Second generation drug-eluting stents: A focus on safety and efficacy of current devices.
Authors: Spione F, Brugaletta S Abstract INTRODUCTION: Percutaneous coronary intervention (PCI) represents the most frequent procedure performed in medicine. Second generation drug eluting stents (DES) have been developed to reduce the rates of late and very late complications of first generation DES. AREAS COVERED: To improve long-term efficacy and safety of patients undergoing PCI, second generation DES have been developed with novel stent platforms, biocompatible durable and biodegradable polymers and newer antiproliferative agents. In this review we provide an overview of second generation DES and their cli...
Source: Expert Review of Cardiovascular Therapy - January 10, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Rise of Endovascular Mechanical Circulatory Support Use for Cardiogenic Shock and High Risk Coronary Intervention: Considerations and Challenges.
Authors: Schwartz B, Jain P, Salama M, Kapur NK Abstract Introduction: Cardiogenic shock due to acute myocardial infarction and decompensated advanced heart failure remains a source of significant morbidity and mortality. Endovascular mechanical circulatory support devices including intra-aortic balloon pump (IABP), percutaneous left ventricular assist devices (Impella and Tandemheart pumps), and veno-arterial extracorporeal oxygenation (VA-ECMO) are utilized for a broadening range of indications. Areas covered: This narrative review explores the specific devices, their distinctive hemodynamic profiles, and practic...
Source: Expert Review of Cardiovascular Therapy - December 29, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Percutaneous techniques for treatment of tricuspid valve dysfunction in congenital heart disease - an emerging therapy.
Authors: Cesna S, Eicken A Abstract INTRODUCTION: Tricuspid valve (TV) dysfunction treatment experiences exponential growth of the interest over the last years. New techniques for percutaneous tricuspid valve treatment are either on the market or in early stages of development. AREAS COVERED: Deficiency of uniform guideline-based recommendations leads to diverse TV dysfunction treatment options. The current review describes the development of surgical techniques for TV dysfunction in Ebstein's anomaly and transition to a variety of new technologies. Then the focus is on the potential of percutaneous interventio...
Source: Expert Review of Cardiovascular Therapy - December 19, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Perfecting Temporary Pacemakers in a Developing Country.
CONCLUSION: There was no significant effect of anatomical site or technique on the failure of TPM insertion. However, with better training and higher experience of the residents, the complications and rate of failures can be reduced. PMID: 33322964 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - December 18, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Response to the letter to the editor entitled "Angiotensin-II receptor blockers or angiotensin converting enzyme inhibitors for the treatment of hypertension amid COVID-19 pandemic".
Response to the letter to the editor entitled "Angiotensin-II receptor blockers or angiotensin converting enzyme inhibitors for the treatment of hypertension amid COVID-19 pandemic". Expert Rev Cardiovasc Ther. 2020 Dec 10;: Authors: Bottino LG, Fuchs FD PMID: 33297777 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - December 12, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Ischaemic heart disease, stroke and their cardiometabolic risk factors in Africa: current challenges and outlook for the future.
Authors: Peer N, Baatiema L, Kengne AP Abstract INTRODUCTION: Although cardiovascular diseases (CVDs) are among the leading causes of death in Sub-Saharan Africa (SSA), prevention is not a priority and effective treatments are not widely available. This perspective discusses the burden, challenges and potential opportunities for improvement of CVD prevention and control efforts in SSA. AREAS COVERED: This paper focuses on ischaemic heart disease and stroke, and their key contributors of obesity, hypertension, diabetes and dyslipidaemia which are well-established, rapidly rising and significant contributors to d...
Source: Expert Review of Cardiovascular Therapy - December 12, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Current clinical management of acute myocardial infarction complicated by cardiogenic shock.
Authors: El Nasasra A, Zeymer U Abstract INTRODUCTION: Cardiogenic shock (CS) remains the leading cause of death among patients admitted with acute myocardial infarction (AMI). Early restoration of blood flow of the infarct-related artery is of paramount importance, either with percutaneous coronary intervention (PCI) or with coronary artery bypass grafting (CABG). In addition early risk stratification is a critical task and required to guide complex decisions on management and therapy of CS after AMI. The use of short-term mechanical circulatory support (MCS) is increasing, although evidence for their effectivenes...
