-evaluation.
Authors: Valentino V, Iavarone A, Amboni M, Moschiano F, Picillo M, Petretta V, Cicarelli G Abstract Apathy is a state of diminished goal-directed speech, motor activity and emotions. The prevalence of apathy in Parkinson's disease (PD) ranges from 16 to 62%. Several studies have investigated the relationships between apathy and other dimensions of PD, but little is known about possible discrepancies between self-evaluation (SE) and caregiver reporting (CR) of this symptom. The aim of this study is twofold: 1) to investigate the differences in apathy evaluations according to the point of view from which apathy is r...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Management of spasticity with onabotulinumtoxinA: practical guidance based on the italian real-life post-stroke spasticity survey.
Authors: Sandrini G, Baricich A, Cisari C, Paolucci S, Smania N, Picelli A Abstract The present paper provides practical guidance on the management of adult spasticity with OnabotulinumtoxinA. Advisory Board members reviewed the available evidence and discussed their personal experiences in order to address the unmet needs in the management of spasticity with botulinum toxin type A identified by the recent Italian Real-Life Post-Stroke Spasticity Survey. Stroke patients should be referred to spasticity services that have adequate facilities and multidisciplinary teams with the necessary training, competence and exp...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

A role for accelerometry in the differential diagnosis of tremor syndromes.
Authors: Bove F, Di Lazzaro G, Mulas D, Cocciolillo F, Di Giuda D, Bentivoglio AR Abstract Accelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. All the patients underwent dopamine transporter imaging (by means of single-photon emission computed tomography) and triaxial accelerometric tremor analysis. The latter rev...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Effectiveness of a digital platform for sharing knowledge on headache management: a two-year experience.
Authors: Raieli V, Correnti E, Sandullo A, Romano M, Marchese F, Loiacono C, Brighina F Abstract It is crucial that all headache specialists receive adequate training. Considering the unsatisfactory results obtained with standard updating courses and the growing need for continuing professional education, a digital platform was developed as a training tool. The platform has been active since 1 October 2014. It is readily accessible to doctors by free registration. Users have access to all the material available on the platform, which includes scientific articles, e-books, presentations and images. Users can share t...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences.
Authors: Rossi P, Little P, De La Torre ER, Palmaro A Abstract Cluster headache (CH) is arguably the most severe pain condition that afflicts humans. The severity of the pain has earned it the nickname "suicide headache". Understanding how CH impacts on those who suffer from it is essential, because this understanding creates empathy, which is so valuable to these patients. On the occasion of Cluster Headache Day 2017, we asked CH patients from different European countries to share their experiences, in order to help people to imagine what it means to live with the condition. Here, we look at some extract...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Add-on perampanel and aggressive behaviour in severe drug-resistant focal epilepsies.
This study aimed to investigate the incidence of aggressiveness in patients with severe drug-refractory focal epilepsy (DRE) who started perampanel (PER) as add-on treatment, and to identify possible predisposing factors. Data on 49 consecutive patients with severe DRE who initiated PER were retrospectively collected. Twelve of the 49 patients experienced aggressiveness as adverse event related to PER treatment, one third of them on low (2-4 mg/day) PER dosages. PER was discontinued in 10/12 patients because of aggressive behaviors. Aggressiveness could appear after several months or even more than one year of PER treatmen...
Source: Functional Neurology - January 19, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Volunteering in hospitals to improve the quality of long stays in rehabilitation units.
Authors: Barbieri M, Malfoni M, Negro S, Maddalena D, Bosone D, Tronconi L PMID: 29306354 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - January 9, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Neurophysiology of the pelvic floor in clinical practice: a systematic literature review.
Authors: Bianchi F, Squintani GM, Osio M, Morini A, Bana C, Ardolino G, Barbieri S, Bertolasi L, Caramelli R, Cogiamian F, Currà A, de Scisciolo G, Foresti C, Frasca V, Frasson E, Inghilleri M, Moderna L, Motti L, Onesti E, Romano MC, Del Carro U Abstract Neurophysiological testing of the pelvic floor is recognized as an essential tool to identify pathophysiological mechanisms of pelvic floor disorders, support clinical diagnosis, and aid in therapeutic decisions. Nevertheless, the diagnostic value of these tests in specific neurological diseases of the pelvic floor is not completely clarified. Seeking to fi...
Source: Functional Neurology - January 9, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

The usefulness of sLORETA in evaluating the effect of high-dose ARA-C on brain connectivity in patients with acute myeloid leukemia: an exploratory study.
Authors: Zarabla A, Ungania S, Cacciatore A, Maialetti A, Petreri G, Mengarelli A, Spadea A, Marchesi F, Renzi D, Gumenyuk S, Strigari L, Maschio M Abstract Cytosine arabinoside (Ara-C) is one of the key drugs for treating acute myeloid leukemia (AML). High intravenous doses may produce a number of central nervous system (CNS) toxicities and contribute to modifications in brain functional connectivity. sLORETA is a software used for localizing brain electrical activity and functional connectivity. The aim of this study was to apply sLORETA in the evaluation of possible effects of Ara-C on brain connectivity in pati...
Source: Functional Neurology - January 9, 2018 Category: Neurology Tags: Funct Neurol Source Type: research