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Condition: Patent Foramen Ovale

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Total 1415 results found since Jan 2013.

Stroke or Transient Ischemic Attack in Patients with Transvenous Pacemaker or Defibrillator and Echocardiographically Detected Patent Foramen Ovale.
CONCLUSIONS: In patients with endocardial leads, the presence of a PFO on routine echocardiography is associated with a substantially increased risk of embolic stroke/TIA. This finding suggests a role of screening for PFOs in patients who require CIEDs, if detected, PFO closure, anticoagulation, or non-vascular lead placement may be considered. PMID: 23946264 [PubMed - as supplied by publisher]
Source: Circulation - August 14, 2013 Category: Cardiology Authors: Desimone CV, Friedman PA, Noheria A, Patel NA, Desimone DC, Bdeir S, Aakre CA, Vaidya VR, Slusser JP, Hodge DO, Ackerman MJ, Rabinstein AA, Asirvatham SJ Tags: Circulation Source Type: research

Cryptogenic stroke
In about a quarter of ischaemic strokes the cause is undetermined, because the investigation is incomplete or delayed, because there are multiple causes or because the stroke is truly cryptogenic. Cryptogenic stroke can be further classified as non‐embolic or embolic. Embolic stroke of undetermined source can be due to paroxysmal atrial fibrillation, minor emboligenic cardiac conditions, atheroembolism, cancer associated and paradoxical embolism through a patent foramen ovale (PFO) or less often a pulmonary fistula. Currently, risk factor control, statins and antiplatelets are the main therapeutic measures to prevent rec...
Source: European Journal of Neurology - January 18, 2015 Category: Neurology Authors: A. C. Fonseca, J. M. Ferro Tags: Invited Review Source Type: research

Patent foramen ovale closure following cryptogenic stroke or transient ischaemic attack: Long‐term follow‐up of 301 cases
Patent foramen ovale has been identified as a conduit for paradoxical embolism resulting in cryptogenic stroke or transient ischemic attack (TIA). We aimed to establish rates of death, recurrent stroke or TIA among patients undergoing PFO closure for stroke or TIA at our unit. A retrospective analysis of all PFO closure patients was performed between May 2004 and January 2013. Follow up was performed by mortality tracing using the Medical Research Information Service of the Office of National Statistics. With regard to stroke or TIA recurrence, written consent forms and questionnaires were mailed with follow up telephone c...
Source: Catheterization and Cardiovascular Interventions - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Mikaeil Mirzaali, Maureen Dooley, Dylan Wynne, Nina Cooter, Lorraine Lee, Peter Haworth, Romi Saha, Nicola Gainsborough, David Hildick‐Smith Tags: Valvular and Structural Heart Diseases Source Type: research

Circadian variation in patients with cryptogenic stroke and patent foramen ovale (P3.252)
Conclusions:These data suggest that strokes occur more frequently in the morning hours in patients with CS and PFO. Hypertension is significantly lower in patients with symptom onset between 0601 and 1200, which may further imply embolism as the potential mechanism of stroke in these patients. Further studies with larger datasets are required to investigate the circadian variation of PFO-attributable strokes.Disclosure: Dr. Daneshmand has nothing to disclose. Dr. Thaler has received personal compensation for activities with St. Jude Medical WL and Gore Associates as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Daneshmand, A., Thaler, D. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Ischemic stroke in a patient with Parry-Romberg syndrome (P4.064)
Conclusions:The only other reported patient with PRS and stroke was also found to have a PFO. It is possible that the elevated ANA seen in this patient correlates with propensity towards small venous clots not seen on ultrasound. This may lead to paradoxical emboli and ischemic strokes. It is important to note this potential association between PRS and ischemic stroke in young patients without other known risk factors. It would be worthwhile to treat this subset of patients with medications for secondary stroke prevention.Disclosure: Dr. Ebiana has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Khosa has nothi...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ebiana, V., Singh, S., Khosa, S., Moheb, N., Trikamji, B., Rao, N., Mishra, S. Tags: General Neurology: Vascular Neurology Source Type: research

Acute Pediatric Ischemic Stroke Management: a window for opportunity? (P4.175)
Conclusions:Pediatric stroke is a rare condition, with one of the most common causes being congenital cardiac disease. Unfortunately, we lack evidence-based guidelines to guide its management. Based upon pathophysiology, we believe children’s significant collateral circulation and outstanding plasticity may broaden the temporal window for intervention in acute stroke.Disclosure: Dr. Pace has nothing to disclose. Dr. Dorn has nothing to disclose. Dr. Kulhari has nothing to disclose. Dr. Kandregula has nothing to disclose. Dr. Bozorgi has nothing to disclose. Dr. Alrajeh has nothing to disclose. Dr. Manjila has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pace, J., Dorn, E., Kulhari, A., Kandregula, K., Bozorgi, A., Alrajeh, M., Manjila, S., Ramos-Estebanez, C. Tags: Child Neurology II Source Type: research

