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Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson's disease – reply
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: S. R. Schreglmann, F. B üchele, G. Kägi, C. R. Baumann, Tags: Letter to the Editor Source Type: research

Corpus callosum agenesis, myopathy and pinpoint pupils: consider Stormorken syndrome
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: A. Alonso ‐Jiménez, C. Ramón, O. Dols‐Icardo, C. Roig, E. Gallardo, J. Clarimón, C. Núñez‐Peralta, J. Díaz‐Manera Tags: Letter to the Editor Source Type: research

Optic nerve sheath diameter measurement in patients with idiopathic normal ‐pressure hydrocephalus
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: M. De Bernardo, N. Rosa Tags: Letter to the Editor Source Type: research

Congenital myasthenic syndrome due to DPAGT1 mutations mimicking congenital myopathy in an Irish family
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: P. Bogdanova ‐Mihaylova, R. P. J. Murphy, M. D. Alexander, J. C. McHugh, A. Reghan Foley, F. Brett, S. M. Murphy Tags: Letter to the Editor Source Type: research

Miller Fisher syndrome associated with a Zika virus infection
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: N. Gibelin, J. Romero, V. Gregoire, M. Kaidomar Tags: Letter to the Editor Source Type: research

18F ‐NaF PET‐MRI: an innovative tool to assess carotid artery plaque vulnerability
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: L. Mechtouff, M. Sigovan, N. Costes, P. Douek, D. Collet ‐Benzaquen, N. Nighoghossian, Y. Berthezene Tags: Letter to the Editor Source Type: research

CLIPPERS mimickers: relapsing brainstem encephalitis associated with anti ‐MOG antibodies
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Authors: G. Berzero, G. Taieb, R. Marignier, N. Younan, J. Savatovsky, D. Leclercq, D. Psimaras Tags: Letter to the Editor Source Type: research

Calendar
(Source: European Journal of Neurology)
Source: European Journal of Neurology - January 22, 2018 Category: Neurology Tags: Calendar Source Type: research

Unknown ‐Onset Strokes with Anterior Circulation Occlusion treated by Thrombectomy after DWI‐FLAIR Mismatch Selection
ConclusionThrombectomy of UOS with anterior circulation occlusion and DWI‐FLAIR mismatch appears to be as safe and efficient as thrombectomy of KOS within 6 hours from onset. This pattern of imaging could be used for patient selection when time of onset is unknown.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 21, 2018 Category: Neurology Authors: Simon Escalard, Benjamin Gory, Ma éva Kyheng, Jean‐Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Julien Labreuche, Mikael Mazighi, Michel Piotin, Raphaël Blanc, Bertrand Lapergue, Robert Fahed, Tags: Original Article Source Type: research

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis
The objective was to develop an evidence‐based clinical practice guideline for the pharmacological treatment of people with MS to guide healthcare professionals in the decision‐making process. MethodsThis guideline has been developed using the GRADE methodology and following the recently updated EAN recommendations for guideline development. Clinical questions were formulated in PICO format (patient, intervention, comparator, outcome) and outcomes were prioritized according to their relevance to clinical practice. An exhaustive literature search up to December 2016 was performed for each question and the evidence is pr...
Source: European Journal of Neurology - January 19, 2018 Category: Neurology Authors: X. Montalban, R. Gold, A. J. Thompson, S. Otero ‐Romero, M. P. Amato, D. Chandraratna, M. Clanet, G. Comi, T. Derfuss, F. Fazekas, H. P. Hartung, E. Havrdova, B. Hemmer, L. Kappos, R. Liblau, C. Lubetzki, E. Marcus, D. H. Miller, T. Olsson, S. Pilling, Tags: EAN Guidelines/CME Article Source Type: research

