Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort
ConclusionsAVEM is useful for non-urgent diagnostic evaluation of events. (Source: Seizure)
Source: Seizure - March 23, 2019 Category: Neurology Source Type: research

Editorial Board
Publication date: March 2019Source: Seizure, Volume 66Author(s): (Source: Seizure)
Source: Seizure - March 23, 2019 Category: Neurology Source Type: research

Editorial: Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort
Publication date: March 2019Source: Seizure, Volume 66Author(s): William O. Tatum (Source: Seizure)
Source: Seizure - March 23, 2019 Category: Neurology Source Type: research

Erratum to “Plasma concentration and clinical effects of perampanel—The Kork experience” [Seizure, 67 (April) (2019), 18–22]
Publication date: Available online 23 March 2019Source: SeizureAuthor(s): Bernhard J. Steinhoff, Elisabeth Hübers, Christoph Kurth, Uta Jürges (Source: Seizure)
Source: Seizure - March 23, 2019 Category: Neurology Source Type: research

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review
ConclusionMEF2C-related epilepsy may be described as a spectrum of manifestations including febrile seizures, myoclonia, and focal-onset or generalized seizures. Electroencephalogram is consistently abnormal, showing findings such as background slowing, multifocal and generalized epileptiform discharges and polyspikes. It remains unclear whether most patients are responsive or refractory to treatment with anti-epileptic medications. (Source: Seizure)
Source: Seizure - March 23, 2019 Category: Neurology Source Type: research

Risk factors for the development of seizures after cranioplasty in patients that sustained traumatic brain injury: a systematic review
Publication date: Available online 21 March 2019Source: SeizureAuthor(s): Robert Spencer, Susruta Manivannan, Feras Sharouf, Muhammad Imran Bhatti, Malik ZabenAbstractDecompressive craniectomy (DC) is used for the treatment of posttraumatic brain injury raised intracranial pressure. Cranioplasty is a reconstructive procedure that restores the structural integrity of the skull following (DC). Seizures are a recognised complication of cranioplasty but its incidence and risk factors in TBI patients are unclear. Accurate prognostication can help direct prophylactic and treatment strategies for seizures. In this systematic revi...
Source: Seizure - March 21, 2019 Category: Neurology Source Type: research

Usefulness of the Liverpool Adverse Events Profile for predicting a high risk of suicidality in people with drug-resistant epilepsy
ConclusionThe LAEP may inform a high risk of suicidality in PWDRE. Referring to this, clinicians can discern suicidal problems in their epilepsy clinics. (Source: Seizure)
Source: Seizure - March 20, 2019 Category: Neurology Source Type: research

Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders
ConclusionThis study further expands the genotypic and phenotypic spectrum of epilepsies associated with GABRG2 variants. More knowledge is still needed about the influence of the environment, genetic background and other epilepsy susceptibility genes on the phenotype of the specific GABRG2 variants. (Source: Seizure)
Source: Seizure - March 20, 2019 Category: Neurology Source Type: research

Reply to ‘Computation of Antiepileptic Drug Retention Rates in the Presence of a Competing Risk’
Publication date: Available online 19 March 2019Source: SeizureAuthor(s): Johan Zelano (Source: Seizure)
Source: Seizure - March 20, 2019 Category: Neurology Source Type: research

Familial Adult Myoclonic Epilepsy: a new expansion repeats disorder
Publication date: Available online 19 March 2019Source: SeizureAuthor(s): Ilaria Lagorio, Federico Zara, Salvatore Striano, Pasquale StrianoAbstractFamilial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least ...
Source: Seizure - March 20, 2019 Category: Neurology Source Type: research

Recent practice patterns in diagnostic procedures anticonvulsants, and antibiotics for children hospitalized with febrile seizure
This study investigated clinical practice patterns for admissions due to FS at a national level.MethodDischarge records were extracted for patients with FS aged
Source: Seizure - March 16, 2019 Category: Neurology Source Type: research

Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures
ConclusionShort burst Clobazam appears to be a safe and effective means to reduce representation with seizures after medication reduction during VEEG recording. This obviously benefits patients but it may also be a cost-effective means to reduce unnecessary health expenditure. (Source: Seizure)
Source: Seizure - March 16, 2019 Category: Neurology Source Type: research

