Disclosing sexual function in the neurorehabilitation setting: are we heading in the right direction?
Authors: Calabrò RS PMID: 32453993 [PubMed - as supplied by publisher] (Source: Functional Neurology)
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

From movement to thought and back: a review on the role of cognitive factors influencing technological neurorehabilitation.
Authors: De Bartolo D, Spitoni GF, Iosa M, Morone G, Ciancarelli I, Paolucci S, Antonucci G Abstract In recent years, cognitive theories have increasingly influenced the approach to motor rehabilitation. The connection between different aspects of cognitive and motor function is increasingly documented, underlining the importance of developing rehabilitation projects that take cognitive aspects into account. The aim of this non-systematic review is to highlight the relationship between cognition and motion and, in the light of new rehabilitation technologies, to better define how aspects of cognition can affect mot...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Psychometric properties of the Italian version of the Barthel Index in patients with Parkinson's disease: a reliability and validity study.
The objective of this psychometric study was to validate the Italian version of the BI in a population of patients with Parkinson's disease (PD). The study was conducted at three neurological and rehabilitation centres in Rome, Italy. The BI was administered to outpatients with PD. The reliability of the scale was assessed using Cronbach's alpha for internal consistency; the intra-class correlation coefficient (ICC) was used to measure its intra- and inter-rater reliability. Pearson's correlation coefficient was calculated to evaluate its validity, comparing it with the Parkinson's disease Questionnaire (PDQ-39), the Itali...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Effects of Constraint-Induced Movement Therapy on upper limb activity according to a bi-dimensional kinematic analysis in progressive multiple sclerosis patients: a randomized single-blind pilot study.
Authors: de Sire A, Mauro A, Priano L, Baudo S, Bigoni M, Solaro C Abstract Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by demyelinization and axonal loss resulting, in 66% of cases, in upper limb motor impairment. The effects of constraint-induced movement therapy (CIMT) have recently been investigated in MS patients. The aim of this randomized single-blind pilot study was to assess the effects of CIMT on upper limb activity, specifically smoothness of movement, in patients affected by progressive MS. Patients affected by MS, and reporting reduced use primarily of one ...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Does a single bout of exercise impacts BDNF, oxidative stress and epigenetic markers in spinal cord injury patients?
Authors: Goldhardt MG, Andreia A, Dorneles GP, da Silva IR, Pochmann D, Peres A, Rostirola Elsner V Abstract Our aim was to evaluate the impact of a single bout of exercise, consisting of a gait training session with body weight support (BWS), on histone acetylation status (global histone H4 and H3 acetylation levels), brain-derived neurotrophic factor (BDNF) levels, and oxidative stress markers in peripheral blood of individuals with chronic spinal cord injury (SCI). We also set out to compare these responses with those recorded after gait training performed using a walker and with no BWS. The subjects (nearly all...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Acute ischemic stroke management in Lebanon: obstacles and solutions.
This study assesses the current practices of physicians in Lebanon routinely involved in ischemic stroke (IS) management. We conducted a prospective observational study of patients hospitalized at 8 different Lebanese hospitals in the period August 1, 2015 to July 31, 2016, with a diagnosis of acute stroke. Baseline characteristics and data on diagnostic studies, as well as treatments received during hospitalization and at discharge, were collected and analyzed. Two hundred and three strokes/transient ischemic attacks (TIAs) were recorded but only 173 patients (85%) with ischemic events were included in the study. The pati...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation.
Authors: Negri M, Gorgora M, Nasser JA, Salles JI, Teixeira S, Arias-Carrión O, Junqueira J, Nicoliche E, Velasques B, Cagy M, Budde H, Basile LF, Orsini M, Friede R, Bastos VH, Ribeiro P Abstract Chronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design ...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

Are paediatric headaches in the emergency department increasing? An Italian experience.
Authors: Vetri L, Messina LM, Drago F, D'Aiuto F, Vanadia F, Brighina F, Raieli V Abstract The aim of this study was to assess admissions, for headache, to the emergency department (ED) of the Di Cristina Children's Hospital in Palermo over a decade. The total number of ED admissions for headache was retrospectively analysed considering two 24- month periods: 2009-2010 and 2017-2018. Total admissions to the ED decreased from 55,613 to 50,096 (-10%) between the two periods considered, while the number of admissions for headache increased by 63.56% (p
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