Perfusion CT in Posterior Circulation Stroke: Predictors and Prognostic Implications of Focal Hypoperfusion
Abstract BackgroundWe aimed to determine predictors of focal hypoperfusion on CT Perfusion (CTP) in patients with acute posterior circulation stroke and its association with long‐term outcome. MethodsWe selected patients with posterior circulation stroke from the Acute STroke Registry and Analysis of Lausanne (ASTRAL) who underwent CTP within 24 hours of stroke onset as part of the stroke imaging protocol. Hypoperfusion was defined as an area of visually well demarcated mean‐transit‐time (MTT) prolongation corresponding to an arterial territory on standard reconstruction CTP imaging maps. Areas of hypoperfusion were ...
Source: European Journal of Neurology - January 19, 2018 Category: Neurology Authors: Lars ‐Peder Pallesen, Dimitris Lambrou, Ashraf Eskandari, Jessica Barlinn, Kristian Barlinn, Heinz Reichmann, Vincent Dunet, Philippe Maeder, Volker Puetz, Patrik Michel Tags: Original Article Source Type: research

3D Neuromelanin ‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease
ConclusionsCR analysis of the SNc using 3D Neuromelanin‐sensitive MRI may serve as a quick and accurate tool to discern between patients with PD and healthy controls.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 17, 2018 Category: Neurology Authors: Shweta Prasad, Albert Stezin, Abhishek Lenka, Lija George, Jitender Saini, Ravi Yadav, Pramod Kumar Pal Tags: Original Article Source Type: research

Multiple sclerosis as a universal disease and the challenges to immigrants in high prevalence countries
This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 17, 2018 Category: Neurology Authors: Victor M Rivera Tags: Editorials Source Type: research

Guillain ‐Barré syndrome in a local area in Japan, 2006‐2015: An epidemiological and clinical study of 108 patients
ConclusionsOur study offered evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than Western countries.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 16, 2018 Category: Neurology Authors: Naoko Matsui, Hiroyuki Nodera, Daisuke Kuzume, Naoki Iwasa, Yuki Unai, Waka Sakai, Yoshimichi Miyazaki, Hiroki Yamazaki, Yusuke Osaki, Takahiro Furukawa, Masahiro Yamasaki, Yuishin Izumi, Susumu Kusunoki, Kokichi Arisawa, Ryuji Kaji Tags: Original Article Source Type: research

Multiple sclerosis: Long ‐term outcomes in ethnic minorities with MS: analysis of a UK population‐based registry
Abstract BackgroundMultiple sclerosis (MS) is most frequent in Caucasian populations. However, studies of MS in other ethnic groups may offer unique insights into genetic and environmental influences on disease, and data on long‐term outcomes in these patients is limited. We have investigated clinical features and time to disability milestones in ethnic minority (EM) patients with MS in a UK population and made comparisons to a Caucasian cohort from the same region. Methods1949 MS patients (1866 Caucasian, 83 EM) were identified from a regional disease registry. Cox proportional hazards regression was used to analyse tim...
Source: European Journal of Neurology - January 16, 2018 Category: Neurology Authors: Meshari O Alsaeed, Katharine E Harding, Owain H Williams, Mark D Willis, James Hrastelj, Emma C Tallantyre, Fady G Joseph, Mark Wardle, Trevor P Pickersgill, Neil P Robertson Tags: Short Communications Source Type: research

Association between β‐cell function estimated by HOMA‐β and prognosis of non‐diabetic patients with ischaemic stroke
This study aimed to investigate the association between β‐cell function and prognosis of non‐diabetic patients with ischaemic stroke. MethodsIschaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β‐cell function (HOMA‐β) was performed and classified into four groups according to quartiles. The outcomes included stroke recurrence, poor functional outcome and all‐cause mortality. ResultsIn a total of 1244 patients, the average age was 62.3 years; 63.1% patients wer...
Source: European Journal of Neurology - January 15, 2018 Category: Neurology Authors: M. Zhou, Y. Pan, J. Jing, Y. Wang, X. Zhao, L. Liu, H. Li, Y. Wang Tags: Original Article Source Type: research