Patent foramen ovale closure versus medical therapy in cases with cryptogenic stroke, meta-analysis of randomized controlled trials
ConclusionPFO closure results in a significant reduction in the recurrence of ischemic stroke compared to medical therapy alone, primarily antiplatelet, among cases with PFO and cryptogenic stroke.
Source: Journal of Neurology - January 22, 2018 Category: Neurology Source Type: research

Patent foramen ovale closure or medical therapy for cryptogenic ischemic stroke: an updated meta-analysis of randomized controlled trials
ConclusionsPFO-C after cryptogenic ischemic stroke is safe and effective to reduce the risk of recurrent stroke and recurrent stroke  + TIA, albeit with an increased risk for NOAF.
Source: Clinical Research in Cardiology - March 2, 2018 Category: Cardiology Source Type: research

Patent foramen ovale closure or medical therapy for cryptogenic ischemic stroke: an updated meta-analysis of randomized controlled trials.
CONCLUSIONS: PFO-C after cryptogenic ischemic stroke is safe and effective to reduce the risk of recurrent stroke and recurrent stroke + TIA, albeit with an increased risk for NOAF. PMID: 29500568 [PubMed - as supplied by publisher]
Source: Clin Med Res - March 2, 2018 Category: Research Authors: Schulze V, Lin Y, Karathanos A, Brockmeyer M, Zeus T, Polzin A, Perings S, Kelm M, Wolff G Tags: Clin Res Cardiol Source Type: research

Patent Foramen Ovale and Cryptogenic Stroke or Transient Ischemic Attack: To Close or Not to Close? A Systematic Review and Meta-Analysis
This study was performed to evaluate the efficacy and safety of the device closure (DC) versus the medical therapy (MT) in patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO.Summary: Randomized controlled trials with active and control groups receiving the DC plus MT and MT alone in patients with history of cryptogenic stroke/TIA and diagnosis of PFO were systematically searched. The main efficacy outcome was stroke recurrence. Subgroup-analyses were performed according to age, shunt size, and presence of atrial septal aneurysm (ASA). Safety endpoints included any serious adverse event (SAE), atria...
Source: Cerebrovascular Diseases - April 12, 2018 Category: Neurology Source Type: research

Patent foramen ovale and stroke
AbstractA patent foramen ovale (PFO) is a highly prevalent finding in cryptogenic ischaemic stroke, particularly in young adults. A common challenge in clinical practice is to distinguish between incidental and pathogenic PFO. Some clinical features and tools such as the Risk of Paradoxical Embolism score may help determining the probability of a stroke-related PFO. Nonetheless, the best therapeutic option to reduce stroke recurrence after a cryptogenic stroke with PFO has been a matter of debate for a long time. We review the mechanisms of stroke-related PFO, together with its clinical features and diagnostic criteria. In...
Source: Journal of Neurology - April 21, 2018 Category: Neurology Source Type: research

Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies.
CONCLUSIONS: In patients with cryptogenic stroke, PFO closure does appeared to be superior to medical therapy in stroke prevention, with an increased incidence of AF. Male, age <45 years, substantial residual shunt, and the history of ASA are the factors that will predict the benefit when PFO is closed. PMID: 29804325 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Chen X, Chen SD, Dong Y, Dong Q Tags: CNS Neurosci Ther Source Type: research

Implications of detection of foramen ovale patent after cryptogenic ischemic stroke
ConclusionPFO ’s (size and complexity) and patients’ characteristics influenced clinical decision when PFO was detected on TEE. The risk for recurrent stroke was not increased in patients who did not undergo PFO closure; although two patients waiting for PFO closure had recurrent stroke, demonstrating its imp ortance.
Source: Journal of Echocardiography - July 14, 2018 Category: Cardiology Source Type: research

Is Patent Foramen Ovale Closure More Effective Than Medical Therapy in Preventing Stroke Recurrence in Patients With Cryptogenic Stroke?: A Critically Appraised Topic
Conclusions: Among patients who had a recent CS attributed to PFO with a large interatrial shunt or with an associated atrial septal aneurysm, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone.
Source: The Neurologist - September 1, 2018 Category: Neurology Tags: Critically Appraised Topics Source Type: research

Implications of detection of foramen ovale patent after cryptogenic ischemic stroke
ConclusionPFO ’s (size and complexity) and patients’ characteristics influenced clinical decision when PFO was detected on TEE. The risk for recurrent stroke was not increased in patients who did not undergo PFO closure; although two patients waiting for PFO closure had recurrent stroke, demonstrating its imp ortance.
Source: Journal of Echocardiography - July 14, 2018 Category: Cardiology Source Type: research