Cause or Consequence: The Relationship Between Cerebral Venous Thrombosis and Idiopathic Intracranial Hypertension
Conclusion: CSVT is a common clinical entity among the causes of IIHT, and it should be taken into consideration in this patient group. However, there is a need for a common guideline for laboratory and imaging methods to understand the etiopathogenesis of childhood IIHT and determine the patients at risk. (Source: The Neurologist)
Source: The Neurologist - September 1, 2019 Category: Neurology Tags: Original Article Source Type: research

Glial Fibrillary Acidic Protein (GFAP) Autoimmunity in the Setting of Seropositive Rheumatoid Arthritis Treated With Etanercept
Conclusion: This case expands on the previously reported cases of GFAP immunoglobulin G autoimmunity by describing an associated inflammatory large fiber peripheral neuropathy. (Source: The Neurologist)
Source: The Neurologist - September 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Dupuytren, Ledderhose, and Peyronie Diseases After Primidone Use For Essential Tremor
Conclusions: There are a few reports associating barbiturate use to connective tissue disorders, and some suggest that drug withdrawal may result in a better prognosis. Therefore, physicians must be aware of such adverse events when caring for patients on long-term barbiturate use. (Source: The Neurologist)
Source: The Neurologist - September 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Intravenous Thrombolysis For Acute Ischemic Stroke in Fabry Disease
Conclusion: The present case supports the scarce data underscoring the safety of intravenous thrombolysis for acute ischemic stroke in Fabry disease patients even when cerebral microbleeds are present. (Source: The Neurologist)
Source: The Neurologist - September 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Safety of Early Repeated Thrombolysis: A Case Report
Conclusion: This case report suggests that further randomized studies may evaluate whether repeated IVtPA may be safe and effective in ERS occurring shortly after a previous stroke when patients experience a period of complete neurological regression, minor disability, and a small infarct volume. Should the hypothesis be confirmed, small volume core and wide volume penumbra at perfusion CT may support the decision of adopting IVtPA repetition. (Source: The Neurologist)
Source: The Neurologist - September 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Recurrent Stroke in Giant Cell Arteritis Despite Immunotherapy
Conclusions: This case highlights several important features of strokes in GCA: the predilection for the dural entry point of cerebral blood vessels, the progression of disease despite steroids, and the need to quickly escalate treatment in these cases. As seen in our patient, however, this disease carries high morbidity and mortality and patients often have poor outcomes despite aggressive immunosuppression. (Source: The Neurologist)
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Fatal Intracerebral Hemorrhage in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL): A Case Report
The main clinical manifestations of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are migraine with aura, ischemic strokes, and progressive cognitive decline. Intracerebral hemorrhage (ICH) has been described in CADASIL, but is not widely recognized. Here we report a case with CADASIL that presented with fatal ICH. A 57-year-old right-handed man of Pakistani descent with history of genetically confirmed CADASIL, hypertension, and mood disorder presented to the emergency department via Emergency Medical Services (EMSs) after he was found down. Initial neurological exami...
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Dural Arteriovenous Fistula With Sinus Thrombosis and Venous Reflux Presenting as Parkinsonism: A Case Report
We present a case of a 57-year-old man with a left transverse sinus DAVF along with sigmoid thrombosis, cortical venous reflux, and congestion, that initially presented as parkinsonism. The patient was alert and fully oriented; however, decreased facial expressions were noted. His left forearm showed rigidity and bradykinesia, and it was difficult for the patient to smoothly perform rapid alternating movement testing. His complaints about hearing a rhythmic bruit above the left ear, particularly when lying down, alerted the physician of the presence of vascular lesions. Magnetic resonance imaging and angiography confirmed ...
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Serum Uric Acid Level and Outcome of Patients With Ischemic Stroke: A Systematic Review and Meta-Analysis
This study aimed to evaluate the correlation between the SUA level and outcome of patients with ischemic stroke by performing a meta-analysis. Materials and Methods: Studies were included by a systematic search of several databases through December 01, 2018, followed by reviewing reference lists of obtained articles. Studies that included odds ratios (ORs) for ischemic stroke outcome per unit SUA level with 95% confidence intervals (95% CIs) were eligible for the meta-analysis. A random-effects model was used to calculate the pooled risk estimate. Publication bias was detected by Begg’s test. Results: Fifteen s...
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Original Articles Source Type: research

