Diagnosis and treatment of HCV heart diseases
Expert Rev Cardiovasc Ther. 2021 Apr 16. doi: 10.1080/14779072.2021.1917383. Online ahead of print.ABSTRACTINTRODUCTION: Hepatitis C virus (HCV) infection is an important cause of a variety of otherwise unexplained heart diseases and myocardial injury. A high prevalence of HCV infection has been noted in patients with hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy and myocarditis. Various arrhythmias, conduction disturbances and QT prolongation were also associated with HCV infection.A possible role of HCV infection in the pathogenesis of diabetes and atherosc...
Source: Expert Review of Cardiovascular Therapy - April 16, 2021 Category: Cardiology Authors: Mohammad Haykal Akira Matsumori Ahmed Saleh Moatez Fayez Hany Negm Mohammad Shalaby Samar Bassuony Source Type: research

Preventing disease progression in Eisenmenger syndrome
Expert Rev Cardiovasc Ther. 2021 Apr 14. doi: 10.1080/14779072.2021.1917995. Online ahead of print.ABSTRACTINTRODUCTION: Eisenmenger syndrome describes a condition in which a congenital heart defect has caused severe pulmonary vascular disease, resulting in reversed (right-left) or bidirectional shunting and chronic cyanosis.AREAS COVERED: In this paper, the progression of congenital heart defects to Eisenmenger syndrome, including early screening, diagnosis and operability are covered. The mechanisms of disease progression in Eisenmenger syndrome and management strategies to combat this, including the role of pulmonary ar...
Source: Expert Review of Cardiovascular Therapy - April 15, 2021 Category: Cardiology Authors: Ana Barradas-Pires Andrew Constantine Konstantinos Dimopoulos Source Type: research

Non-invasive Rapid Cardiac Magnetic Resonance for the Assessment of Cardiomyopathies in Low-Middle Income Countries
This article will review cardiovascular disease in LMICs and the current role of CMR in cardiac diagnosis and enable targeted therapy, discussing the main obstacles to prevent the adoption of CMR in LMICs. We will then review the potential utility of abbreviated, cost-effective CMR protocols to improve cardiac diagnosis and care, the clinical indications of the exam, current evidence and future directions.EXPERT OPINION: Rapid CMR protocols, provided that they are utilized in potentially high yield cases, could reduce cost and increase effectiveness. The adoption of these protocols, their integration into care pathways, an...
Source: Expert Review of Cardiovascular Therapy - April 10, 2021 Category: Cardiology Authors: Katia Menacho Medina Andreas Seraphim Diana Katekaru Amna Abdel-Gadir Yuchi Han Mark Westwood J Malcolm Walker James C Moon Anna S Herrey Source Type: research

Transcatheter Tricuspid Valve Repair and Replacement: A Landscape Review of Current Techniques and Devices for the Treatment of Tricuspid Valve Regurgitation
Expert Rev Cardiovasc Ther. 2021 Apr 9. doi: 10.1080/14779072.2021.1915133. Online ahead of print.ABSTRACTIntroductionTricuspid regurgitation is a prevalent and undertreated cardiac pathology impacting millions across the globe. While historically surgical interventions for isolated tricuspid regurgitation were largely avoided due to data citing poor surgical outcomes, advances in transcatheter techniques and imaging modalities have reframed the approach to tricuspid valve disease in promising new ways.Areas CoveredHere we sought to provide a landscape review of the current state of the field for transcatheter tricuspid va...
Source: Expert Review of Cardiovascular Therapy - April 9, 2021 Category: Cardiology Authors: Kusha Rahgozar Edwin Ho Ythan Goldberg Mei Chau Azeem Latib Source Type: research

