What It ’s Like to Live With Stiff Person Syndrome

twIn an emotional social-media video posted Dec. 8, singer Celine Dion informed fans that she has been diagnosed with a rare neurological disease called stiff person syndrome. A diagnosis wasn’t easy or straightforward. “I’ve been dealing with problems with my health for a long time…we now know this is what’s been causing all of the spasms that I’ve been having,” said Dion, who is 54. Here’s what to know about the condition and what it feels like. What is stiff person syndrome? According to the National Institute of Neurological Disorders and Stroke, stiff person syndrome has similarities to autoimmune disease, in which the body’s immune system attacks its own cells. The condition is linked to higher levels of antibodies that bind to an enzyme called glutamic acid decarboxylase (GAD), which works on a brain chemical, GABA, responsible for inhibiting activity in the central nervous system. GABA is normally in balance with another chemical that stimulates nerves, which, in the case of muscles, makes them contract. [time-brightcove not-tgx=”true”] “Something in the software goes wrong, and the inhibitory system starts to malfunction,” says Dr. Avi Almozlino, chief of neurology at Newton Wellesley Hospital, part of the Massachusetts General Hospital-Brigham system. “The inhibitory signals become weaker and weaker, and the excitatory signals start to take over, contracting the muscles uncontrollabl...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Disease healthscienceclimate Source Type: news