Corrigendum to “Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy” [Seizure 64 January (2019) 8–15]
Publication date: Available online 14 March 2019Source: SeizureAuthor(s): Arun Raj Antony, Sergiu Abramovici, Robert Todd Krafty, Jullie Pan, Robert Mark Richardson, Anto Bagic, Zulfi Haneef (Source: Seizure)
Source: Seizure - March 14, 2019 Category: Neurology Source Type: research

Intraoperative ultrasonography (ioUS) characteristics of focal cortical dysplasia (FCD) type II b
ConclusionOur study confirms the potentials of ioUS as a valuable diagnostic tool to guide FCD surgeries. (Source: Seizure)
Source: Seizure - March 13, 2019 Category: Neurology Source Type: research

Impact of Withdrawal of Antiepileptic Medication on the Duration of Focal Onset Seizures
ConclusionsAlthough AED withdrawal increases the likelihood for epileptic seizures, it did not prolong the seizure duration, nor did it increase the rate of secondary generalization in our study. (Source: Seizure)
Source: Seizure - March 9, 2019 Category: Neurology Source Type: research

Migrating focal seizures in Autosomal Dominant Sleep-related Hypermotor Epilepsy with KCNT1 mutation
Publication date: Available online 7 March 2019Source: SeizureAuthor(s): Matteo Cataldi, Lino Nobili, Federico Zara, Romina Combi, Giulia Prato, Thea Giacomini, Valeria Capra, Patrizia De Marco, Luigi Ferini-Strambi, Maria Margherita Mancardi (Source: Seizure)
Source: Seizure - March 8, 2019 Category: Neurology Source Type: research

Improving Post-Hypoxic Myoclonus using Cannabidiol
Publication date: Available online 6 March 2019Source: SeizureAuthor(s): Johann Philipp Zöllner, Anna H. Noda, Felix Rosenow, Adam Strzelczyk (Source: Seizure)
Source: Seizure - March 7, 2019 Category: Neurology Source Type: research

Akinetopsia with achromatopsia due to focal epilepsy
Publication date: Available online 6 March 2019Source: SeizureAuthor(s): Kengo Maeda, Yoshiko Sugihara, Tomoyuki Shiraishi (Source: Seizure)
Source: Seizure - March 7, 2019 Category: Neurology Source Type: research

Plasma concentration and clinical effects of perampanel—The Kork experience
ConclusionOur data do not indicate a reliable therapeutic range for PER plasma concentrations. Individual reference ranges varied widely. Therapeutic drug monitoring (TDM) may still be helpful in certain clinical situations. (Source: Seizure)
Source: Seizure - March 7, 2019 Category: Neurology Source Type: research

Reliability of reported peri-ictal behavior to identify psychogenic nonepileptic seizures
ConclusionsQuantitative analysis of patient- and observer-reported peri-ictal behaviors objectively changed the likelihood that a patient’s seizures were psychogenic, but these reports were not reliable enough to be diagnostic in isolation. Instead, our scores may identify patients with “probable” PNES that, in the right clinical context, may warrant further diagnostic assessment. (Source: Seizure)
Source: Seizure - March 6, 2019 Category: Neurology Source Type: research

Comparing long-term outcomes of epilepsy patients from a single-visit outreach clinic with a conventional epilepsy clinic: A cross-sectional observational study from India
ConclusionsEven single-visit epilepsy clinics may be an effective option for reducing treatment gap in limited-resource regions of the world. (Source: Seizure)
Source: Seizure - March 4, 2019 Category: Neurology Source Type: research

Novel epilepsy phenotype associated to a known SCN8A mutation
Publication date: Available online 4 March 2019Source: SeizureAuthor(s): Roberta Epifanio, Nicoletta Zanotta, Roberto Giorda, Alessandra Bardoni, Claudio Zucca (Source: Seizure)
Source: Seizure - March 4, 2019 Category: Neurology Source Type: research

Plasma concentration and clinical effects of perampanel – the Kork experience
ConclusionOur data do not indicate a reliable therapeutic range for PER plasma concentrations. Individual reference ranges varied widely. Therapeutic drug monitoring (TDM) may still be helpful in certain clinical situations. (Source: Seizure)
Source: Seizure - March 1, 2019 Category: Neurology Source Type: research