Meta-Analysis Comparing Direct Oral Anticoagulants to Vitamin K Antagonists for The Management of Left Ventricular Thrombus
Expert Rev Cardiovasc Ther. 2021 Apr 8. doi: 10.1080/14779072.2021.1915134. Online ahead of print.ABSTRACTINTRODUCTION: To compare vitamin K antagonist (VKAs) and direct oral anticoagulants (DOACs) treatment in patients with left ventricular (LV) thrombus. The primary outcome was stroke or systemic embolism (SSE). Secondary outcomes were thrombus resolution, bleeding, and death.AREAS COVERED: Five observational studies were included (total n=700; VKAs n = 480; DOACs n = 220). There was a trend toward less SSE with VKAs compared to DOACs (5.2% vs. 9%; OR = 0.54, 95% CI= 0.29-1.01, p = 0.05). No significant difference betwee...
Source: Expert Review of Cardiovascular Therapy - April 8, 2021 Category: Cardiology Authors: Hesham K Abdelaziz Michael Megaly Maciej Debski Amr Abdelrahman Shehab Abdelaziz Diaa Kamal Billal Patel Ranjit More Tawfiq Choudhury Source Type: research

Evaluation of coronary plaques and atherosclerosis using optical coherence tomography
Expert Rev Cardiovasc Ther. 2021 Apr 7. doi: 10.1080/14779072.2021.1914588. Online ahead of print.ABSTRACTINTRODUCTION: Coronary angiography (CAG) is the standard modality for assessing coronary stenosis; however, it has limitations in assessing coronary plaque morphology. Optical coherence tomography (OCT) is a high-resolution (10-20μm) light-based intravascular imaging technique that can identify more detailed coronary plaque morphology compared to other intravascular imaging modalities. OCT is remarkable for characterizing fibrous, fibrocalcific, and lipid-rich plaques. The capabilities of OCT are well suited for dis...
Source: Expert Review of Cardiovascular Therapy - April 7, 2021 Category: Cardiology Authors: Kunihiro Shimamura Takashi Kubo Takashi Akasaka Source Type: research

Antinociceptive Effect of Ranolazine and Trimetazidine
In this study, it was aimed to evaluate the antinociceptive effects of Ranolazine and Trimetazidine.METHODS: Sixty patients who were started on trimetazidine or ranolazine treatment were included in the study. The patients were evaluated with Seattle angina questionnaire (SAQ), Visual Analog Scale (VAS) and State Anxiety Inventory (STAI) on the first day of treatment and at the 1st month follow-up.RESULTS: The SAQ scores of the patients given ranolazine were statistically significantly higher than the patients given trimetazidine. The most significant increase was observed in terms of treatment satisfaction (53.03±8...
Source: Expert Review of Cardiovascular Therapy - April 7, 2021 Category: Cardiology Authors: Hatice Tolunay Source Type: research

Evaluation of coronary plaques and atherosclerosis using optical coherence tomography
Expert Rev Cardiovasc Ther. 2021 Apr 7. doi: 10.1080/14779072.2021.1914588. Online ahead of print.ABSTRACTINTRODUCTION: Coronary angiography (CAG) is the standard modality for assessing coronary stenosis; however, it has limitations in assessing coronary plaque morphology. Optical coherence tomography (OCT) is a high-resolution (10-20μm) light-based intravascular imaging technique that can identify more detailed coronary plaque morphology compared to other intravascular imaging modalities. OCT is remarkable for characterizing fibrous, fibrocalcific, and lipid-rich plaques. The capabilities of OCT are well suited for dis...
Source: Expert Review of Cardiovascular Therapy - April 7, 2021 Category: Cardiology Authors: Kunihiro Shimamura Takashi Kubo Takashi Akasaka Source Type: research

Antinociceptive Effect of Ranolazine and Trimetazidine
In this study, it was aimed to evaluate the antinociceptive effects of Ranolazine and Trimetazidine.METHODS: Sixty patients who were started on trimetazidine or ranolazine treatment were included in the study. The patients were evaluated with Seattle angina questionnaire (SAQ), Visual Analog Scale (VAS) and State Anxiety Inventory (STAI) on the first day of treatment and at the 1st month follow-up.RESULTS: The SAQ scores of the patients given ranolazine were statistically significantly higher than the patients given trimetazidine. The most significant increase was observed in terms of treatment satisfaction (53.03±8...
Source: Expert Review of Cardiovascular Therapy - April 7, 2021 Category: Cardiology Authors: Hatice Tolunay Source Type: research