Source: Expert Review of Cardiovascular Therapy - December 9, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Transradial versus Transfemoral artery catheterization: A comparative meta-analysis on cerebrovascular accidents.
Authors: Virk HUH, Ullah W, Ahmed M, Chattarjee S, Witzke CF, Banka S PMID: 33290666 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - December 9, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Optical Coherence Tomography based treatment approach for patients with Acute Coronary Syndrome.
We report both the definitions of each mechanism and its frequency as reported in the literature to date. Finally, we present an algorithm based on the findings in the review that gives an outlined approach to perform intervention on ACS patients. EXPERT OPINION: Although the most common and most accepted intervention in ACS cases is stent implantation, data suggest a stentless approach in cases of plaque erosion, which generally occurs in younger patients presenting with an acute coronary syndrome that have TIMI flow of 2/3 and either a small or large burden of thrombus and underlying stenosis of less than 50%. PM...
Source: Expert Review of Cardiovascular Therapy - December 4, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Tricuspid regurgitation: when is it time for surgery?
Authors: Tagliari AP, Perez D, Taramasso M Abstract INTRODUCTION: The interest in tricuspid regurgitation (TR) surgical treatment has grown in the last years, mostly motivated by the trend for early intervention and the development of minimally invasive surgical techniques. Despite this, there is still a lack of evidence regarding when to intervene in functional tricuspid regurgitation outside the context of left-sided valve surgery and when is the best time to approach primary tricuspid regurgitation. AREAS COVERED: Herein, we present the state-of-the-art in tricuspid regurgitation surgical intervention, cover...
Source: Expert Review of Cardiovascular Therapy - November 29, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

In silico approaches for transcatheter aortic valve replacement inspection.
Authors: Luraghi G, Rodriguez Matas JF, Migliavacca F Abstract INTRODUCTION: Increasing applications of transcatheter aortic valve replacement (TAVR) to treat high- or medium-risk patients with aortic diseases have been proposed in recent years. Despite its increasing use, many influential factors are still to be understood. Furthermore, innovative applications of TAVR such as in bicuspid aortic valves or in low-risk patients are emerging in clinical use. Numerical analyses are increasingly used to reproduce clinical treatments. The future trends in this area are foreseen for in silico trials and personalized m...
Source: Expert Review of Cardiovascular Therapy - November 19, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Role of Dietary Salt and Alcohol Use Reduction in The Management of Hypertension.
Authors: Wake AD Abstract INTRODUCTION: Despite the improved treatment protocol of hypertension, the magnitude of the disease and its related burden remains raised. Hypertension makes up the leading cause of stroke, kidney disease, arterial disease, eye disease, and cardiovascular disease (CVD) growth. AREAS COVERED: This review provides the overview of the role of dietary salt and alcohol use reduction in the management of hypertension, brief history of alcohol, the vascular endothelium functions, the effects of alcohol use on blood pressure (BP), the mechanisms of alcohol, brief history of salt, the effects o...
Source: Expert Review of Cardiovascular Therapy - November 18, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

'Will the king ever be dethroned?' The relationship and the future of oral anticoagulation therapy versus LAA closure devices.
Authors: Burlacu A, Genovesi S, Artene B, Covic A PMID: 33176513 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - November 14, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Chronic total occlusion percutaneous coronary intervention: managing perforation complications.
Authors: Moroni F, Brilakis ES, Azzalini L Abstract INTRODUCTION –: Coronary artery perforation (CAP) is an infrequent (
Source: Expert Review of Cardiovascular Therapy - November 12, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

New developments in catheter ablation for patients with congenital heart disease.
Authors: Le Bloa M, Abadir S, Nair K, Mondésert B, Khairy P Abstract Introduction: There are numerous challenges to catheter ablation in patients with congenital heart disease (CHD), including access to cardiac chambers, distorted anatomies, displaced conduction systems, multiple and/or complex arrhythmia substrates, and excessively thickened walls or interposed material. Areas covered: Herein, we review recent developments in catheter ablation strategies for patients with CHD that are helpful in addressing these challenges. Expert opinion: Remote magnetic navigation overcomes many challenges associated with...
Source: Expert Review of Cardiovascular Therapy - November 11, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries - A Systematic Review and Meta-Analysis.