The origins of the fight against rabies: a journey between the history of neuroscience and university museum collections.
Authors: Garbarino MC Abstract Although rabies, or hydrophobia, is one of the so-called forgotten tropical diseases, it still kills thousands of people each year, especially children living in rural areas of Asia and Africa. This terrible disease was once a much-feared threat throughout Europe, whose terrifying symptoms were described in a vast body of literature that was based on both science and popular beliefs. One notable individual whose name is linked to the fight against this disease is Adelchi Negri, a brilliant but unfortunate pupil of Camillo Golgi. At the beginning of the 20th century, Negri observed pec...
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

The need for broader admission criteria for high specialty neurorehabilitation wards in the Italian Health System: not only post-comatose patients.
Authors: Formisano R PMID: 32454002 [PubMed - as supplied by publisher] (Source: Functional Neurology)
Source: Functional Neurology - May 27, 2020 Category: Neurology Tags: Funct Neurol Source Type: research

The nine circles of EBM hell.
Authors: Iosa M, Antonucci G, Paolucci S PMID: 31556384 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The impact of an aquatic exercise program on BDNF levels in Parkinson's disease patients: short-and long-term outcomes.
Authors: da Silva Germanos S, Vieira B, Reichert Vital da Silva I, da Cunha JJ, Nique S, Striebel V, Pochmann D, Rostirola Elsner V Abstract The present study aimed to analyze the short-and long-term effects of an aquatic exercise program on plasma brain-derived neurotrophic factor (BDNF) levels in individuals with Parkinson's disease (PD). The aquatic exercise program lasted one month, and consisted of two sessions per week (1 hour per session). Blood samples were collected at four different timepoints: pre-intervention (T0), immediately after the first session (T1), 48 hours after the first session (T2), and 1 mo...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Obstructive sleep apnea: neurocognitive and behavioral functions before and after treatment.
Authors: Turner K, Zambrelli E, Lavolpe S, Baldi C, Furia F, Canevini MP Abstract Obstructive sleep apnea syndrome (OSAS) is a sleep disorder characterized by repetitive episodes of upper airway obstruction. The aim of this study was to evaluate whether continuous positive airway pressure (CPAP) treatment is linked to improvements in cognitive abilities and emotional functions of patients with OSAS. Following the exclusion of four subjects for non-adherence to CPAP treatment, the final study sample was composed of 16 patients with moderate-to-severe OSAS, who were assessed both prior to and after 3 months of CPAP t...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Risk factors and subtypes of ischemic stroke in young patients: an observational study from a teaching hospital in Saudi Arabia.
Authors: Shahid R Abstract Young adults are a key part of any society and the psychosocial and economic burden of any chronic or devastating disease in this particular group has significant consequences and impacts negatively on the development of the society as a whole. Although stroke in this age group is relatively rare, its consequences, in terms of lifelong dependence and disability, are substantial. Therefore, it is important to address this issue. In this retrospective epidemiological study, we analyzed the medical records of young patients (aged 18- 45 years) with a diagnosis of stroke during the study peri...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Wearable sensors, cerebral palsy and gait assessment in everyday environments: is it a reality? - A systematic review.
Authors: Rozin Kleiner AF, Bellomo A, Pagnussat AS, de Athayde Costa E Silva A, Sforza C, Cicuto Ferreira Rocha NA Abstract This systematic review aimed to investigate emerging methods used to quantify gait parameters in children with cerebral palsy (CP) in everyday environments. The StArt computational tool automatically screened the following databases: ACM, Engineering Village, IEEE, PubMed, Scopus and Web of Science from inception to June 2018. Studies reporting the use of wearable sensors to assess gait in daily settings in children with CP were included. Data regarding 1563 studies were extracted, but only th...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