Sociocultural representations of epilepsy in the Central African Republic: a door-to-door survey
ConclusionsEpilepsy misconceptions are highly prevalent in rural sub-Saharan Africa. Understanding misrepresentations is an essential phase to develop culturally appropriate interventional programs in order to improve medical treatment adherence, quality of life, and to decrease stigma. Campaigns to raise awareness are needed in urban and rural population to reduce misconception and combat stigmatization. (Source: Seizure)
Source: Seizure - February 27, 2019 Category: Neurology Source Type: research

Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: a multiple case-study
ConclusionOur study suggests positive effects of TLE surgery in the very long-term course of ≥ 15 years postoperatively. Long-term seizure-freedom appears to have the strongest impact on patients’ subjectively perceived psycho-social and cognitive outcome and may even outweigh actual memory disturbances and/or decline. Overall, our data do not support the assumption of a generally accelerated cognitive decline in patients with TLE. (Source: Seizure)
Source: Seizure - February 25, 2019 Category: Neurology Source Type: research

Ryanodine receptor 2 (RYR2) mutation: a potentially novel neurocardiac calcium channelopathy manifesting as primary generalised epilepsy
ConclusionWe propose that the RYR2 mutation is a potentially novel neurocardiac calcium channelopathy that may manifest with either CPVT or GGE depending on selective involvement of RYR2 receptors expressed in the heart or in the brain. RYR2 mutant mice have demonstrated spontaneous EEG-positive seizures independent of cardiac arrhythmia. Whole exome sequencing analyses have identified RYR2 as a candidate gene in GGE. This case is a reminder for careful assessment of episodes of transient loss of consciousness in an individual with CPVT, so as to not mistake possible neurogenic seizure for cardiogenic syncope, carrying obv...
Source: Seizure - February 23, 2019 Category: Neurology Source Type: research

The effect of perampanel on aggression and depression in patients with epilepsy: A short-term prospective study
ConclusionsThe present findings indicate that PER increases assessment scores indicative of aggression as well as depression. No additional aggression-augmenting effect was seen with concomitant AED administration. (Source: Seizure)
Source: Seizure - February 22, 2019 Category: Neurology Source Type: research

Resident training and interrater agreements using the ACNS critical care EEG terminology
CONCLUSIONSOur data suggests that with minimal investment, adult neurology residents at various stages of training can effectively learn the ACNS critical care EEG Terminology. (Source: Seizure)
Source: Seizure - February 21, 2019 Category: Neurology Source Type: research

Depression in people with epilepsy in West China: Status, risk factors and treatment gap
ConclusionsThe prevalence of depression and the rate of suicide risk for PWE in West China are high. A large TG for depression exists in PWE. Clinicians should focus on depression and suicidality for PWE and identify the related risk factors in a timely manner so as to reduce the incidence of depression and suicide. Management including public education as well as professional training of neurologists are necessary to fill the TG. (Source: Seizure)
Source: Seizure - February 21, 2019 Category: Neurology Source Type: research

Depression and quality of life in patients with epilepsy in Northwest Greece
ConclusionPatients with epilepsy in Northwest Greece had higher rates of depression than reported in patients with epilepsy and poorer QoL compared to controls. The adverse effects of AEDs were related to depression in our study, while the adverse effects of AEDs and depression were more powerful predictors of QoL compared to demographics and other characteristics of epilepsy. (Source: Seizure)
Source: Seizure - February 21, 2019 Category: Neurology Source Type: research

Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian Population
ConclusionsWe found significant associations of some HLA alleles with specific cADRs to CBZ and PHT in North Indians, which may need to be tested before AED-initiation; only screening for HLA-B*15:02 may not help in this population. (Source: Seizure)
Source: Seizure - February 21, 2019 Category: Neurology Source Type: research

A neuropsychological model for the pre-surgical evaluation of children with focal-onset epilepsy: An integrated approach
Publication date: Available online 16 February 2019Source: SeizureAuthor(s): Linda M. Gonzalez, Jacquie A. WrennallAbstractThis review explores the complexities of pre-surgical neuropsychological assessment for children with focal-onset epilepsy. A model is proposed outlining a range of factors that potentially influence the neuropsychological formulation. These factors include a developmental, epilepsy, psychological and cognitive dimension, together with family and social context and intrinsic factors. This model is child-centered and recognizes that these factors will be weighted differently for each individual. In some...
Source: Seizure - February 17, 2019 Category: Neurology Source Type: research

Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy
ConclusionsDRE patients with shorter duration of epilepsy may be better candidates for VNS rather than those who are younger at onset and implantation. Several EEG or HRV features may have predictive value but more research is needed. (Source: Seizure)
Source: Seizure - February 16, 2019 Category: Neurology Source Type: research

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome
ConclusionOur study highlights the significant utility of NGS panels in the genetic diagnosis of pediatric epilepsy. Our findings indicate that KCND3 pathogenic variants may be responsible for a wider phenotypic spectrum than previously thought, by including childhood epileptic encephalopathy. Furthermore, this study provides evidence that GRIN1 and HCN1 are candidate genes for Dravet and Dravet-like phenotypes. (Source: Seizure)
Source: Seizure - February 16, 2019 Category: Neurology Source Type: research

Ictal biting injuries in the epilepsy monitoring unit, a cohort study of incidence and semiological significance
ConclusionsOral biting is a common complication in the epilepsy monitoring unit. Its presence suggests a tonic or clonic component but is of no help in localizing seizure onset. (Source: Seizure)
Source: Seizure - February 15, 2019 Category: Neurology Source Type: research

Editorial Board
Publication date: February 2019Source: Seizure, Volume 65Author(s): (Source: Seizure)
Source: Seizure - February 14, 2019 Category: Neurology Source Type: research

Seizure Detection Devices for use in Antiseizure Medication Clinical Trials: A Systematic Review
This study characterizes the current capabilities of seizure detection device (SDD) technology and evaluates the fitness of these devices for use in anti-seizure medication (ASM) clinical trials.MethodsThrough a systematic literature review, 36 wireless SDDs featured in published device validation studies were identified. Each device’s seizure detection capabilities that addressed ASM clinical trial primary endpoint measurement needs were cataloged.ResultsThe two most common types of seizures targeted by ASMs in clinical trials are generalized tonic-clonic (GTC) seizures and focal with impaired awareness (FIA) seizur...
Source: Seizure - February 14, 2019 Category: Neurology Source Type: research

Natural history of patients with psychogenic nonepileptic seizures
ConclusionMore than half of the patients with untreated PNES may become free of seizures after they receive a definite diagnosis and with the passage of time. Longer duration of PNES before the patients received a definite diagnosis may affect their long-term outcome. (Source: Seizure)
Source: Seizure - February 12, 2019 Category: Neurology Source Type: research

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy
This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE).MethodsBrain magnetic resonance imaging (MRI) studies were retrospectively analyzed by two blinded radiologists. The Fazekas and Scheltens scales were used to assess the degree of leukoaraiosis and hippocampal atrophy in 33 patients with non-lesional LOE, 41 patients with clinical signs of SVD (eg, recent history of transient ischemic attack [TIA] or lacunar stroke), and 26 healthy controls, all>60 years of age.ResultsMean age in epilepsy patients was 70.9 (±6.6) y...
Source: Seizure - February 9, 2019 Category: Neurology Source Type: research

Disappearance of symptomatic generalized 3-Hz discharges after focal surgery in a patientwithtuberous sclerosis
Publication date: Available online 7 February 2019Source: SeizureAuthor(s): Samy Mohamed Lemine Dadah, Marc Guenot, Alexandra Montavont, Bouchra El M’kaddem, Virginie Levrat, Alexis Arzimanoglou, Philippe Ryvlin, Karine Ostrowsky-Coste (Source: Seizure)
Source: Seizure - February 8, 2019 Category: Neurology Source Type: research

The clinical characteristics and related factors of tremor in patients with epilepsy
Publication date: Available online 7 February 2019Source: SeizureAuthor(s): Yingfeng Xiao, Weixi Xiong, Lu Lu, Jiani Chen, Yingying Zhang, Xinyue Jiang, Dong ZhouAbstractPurposeTremor is frequently observed in patients with epilepsy (PWE), which is generally attributed to the side-effect of antiepileptic drugs (AEDs) particularly valproate (VPA) with largely unknown mechanisms. The study aimed to assess the clinical features and related factors of tremor in PWE with tremor.MethodsPWE with tremor and a control group of age- and sex-matched PWE without tremor were enrolled. Detailed demographic and clinical information for e...
Source: Seizure - February 8, 2019 Category: Neurology Source Type: research