Conclusion: Intravascular lithotripsy can offer a significant improvement in the vessel lumen to facilitate coronary stent delivery and deployments in severely calcified coronary arteries. PMID: 33135511 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - November 4, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

COVID-19 myocarditis and prospective heart failure burden.
Authors: Shchedrygina A, Nagel E, Puntmann VO, Valbuena-Lopez S Abstract INTRODUCTION: COVID-19 is causing considerable morbidity and mortality worldwide. Serious respiratory complications aside, the heart is also frequently involved. The mechanisms and the extent of the myocardial injury, along with the short and long-term cardiovascular (CV) outcomes in COVID-19 survivors remain unclear. AREAS COVERED: myocardial injury has been found in a considerable proportion of hospitalized COVID-19 patients and is associated with a worse prognosis. The late onset of CV complications with myocarditis-like changes reveale...
Source: Expert Review of Cardiovascular Therapy - October 30, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Angiotensin-II receptor blockers or angiotensin converting enzyme inhibitors for the treatment of hypertension amid COVID-19 pandemic.
Authors: Kow CS, Hasan SS PMID: 33112190 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - October 29, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Reply: Empagliflozin effects on cardiac remodeling: re-shaping the future of heart failure prevention.
Authors: Garcia-Ropero A, Santos-Gallego CG, Badimon JJ PMID: 33092427 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - October 25, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Positive and Negative Cardiovascular Effects of Cannabis.
Authors: Adamson MB, Di Giovanni B, Delgado DH Abstract INTRODUCTION: The use of cannabis and its derivatives have increased steadily over the past few decades, prompting patients and clinicians to increasingly inquire about its health effects and safety profile. However, despite promising evidence suggesting therapeutic utilization, cannabis remains a controlled substance in most countries and is largely considered to have no medical or recreational benefit; thus, a lack of observational studies and randomized control trials exist to outline positive and negative health implications. Ultimately this leaves patient...
Source: Expert Review of Cardiovascular Therapy - October 20, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Multidetector Computed Tomography in Transcatheter Aortic Valve Replacement: an update on technological developments and clinical applications.
Authors: Abd Alamir M, Nazir S, Alani A, Golub I, Gilchrist IC, Aslam F, Dhawan P, Changal K, Ostra C, Soni R, Elzanaty A, Budoff M Abstract INTRODUCTION: Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of patients with underlying sever aortic valve stenosis across all spectrum of the disease. CT imaging is so crucial to the pre procedural planning, to incorporate the information from the CT imaging in the decision making intraprocedurally and to predict and identity the post procedural complications. AREAS COVERED: In this article, we review available studies on CT role in TAVR p...
Source: Expert Review of Cardiovascular Therapy - October 20, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Incidence and outcomes of infective endocarditis following transcatheter aortic valve implantation.
Authors: Allen CJ, Patterson T, Chehab O, Cahill T, Prendergast B, Redwood SR Abstract INTRODUCTION: Prosthetic valve infective endocarditis is a feared and potentially catastrophic complication of valvular intervention. Transcatheter aortic valve implantation has transformed the modern management of aortic stenosis and vastly altered the demographics of those patients undergoing valve replacement. AREAS COVERED: As a relatively nascent development, what TAVI means for the epidemiology of infective endocarditis, how to identify those patients undergoing the procedure at greatest risk, and how best to prevent an...
Source: Expert Review of Cardiovascular Therapy - October 20, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Coronary Atherosclerotic Plaque Progression: Contributing Factors in Statin-Treated Patients.
Authors: Clark Iii D, Puri R, Nissen SE Abstract INTRODUCTION: Coronary atheroma progression correlates with adverse cardiovascular events among individuals with coronary artery disease. Atherosclerosis imaging, including coronary intravascular ultrasound (IVUS), has provided novel insights into the biologic contributors to atheroma progression or regression, improving the efficiency of drug development by identifying therapies most likely to succeed in clinical outcomes trials. AREAS COVERED: Despite widespread use of statins, residual risk for adverse events is high among individuals with cardiovascular disea...
Source: Expert Review of Cardiovascular Therapy - October 15, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Is it Possible to Prevent Cerebral Embolization by Improving the Design and Technology of Carotid Stent Implantation?