ERIGO: a possible strategy to treat orthostatic hypotension in progressive supranuclear palsy? A feasibility study.
Authors: Sorbera C, Portaro S, Cimino V, Leo A, Accorinti M, Silvestri G, Bramanti P, Naro A, Calabrò RS Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disease of the central nervous system, presenting with different clinical phenotypes, all involving the extrapyramidal system. Orthostatic hypotension (OH) is a common symptom of cardiovascular autonomic dysfunction. OH is defined as a fall in systolic blood pressure of at least 20 mmHg and/or a fall in diastolic blood pressure of at least 10 mmHg on standing or head-up tilt. In this pilot study, we tested the feasibility and efficacy of...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Influence of neurorehabilitation on stroke-induced modifications of the quadriceps muscle in elderly subacute stroke patients with paresis.
Authors: Ciancarelli I, Mariangeli F, Tonin P, Ciofani E, Garo ML, Ciancarelli MGT Abstract The influence of intensive multifunctional neurorehabilitation on post-stroke changes at the level of the paretic leg quadriceps muscle was examined in elderly subacute stroke patients. We assessed paretic leg muscle mass thickness and muscle fatty infiltration thickness, as well as clinical outcome measures (National Institutes of Health Stroke Scale, modified Ranking Scale, and Barthel Index) both before and after neurorehabilitation. Improved outcome measures (p ≤ 0.01) and increased muscle mass thickness (p = 0.005) w...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Motor cortex function in fibromyalgia: a pilot study involving near-infrared spectroscopy and co-recording of laser-evoked potentials.
Authors: Gentile E, Ricci K, Delussi M, de Tommaso M Abstract Interaction between the motor and nociceptive systems seems to play an important role in chronic pain. In this pilot study we used a combination of functional near-infrared spectroscopy (FNIRS) and laserevoked potentials (LEPs) during concurrent finger tapping task and noxious laser stimulation in fibromyalgia (FM) patients and controls. The study included 9 healthy subjects and 15 FM patients. During concurrent FNIRS and LEP recording, participants were required either to remain in resting relaxed condition or to execute a finger tapping task with the r...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Low back pain related to a sacral insufficiency fracture: role of paravertebral oxygen-ozone therapy in a paradigmatic case of nociplastic pain.
We describe the case of a 68-year-old woman with an acute episode of severe low back pain (LBP) resistant to opioids, who had experienced a sacral insufficiency fracture (SIF) two years earlier. At clinical examination, patient reported constant, dull, non-localizable pain at lumbar and sacral level, exacerbated by paravertebral palpation, particularly at L4-L5 and the sacroiliac joint, with a concomitant and remittent neuropathic component, difficult to localize at lumbar and sacral level. The latest magnetic resonance imaging study revealed disc herniations at L3-L4, L4-L5, and L5-S1 levels. The patient was treated with ...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Rehabilitation assisted by robotic and electromechanical devices for persons with neurological disabilities: an Italian consensus conference.
Authors: Boldrini P, Bonaiuti D, Mazzoleni S, Posteraro F PMID: 31556393 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Robots for stroke rehabilitation: not all that glitters is gold.
Authors: Morone G PMID: 31172933 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Visual-spatial training in patients with sub-acute stroke without neglect: a randomized, single-blind controlled trial.
Authors: Tramontano M, Dell'Uomo D, Cinnera AM, Luciani C, Di Lorenzo C, Marcotulli M, Vona F, Mercuro A, Abbruzzese S Abstract Many people who have suffered a stroke will experience sensorimotor impairments that disrupt their performance of motor skills, including balance and gait. Furthermore, stroke-induced brain damage can Result in visual disorders that may significantly impact performance of normal daily activities. The primary aim of this study was to investigate the effects, on balance, of visual-spatial training as an add-on intervention to conventional neurorehabilitation in patients with subacute stroke ...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Hearing and cognitive impairment: a functional evaluation of associative brain areas in patients affected by Alzheimer's disease.
We examined 131 diagnosed AD patients and a control group (CG) of 36 normal subjects. After a complete clinical investigation, focused on hearing function, all subjects underwent a brain FDG PET/CT. AD subjects vs CG showed reduced glucose consumption in BA 6,7,8,39, whereas we did not find differences in the primary auditory cortex. In AD, connectivity analyses showed a positive correlation of the primary auditory cortex with BA 6,8,21,31,39,40,42 and a negative correlation with BA 19, cerebellum and basal ganglia. Our findings suggest that neurological evaluation of patients with hearing loss might allow earlier (preclin...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The role of Personal KinetiGraph ™ fluctuator score in quantifying the progression of motor fluctuations in Parkinson's disease.
In conclusion, PKG FS can distinguish EF from TF, as well as dyskinetic from non-dyskinetic patients, but cannot discriminate subtler MF. PKG may provide objective MF measures for routine PD management and clinical trials. PMID: 31172936 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Evaluation of the psychometric properties of the Barthel Index in an Italian ischemic stroke population in the acute phase: a cross-sectional study.
This study demonstrates the psychometric properties of the IcaBI in an Italian stroke population, and therefore shows that the scale can be considered a valid and reliable assessment tool for measuring functional disability in Italian acute ischemic stroke survivors. PMID: 31172937 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Augmentative and alternative communication improves quality of life in the early stages of amyotrophic lateral sclerosis.
In conclusion, in this study we highlighted how early AAC-T in patients with ALS may be a valuable tool to demonstrate how specific strategies and low-technology aids can improve QoL of these patients and their caregivers, also decreasing stress and depression. PMID: 31172938 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Effectiveness of intensive neurorehabilitation in obese subacute stroke patients.
Authors: Ciancarelli I, Tonin P, Garo ML, Tozzi Ciancarelli MG Abstract The relationship between abdominal subcutaneous adipose tissue thickness (aSAT), body fat percentage (BFP), waist-to-hip ratio (WHR) and body mass index (BMI) and outcome measures of neurological deficit and functional recovery was evaluated in obese subacute stroke patients before and after neurorehabilitation. Decreased National Institutes of Health Stroke Scale (p = 0.0001) and modified Rankin Scale (mRS) (p= 0.002) scores, as well as increased Barthel Index (p= 0.0001) scores were detected after neurorehabilitation. Decreased BMI, aSAT, BFP...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

