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Condition: Patent Foramen Ovale

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Total 1415 results found since Jan 2013.

Closure of Patent Foramen Ovale and Cryptogenic Stroke: Unresolved Issues
AbstractPurpose of ReviewThis review summarises the results of randomised trials comparing closure of patent foramen ovale (PFO) with antithrombotic therapy in patients with cryptogenic stroke.Recent FindingsInitially, three randomised trials failed to show superiority of PFO closure over antithrombotic therapy in patients with cryptogenic stroke. Three recently performed trials and the prolongation of an earlier trial provided evidence that PFO closure in patients with cryptogenic stroke and an age range of 18 –60 years is superior to stroke prevention with antiplatelet therapy. PFO closure was not superior to anticoag...
Source: Current Neurology and Neuroscience Reports - October 17, 2018 Category: Neuroscience Source Type: research

Evaluating the cost-effectiveness of percutaneous closure of a patent foramen ovale versus medical management in patients with a cryptogenic stroke: from the UK payer perspective.
CONCLUSION: Percutaneous closure of a PFO is cost-effective compared with antiplatelet therapy alone, underlining the economic benefits potentially afforded by this treatment in selected patients. PMID: 30424680 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - November 16, 2018 Category: Health Management Tags: J Med Econ Source Type: research

Closing the gap on patent foramen ovale and cryptogenic stroke.
Authors: Darmoch F, Al-Khadra Y, Bacha HM, Soud M, Alraies MC Abstract Introduction: The treatment options for prevention of recurrent of cryptogenic stroke in patients with patent foramen ovale (PFO) have been intensely debated in the recent decades. The suggested options were percutaneous closure of PFO versus medical therapy. However, up to these date there is a controversy regarding the indication of percutaneous closure. Multiple meta-analysis and recent randomized control trials showed the benefit of PFO closure when compared with medical therapy alone. Areas covered: The article reviews the prevalence, physi...
Source: Expert Review of Cardiovascular Therapy - June 13, 2019 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Stroke in the Young: a Global Update
AbstractPurpose of ReviewWe aim to evaluate the epidemiology, racial and gender disparity, etiology, and treatment of stroke in the younger population.Recent FindingsThe younger age group without vascular risk factors exhibits an increased prevalence of cardio-embolism in context of patent foramen ovale/atrial septal aneurysm strokes, from other determined etiology of non-atherosclerotic vasculopathy including dissection, inherited or acquired thrombophilia, and other unusual causes of stroke. Ethnic disparities also exist in certain populations.SummaryThe prevalence of stroke in the young is increasing due to several fact...
Source: Current Neurology and Neuroscience Reports - November 24, 2019 Category: Neuroscience Source Type: research

Clinical RoPE (cRoPE) score predicts patent foramen ovale detection among stroke patients: a multicenter observational study
ConclusionsConclusions:  cRoPE might help in stratification of patients with CS, allowing accurate esteem of the likelihood of PFO to be found, especially in cases when neuroimaging is inconclusive.
Source: Neurological Sciences - May 8, 2020 Category: Neurology Source Type: research

Structural heart intervention for prevention of embolic and hemorrhagic stroke: The new field of neurocardiology.
Abstract Cardiogenic stroke (CS), characteristic causes of which include atrial fibrillation (AF) and right-to-left shunting due to a patent foramen ovale (PFO), has a well-known tendency to be associated with a more extensive ischemic area. This may result in severe neurological damage, and require strict life-long antithrombotic therapy. However, the fact that some patients have problems complying with the requirement for extended oral antithrombotic treatment has motivated the development of alternative approaches for stroke prevention. Heart structures such as the left atrial appendage (LAA) and PFO are potent...
Source: Journal of Cardiology - May 28, 2020 Category: Cardiology Authors: Morino Y, Nakajima Y Tags: J Cardiol Source Type: research

Comparison of antithrombotic strategies in patients with cryptogenic stroke and patent foramen ovale: an updated meta-analysis
ConclusionsOAC was more effective than APT in reducing the risk of stroke recurrence in patients with PFO and CS, without a significant increase in the risk of major bleedings. Our findings support the need for further randomized data focused on the comparison of antithrombotic strategies in this setting.
Source: Cardiovascular Drugs and Therapy - September 11, 2020 Category: Cardiology Source Type: research

