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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Nasu-Hakola Disease With Stroke-like Attack: A Case Report
Alzheimer Dis Assoc Disord. 2023 Feb 20. doi: 10.1097/WAD.0000000000000547. Online ahead of print.ABSTRACTHomozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are known to cause Nasu-Hakola disease, which is a rare cause of progressive presenile dementia. A 36-year-old woman presented with repetitive seizures, a 5-year history of progressive behavioral and cognitive changes, and an affected sibling. Magnetic resonance imaging of the brain revealed an ischemic lesion in the left medial temporal lobe. Extensive evaluation of juvenile stroke revealed that viral and autoimmune encephalitide...
Source: Alzheimer Disease and Associated Disorders - February 23, 2023 Category: Psychiatry Authors: Azra Rashid Nezhad Nahid Olfati Ali Shoeibi Fariborz Rezaei Talab Mohsen Soltani Sabi Source Type: research

Dietary energy restriction in  neurological diseases: what’s new?
AbstractEnergy-restricted diet is a specific dietary regimen, including the continuous energy-restricted diet and the intermittent energy-restricted diet. It has been proven effective not only to reduce weight and extend the lifespan in animal models, but also to regulate the development and progression of various neurological diseases such as epilepsy, cerebrovascular diseases (stroke), neurodegenerative disorders (Alzheimer's disease and Parkinson's disease) and autoimmune diseases (multiple sclerosis). However, the mechanism in this field is still not clear and a systematic neurological summary is still missing. In this...
Source: European Journal of Nutrition - February 21, 2023 Category: Nutrition Source Type: research

Recurrent thrombotic events after disappearance of antiphospholipid autoantibodies: A long-term longitudinal study in patients with antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of thrombosis and/or pregnancy morbidity related to the presence of persistent antiphospholipid autoantibodies (aPL) [1]. The most frequent clinical manifestations of APS are thrombotic events and death may be caused by stroke, myocardial infarction, pulmonary embolism or catastrophic APS [2]. APS treatment is based on long term anticoagulation [3].
Source: Thrombosis Research - February 9, 2023 Category: Hematology Authors: Thomas Ballul, Arthur Mageau, Pascale Roland Nicaise, Nadine Ajzenberg, Andrey Strukov, Antoine Dossier, Diane Rouzaud, Thomas Papo, Karim Sacr é Tags: Letter to the Editors-in-Chief Source Type: research

Distinct lesion features and underlying mechanisms in patients with acute multiple infarcts in multiple cerebral territories
CONCLUSION: The etiologies and mechanisms of patients with AMIMCT were more complex than those without AMIMCT. The distribution characteristics of infarct lesions might have important implications for the identification of etiology and mechanism in the future, which could further guide and optimize clinical diagnostic strategies.PMID:36726748 | PMC:PMC9885093 | DOI:10.3389/fneur.2022.1102505
Source: Atherosclerosis - February 2, 2023 Category: Cardiology Authors: Yuhui Sha Guangsong Han Yuehui Hong Juanjuan Wu Mingyu Tang Yicheng Zhu Lixin Zhou Jun Ni Source Type: research

Early high-dose intravenous immunoglobulin for refractory heparin-induced thrombocytopenia with stroke: Two case reports
Heparin-induced thrombocytopenia (HIT) is a drug reaction caused by anti-platelet factor 4 (PF4)/heparin antibodies of the IgG class that activate through Fc γ receptors on platelets and monocytes. They consume platelets and increase thrombin generation.1 HIT occurs 5 to 14 days after the start of heparinization.2 Management of HIT involves discontinuing heparin and switching to an alternative anticoagulant to prevent thrombosis and normalize platelet l evels.3–5 Autoimmune HIT (aHIT), which maintains marked heparin-independent platelet activation even after discontinuing heparin, has recently attracted attention.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2023 Category: Neurology Authors: Naoki Makita, Tomoyuki Ohara, Yukiko Tsuji, Tetsuhiro Ueda, Takuma Nakamura, Toshiki Mizuno, Masahiro Makino Tags: Case Report Source Type: research

IJERPH, Vol. 20, Pages 1682: Low-Grade Inflammation and Role of Anti-Inflammatory Diet in Childhood Obesity
At present, pediatric obesity is a significant public health concern. We have seen a surge of disorders that are obesity-related, e.g., insulin resistance (IR), type 2 diabetes mellitus (T2DM), high blood pressure, heart disease, stroke, cancer, non-alcoholic fatty liver disease (NAFLD), autoimmune disorders and many more. The mechanisms linking these diseases to excess body weight are related to low-grade inflammation (LGI). Although there is a limited number of studies assessing this immune process in childhood obesity, they indicate its significant importance for the health of future generations. There is a need fo...
Source: International Journal of Environmental Research and Public Health - January 17, 2023 Category: Environmental Health Authors: Ewelina Polak-Szczyby ło Tags: Review Source Type: research

Distinct lesion features and underlying mechanisms in patients with acute multiple infarcts in multiple cerebral territories
ConclusionThe etiologies and mechanisms of patients with AMIMCT were more complex than those without AMIMCT. The distribution characteristics of infarct lesions might have important implications for the identification of etiology and mechanism in the future, which could further guide and optimize clinical diagnostic strategies.
Source: Frontiers in Neurology - January 16, 2023 Category: Neurology Source Type: research

Increased Risk of Cardiovascular Diseases in Rheumatoid Arthritis: A Systematic Review
This study systematically reviews various CV diseases that might occur with RA including heart failure (HF), coronary artery disease, acute coronary syndrome, ischemic heart disease, stroke, cardiac death, venous thromboembolism, and valvular diseases. The relation between these complications and RA is specifically assessed. Systematic search was carried out on literature reporting the risk of each of the CV diseases in RA patients from databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases searched were MEDLINE (through PubMed) and Google Scholar ...
Source: Atherosclerosis - January 12, 2023 Category: Cardiology Authors: Hadi Farhat Huma Irfan Kanmani Muthiah Namratha Pallipamu Sogand Taheri Suvedha S Thiagaraj Twisha S Shukla Sai Dheeraj Gutlapalli Sheiniz Giva Sai Sri Penumetcha Source Type: research

The role of STING signaling in central nervous system infection and neuroinflammatory disease
This article is categorized under: Neurological Diseases> Molecular and Cellular Physiology Infectious Diseases> Molecular and Cellular Physiology Immune System Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - January 12, 2023 Category: Biomedical Science Authors: Lauren E. Fritsch, Colin Kelly, Alicia M. Pickrell Tags: Advanced Review Source Type: research