European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre ‐hospital management of stroke
ConclusionsThese guidelines inform on the contemporary approach to patients with suspected stroke in the pre‐hospital setting. Further studies, preferably randomized controlled trials, are required to examine the impact of particular interventions on quality parameters and outcome. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 12, 2018 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G. A. Ford, A. C. Fonseca, G. J. Luijckx, J. Korv, N. P érez Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guideline Source Type: research

Brand ‐to‐Generic Levetiracetam Switching: a four‐years prospective observational real‐life study
ConclusionIn our sample, brand‐to‐generic LEV switching was effective and safe in both mono‐and polytherapy regardless epilepsy syndromes.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 11, 2018 Category: Neurology Authors: Michele Trimboli, Emilio Russo, Laura Mumoli, Giovanni Tripepi, Francesco Fortunato, Giovanni Mastroianni, Francesca Abate, Giovambattista De Sarro, Antonio Gambardella, Angelo Labate Tags: Original Article Source Type: research

Antibody response to seasonal influenza vaccination in patients with multiple sclerosis receiving immunomodulatory therapy
ConclusionThese findings suggest that patients with multiple sclerosis receiving fingolimod or natalizumab should be considered for a second dose of the vaccine in cases of insufficient protection. Our results further indicate that new immunomodulatory treatment regimens should be systematically evaluated for their influence on influenza‐specific vaccine responses. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 6, 2018 Category: Neurology Authors: H. K. Olberg, G. E. Eide, R. J. Cox, Å. Jul‐Larsen, S. L. Lartey, C. A. Vedeler, K.‐M. Myhr Tags: Original Article Source Type: research

Effect of dimethyl fumarate on gray and white matter pathology in subjects with relapsing multiple sclerosis: a longitudinal study
Abstract BackgroundDimethyl fumarate (DMF) is an oral treatment for relapsing remitting multiple sclerosis (RRMS) with anti‐inflammatory and possible neuroprotective properties. Its effect on white matter (WM) and gray matter (GM) pathology is still not fully understood. ObjectiveTo characterize the effect of DMF on normal appearing WM (NAWM) and thalamic pathology longitudinally. MethodsIn this observational, longitudinal, 24‐month MRI study, 75 RRMS treated with DMF and 40 age‐ and sex‐ matched healthy individuals (HIs) were enrolled. Regional diffusion tensor imaging (DTI) metrics and tract based spatial statist...
Source: European Journal of Neurology - January 5, 2018 Category: Neurology Authors: Robert Zivadinov, Jesper Hagemeier, Niels Bergsland, Eleonora Tavazzi, Bianca Weinstock ‐Guttman Tags: Original Article Source Type: research

Survey of diagnostic and treatment practices for multiple sclerosis in Europe, part 2: progressive MS, paediatric MS, pregnancy and general management
ConclusionsResults of part 2 of the survey of diagnostic and treatment practices for MS in Europe largely mirror results for part 1, with neurologists in general agreement about the treatment and management of SPMS, PPMS, pregnancy and paediatric MS as well as the general management of MS. However, there are also many areas of disagreement, indicating the need for evidence‐based recommendations and/or guidelines.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Oscar Fern ández, Mario Delvecchio, Gilles Edan, Sten Fredrikson, Gavin Giovannoni, Hans‐Peter Hartung, Eva Havrdova, Ludwig Kappos, Carlo Pozzilli, Per Soelberg Soerensen, Björn Tackenberg, Patrick Vermersch, Giancarlo Comi Tags: Original Article Source Type: research

Thrombectomy Outcomes for Acute Stroke Patients with Anterior Circulation Tandem Lesions: A Clinical Registry and an Update of Systematic Review with Meta ‐Analysis
ConclusionsOur data reports an association between acute stenting and successful reperfusion rates in stroke patients with tandem lesion treated with MT. Further studies are warranted to determine the intracranial bleeding risk after MT and stenting according to the antiplatelet therapy.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Udi Sadeh ‐Gonik, Noam Tau, Tal Friehmann, Serge Bracard, René Anxionnat, Anne‐Laure Derelle, Romain Tonnelet, Liang Lia, Sébastien Richard, Xavier Armoiry, Benjamin Gory Tags: Original Article Source Type: research

