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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis
Hamostaseologie. 2021 Dec;41(6):447-457. doi: 10.1055/a-1661-1908. Epub 2021 Dec 23.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial wall that leads to the build-up of occluding atherosclerotic plaques. Its clinical sequelae, myocardial infarction and stroke, represent the most frequent causes of death worldwide. Atherosclerosis is a multifactorial pathology that involves traditional risk factors and chronic low-grade inflammation in the atherosclerotic plaque and systemically. This process is accompanied by a strong autoimmune response that involves autoreactive T cells in lymph nodes and atherosc...
Source: Hamostaseologie - December 23, 2021 Category: Hematology Authors: Timoteo Marchini Tijani Abogunloko Dennis Wolf Source Type: research

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia
CONCLUSIONS: Vaccine-induced immune thrombotic thrombocytopenia is a serious complication of vaccination that is not feasible to anticipate or prevent. When the patient presents with sustained headache, neurologic symptoms/signs, abdominal pain, dyspnea, or limb pain/swelling beginning 5–30 days post vaccination, platelet count and d-dimer must be measured, and imaging for thrombosis performed. Confirmation of vaccine-induced immune thrombotic thrombocytopenia diagnosis should be ordered (platelet factor 4/polyanion enzyme-linked immunosorbent assay; platelet factor 4–enhanced platelet activation testing) as treatm...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Review Article Source Type: research

Spontaneous Heparin-Induced Thrombocytopenia Presenting as Acute Ischemic Stroke
Consider spontaneous heparin-induced thrombocytopenia in the differential diagnosis of a patient presenting with acute ischemic stroke in the setting of thrombocytopenia.
Source: Neurology Clinical Practice - December 13, 2021 Category: Neurology Authors: Becker, C. J., Heston, A. L., Carrera, J. F. Tags: Autoimmune diseases, All Clinical Neurology, All Cerebrovascular disease/Stroke, Infarction Case Source Type: research

A one-year longitudinal evaluation of cerebrospinal fluid and blood neurochemical markers in a patient with cryptococcal meningitis complicated by ischemic stroke.
Cryptococcal meningitis (CCM) is caused by the encapsulated basidiomycetous yeast Cryptococcus neoformans and is one of the most common central nervous system (CNS) infections in immunocompromised subjects [1 –4]. In this regard, autoimmune diseases, sarcoidosis, glucocorticoid treatment, solid-organ transplantation, hematologic malignancies, diabetes mellitus, chronic renal failure are well-known predisposing factors for CCM in HIV-negative patients [1–4]. Sources of C. neoformans are excrement of b irds such as pigeons, contaminated soil, and the bark of several tree species [1].
Source: Journal of the Neurological Sciences - December 13, 2021 Category: Neurology Authors: Samir Abu-Rumeileh, Tamara Garibashvili, J ürgen Benjamin Hagemann, Veronika Still, Franziska Bachhuber, Markus Otto, Hayrettin Tumani, Makbule Senel Tags: Letter to the Editor Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Prevalence and economic burden of major comorbidities in multiple sclerosis
ConclusionsOur study provides evidence of the burden of comorbidities in MS. Comorbidity is common in MS and produce additive costs.Key messagesThe use of administrative data for tracking the MS comorbidity could help knowledge gaps.When additivity situation is involved, preventive policies could lead to monetary savings.
Source: The European Journal of Public Health - October 20, 2021 Category: General Medicine Source Type: research

Thrombotic Thrombocytopenic Purpura Without Schistocytes: Beware of Misdiagnosis
A 43-year-old woman was admitted for acute unusual headache, vertigo, and left upper limb weakness. She had been complaining of asthenia for the past few weeks. Her medical history included uterine cervix cancer treated with conisation and 2 pregnancies without serious complications. No allergy or recent drug introduction was noted. After ruling out current pregnancy, magnetic resonance imaging (MRI) was immediately performed and showed recent ischemic strokes in multiple territories. Doppler ultrasound imaging showed no carotid or vertebral arteries lesion. Electrocardiogram showed no ST elevation or atrial fibrillation, ...
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Decker, P., Moulinet, T., Revuz, S., Perez, P., Jaussaud, R. Tags: Autoimmune diseases, Hematologic, All Cerebrovascular disease/Stroke Case Source Type: research

Complications of Hepatocellular Carcinoma patients post living Donor Liver Transplantation
ConclusionThere was no statistical significance for those within or out side the Milan criteria or UCSF criteria and its impact on the occurrence of graft rejection, sepsis, vascular complications, death, HCC recurrence and biliary complications post-transplant.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Large-vessel vasculitis in graft-versus-host disease: a case report
ConclusionThe life-threatening vascular complications associated with large-vessel vasculitis include arterial aneurysms and dissections, and ischemic or hemorrhagic stroke. Thus, this rare immunological association needs to be recognized and treated in a timely manner to prevent the long-term complications.
Source: Journal of Medical Case Reports - September 28, 2021 Category: General Medicine Source Type: research

Integrative Therapy Combining Chinese Herbal Medicines With Conventional Treatment Reduces the Risk of Cardiovascular Disease Among Patients With Systemic Lupus Erythematosus: A Retrospective Population-Based Cohort Study
In conclusion, CHM use reduced the risk of CVD among patients with SLE in Taiwan. Further randomized studies may be needed to determine the definite causal relationship between CHM use and its protective effects against CVD among patients with SLE.
Source: Frontiers in Pharmacology - September 27, 2021 Category: Drugs & Pharmacology Source Type: research

The TWEAK/Fn14/CD163 axis-implications for metabolic disease
Rev Endocr Metab Disord. 2021 Sep 20. doi: 10.1007/s11154-021-09688-4. Online ahead of print.ABSTRACTTWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. TWEAK control of these events is via an expanding list of intracellular signalling pathways which include NF-κB, ERK/MAPK, Notch, EGFR and AP-1. Two receptors have been identified for TWEAK - Fn14, which targets the membrane bound form of TWEAK, and CD163, which scavenges the soluble form o...
Source: ENDOCR REV - September 20, 2021 Category: Endocrinology Authors: Wiktoria Ratajczak Sarah D Atkinson Catriona Kelly Source Type: research

The TWEAK/Fn14/CD163 axis —implications for metabolic disease
AbstractTWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. TWEAK control of these events is via an expanding list of intracellular signalling pathways which include NF- κB, ERK/MAPK, Notch, EGFR and AP-1. Two receptors have been identified for TWEAK – Fn14, which targets the membrane bound form of TWEAK, and CD163, which scavenges the soluble form of TWEAK. TWEAK appears to elicit specific events based on the receptor to which it binds, ...
Source: Reviews in Endocrine and Metabolic Disorders - September 20, 2021 Category: Endocrinology Source Type: research

Vaccine-Induced Immune Thrombotic Thrombocytopenia with Concurrent Arterial and Venous Thrombi Following Ad26.COV2.S Vaccination
We describe a case of simultaneous venous and arterial thrombosis associated with severe thrombocytopenia following Ad26.COV2.S vaccination.
Source: Journal of Stroke and Cerebrovascular Diseases - September 18, 2021 Category: Neurology Authors: Andreas Charidimou, Shilpa Samudrala, Anna M. Cervantes-Arslanian, J. Mark Sloan, Hormuzdiyar H. Dasenbrock, Ali Daneshmand Tags: Case Report Source Type: research