Authors: Osipova O, Popova I, Starodubtsev V, Bugurov S, Karpenko A Abstract INTRODUCTION: The prevention of atherosclerotic plaque fragmentation during carotid artery stenting is a fundamental problem in decreasing the risk for disability of patients. The goal of this review is to clarify whether the stent design can have a decisive impact on the rate of intraoperative and postoperative complications. AREAS COVERED: Different designs of the carotid stents are briefed and the advantages and disadvantages of different stent designs are discussed as well as the results of their clinical use. Various solutions are...
Source: Expert Review of Cardiovascular Therapy - October 7, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Transcatheter aortic valve replacement: potential use in lower-risk aortic stenosis.
Authors: Laricchia A, Khokhar AA, Gallo F, Giannini F, Colombo A, Latib A, Mangieri A Abstract INTRODUCTION: The widespread use of transcatheter aortic valve implantation (TAVI) is expanding to low-risk patients. Nevertheless, a low clinical risk does not always correspond to a low procedural risk for the percutaneous approach. AREAS COVERED: The initial trials on TAVI in low-risk populations had encouraging results, showing non-inferiority in comparison to surgical aortic valve replacement (SAVR). However, the low-risk definition is based on risk score calculators developed for the surgical setting and not inc...
Source: Expert Review of Cardiovascular Therapy - October 7, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Antithrombotic Strategies for Patients with Coronary and Lower Extremity Peripheral Artery Diseases: A Narrative Review.
Authors: De Luca L, Bonaca MP, Magnani G Abstract INTRODUCTION: Patients with coexisting coronary artery disease (CAD) and peripheral artery disease (PAD) present a very high rate of cardiovascular (CV) morbidity and mortality. Several studies have demonstrated that different regimens of antithrombotic therapies may reduce adverse CV events in patients with CAD or PAD. However, data on optimal antithrombotic combination to use in these very high-risk patients are scarce and conflicting. AREAS COVERED: This paper reviews current data on antithrombotic therapies tested in CAD patients with concomitant lower extre...
Source: Expert Review of Cardiovascular Therapy - October 7, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Duchenne Muscular Dystrophy: an overview to the Cardiologist.
The objective of this brief review is to update the cardiologists by highlighting the most relevant aspects of treatment and follow-up, in a practical and concise way. PMID: 32985912 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - September 30, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Human African Trypanosomiasis & Heart.
Human African Trypanosomiasis & Heart. Expert Rev Cardiovasc Ther. 2020 Sep 23;: Authors: Ortiz HIA, Farina JM, Saldarriaga C, Mendoza I, Sosa Liprandi A, Wyss F, Burgos LM, Alexander B, Baranchuk A Abstract INTRODUCTION: Human African Trypanosomiasis is a neglected tropical disease resulting from the infection with the parasite Trypanosoma brucei. Neurological compromise often dominates, and the impact of cardiovascular involvement has not been fully investigated. Recently, publications indicate that cardiovascular compromise is more frequent than previously thought. Early detection of cardiac com...
Source: Expert Review of Cardiovascular Therapy - September 26, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Is the true clinical value of high sensitivity troponins as a biomarker of risk? The concept that detection of high-sensitivity troponin "never means nothing".
Is the true clinical value of high sensitivity troponins as a biomarker of risk? The concept that detection of high-sensitivity troponin "never means nothing". Expert Rev Cardiovasc Ther. 2020 Sep 23;: Authors: Hinton J, Gabara L, Curzen N Abstract INTRODUCTION: High sensitivity troponin (hs-cTn) assays are central to the diagnosis of myocardial infarction (MI). Their increased sensitivity has facilitated rapid pathways for the exclusion of MI. However, hs-cTn is now more readily detectable in patients without symptoms typical of MI, in whom a degree of myocardial injury is assumed. Recently,...
Source: Expert Review of Cardiovascular Therapy - September 24, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Naxos disease - a narrative review.
This article reviews historic background, epidemiology, clinical characteristics, genetics, and pathogenesis as well as therapeutic management and future perspectives. Expert opinion The principles of evaluation and treatment are based on arrhythmogenic right ventricular cardiomyopathy (ARVC) and general heart failure guidelines, because specific data on Naxos disease are limited. Therefore, larger registries on Naxos disease are welcome in order to gain more knowledge about clinical course and risk stratification. Translational research on pathophysiological mechanisms has evolved, including promising approaches using ste...
Source: Expert Review of Cardiovascular Therapy - September 24, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers and Outcomes in patients with COVID-19: A Systematic Review and Meta-Analysis.