Quality of Life of Myasthenia Gravis Patients in Regard to Epidemiological and Clinical Characteristics of the Disease
Background: Myasthenia gravis (MG) affects overall quality of life (QoL). The aim of the research was to evaluate QoL in patients suffering from MG in regard to epidemiological and clinical factors of the disease. Methods: The study included 70 patients. The severity of clinical manifestation was estimated using quantitative MG score and MG composite score. Patients were classified by using Myasthenia Gravis Foundation of America Classification. The Questionnaire of Life Quality Specific for Myasthenia Gravis-15 items (MGQOL15) is developed for QoL assessment in patients suffering from MG. In addition to the MGQOL15 r...
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Original Articles Source Type: research

Etiological Classification of Cerebral Ischemic Stroke by the TOAST, SSS-TOAST, and ASCOD Systems: The Impact of Observer’s Experience on Reliability
Conclusions: Observer’s experience may affect the reliability of etiological classification systems in patients with ischemic stroke. (Source: The Neurologist)
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Original Articles Source Type: research

Transverse Sinus Thrombosis in Neurobrucellosis: A Rare Complication
No abstract available (Source: The Neurologist)
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Progress in Pharmacological and Surgical Management of Tourette Syndrome and Other Chronic Tic Disorders
Conclusions: Both typical and atypical antipsychotic agents are mainstays of pharmacological treatment of TS and other chronic tic disorder patients; however, their use is limited by serious side effects considering their potential of dopamine blockade. Because of the phenotypic variability, no medication has proven effective for all persons with TS and other chronic tic disorders. Botulinum toxin has emerged as a good therapeutic option, especially for focal and dystonic tics. But, their uses are limited by lack of sufficient evidence and high cost. Surgical treatment is considered in medically refractory and severely d...
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Review Article Source Type: research

Late-onset Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Presenting With Auditory Agnosia
Conclusions: MELAS is a disorder with clinical variability. Neuroimaging studies during stroke-like episodes in MELAS can provide significant clues to the underlying disorder. Although patients typically present in childhood, the first stroke-like episode can occur later in life in some patients, potentially related to a lower heteroplasmy level. (Source: The Neurologist)
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series
Pilocytic astrocytomas (PA) are highly vascular tumors with vascular endothelial growth factor (VEGF)–vascular endothelial growth factor receptor-2 (VEGFR-2) signaling present in the tumor vasculature. PA may, therefore, be responsive to VEGF blockade with bevacizumab (BEV). Data regarding the use of BEV in refractory PA in adults are limited primarily to case reports and case series of patients with recurrent PA. We conducted a single-center, retrospective cohort study from 2009 to 2018. We screened 426 patients with pathologically confirmed PA. We identified 5 adult patients with PA who received BEV at our institut...
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Incidence of Seizures in Fat Embolism Syndrome Over a 10-Year Period: Analysis of the National Inpatient Sample Database
Conclusions: The rate of seizure and epilepsy in patients with FES is low when compared with rates in all hospitalized patients or in patients with other causes of acute neurological injury such as intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury. Further studies are needed to provide recommendations for antiepileptic medication use in FES. (Source: The Neurologist)
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Original Article Source Type: research

Risk of Neurological Toxicities Following the Use of Different Immune Checkpoint Inhibitor Regimens in Solid Tumors: A Systematic Review and Meta-analysis
The objective of this study was to assess risk of neurological toxicities following the use of different immune checkpoint inhibitor (ICI) regimens in solid tumors. Methods: Pubmed, Embase, and ClinicalTrials.gov databases were searched for publications, and data were analyzed using Review Manager 5.3 software to compare the risk of immune-related and nonspecific neurological complications potentially triggered by ICIs to controls. Results: In total 23 randomized clinical trials comprising 11,687 patients were included in this meta-analysis. Patients with PD-L1 (OR, 0.29; 95% confidence interval [CI], 0.18-0.48; P0.0...
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Original Article Source Type: research

What is the Role of Tumor-treating Fields in Newly Diagnosed Glioblastoma?
The objective is to critically appraise the current evidence for the use of TTFields as adjunctive treatment to newly diagnosed GBM. The objective was addressed through the development of a structured, critically appraised topic. We incorporated a clinical scenario, background information, a structured question, literature search strategy, evidence summary, clinical bottom lines, and expert discussion. Participants included consultant and resident neurologists, a medical librarian, clinical epidemiologists, and content experts in the field of neurooncology. A randomized controlled trial was selected for critical appraisal....
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Critically Appraised Topics Source Type: research