An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety
Expert Rev Cardiovasc Ther. 2021 Apr 2:1-12. doi: 10.1080/14779072.2021.1905520. Online ahead of print.ABSTRACTIntroduction: In the 20 years since its introduction to the palette of intravenous hemodynamic therapies, the inodilator levosimendan has established itself as a valuable asset for the management of acute decompensated heart failure. Its pharmacology is notable for delivering inotropy via calcium sensitization without an increase in myocardial oxygen consumption.Areas covered: Experience with levosimendan has led to its applications expanding into perioperative hemodynamic support and various critical care setting...
Source: Expert Review of Cardiovascular Therapy - March 19, 2021 Category: Cardiology Authors: Matthias Heringlake Julian Alvarez Dominique Bettex Stefaan Bouchez Sonja Fruhwald Massimo Girardis Elena Grossini Fabio Guarracino Antoine Herpain Wolfgang Toller Luigi Tritapepe Piero Pollesello Source Type: research

An update on levosimendan in acute cardiac care: Applications and recommendations for optimal efficacy and safety
Expert Rev Cardiovasc Ther. 2021 Mar 19. doi: 10.1080/14779072.2021.1905520. Online ahead of print.ABSTRACTIntroductionIn the 20 years since its introduction to the palette of intravenous hemodynamic therapies, the inodilator levosimendan has established itself as a valuable asset for the management of acute decompensated heart failure. Its pharmacology is notable for delivering inotropy via calcium sensitization without an increase in myocardial oxygen consumption.Areas coveredExperience with levosimendan has led to its applications expanding into perioperative hemodynamic support and various critical care settings, as we...
Source: Expert Review of Cardiovascular Therapy - March 19, 2021 Category: Cardiology Authors: Matthias Heringlake Julian Alvarez Dominique Bettex Stefaan Bouchez Sonja Fruhwald Massimo Girardis Elena Grossini Fabio Guarracino Antoine Herpain Wolfgang Toller Luigi Tritapepe Piero Pollesello Source Type: research

Current challenges and prevention strategies for chronic total occlusion (CTO) complications
Expert Rev Cardiovasc Ther. 2021 Mar 17. doi: 10.1080/14779072.2021.1905521. Online ahead of print.ABSTRACTIntroduction: Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) can be challenging, but high success rates (85-90%) are currently achieved at experienced centers with approximately 3% risk for a major periprocedural complication.Areas covered: CTO PCI complications can be categorized according to location such as cardiac and non-cardiac (vascular access complications, thromboembolic complications, contrast-related and radiation injury) complications. Cardiac complications are further subdivided...
Source: Expert Review of Cardiovascular Therapy - March 17, 2021 Category: Cardiology Authors: Judit Karacsonyi Evangelia Vemmou Ilias Nikolakopoulos Imre Ungi Nidal Abi Rafeh Ahmed ElGuindy Lorenzo Azzalini M Nicholas Burke Emmanouil S Brilakis Source Type: research

Clinical outcomes following rhythm control for atrial fibrillation: Is early better?
Expert Rev Cardiovasc Ther. 2021 Mar 10. doi: 10.1080/14779072.2021.1902307. Online ahead of print.ABSTRACTINTRODUCTION: An integral aspect of atrial fibrillation (AF) management involves better symptom control, incorporating a rate control, rhythm control or a combination strategy. The 2020 ESC Guidelines suggest that rhythm control strategy should be recommended for symptomatic patients, to mitigate their symptoms and improve the quality of life. However, adequately powered randomised control trials and prospective 'real world' registries are needed to fully assess the impact of early rhythm control strategies on clinica...
Source: Expert Review of Cardiovascular Therapy - March 15, 2021 Category: Cardiology Authors: Agnieszka Kotalczyk Wern Yew Ding Dhiraj Gupta D J Wright Gregory Y H Lip Source Type: research