CONCLUSION: use of ACEI/ARB was not associated with increased mortality or severe COVID-19. PMID: 32945216 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - September 20, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Correction.
Authors: PMID: 32931353 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - September 17, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Rivaroxaban for the treatment of venous thromboembolism in pediatric patients.
Authors: Cohen O, Levy-Mendelovich S, Ageno W Abstract INTRODUCTION: Anticoagulant therapy is in use for both prevention and treatment of venous and arterial thromboembolic disorders. Delivering safe and effective anticoagulation in the pediatric population is challenging, since the available standard therapy with parenteral UFH and LMWH is troublesome for most pediatric patients, and VKAs require frequent INR monitoring due to the unpredictable pharmacokinetics and numerous food and drug interactions. Rivaroxaban, a direct FXa inhibitor, offers the convenience of oral administration and predictable pharmacokinetic...
Source: Expert Review of Cardiovascular Therapy - September 17, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Cancer-associated venous thromboembolism and the non-vitamin K antagonist oral anticoagulants: a review of clinical outcomes and patient perspectives.
Authors: Overvad TF, Larsen TB, Søgaard M, Albertsen IE, Ording AG, Noble S, Højen AA, Nielsen PB Abstract INTRODUCTION: Cancer-associated venous thromboembolism remains an important but challenging aspect in the treatment of patients with cancer. Recently, alternatives to injection of low-molecular-weight heparin (LMWH) have been introduced, the non-vitamin K antagonist oral anticoagulants (NOACs), which could potentially alleviate patients from burdensome daily injections. AREAS COVERED: This review discusses the available evidence exploring the role of NOACs in the treatment and secondary preve...
Source: Expert Review of Cardiovascular Therapy - September 13, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Empagliflozin effects on cardiac remodeling: re-shaping the future of heart failure prevention.
Authors: Katsiki N, Kotsa K, Kotsis V PMID: 32897742 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - September 10, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Cost-utility analysis of home-based cardiac rehabilitation as compared to usual post-dischargecare: systematic review and meta-analysis of randomized controlled trials.
Authors: Bakhshayeh S, Hoseini B, Bergquist R, Nabovati E, Gholoobi A, Mohammad-Ebrahimi S, Eslami S Abstract INTRODUCTION: . Determining cost-utility differences between home-based cardiac rehabilitation (HBCR) on the one hand, and usual post-discharge care (UC) on the other, can improve resource-allocation in healthcare settings. AREAS COVERED: . In June 2019, PubMed, Web of Science, Scopus and Cochrane library were searched for randomized controlled HBCR trials. Standardized mean differences (SMDs) of cost and quality-adjusted life years (QALYs) between HBCRs and UCs were calculated using random effect model...
Source: Expert Review of Cardiovascular Therapy - September 9, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Effects of physical exercise on the autonomic nervous system in patients with coronary artery disease: A systematic review.
The objective of this systematic review was to investigate the effects of physical exercise on heart rate variability in individuals with coronary artery disease (CAD). The PubMed, PEDro, Scielo, Lilacs and Cochrane databases were systematically searched, for articles which performed supervised exercises in phase II of cardiac rehabilitation in patients with CAD.Expert opinion: Given the differences between studies on interventions and population characteristics, it is difficult to justify similarities or divergences in terms of results. In addition to the variation in sample size, intervention duration, carrying out an ad...
Source: Expert Review of Cardiovascular Therapy - September 6, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Current Challenges in Cardiac Rehabilitation: Strategies to Overcome Social Factors and Attendance Barriers.
Authors: Chindhy S, Taub PR, Lavie CJ, Shen J Abstract Introduction Cardiac rehabilitation (CR) significantly reduces secondary cardiovascular events and mortality and is a class 1A recommendation by the American Heart Association (AHA) and American College of Cardiology (ACC). However, it remains an underutilized intervention and many eligible patients fail to enroll or complete CR programs. The aim of this review is to identify barriers to CR attendance and discuss strategies to overcome them. Areas Covered Specific barriers to CR attendance and participation will be reviewed. This will be followed by a discussio...
Source: Expert Review of Cardiovascular Therapy - September 6, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Outcomes of Percutaneous Intervention in In-stent versus De-novo Chronic Total Occlusion: A Meta-analysis.