Stroke Characteristics, Risk Factors, and Outcomes in Transgender Adults: A Case Series
Conclusions: Understanding unique vulnerabilities of the transgender community for cerebrovascular events is essential to provide culturally appropriate counseling for harm reduction. (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia
Posterior cortical atrophy (PCA) and logopenic variant primary progressive aphasia (LvPPA) are considered early-onset dementias most commonly caused by Alzheimer pathology. PCA is characterized by a progressive decline in higher order visual processing functions, whereas LvPPA is a form of primary progressive aphasia. The clinical presentation of both syndromes is typically earlier in life relative to the more typical “amnestic” form of Alzheimer disease. Prominent language deficits have been well described in PCA. Here, we describe the case of a 56-year-old man presenting with overlapping anatomic, clinical, a...
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Next-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Leptomeningeal Carcinomatosis: Review of 2 Cases
Conclusions: The next-generation EGFR-TKIs may have improved success in treatment of leptomeningeal metastases in non–small cell lung adenocarcinoma when compared with the first-generation and second-generation EGFR-TKIs. Next-generation EGFR-TKI monotherapy should be considered in select patients with leptomeningeal metastases from lung adenocarcinoma. More research is needed to review this potential therapeutic option, especially for use as first-line therapy. (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Cardioembolic Sources in Patients With Small Single Subcortical Infarcts
Transthoracic echocardiogram (TTE) is widely used as part of the work-up for ischemic stroke. However, the added utility of TTE in the management of small single subcortical infarcts (SSSI) has not been extensively evaluated. Therefore, we aimed to determine the frequency of high-risk and medium-risk cardioembolic sources diagnosed by TTE in SSSI patients, and whether the findings altered clinical management. We performed a retrospective analysis of a prospective cohort of patients with confirmed acute ischemic stroke enrolled in a single-center observational registry between August 2012 and July 2014. We assessed infarct ...
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Emergency Neurology Oral Cases for Trainee Assessment and Education
Conclusions: Case-based assessment in neurology training allows for rapid evaluation of trainees’ abilities to critically think. There is general agreement from attendings and trainees that case-based assessment is a useful and positive learning tool. The responses from this survey are being used to modify the cases for future examinations. (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Ischemic Stroke Incidence in Patients With Microvascular Ocular Motor Palsy Versus Patients With Lacunar Ischemic Stroke
Conclusions: Patients with presumed mOCP seem to share similar incidence of subsequent ischemic stroke with patients with LS. Presumed mOCP may be an underrecognized independent risk factor for ischemic stroke. (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research

Editorial Response
No abstract available (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research

Are Postprocedural Blood Pressure Goals Associated With Clinical Outcome After Mechanical Thrombectomy for Acute Ischemic Stroke?
Mechanical thrombectomy (MT) is the standard of care for patients who present with an acute ischemic stroke within 6 hours of symptom onset, and up to 24 hours in appropriately selected patients. However, optimal postoperative management of these patients remains uncertain, especially with regard to blood pressure control. To review the existing literature to define potential blood pressure goals in the immediate postoperative period in patients who undergo MT for acute ischemic stroke. The topic was defined through a clinical scenario and the subsequent development of a targeted clinical question. A literature search was ...
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Critically Appraised Topics Source Type: research

Does High Cerebral Microbleed Burden Increase the Risk of Intracerebral Hemorrhage After Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke?
Conclusions: CMBs are associated with an increased risk of postthrombolysis ICH; however, the clinical implications have yet to be determined. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Critically Appraised Topics Source Type: research