A novel neurocognitive rehabilitation tool in the recovery of hemiplegic hand grip after stroke: a case report.
Authors: Paolucci T, Capobianco SV, Vinciguerra SM, Cilli M, Villani C, Saraceni VM Abstract Stroke has significant physical, psychological and social consequences. Recent rehabilitation approaches suggest that cognitive exercises with dual-task (sensory-motor) exercises positively influence the recovery and function of the hemiplegic hand grip. The purpose of this study was to describe a rehabilitation protocol involving the use of a new neurocognitive tool called "UOVO" for hand grip recovery after stroke. A 58-year-old right-handed male patient in the chronic stage of stroke, presenting with left-sided...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Music and neurorehabilitation: Yes, we can!
Authors: Raglio A Abstract PMID: 30663962 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports.
Authors: Gómez-Ochoa SA, Espín-Chico BB, Pinilla-Monsalve GD, Kaas BM, Téllez-Mosquera LE Abstract Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome occurring predominantly in elderly females and in the setting of non-ketotic hyperglycemia (NKH). A systematic review was conducted in accordance with the PRISMA statement. Studies published between 1980 and 2018 that reported demographic, clinical, laboratory and imaging features from patients with HCB were screened. 136 studies describing 286 patients were included in the analysis. The patients included had a me...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Recovery of circadian melatonin rhythm after a melatonin holiday in daytime haemodialysis patients on long-term exogenous melatonin.
Authors: Sparla S, Koch B, Bosma R, Nagtegaal E Abstract The effects of exogenous melatonin on sleep diminish after its long-term use in haemodialysis patients. Our aim was to determine whether melatonin levels accumulate after chronic (at least three months) use of exogenous melatonin, 5 mg daily, and whether discontinuation of this treatment improves endogenous melatonin production and improves the circadian sleep-wake rhythm. In this case series, stable haemodialysis patients discontinued their chronic exogenous melatonin usage for seven days and melatonin concentrations in saliva were analysed. The primary endp...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Multiple sclerosis and non-dystrophic myotonias: do they share a common pathophysiology?
Authors: Portaro S, Naro A, Russo M, Bramanti P, Lauria P, D'Aleo G, La Rosa G, Bramanti A, Calabrò RS Abstract Some patients with multiple sclerosis (MS) complain of symptoms, such as myokymia, myotonia, spasms, and stiffness, which have been demonstrated to be due to a concurrent non-dystrophic myotonia, i.e. myotonia congenita or paramyotonia congenita. Beyond the known casual association between MS and non-dystrophic myotonia, a channelopathy representing a primary trait of MS rather than an epiphenomenon of demyelization (i.e., an acquired channelopathy) may exist. Indeed, the finding of MS patients wit...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