Pressure and Pipes: from neuroimaging to virtual measurement
This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Marialuisa Zedde, Rosario Pascarella Tags: Editorials Source Type: research

Increase in Neutrophil after r ‐tPA Thrombolysis Predicts Poor Functional Outcome of Ischemic Stroke: A Longitudinal Study
Abstract BackgroundNeutrophil, a pivotal immune responder to ischemic brain insult, has been involved in neuroplasticity and increases after stroke. r‐tPA, a promising treatment improving neuroplasticity, promotes neutrophil degranulation. However, the dynamic profile of neutrophil after r‐tPA treatment and its effect on neurological recovery after stroke is not well studied. MethodsWe measured cell counts of neutrophil, lymphocyte, and their ratio (NLR) on admission and 24 hours after r‐tPA infusion in 372 consecutively recruited acute ischemic stroke patients (mean age 64 years). Death or major disability at 3 mont...
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Jijun Shi, Hao Peng, Shoujiang You, Yuanyuan Liu, Jiaping Xu, Yingying Xu, Huihui Liu, Rongfang Shi, Yongjun Cao, Chun ‐Feng Liu Tags: Original Article Source Type: research

How often is the diagnosis of the permanent vegetative state incorrect? A review of the evidence
ConclusionsSignificant misdiagnosis of awareness, with an apparently ‘vegetative’ patient having good awareness, is rare. Careful neurological assessment of the cause and routine measurement of awareness using the Coma Recovery Scale‐ Revised should further reduce mistakes.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Derick T Wade Tags: Reviews Source Type: research

Rasagiline improves polysomnographic sleep parameters in patients with Parkinson's disease: A double ‐blind, baseline‐controlled trial
ConclusionsIn PD patients with sleep disturbances rasagiline showed beneficial effects on sleep quality as measured by polysomnography likely neither related to motor improvement nor translating into improved overall sleep quality perception by patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Wiebke Schrempf, Mareike Fauser, Miriam Wienecke, Sebastian Brown, Antonia Maa ß, Christiana Ossig, Karolin Otto, Moritz D. Brandt, Matthias Löhle, Uta Schwanebeck, Xina Graehlert, Heinz Reichmann, Alexander Storch Tags: Original Article Source Type: research

Global transcriptome profiling of mild relapsing remitting versus primary progressive Multiple Sclerosis
ConclusionOur analyses show significant differences between mRRMS and PPMS gene expression. Surprisingly, the differentially expressed genes are mostly involved in immunological and inflammatory pathways, suggesting that the difference in MS phenotypes is caused primarily by a difference in immune responses. It should be kept in mind that our analyses were in peripheral blood only, and that the observed differences in inflammatory pathways may be a substrate of the analysed tissue. Further research into gene expression differences between disease courses including analyses in CNS tissue are warranted.This article is protec...
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Marcus W. Koch, Yaroslav Ilnytskyy, Andrey Golubov, Luanne M. Metz, V.Wee Yong, Olga Kovalchuk Tags: Original Article Source Type: research

Peripheral nerves are pathologically small in Cerebellar Ataxia Neuropathy Vestibular Areflexia Syndrome (CANVAS): A controlled ultrasound study
Abstract BackgroundSensory neuronopathy is a cardinal feature of Cerebellar Ataxia Neuropathy Vestibular Areflexia Syndrome (CANVAS). Having observed that two patients with CANVAS had small median and ulnar nerves on ultrasound, we set out to examine this finding systematically in a cohort of patients with CANVAS, and compare them with both healthy controls and a cohort of patients with axonal neuropathy. We have previously reported preliminary findings in seven of these CANVAS patients and seven healthy controls. MethodsWe compared the ultrasound cross‐sectional area of median, ulnar, sural and tibial nerves of 14 CANVA...
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Luciana Pelosi, Eoin Mulroy, Ruth Leadbetter, Dean Kilfoyle, Andrew M Chancellor, Stuart Mossman, Laurie Wing, Teddy Y Wu, Richard H Roxburgh Tags: Original Article Source Type: research