Rare Phenomenon of Limb-shaking TIA, Resolved With Intracranial Wingspan Stenting
Conclusions: It is vitally important to differentiate LS-TIA from focal seizures. This is the first documented case report of complete resolution of LS-TIA symptoms following an intracranial Wingspan stenting. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Radiologic and Histopathologic Features in an Intracranial Localized Castleman Disease: A Case Report and Review of Literature
Conclusions: Our case and review of the literature show the value of the extensive brain edema on neuroimaging finding to the differential diagnosis for a solitary mass arising from the meninges. We emphasize on the need for histologic examination when the diagnosis of meningioma is not entirely clear. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review
Conclusions: To the author’s knowledge, there are 3 cases in the literature of nonconvulsive SE with JHR in neurosyphilis, and the present report was the first to describe the occurrence of GCSE secondary to JHR in neurosyphilis. Another important finding, in this case, was the isolated unilateral mydriatic tonic pupil, rarely reported as an early isolated symptom of neurosyphilis. In this way, it is essential that patients presenting with isolated unilateral tonic pupil receive an adequate investigation for syphilis. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Bilateral Optic Perineuritis as Initial Presentation of Giant Cell Arteritis
We present a clinical case in which the presenting ocular feature of the disease was a peripheral monocular visual field defect secondary to optic perineuritis. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Facial Onset Motor and Sensory Neuronopathy Syndrome With a Novel TARDBP Mutation
Conclusions: This is the first time that a novel mutation in TARDBP gene was identified in a patient with FOSMN syndrome, which further suggested a link between FOSMN and amyotrophic lateral sclerosis. Our findings widen the spectrum of TARDBP-related motor neuron diseases. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Transcranial Doppler Evaluation in Takayasu Arteritis With Oculo-Cerebrovascular Complications
Conclusions: Retinal ischemia in young women should prompt emergent inflammatory and systemic vascular evaluation. In our subject, prolonged right retinal ischemia had dismal prognosis despite carotid-aortic revascularization, whereas left retinal boxcarring reversed. Surgical revascularization is recommended for severely symptomatic oculo-cerebrovascular disease, once inflammation is better controlled with immunosuppressive therapy. TCD documented the presence and monitored the subsequent resolution of blood flow changes causing retinal and brain hypoxia. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Sturge-Weber Syndrome Coexisting With Moyamoya Disease in the Fifth Decade: A Case Report and Literature Review
Sturge-Weber syndrome (SWS) is a sporadically occurring neurocutaneous syndrome characterized by port-wine stain over the face, ocular abnormalities (glaucoma and choroidal hemangioma), and leptomeningeal angiomas. It is usually diagnosed in infancy, but it may occasionally present in adulthood with seizures or stroke-like episodes. Here, we report a 46-year-old male patient, having SWS coexisting with moyamoya disease, attending our hospital due to sudden loss of consciousness. We also searched PubMed (from its earliest date to August 2014) for case reports mentioning that SWS presents in adulthood. We identified 31 patie...
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Type and Duration of Exercise in the SAMMPRIS Trial
Conclusions: The type of self-reported exercise performed by SAMMPRIS patients included mostly walking or other aerobic activity and increased significantly during follow-up. (Source: The Neurologist)
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Original Articles Source Type: research

Can Admission BNP Level Predict Outcome After Intravenous Thrombolysis in Acute Ischemic Stroke?
Objective: Our study aimed to determine the prognostic value of elevated Brain Natriuretic Peptide (BNP) among patients who received intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Background: The elevation in BNP level is correlated with infarct size, poststroke mortality, and CHADS2 score. Currently, there is a lack of validated biomarker to predict the outcome in patients with acute ischemic stroke, and there is a complex interaction amongst multiple variables. Design/Methods: A retrospective review of medical records of patients admitted to our institution with acute ischemic stroke was performed...
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Original Articles Source Type: research

A Comparison of the Clinical Characteristics and Outcomes of Cryptococcal Meningitis in HIV-negative Individuals With and Without Immunosuppression
This study aimed to compare the presentation and outcome of CM in patients who are human immunodeficiency virus (HIV) negative with and without immunosuppression. We reviewed 255 clinical records from patients with CM who are HIV negative. The demographic and clinical characteristics, cerebrospinal fluid profiles, brain magnetic resonance imaging, treatment, and outcomes of these individuals were retrospectively analyzed. Among the 255 patients with CM, 91 (35.7%) appeared immunocompetent. CM was present in a younger population in the immunocompetent group (above 50 y, 19.8% vs. 32.3%, P=0.026), with higher initial ...
Source: The Neurologist - December 27, 2018 Category: Neurology Tags: Original Articles Source Type: research

Clinical Mitochondrial Medicine
No abstract available (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Book Review Source Type: research

Clinical Correlations of Positive Herpes Simplex PCR in Cerebrospinal Fluid
Objectives: Herpes simplex viruses (HSV) can produce encephalitis (HSE), which requires early detection, typically using polymerase chain reaction (PCR) in cerebrospinal fluid (CSF). However, other neurological conditions not directly caused by HSV may also present with a positive HSV PCR in the CSF (NCNHPCR+). We aimed to analyze the clinical features of both groups of patients (HSE vs. NCNHPCR+) and to consider the potential relevance of this finding in the latter. Methods: A retrospective analysis of clinical presentation, workup (CSF, EEG, and MRI) and outcome of patients with an HSV+ result in CSF was conducted f...
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Original Article Source Type: research

Clinical Presentation and Cranial MRI Findings of Listeria monocytogenes Encephalitis: A Literature Review of Case Series
Conclusions: Listeria encephalitis is a severe disease and should be remembered in cases admitted with symptoms related to the brainstem and cranial nerve dysfunction. Cranial magnetic resonance imaging with brainstem and cerebellum involvements and contrast enhancement with or without abscess are particularly suggestive of the listeria-related infection. (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Review Article Source Type: research