From paper to informatics: the Post Soft Care-App, an easy-to-use and fast tool to help therapists identify unmet needs in stroke patients.
Authors: De Bartolo D, Morone G, Lupo A, Aloise F, Baricich A, Di Francesco D, Calderone C, Cisari C, Verdecchia G, Sandrini G, Pistarini C, Antonucci G, Smania N, Paolucci S, Iosa M Abstract Even after rehabilitation, post stroke patients remain disabled. The Post Stroke Checklist (PSC) was developed to highlight unmet needs of community-dwelling stroke patients. The present study set out to validate Post Soft Care-App, designed to administer the PSC using smartphones and tablets, in order to monitor unmet needs in chronic patients. Fifty-three patients and fifteen physiotherapists were enrolled. The therapists ad...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Automated mechanical peripheral stimulation and postural control in subjects with Parkinson's disease and freezing of gait: a randomized controlled trial.
This study aimed to investigate the effects of AMPS on postural control in individuals with PD and FOG. Thirty-three subjects participated in this randomized controlled trial. Participants were allocated to two groups: AMPS and AMPS SHAM. Subjects underwent eight sessions of real (AMPS) or placebo AMPS (AMPS SHAM) once every three/four days. Postural control was assessed by means of posturography before the first and after the eighth session of treatment. We did not find positive effects of AMPS on center of pressure parameters. Thus, it seems that AMPS has no positive effect in terms of improving static postural control i...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations.
Authors: Aragona B, De Luca R, Piccolo A, Le Cause M, Destro M, Casella C, Filoni S, Calabrò RS Abstract Post-stroke apathy is considered to be one of the clinical consequences of lesions affecting the structures of the prefrontal cortex, basal ganglia, thalamus and limbic system. However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying etiology and comorbidities. A 62-year-old man, affected by hemorrhagic stroke in the left thalamus, presented with mood depression, anhedonia, hyporexia and marked apathy. The patient underwent clinical evaluation b...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

