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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Unusual Presentation of Cerebral Lupus: A Case Report of Parkinsonism in Cerebral Lupus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multisystem involvement that follows a relapsing and remitting course. It is characterized by an immune-mediated response to own body defense mechanism and mistakenly attacked healthy cells of the skin, joints, kidneys, blood cells, and nervous system. Cerebral lupus refers to a constellation of neurological and/or behavioral clinical syndromes in patients with SLE. The spectrum of presentation can vary widely ranging from mild symptoms such as headaches, slight cognitive dysfunction, and mood disorders to more serious conditions like seizures, stroke,...
Source: Case Reports in Neurology - September 13, 2021 Category: Neurology Source Type: research

Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment
Biol Chem. 2021 Aug 30. doi: 10.1515/hsz-2021-0256. Online ahead of print.ABSTRACTAstrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse m...
Source: Biological Chemistry - August 29, 2021 Category: Chemistry Authors: Samantha Schmaul Nicholas Hanuscheck Stefan Bittner Source Type: research

Lupus anticoagulant and ischemic strokes: about two case reports
We report here two cases of stroke associated with the presence of LA, and recall the strategy for screening for LA.PMID:34427558 | DOI:10.1684/abc.2021.1662
Source: Annales de Biologie Clinique - August 24, 2021 Category: Biochemistry Authors: Julie Hilaire Clara Noizat Minh-Toan Duong Maxime Delrue Dominique Herv é Alain Stepanian Marie Neuwirth Arezki Hadj-Ali B érangère S Joly Agn ès Veyradier Virginie Siguret Nicolas B éranger Source Type: research

Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
ConclusionThe novel reclassification algorithm of patients with adult diabetes was reproducible in this population from northern Ukraine. It may be beneficial for the patients in the SIDD subgroup to initiate earlier insulin treatment or other anti-diabetic modalities to preserve β-cell function. Long-term diabetes cases with preserved β-cell function and lower risk for microvascular complications represent an interesting subgroup of patients for further investigations of protective mechanisms.
Source: Frontiers in Genetics - July 2, 2021 Category: Genetics & Stem Cells Source Type: research

Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950
Pharmacol Rev. 2021 Jul;73(3):968-1000. doi: 10.1124/pharmrev.120.000171.ABSTRACTActivation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces pyroptosis (lytic cell death). These events drive chronic inflammation, and as such, NLRP3 has been implicated in a large number of human diseases. These range from autoimmune conditions, the simplest of which is NLRP3 gain-of-function mutations leading to an orphan disease, cryopyrin-associated period syndrome, to large disease burden indications, such as atheroscl...
Source: Pharmacological Reviews - June 12, 2021 Category: Drugs & Pharmacology Authors: Sarah E Corcoran Reena Halai Matthew A Cooper Source Type: research

Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report
We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE. Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Re-evaluation of cerebrospinal fluid (CSF) samples revealed autoantibodies targeting CASPR2 at an immunoglobulin G titer of 1:1. The clinical presentation of subacute onset seizures, abnormal electroencephalography, hypermetabolism on positron emission tomography, good immunotherapy response, and the presence of specific antibodies in serum supports a diagnosis of autoimmune LE. Intervention: The patient received glucocorticoids (1â€...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research