Patent foramen ovale closure in the management of cryptogenic stroke: a review of current literature and guideline statements.
CONCLUSION: PFO closure can be considered for the prevention of recurrent cryptogenic stroke in patients aged ≤60 years after a thorough evaluation and discussion about benefits and potential risks (including but not limited to atrial fibrillation) of the procedure. Accumulating evidence supports prognostic, quality of life, and economic benefit from percutaneous PFO closure with newer generation closure devices in the right subset of patients. PMID: 33460329 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Importance of Persistent Right-to-Left Shunt After Patent Foramen Ovale Closure in Cryptogenic Stroke Patients.
Abstract Percutaneous closure of patent foramen ovale (PFO) is widely performed to prevent recurrent stroke or transient ischemic attack in patients with cryptogenic stroke. However, the influence of different degrees of right-to-left shunting (RLS) has rarely been reported. We retrospectively evaluated the cases of 268 patients with cryptogenic stroke who underwent PFO closure at our hospital from April 2012 through April 2015. In accordance with RLS severity, we divided the patients into 2 groups: persistent RLS during normal breathing and the Valsalva maneuver (n=112) and RLS only during the Valsalva maneuver (...
Source: Texas Heart Institute Journal - August 1, 2020 Category: Cardiology Authors: He L, Cheng G, Du Y, Zhang Y Tags: Tex Heart Inst J Source Type: research

Brain Infarction MRI Pattern in Stroke Patients with Intracardiac Thrombus
Conclusions: ICT-related stroke is associated with acute SCCI presence on MRI.Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT04456309.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 17, 2021 Category: Neurology Source Type: research

Current Challenges and Future Directions in Handling Stroke Patients With Patent Foramen Ovale —A Brief Review
The role of patent foramen ovale (PFO) in stroke was debated for decades. Randomized clinical trials (RCTs) have shown fewer recurrent events after PFO closure in patients with cryptogenic stroke (CS). However, in clinical practice, treating stroke patients with coexisting PFO raises some questions. This brief review summarizes current knowledge and challenges in handling stroke patients with PFO and identifies issues for future research. The rationale for PFO closure was initially based on the concept of paradoxical embolism from deep vein thrombosis (DVT). However, RCTs did not consider such details, limiting their impac...
Source: Frontiers in Neurology - April 28, 2022 Category: Neurology Source Type: research

A Review of the Role of Transthoracic and Transesophageal Echocardiography, Computed Tomography, and Magnetic Resonance Imaging in Cardioembolic Stroke
Med Sci Monit. 2022 Jun 22;28:e936365. doi: 10.12659/MSM.936365.ABSTRACTStroke is a major source of morbidity and mortality worldwide, accounting for the second largest cause of mortality and the third greatest cause of disability. Stroke is frequently preceded by a transient ischemic attack (TIA). The etiologies of 20-30% of ischemic strokes are unknown, and thus are termed "cryptogenic strokes". About 25% of ischemic strokes are cardioembolic. Strokes occur at a rate of around 2% per year in individuals with heart failure with reduced ejection fraction (HFrEF), with a strong correlation between stroke risk and the degree...
Source: Medical Science Monitor - June 22, 2022 Category: Research Authors: Sergiu Florin Arnautu Diana Aurora Arnautu Ana Lascu Andrei A Hajevschi Ciprian Ilie Ilie Rosca Abhinav Sharma Dragos Catalin Jianu Source Type: research

Ischemic stroke in young patients in Medell ín, Colombia
CONCLUSIONS: The high frequency of traditional risk factors in young patients highlights the need to optimize primary and secondary prevention plans. This study provides new insights about the relevance of illicit substance abuse in Colombia as a cause of stroke in young patients, unlike the previous one conducted in Bogotá. Infectious causes were other peculiarities found. It is necessary to investigate the reasons for the high proportion of undetermined causes.PMID:36138366 | DOI:10.1186/s12883-022-02895-9
Source: Atherosclerosis - September 22, 2022 Category: Cardiology Authors: Juan Diego Vargas-Murcia Sandra Patricia Isaza-Jaramillo Dionis Magnary Vallejo-Mesa Daniela Carvajal-Mu ñoz Source Type: research

Effect of atrial septal dilation tumor and patent foramen rotundus on cryptogenic ischemic stroke in young and middle-aged patients
Conclusion: Atrial septal aneurysm combined with PFO and PFO are independent influencing factors factor for the occurrence of cryptogenic ischemic stroke in young and middle-aged people, which is worthy of further study.Keywords: Atrial septal aneurysm; Cryptogenic ischemic stroke; Influencing factors; Patent foramen ovale; Young and middle-aged.
Source: African Health Sciences - October 28, 2022 Category: African Health Authors: Tengtao Ling, Dongxing Xie Source Type: research

Percutaneous Patent Foramen Ovale Closure After Stroke
Korean Circ J. 2022 Nov;52(11):801-807. doi: 10.4070/kcj.2022.0258.ABSTRACTPercutaneous patent foramen ovale (PFO) closure in patients with a prior PFO-associated stroke showed a risk reduction of the stroke recurrence compared to the medical therapy alone in recent several studies. Nevertheless, optimal patient selection for PFO closure has not been clarified. In this paper, we discuss the characteristics of PFO-associated strokes and discuss the recently published evidence and patient selection for PFO closure in patients with ischemic stroke. The lesions characteristics of PFO-associated stroke are associated with multi...
Source: Korean Circulation Journal - November 8, 2022 Category: Cardiology Authors: Oh-Hyun Lee Jung-Sun Kim Source Type: research