Right Insular Cortex Ischemia Caused by Middle Cerebral Artery Occlusion: A Possible Pathogenesis of Decreased Sympathetic Nervous System Activity?
No abstract available (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Letter to the Editor Source Type: research

Thrombolysis After Protamine Reversal of Heparin for Acute Ischemic Stroke After Cardiac Catheterization: Case Report and Literature Review
Conclusions: There are limited reports of protamine reversal of heparin before IV-tPA administration. To our knowledge, there are only 6 AIS cases including ours. Three cases received 0.6 mg/kg of tPA dose. All have favorable outcomes and no intracranial hemorrhage was reported. Protamine reversal of heparin for AIS after CC seems to be safe. Further studies are needed to confirm the therapeutic safety and efficacy of this strategy. (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Disseminated High-grade Glioma in a Long-term Survivor of Medulloblastoma: Implications and Management of Radiation-induced Malignancies
We describe a gentleman diagnosed with a posterior fossa medulloblastoma in 1998, successfully treated with craniospinal radiation therapy (RT) and posterior fossa RT boost, followed by 12 months of adjuvant chemotherapy. Nineteen years later, at the age of 28, the patient presented with multiple cranial neuropathies and was found to have disseminated high-grade glioma with leptomeningeal dissemination. In addition to the salient features of this case, we provide a brief review of RT-induced malignancies and the need for further research regarding surveillance and prevention strategies. (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

High-resolution Intracranial Vessel Wall Imaging in Monitoring Treatment Response in Primary CNS Angiitis
Conclusions: Our report illustrates the utility of HR-VWI in diagnosing a case of PCNS angiitis through the demonstration of a vasculitic pattern of mural enhancement. Furthermore, it has provided evidence of disease response to treatment, assisting us in modifying treatment accordingly. Tracking disease activity and response to treatment in cases of central nervous system vasculitis can be another important use of HR-VWI in clinical practice besides assisting in establishing the diagnosis. (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera
Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Here we report a case of a 70-year-old man with prior stroke and PV who developed Guillain-Barré syndrome, an acute inflammatory demyelinating disorder of peripheral nerves causing ascending paresis, numbness, and pare...
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Anti-aquaporin-4 Antibody Positive Optic Neuritis Following Scrub Typhus in an Elderly Female
Conclusions: Optic neuritis (ON) associated with scrub typhus is extremely rare. Our case support that scrub typhus could trigger ON in a lifelong asymptomatic patient with AQP4-Ab and AQP4-Ab should be considered in a very old age patient with suspected postinfectious inflammatory ON. (Source: The Neurologist)
Source: The Neurologist - November 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Inter-rater Agreement for the Diagnosis of Stroke Versus Stroke Mimic: Erratum
No abstract available (Source: The Neurologist)
Source: The Neurologist - September 1, 2018 Category: Neurology Tags: Erratum Source Type: research

Is Patent Foramen Ovale Closure More Effective Than Medical Therapy in Preventing Stroke Recurrence in Patients With Cryptogenic Stroke?: A Critically Appraised Topic
Conclusions: Among patients who had a recent CS attributed to PFO with a large interatrial shunt or with an associated atrial septal aneurysm, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. (Source: The Neurologist)
Source: The Neurologist - September 1, 2018 Category: Neurology Tags: Critically Appraised Topics Source Type: research

Investigation of the Video-EEG Findings and Clinical Data in Patients Diagnosed With Epilepsy and Psychosis
Conclusions: Although our sample size could be considered small, slowed EEG background activity, and the marked frequency of initial precipitant factors such as status epilepticus, perinatal cerebral injury, and detected neuronal autoantibodies suggested that EP is associated with more extensive involvement. EP is not a contraindication for epilepsy surgery, when appropriately investigated preoperatively. (Source: The Neurologist)
Source: The Neurologist - September 1, 2018 Category: Neurology Tags: Original Article Source Type: research

Response to BRAF/MEK Inhibition After Progression With BRAF Inhibition in a Patient With Anaplastic Pleomorphic Xanthoastrocytoma
We present the case of an anaplastic PXA initially treated with the BRAF inhibitor vemurafenib. After progression of disease the MEK inhibitor trametinib was added to the regimen leading to radiographic improvement. The rationale for combined BRAF and MEK inhibition in PXA is reviewed. (Source: The Neurologist)
Source: The Neurologist - September 1, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research