TIA patients with higher ABCD3-I scores are prone to a higher incidence of intracranial stenosis, unstable carotid plaques and multiple-vessel involvement.
Authors: Yu Q, Miao W, Han J Abstract The ABCD3-I criteria have proved to be effective for use in regular clinical practice to assist in transient ischemic attack (TIA) risk stratification and treatment. In this prospective study we aimed to explore the relationships between risk stratification and arterial stenosis location, carotid plaque morphology and vessel involvement in 90 TIA patients, stratifying risk by ABCD3-I scores. Clinical variables such as total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, homocysteine and high-sensitive C-reactive protein levels were reco...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Is there a correlation between urological and cardiovascular dysfunction in Parkinson's disease?
Authors: Brusa L, Rocchi C, Ponzo V, Stanzione P, Finazzi E, Attanasio A Abstract It is well established that non-motor symptoms are a core feature of Parkinson's disease (PD). A dysregulation of the autonomic nervous system seems to be present in PD, supporting the coexistence of urological and cardiovascular non-motor features. We evaluated whether bladder dysfunctions in patients with PD are linked to blood pressure dysregulation. Twenty-eight mild PD patients, previously submitted to a urodynamic evaluation, underwent 24-hour ambulatory blood pressure and heart rate monitoring to allow assessment of their circa...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Cross-cultural adaptation and validation in the Italian population of the wolf motor function test in patients with stroke.
The objective of this study was to translate and culturally adapt the WMFT for the Italian population (WMFT-IT) and examine its reliability and validity in Italian post-stroke adults with chronic hemiplegia or hemiparesis. The original scale was translated into Italian and culturally adapted in accordance with international guidelines. Its internal consistency and stability were examined using the Cronbach's alpha (α) coefficient and the intra-class correlation coefficient (ICC), respectively. Its concurrent validity was evaluated using the Pearson's correlation coefficient to compare the instrument with the Italian ...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The dawn of algometry: Paolo Mantegazza's research on pain.
Authors: Cani V Abstract By the 1860s, Paolo Mantegazza was a professor of general pathology at the University of Pavia, where he had graduated in medicine in 1854. There, he founded Italy's first laboratory of experimental pathology and did his first research on pain, the subject of various communications presented to the Istituto Lombardo in Milan. In 1880, Mantegazza published Physiology of Pain, one of the several "physiologies" (of pleasure, of love, of hatred, of woman) that he wrote during his career. In this book, a testament to his scientific versatility, experimental observations supplemented hi...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Errata corrige Functional Neurology 2018;33:2 Article: Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome?
Authors: Abstract PMID: 30457962 [PubMed] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Chronic stroke: an oxymoron or a challenge for rehabilitation?
Authors: Baricich A, Carda S Abstract PMID: 30457963 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Effects of a nutraceutical combination in patients with chronic lumbosacral radicular pain.
Authors: Geroin C, Tamburin S, Pagano G, Gandolfi M, Tinazzi M Abstract Drugs used for the treatment of chronic lumbosacral radicular pain (LRP) may have frequent adverse effects leading to medication withdrawal. The use of add-on nutraceuticals, which have no side effects, may therefore play a role in LRP treatment. We performed a six-week, single-center, open label prospective uncontrolled clinical study to evaluate the effect of a nutraceutical combination (Noxiall®) used as an add-on therapy in patients with chronic LRP. Fifteen patients were treated with Noxiall® twice a day for 10 consecutive days, fo...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.
Authors: Lupo A, Cinnera AM, Pucello A, Iosa M, Coiro P, Personeni S, Gimigliano F, Iolascon G, Paolucci S, Morone G Abstract Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute str...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

The required coefficient of friction in Parkinson's disease: people with freezing of gait.
Authors: Rozin Kleiner AF, Cubillos DM, Pinto C, Salazar AP, Marchese RR, Barros RML, Galli M, Pagnussat AS Abstract The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Non-pharmacological interventions for agitation/aggressive behaviour in patients with dementia: a randomized controlled crossover trial.
Authors: Dimitriou TD, Verykouki E, Papatriantafyllou J, Konsta A, Kazis D, Tsolaki M Abstract Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. This trial is a randomized controlled crossover trial conducted in Greece. The following measures were used: the Mini-Mental State Examination, Addenbrooke's Cognitive Examination Revised, Geriatric Depression Scale, Functiona...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats.
In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period. On day 15, pain tolerance was assessed through the tail flick test, and two days later the rats were investigated for anxiety in an elevated plus maze (EPM). Indices of oxidative stress (levels of malondialdehyde, glutathione, nitrite/nitrate and catalase activity in the VTA) were then studied in the animals. Malondialdehyde in the VTA was found to be reduced in the SI rats compared with...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.
Authors: Gatto RG, Mustafi SM, Amin MY, Mareci TH, Wu YC, Magin RL Abstract Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

An acute neurological complication of Crohn's disease.
Authors: Battista F, Tinella E, Colosimo C Abstract PMID: 30457970 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Shaping a pain-free future for cluster headache patients. The Declaration of Paris.
Authors: Rossi P, Bruce S, De Pascual MA, Muller H, Tyminski EK, De La Torre ER Abstract PMID: 30457971 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Shorter acute care hospital stay, longer stay in post-acute care facilities.
Authors: Formisano R, Contrada M, Aloisi M PMID: 29984682 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research