Persistent mucosal damage and the risk of epilepsy in people with celiac disease
ConclusionsIn a population‐based study of CD individuals, persisting VA on follow up biopsy was associated with reduced future risk of developing epilepsy but did not influence emergency epilepsy‐related hospital admissions. Mechanisms as to why persistent VA confers this benefit requires further exploration.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Matthew Kurien, Jonas F Ludvigsson, David S Sanders, Haley M. Zylberberg, Peter H Green, Hel éne E.K. Sundelin, Benjamin Lebwohl Tags: Original Article Source Type: research

A critical appraisal of Randomized Controlled Trials on Intravenous Phenytoin in Convulsive Status Epilepticus
ConclusionOverall, most evidence from RCTs support the use of IV PHT immediately after IV diazepam, even if seizures have not recurred. The recommendation supporting the use of IV PHT as second‐line treatment in benzodiazepine‐resistant convulsive SE derived from RCTs is weak. This is emblematic of the lack of robust evidence from large RCTs to inform clinical practice on how to treat SE after failure of first‐line drugs. IV PHT given immediately after first‐line benzodiazepines could prolong their short antiepileptic effect and prevent seizure recurrence.This article is protected by copyright. All rights reserved....
Source: European Journal of Neurology - December 30, 2017 Category: Neurology Authors: Francesco Brigo, Nicola Luigi Bragazzi, Simona Lattanzi, Raffaele Nardone, Eugen Trinka Tags: Reviews Source Type: research

Insular damage, death, and newly diagnosed atrial fibrillation in intracerebral hemorrhage: stroke ‐induced heart injury as the potential missing link
This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 30, 2017 Category: Neurology Authors: Lauren M. Mai, Luciano A. Sposato Tags: Editorials Source Type: research

Severe methylenetetrahydrofolate reductase (MTHFR) deficiency: a rare, treatable cause of complicated hereditary spastic paraplegia
ConclusionsSevere MTHFR deficiency can be a rare, treatable cause of autosomal recessive complicated HSP. Its screening should be part of the diagnostic flowchart for these disorders.This article is protected by copyright. All rights reserved. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 29, 2017 Category: Neurology Authors: Alessia Perna, Marcella Masciullo, Anna Modoni, Elena Cellini, Elena Parrini, Enzo Ricci, Alice M. Donati, Gabriella Silvestri Tags: Short Communications Source Type: research

Non ‐alcoholic Fatty Liver Disease is associated with stroke severity and progression of brainstem infarctions
Abstract BackgroundNon‐alcoholic fatty liver disease (NAFLD) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance, and type 2 diabetes mellitus (T2DM). We sought to assess the association between a specific stroke subgroup, brainstem infarctions (BSIs), and NAFLD. Furthermore, we evaluated whether NAFLD is an independent risk factor in patients with BSIs. MethodsNAFLD was assessed in 306 radiologically confirmed BSIs patients via liver ultrasound. Differences between patients with and without NAFLD were compared. Data associated with stroke severity and progression after admission was collected. R...
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Haiyan Li, Biao Hu, Wei Lei, Li Zhou, Lei Zhang, Yinyao Lin, Bing Qin, Yongqiang Dai, Zhengqi Lu Tags: Original Article Source Type: research

Can a cognitive rehabilitation program in early stages of Parkinson's disease improve cognition, apathy and brain functional connectivity for up to 18 months?
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: A. Daniele, F. Panza Tags: Editorial Source Type: research

