Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation.
This study provides further preclinical evidence of the PC-like effect of statins in brain tissue, supporting their beneficial effects in improving stroke outcome after prophylactic treatments.
PMID: 31734315 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Carloni S, Balduini W Tags: Exp Neurol Source Type: research
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