Epileptic Seizure Detection Using Cross-Bispectrum of Electroencephalogram Signal
ConclusionsThe results show that the proposed method distinguishes better between ictal and inter-ictal iEEG epochs than other seizure detection methods. The proposed method has a higher accuracy index than achievable with a number of previously described approaches. Also, the method is rapid and easy and may be helpful in online epileptic seizure detection and prediction systems. (Source: Seizure)
Source: Seizure - February 5, 2019 Category: Neurology Source Type: research

Seizure outcome and epilepsy patterns in patients with cerebral palsy
ConclusionA total of 45% of patients with CP and epilepsy achieved remission (with and without antiepileptics) but after a relatively long treatment duration. Remission was affected by patient- and epilepsy-related factors. More studies are required to further evaluate these factors. (Source: Seizure)
Source: Seizure - February 3, 2019 Category: Neurology Source Type: research

CADASIL presenting with focal and generalised epilepsy due to a novel NOTCH3 mutation
Publication date: Available online 30 January 2019Source: SeizureAuthor(s): Benson S. Chen, James Cleland, Richard I. King, Neil E. Anderson (Source: Seizure)
Source: Seizure - January 31, 2019 Category: Neurology Source Type: research

Switching from Traditional Sodium Channel Blockers to Lacosamide in Patients With Epilepsy
ConclusionsOur study shows that switching from traditional SCBs to LCM is usually successful and the likelihood of a successful switch is higher in patients when the reason for the switch is adverse effects or concerns about metabolic derangement on traditional SCBs. (Source: Seizure)
Source: Seizure - January 31, 2019 Category: Neurology Source Type: research

Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier
Publication date: Available online 30 January 2019Source: SeizureAuthor(s): Robert Daniel Nass, Niels Hansen, Carlos Quesada, Theodor Rüber, Cornelia Kornblum, Gábor Zsurka, Philipp Hermann, Albert Becker, Florian Gärtner, Elke Hattingen, Wolfgang Block, Eike Steidl, Christian E. Elger, Rainer Surges, Wolfram S. Kunz (Source: Seizure)
Source: Seizure - January 30, 2019 Category: Neurology Source Type: research

Factors associated with seizure-related motor vehicle accidents among patients with epilepsy in West China
ConclusionThe interval of seizure freedom, number of AEDs taken, and type of motor vehicle should be considered when counseling patients with epilepsy on driving. A longer seizure-free interval suggested a compromised risk of seizure-related MVA. (Source: Seizure)
Source: Seizure - January 30, 2019 Category: Neurology Source Type: research

Seizures in Children with HIV infection in South Africa: A retrospective case control study
ConclusionsThis study provides new data highlighting the complex clinical presentation and management challenges of HIV-infected children with seizures. (Source: Seizure)
Source: Seizure - January 29, 2019 Category: Neurology Source Type: research

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy:identification of a new KCND3 phenotype and novel genes causing Dravet syndrome
ConclusionOur study highlights the significant utility of NGS panels in the genetic diagnosis of pediatric epilepsy. Our findings indicate that KCND3 pathogenic variants may be responsible for a wider phenotypic spectrum than previously thought, by including childhood epileptic encephalopathy. Furthermore, this study provides evidence that GRIN1 and HCN1 are candidate genes for Dravet and Dravet-like phenotypes. (Source: Seizure)
Source: Seizure - January 29, 2019 Category: Neurology Source Type: research

Diagnostic Usefulness of Arterial Spin Labeling in MR Negative Children with New Onset Seizures
ConclusionTo our knowledge, this is the first study to assess the usefulness of ASL MRI to assist in localizing the seizure focus in MR-negative children with new onset seizures. The combined use of ASL with EEG and structural MRI may play an important role in the evaluation of pediatric epilepsy. (Source: Seizure)
Source: Seizure - January 28, 2019 Category: Neurology Source Type: research