Serum Neurofilament Light Chain in Patients with Acute Cerebrovascular Events
Abstract Background and PurposeSerum Neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and TIA. MethodsNested within a prospective cohort study, we compared serum neurofilament light chain levels (sNfL) drawn within 24 hours from symptom onset in patients with AIS or TIA. Patients without MRI on admission were excluded. We assessed if sNfL are associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs TIA, (iii) infarct size on admission diffusion weighted imaging (MR‐DWI), and (iv) functional outcome at 3 months. ResultsWe ana...
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Gian Marco De Marchis, Mira Katan, Christian Barro, Joachim Fladt, Christopher Traenka, David J Seiffge, Lisa Hert, Henrik Gensicke, Giulio Disanto, Raoul Sutter, Nils Peters, Hakan Sarikaya, Barbara Goeggel ‐Simonetti, Marwan El‐Koussy, Stephan Engel Tags: Original Article Source Type: research

The iNPH Radscale; a radiological scale for structured evaluation of idiopathic normal pressure hydrocephalus
Abstract Background and purposeDespite the important role of imaging in diagnosing idiopathic normal pressure hydrocephalus (iNPH), a structured overall assessment of radiological signs is still lacking. The purpose of this study was to construct a radiological scale, composed of morphological signs of iNPH, and compare it with clinical symptoms. MethodsIn this prospective, population based study of iNPH, 168 individuals (93 females, 75 males), mean age 75 years (range 66‐92 years), underwent a computed tomography (CT) of the brain and a neurological examination with assessment of clinical symptoms according to Hellstr&o...
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Karin Kockum, Otto Lilja ‐Lund, Elna‐Marie Larsson, Michelle Rosell, Lars Söderström, Johan Virhammar, Katarina Laurell Tags: Original Article Source Type: research

Tafamidis delays neurological progression comparably across Val30Met and non ‐Val30Met genotypes in transthyretin familial amyloid polyneuropathy
ConclusionsThis baseline‐adjusted analysis demonstrated that tafamidis treatment delayed neurological progression comparably in Val30Met and non‐Val30Met patients across a range of baseline NIS‐LL values. Neurological progression in these two genotype groups may be more similar than previously considered. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 26, 2017 Category: Neurology Authors: B. K. Gundapaneni, M. B. Sultan, D. J. Keohane, J. H. Schwartz Tags: Original Article Source Type: research

Clinical usefulness of prognostic biomarkers in optic neuritis
Abstract Background and purposedifferent biological and radiological biomarkers predict clinical conversion to multiple sclerosis (MS) after a clinically isolated syndrome (CIS). We aimed to explore their role in predicting the outcome of patients with optic neuritis (ON), a CIS considered to have a benign prognosis. Methodswe prospectively followed 68 consecutive ON patients. Magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) studies including oligoclonal IgG bands (OCGB), lipid‐specific oligoclonal IgM bands (LS‐OCMB) and neurofilament light chain (NFL) quantification were performed at disease onset. Conv...
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: Amalia Tejeda ‐Velarde, Lucienne Costa‐Frossard, Susana Sainz de la Maza, Ángela Carrasco, Mercedes Espiño, Carmen Picón, Inmaculada Toboso, Paulette E Walo, Daniel Lourido, Alfonso Muriel, José C Álvarez‐Cermeño, Luisa M Villar Tags: Original Article Source Type: research

Vascular risk factors and depression in Parkinson's disease
This study aims to address the vascular depression hypothesis in Parkinson's disease (PD) from a large cohort of Chinese population. MethodsA cross‐sectional analysis of 1784 Chinese patients with PD was conducted. Patients were divided into absence of depression (score ≤ 20) and presence of depression (score> 20) based on the assessment of Hamilton Depression Rating Scale (HDRS). Other clinical assessments included Unified PD Rating Scale (UPDRS), Hamilton Anxiety Rating Scale (HARS), Frontal assessment battery (FAB) and Montreal Cognitive Assessment (MoCA). ResultsPatients with depression showed higher proportion...
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: Ruwei Ou, Qianqian Wei, Yanbing Hou, Xiaoqin Yuan, Wei Song, Bei Cao, Hui Liu, Lingyu Zhang, Yongping Chen, Huifang Shang Tags: Original Article Source Type: research