Differences in coronary artery disease and outcomes of percutaneous coronary intervention with drug-eluting stents in women and men
Expert Rev Cardiovasc Ther. 2021 Mar 12. doi: 10.1080/14779072.2021.1902806. Online ahead of print.ABSTRACTINTRODUCTION: Despite common perceptions, coronary artery disease (CAD) is not a male-specific condition, and sex-based differences do occur in many aspects, including clinical outcomes after percutaneous coronary intervention (PCI) with stent implantation. New-generation drug-eluting stent (DES) significantly improved post-PCI outcomes. However, no sex-specific guidelines on PCI and the use of DES are available as current evidence was derived from clinical trials enrolling predominantly male patients.AREAS COVERED: T...
Source: Expert Review of Cardiovascular Therapy - March 12, 2021 Category: Cardiology Authors: Antonio Greco Davide Capodanno Source Type: research

Antithrombotic treatment in primary percutaneous coronary intervention
Expert Rev Cardiovasc Ther. 2021 Mar 11. doi: 10.1080/14779072.2021.1902807. Online ahead of print.ABSTRACTINTRODUCTION: Despite a timely mechanical reperfusion with primary percutaneous coronary intervention (pPCI) patients presenting with ST-elevation myocardial infarction (STEMI) display an increased risk of adverse cardiovascular events. Several studies have demonstrated that guideline-directed antithrombotic therapy is effective to reduce this risk. However, there is still much to be accomplished to improve antithrombotic therapies in this clinical setting.AREAS COVERED: This paper reviews current data on antithrombot...
Source: Expert Review of Cardiovascular Therapy - March 11, 2021 Category: Cardiology Authors: Felix Voll Constantin Kuna Gjin Ndrepepa Adnan Kastrati Salvatore Cassese Source Type: research

Aortic valve stenosis and cancer: a common and complex association
Expert Rev Cardiovasc Ther. 2021 Mar 10. doi: 10.1080/14779072.2021.1902306. Online ahead of print.ABSTRACTINTRODUCTION: The prevalence of aortic valve stenosis (AS) and malignancy are both high, especially in elderly people and in developed countries. These two conditions frequently coexist and share the same risk factors, as atherosclerotic disease.AREA COVERED: The progression of calcified AS may be accelerated by both cardiovascular risk factors and cancer treatments, such as radiotherapy. The standard treatment for symptomatic severe AS is surgical aortic valve replacement, however in cancer patients transcatheter imp...
Source: Expert Review of Cardiovascular Therapy - March 10, 2021 Category: Cardiology Authors: Silvia Frattini Giovanni Troise Carlo Fucci Gregg S Pressman Pompilio Faggiano Source Type: research

Predictors of recurrent atrial fibrillation following catheter ablation
Expert Rev Cardiovasc Ther. 2021 Mar 7:1-10. doi: 10.1080/14779072.2021.1892490. Online ahead of print.ABSTRACTINTRODUCTION: Atrial fibrillation (AF) is a complex and multi-factorial rhythm disorder. Catheter ablation is widely used for the management of AF. However, it is limited by relapse of the arrhythmia necessitating repeat procedures.AREAS COVERED: This review aims to discuss the predictors of post-ablation recurrent AF including age, gender, genetic predisposition, AF type and duration, comorbidities, lifestyle factors, echocardiographic parameters of heart chambers, left atrial fibrosis and ablation strategies and...
Source: Expert Review of Cardiovascular Therapy - March 8, 2021 Category: Cardiology Authors: Sanghamitra Mohanty Domenico G Della Rocca Carola Gianni Chintan Trivedi Angel Quintero Mayedo Bryan MacDonald Andrea Natale Source Type: research