CONCLUSION: PCI for in-stent CTO might be associated with higher odds of MACE and MI compared to PCI for de-novo CTO. These complications, however, do not translate into an increased risk of cardiovascular mortality or failure of procedure. PMID: 32842807 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - August 28, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

COVID-19 and Renin-Angiotensin System Modulators: What Do We Know So Far?
Authors: de la Cruz A, Ashraf S, Vittorio TJ, Bella JN Abstract INTRODUCTION: . The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory system-coronavirus-2 (SARS-CoV-2), is an important medical problem worldwide. Increased risk of mortality has been reported in patients with cardiovascular disease, such as hypertension (HTN). SARS-CoV-2 invades the pulmonary alveolar epithelial cells by binding to the surface receptor, angiotensin-converting enzyme 2 (ACE2). Renin-angiotensin system (RAS) modulators can increase levels of ACE2. Thus, concerns have been raised regarding an increased ri...
Source: Expert Review of Cardiovascular Therapy - August 28, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Efficacy and Safety of Transradial and Transfemoral Approach in Treatment of Coronary Chronic Total Occlusion: A Systematic Review and Meta-Analysis.
Authors: Soud M, SayedAhmad Z, Kajy M, Alahdab F, Darmoch F, Al-Khadra Y, Pacha HM, Sattar Y, Ullah W, King F, Saad AB, Alhatemi G, Hakim Z, Ali OA, Glazier JJ, Alraies MC Abstract BACKGROUND: Transradial coronary intervention (TR) has been shown to be associated with lower bleeding and length of stay compared to femoral artery access for coronary artery interventions. There is limited data on the efficacy and the safety of the TR for percutaneous coronary intervention (PCI) of coronary chronic total occlusion (CTO), particularly in comparison with the transfemoral approach (TF). Objectives: We sought to study the ...
Source: Expert Review of Cardiovascular Therapy - August 24, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Evaluation of inter-patient variability in the pharmacodynamic indices of warfarin.
Authors: Sridharan K, Al Banny R, Qader AM, Ahmed A Abstract OBJECTIVES: Warfarin exhibits huge inter-individual variability in therapeutic response. We assessed the extent and the factors affecting inter-individual variability in the anticoagulation control using pre-validated pharmacodynamic indices. METHODS: Patients receiving warfarin for at least 6 months were recruited. CHA₂DS₂-VASc, HASBLED, SAMe-TT2R2 scores, warfarin sensitive index (WSI), log-INR variability and warfarin composite measure (WCM) were assessed. National Institute for Health and Care Excellence (NICE) guideline was adhered for assess...
Source: Expert Review of Cardiovascular Therapy - August 23, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Focus on a rare clinical entity: unicuspid aortic valve disease.
This article aims to give an overview on the most recent literature addressing the pathophysiology, the diagnostic tools and appropriate surgical therapy options of unicuspid aortic valve. Due to the rare prevalence, the understanding of pathophysiology is still missing. Further, symptomatic aortic valve disease are seen much earlier life-stage in this cohorts. Thus, it highlights the several surgical treatment options with pro and contra especially for the young adult cohorts. EXPERT OPINION: Large scale prospective observational studies using standardized diagnostic criteria are needed to reveal the clinical course. ...
Source: Expert Review of Cardiovascular Therapy - August 21, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Update on diagnosis and management of neoplastic pericardial disease.
Authors: Avondo S, Andreis A, Casula M, Imazio M Abstract INTRODUCTION: Pericardial neoplasms are uncommon, mostly due to secondary involvement of the pericardium by extracardiac tumors. Clinical presentation is nonspecific, frequently leading to a delayed diagnosis. Moreover, both benign and malignant pericardial tumors may be associated with myocardial infiltration and mechanical compression of cardiac chambers, possibly precipitating clinical conditions. Pericardial tumors are indeed a diagnostic and therapeutic clinical challenge. AREAS COVERED: This review aims to provide an overview of the main clinical c...
Source: Expert Review of Cardiovascular Therapy - August 18, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Effect of ambrisentan on echocardiographic and Doppler measures from patients in China with pulmonary arterial hypertension.
