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Condition: Autoimmune Disease
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Total 584 results found since Jan 2013.
Cardiovascular events and risk in patients with systemic lupus erythematosus: Systematic literature review and meta-analysis
CONCLUSIONS: This meta-analysis found an increased risk of stroke, MI, CVD, and hypertension in patients with SLE compared with the general population, despite substantial heterogeneity across the included studies.PMID:36547368 | DOI:10.1177/09612033221147471
Source: Lupus - December 22, 2022 Category: Rheumatology Authors: Natalia Bello Kristin J Meyers Jennifer Workman Louise Hartley Maureen McMahon Source Type: research
What It ’s Like to Live With Stiff Person Syndrome
twIn an emotional social-media video posted Dec. 8, singer Celine Dion informed fans that she has been diagnosed with a rare neurological disease called stiff person syndrome. A diagnosis wasn’t easy or straightforward. “I’ve been dealing with problems with my health for a long time…we now know this is what’s been causing all of the spasms that I’ve been having,” said Dion, who is 54.
Here’s what to know about the condition and what it feels like.
What is stiff person syndrome?
According to the National Institute of Neurological Disorders and Stroke, stiff person syndrome has...
Source: TIME: Health - December 9, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Disease healthscienceclimate Source Type: news
Regulatory T lymphocytes as a therapy for ischemic stroke
AbstractUnrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+CD25+Foxp3+ regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and regain immune homeostasis after stroke. Accumulating evidence confirms that Treg cells are neuroprotective at the acute stage after stroke and promote brain repair at the chronic phases. The beneficial effects of Treg cells are mediated by diverse mechanisms involving cell –cell interactions and soluble factor release. Multiple types of cells, including both immune cells and non-i...
Source: Seminars in Immunopathology - December 5, 2022 Category: Pathology Source Type: research
Research progress on Mincle as a multifunctional receptor
This article will review the various functions of Mincle, such as mediating sterile inflammation of tissues to accelerate disease progression, initiating immune responses to fight infection and promoting tumor progression.PMID:36436471 | DOI:10.1016/j.intimp.2022.109467
Source: International Immunopharmacology - November 27, 2022 Category: Allergy & Immunology Authors: Xinliang Huang Qinwei Yu Luyong Zhang Zhenzhou Jiang Source Type: research
Management and long-term outcomes of patients with chronic inflammatory diseases experiencing ST-segment elevation myocardial infarction: The SCALIM registry
CONCLUSIONS: Approximately 1 in 20 patients with STEMI has CID. We found no effect of CID on long-term survival. However, patients on corticosteroid therapy appeared to have higher rates of death during follow-up. Whether this finding is related to the use of corticosteroids or to the more progressive nature of their condition warrants further investigation.PMID:36372664 | DOI:10.1016/j.acvd.2022.09.003
Source: Archives of Cardiovascular Diseases - November 13, 2022 Category: Cardiology Authors: Marouane Boukhris Nicolas Dupire Benjamin Dousset Val érie Pradel Patrice Virot Julien Magne Victor Aboyans Source Type: research
New insights into the comorbid conditions of Turner syndrome: results from a long-term monocentric cohort study
ConclusionsThis cohort study confirms the need for continuous, structured and multidisciplinary lifelong monitoring of TS, thus ensuring the early diagnosis of important comorbid conditions, including cancer, and their appropriate and timely treatment. In addition, these data highlight the need for the increased surveillance of specific types of cancer in TS, including thyroid carcinoma.
Source: Journal of Endocrinological Investigation - November 11, 2022 Category: Endocrinology Source Type: research
An update on emerging immunological targets and their inhibitors in the treatment of psoriasis
Int Immunopharmacol. 2022 Oct 28;113(Pt A):109341. doi: 10.1016/j.intimp.2022.109341. Online ahead of print.ABSTRACTPsoriasis is a non-communicable, heterogeneous, autoimmune, inflammatory skin disease characterised by reddish, scaly plaques that grow over time. Psoriasis affects people in all countries with all age groups. The World Psoriasis Day organisation claims that out of 125 million people on this planet - Psoriasis affects about 2.5% to 3% of the population. The symptoms of psoriasis are unpredictable, and there are several external factors and associated comorbidities including psoriatic arthritis, renal failure,...
Source: International Immunopharmacology - November 3, 2022 Category: Allergy & Immunology Authors: Siddhi Parab Gaurav Doshi Source Type: research
U.S. FDA Approves TECVAYLI ™ (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., October 25, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved TECVAYLI™ (teclistamab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.1 TECVAYLI™ is a first-in-class, bispecific T-cell engager antibody that is administered as a subcutaneous treatment.1 This off-the-shelf (or ready to use) therapy uses innovative science to ac...
Source: Johnson and Johnson - October 25, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Pristane attenuates atherosclerosis in Apoe < sup > -/- < /sup > mice via IL-4-secreting regulatory plasma cell-mediated M2 macrophage polarization
Biomed Pharmacother. 2022 Nov;155:113750. doi: 10.1016/j.biopha.2022.113750. Epub 2022 Sep 29.ABSTRACTAtherosclerosis, an inflammatory progressive vascular disease, causes heart disease and stroke worldwide. B cells with immune suppressive functions have been implicated in autoimmune, inflammatory, and cardiovascular diseases. However, the precise role of regulatory B cells and the interaction with macrophages in atherosclerosis remains undefined. In our study, eight-week-old female apolipoprotein E null (Apoe-/-) mice were treated with a single dose of vehicle or pristane and then placed on an atherogenic diet for 12 week...
Source: Atherosclerosis - October 22, 2022 Category: Cardiology Authors: Yimin Huang Kongyang Ma Rencai Qin Yaxiong Fang Jingquan Zhou Xiaoyan Dai Source Type: research
Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review
Conclusions: The presence of MDD was identified as a risk factor for both the development and the worsening of a range of comorbidities. These results highlight the importance of addressing depression early in its course and the need for integrating mental and general health care.PMID:36264099 | DOI:10.4088/JCP.21r14328
Source: Journal of Clinical Psychiatry - October 20, 2022 Category: Psychiatry Authors: Alix M Arnaud Teri S Brister Ken Duckworth Phyllis Foxworth Tonya Fulwider Ellison D Suthoff Brian Werneburg Izabela Aleksanderek Marcia L Reinhart Source Type: research