Clinical Outcomes of Renal and Liver Transplant Patients undergoing Transcatheter Aortic Valve Replacement: Analysis of National Inpatient Sample Database.
CONCLUSION: Compared to non-transplant patients, TAVR appears to be associated with similar odds of major systemic complications or mortality in patients with a history of kidney or liver transplant. PMID: 33615950 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - February 23, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Patent foramen ovale closure for secondary prevention of cryptogenic stroke.
Authors: Kolte D, Palacios IF Abstract Introduction: A patent foramen ovale (PFO) is highly prevalent among the adult population. It allows shunting of blood through the inter-atrial septum and has been associated with cryptogenic stroke, transient ischemic attack, platypnea-orthodeoxia syndrome, decompression sickness (e.g. deep-water divers), and migraines. Areas Covered: In this manuscript, we will review the anatomy of PFO with particular emphasis on the factors associated with increased risk of paradoxical embolization, as well as the different modalities for the diagnosis of PFO. We will discuss medical, surg...
Source: Expert Review of Cardiovascular Therapy - February 20, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Post-PCI Outcomes in STEMI Patients with Coronary Ectasia: Meta-analysis.
Authors: Mir T, Sattar Y, Uddin M, Changal KH, Kumar K, Attique HB, Kabashneh S, Zafrullah W, Lohia P, Alraies MC, Blank N, Afonso L Abstract BACKGROUND: Coronary ectasia (CE) is defined as dilation of the coronary artery, 1.5 times of the surrounding vessel. Outcomes of percutaneous intervention (PCI) in patients with CE presenting as ST-elevated myocardial infarction (STEMI) remains a topic of debate. METHODS: Studies comparing outcomes of PCI in CE versus no-ectasia (NE) STEMI patients were identified. Baseline angiographic characteristics including thrombolysis in myocardial infarction (TIMI) 0-1 flow, righ...
Source: Expert Review of Cardiovascular Therapy - February 17, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Clinical Outcomes of Patients with Diabetes Mellitus and Acute ST-elevation Myocardial Infarction Following Fibrinolytic Therapy: A Nationwide Inpatient Sample (NIS) Database Analysis.
Authors: Ullah W, Saleem S, Zahid S, Sattar Y, Mukhtar M, Younas S, Pasha A, Inayat A, Fischman DL, Alraies MC Abstract BACKGROUND: The impact of diabetes mellitus (DM) on clinical outcomes of acute ST-segment elevation myocardial infarction (STEMI) following fibrinolytic therapy remains uncertain. METHODS: We queried the National Inpatient Sample (NIS) for STEMI patients who received fibrinolytic therapy. Categorical and continuous variables were compared using the unadjusted odds ratio (uOR) and t-test analysis, respectively. A binary logistic regression model was used to control the outcomes for patient demo...
Source: Expert Review of Cardiovascular Therapy - February 13, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Predicting and Measuring Mortality Risk After Transcatheter Aortic Valve Replacement.
Authors: Gupta T, Joseph DT, Goel SS, Kleiman NS Abstract Introduction: Over the last decade, transcatheter aortic valve replacement (TAVR) has emerged as a treatment option for most patients with severe symptomatic aortic stenosis (AS). With growing indications and exponential increase in the number of TAVR procedures, it is important to be able to accurately predict mortality after TAVR. Areas covered: Herein, we review the surgical and TAVR-specific mortality prediction models (MPM's) and their performance in their original derivation and external validation cohorts. We then discuss the role of other important r...
Source: Expert Review of Cardiovascular Therapy - February 10, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Percutaneous Coronary Intervention in Patients with Cardiac Allograft Vasculopathy: A Nationwide Inpatient Sample (NIS) Database Analysis.
Conclusion: PCI in CAV may be associated with increased in-hospital complications and higher resource utilization. PMID: 33507114 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - January 30, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Predictors and risk factors of short-term readmission of acute pericarditis.
Conclusion: Chronic comorbidities, prolonged hospitalization, and admission to a short-term hospital/left against medical advice admission to metropolitan teaching hospital were associated with a higher risk of 30-day readmission. PMID: 33499696 [PubMed - as supplied by publisher] (Source: Expert Review of Cardiovascular Therapy)
Source: Expert Review of Cardiovascular Therapy - January 28, 2021 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research