Seizure freedom after intracranial electrode implantation in pharmacoresistant epilepsy
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: V. ‐H. Nguyen‐Michel, S. Dupont, L. Thivard, B. Mathon, V. Lambrecq, D. Hasboun, V. Navarro, M.‐O. Habert, S. Clemenceau, M. Baulac, C. Adam Tags: Letter to the Editor Source Type: research

Telemedicine in neurology: where are we going?
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: A. Bramanti, R. S. Calabr ò Tags: Letter to the Editor Source Type: research

The association of intracranial aneurysms and meningiomas: a hospital ‐based case−control study
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: W. M. Sluis, G. J. E. Rinkel, B. K. Velthuis, Y. M. Ruigrok Tags: Letter to the Editor Source Type: research

Comments on: ‘Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson's disease – a randomized controlled trial’
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: R. M. Sim ões, A. Castro Caldas, J. J. Ferreira Tags: Letter to the Editor Source Type: research

Catastrophic primary angiitis of the central nervous system
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: H. Boysson, C. Pagnoux Tags: Letter to the Editor Source Type: research

Cervical artery dissection in two monozygotic twin ‐pairs
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Authors: T. Brandt, M. Kloss, A. Lindner, P. Erhart, C. Grond ‐Ginsbach, S. T. Engelter Tags: Letter to the Editor Source Type: research

Calendar
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 22, 2017 Category: Neurology Tags: Calendar Source Type: research

Insular damage, new ‐onset atrial fibrillation and outcome after acute intracerebral hemorrhage
ConclusionsThe frequency of nAF in our patients was 6.0%. Insular damage was a risk factor for nAF and an independent predictor of death at 3 months. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 15, 2017 Category: Neurology Authors: L. Prats ‐Sánchez, D. Guisado‐Alonso, C. Painous, F. Fayos, E. Pascual‐Goñi, R. Delgado‐Mederos, A. Martínez‐Domeño, P. Camps‐Renom, J. Martí‐Fàbregas Tags: Original Article Source Type: research

Familial hypercholesterolaemia in patients with ischaemic stroke or transient ischaemic attack
ConclusionsThe frequency of potential FH, based on clinical criteria, in patients with acute ischaemic stroke or TIA was 11.5% and that of probable/definite FH (1.3%) was similar to recently reported counts for patients with acute coronary syndrome (1.6%). FH screening using the DLCNA is feasible in clinical routine and should be considered as part of the usual diagnostic work‐up. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 14, 2017 Category: Neurology Authors: T. Toell, L. Mayer, R. Pechlaner, S. Krebs, K. Willeit, C. Lang, C. Boehme, B. Prantl, M. Knoflach, J. Ferrari, P. Fuchs, W. Prokop, A. Griesmacher, W. Lang, S. Kiechl, J. Willeit Tags: Original Article Source Type: research

Apathy in rapid eye movement sleep behaviour disorder is common and under ‐recognized
ConclusionsApathy is common in RBD and is underestimated by a single self‐report question. Recognition of apathy as a distinct neuropsychiatric feature in RBD could aid targeted treatment interventions and might contribute to the understanding of prodromal PD. (Source: European Journal of Neurology)
Source: European Journal of Neurology - December 14, 2017 Category: Neurology Authors: T. R. Barber, K. Muhammed, D. Drew, M. Lawton, M. Crabbe, M. Rolinski, T. Quinnell, Z. Zaiwalla, Y. Ben ‐Shlomo, M. Husain, M. T. M. Hu Tags: Original Article Source Type: research

Grading scales in subarachnoid hemorrhage − many options, but do we have a winner?
(Source: European Journal of Neurology)
Source: European Journal of Neurology - December 11, 2017 Category: Neurology Authors: V. Rajajee Tags: Editorial Source Type: research