Authors: Zhao QH, Peng FH, Yu ZX, Zhang GC, Ji QS, Wang Y, Liu JM, Huo Y, Zeng XF, Li JH, Zi L, Jing ZC Abstract BACKGROUND: We retrospectively evaluated the echocardiographic data of ambrisentan-treated patients with pulmonary arterial hypertension (PAH) (NCT01808313). METHODS: Change from baseline in right ventricle (RV) systolic function, right heart structure, and pulmonary artery systolic pressure (PASP) prognosis to Weeks 12 and 24 was evaluated by echocardiography. RESULTS: In the overall population, the mean tissue Doppler-derived tricuspid lateral annular systolic velocity (S') increased by 0.6 cm/...
Source: Expert Review of Cardiovascular Therapy - August 18, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Tissue engineered heart valves for transcatheter aortic valve implantation: current state, challenges, and future developments.
Authors: Poulis N, Zaytseva P, Gähwiler E, Motta SE, Fioretta ES, Cesarovic N, Falk V, Hoerstrup SP, Emmert MY Abstract INTRODUCTION: The establishment of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic stenosis. However, with TAVI being approved for low-risk patients, valve durability is becoming of central importance. Here, we summarize how tissue engineered heart valves (TEHVs) may provide a clinically-relevant durable valve replacement compatible with TAVI. AREAS COVERED: Since its introduction, TAVI prostheses have advanced in design and development. Ho...
Source: Expert Review of Cardiovascular Therapy - August 15, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Cardiopulmonary exercise testing - refining the clinical perspective by combining assessments.
Authors: Arena R, Canada JM, Popovic D, Trankle CR, Del Buono M, Lucas A, Abbate A Abstract INTRODUCTION: Cardiorespiratory fitness (CRF) is now established as a vital sign. Cardiopulmonary exercise testing (CPX) is the gold-standard approach to assessing CRF. AREAS COVERED: A body of literature spanning several decades clearly supports the clinical utility of CPX in those who are apparently health and at risk for chronic disease as well as numerous patient populations. While CPX, in and of itself, is a valid and reliable clinical assessment, combining findings with other available assessments may provide a mor...
Source: Expert Review of Cardiovascular Therapy - August 13, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Aspirin and low dose rivaroxaban - the dual pathway concept in patients with stable atherosclerotic disease: a comprehensive review.
Authors: Parascandolo E, Eisen A Abstract INTRODUCTION: Cardiovascular disease is the leading cause of morbidity and mortality in adults in western nations. In the last decades, tremendous research has been conducted in the field of secondary prevention in order to reduce recurrent cardiovascular events. This review summarizes the novel dual pathway concept of aspirin and very low-dose rivaroxaban, from mechanisms to clinical practice. AREAS COVERED: The COMPASS trial demonstrated that in patients with stable atherosclerotic disease, very low-dose rivaroxaban, a direct factor Xa inhibitor, when combined with as...
Source: Expert Review of Cardiovascular Therapy - August 13, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Association of the Metabolic Syndrome with Target Organ Damage: Focus on the Heart, Brain and Central Arteries.
Authors: Saeed S, Waje-Andreassen U, Nilsson PM Abstract INTRODUCTION: The metabolic syndrome (MetS) is an adverse metabolic state composed of obesity, hyperglycemia/pre-diabetes, hypertension and dyslipidemia. It substantially increases the risk of type 2 diabetes, cardiovascular disease (CVD) and mortality, and has a huge impact on public health. AREA COVERED: The present review gives an update on the definition and prevalence of MetS, and its impact on cardiac structure and function as well as on the brain and central arteries. The association with CVD and mortality risk is discussed. Focus is mainly directe...
Source: Expert Review of Cardiovascular Therapy - August 13, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Balloon-expandable versus self-expanding transcatheter aortic valve replacement: a comparison and evaluation of current findings.
Authors: Costa G, Criscione E, Reddavid C, Barbanti M Abstract INTRODUCTION: Currently, several balloon-expandable(BE) and self-expanding(SE) transcatheter aortic valves(TAVs) are available in clinical practice.Each of them has potential advantages and disadvantages that must be taken into account. AREAS COVERED: New-generation BE and SE TAVs showed similar mid-term outcomes after transfemoral transcatheter aortic valve replacement(TAVR) and better results compared to early-generation devices.BE TAVs showed better results in terms of residual paravalvular regurgitation(PVR) and permanent pacemaker implantation(...
Source: Expert Review of Cardiovascular Therapy - August 13, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research