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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

New insights into the comorbid conditions of Turner syndrome: results from a long-term monocentric cohort study
ConclusionsThis cohort study confirms the need for continuous, structured and multidisciplinary lifelong monitoring of TS, thus ensuring the early diagnosis of important comorbid conditions, including cancer, and their appropriate and timely treatment. In addition, these data highlight the need for the increased surveillance of specific types of cancer in TS, including thyroid carcinoma.
Source: Journal of Endocrinological Investigation - July 30, 2022 Category: Endocrinology Source Type: research

Clinical Characteristics  of Inpatients With New-Onset Diabetes Mellitus in Eastern China: Based on Novel Clustering Analysis
ConclusionsThe inpatients with new-onset diabetes in Eastern China had the unique clustering distribution. The clinical characteristics, treatments, and diabetes-related complications and comorbidities of the five subgroups were different, which may provide the basis for precise treatments of diabetes.
Source: Frontiers in Endocrinology - July 27, 2022 Category: Endocrinology Source Type: research

E-061 Moyamoya syndrome patients have low vitamin D
ConclusionOur data indicate a large proportion of moyamoya syndrome patients are deficient in vitamin D, which we hypothesize contributes to pathological severity. Future studies incorporating vitamin D supplementation may act as a novel intervention for this patient population that currently has few treatment options.Disclosures J. Fraser: None. L. Whitnel: None. J. Roberts: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Whitnel, L., Roberts, J. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

O-015 What can systemic and intracranial proteomic profiles tell us about why some TICI 3 patients do better than others?
In conclusion, intracranial and systemic proteomic differences in TICI 3 subjects may inform why some outcomes are superior to others. Preliminary data presented here provide a springboard for further investigation into how proteins may serve as prognostic biomarkers or therapeutic targets in a subset of MT subjects.Disclosures B. Maglinger: None. J. Frank: None. L. Sheikhi: None. S. Pahwa: None. D. Dornbos: None. C. Rupareliya: None. C. McLouth: None. A. Trout: None. J. Turchan-Cholewo: None. A. Stowe: 4; C; Cerelux, LLC. J. Fraser: 1; C; AHA. 2; C; Penumbra, Medtronic, Stream Biomedical. 4; C; Fawkes Biotechnology; Cerel...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Maglinger, B., Frank, J., Sheikhi, L., Pahwa, S., Dornbos, D., Rupareliya, C., McLouth, C., Trout, A., Turchan-Cholewo, J., Stowe, A., Fraser, J., Pennypacker, K. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

178 The association between bullous pemphigoid and schizophrenia: A systematic review and meta-analysis
Background: Bullous pemphigoid (BP) is a common autoimmune disorder characterized by pruritic, tense blisters. BP is often seen in the elderly and is associated with BP180 and BP230 autoantibodies against the epidermal basement membrane zone (BMZ) which result in blister formation via the separation of the dermis and epidermis. Earlier studies demonstrated an association between BP and various neurologic diseases such as stroke, Parkinson ’s disease, and dementia, but few have explored the relationship between BP and schizophrenia specifically.
Source: Journal of Investigative Dermatology - July 20, 2022 Category: Dermatology Authors: B. Cannata, F. Noor, W. Guo, K.W. Lu, S. Na, D. Lozeau Source Type: research

TREGking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain Axis
The human gastrointestinal tract has an enormous and diverse microbial community, termed microbiota, that is necessary for the development of the immune system and tissue homeostasis. In contrast, microbial dysbiosis is associated with various inflammatory and autoimmune diseases as well as neurological disorders in humans by affecting not only the immune system in the gastrointestinal tract but also other distal organs. FOXP3+ regulatory T cells (Tregs) are a subset of CD4+ helper T cell lineages that function as a gatekeeper for immune activation and are essential for peripheral autoimmunity prevention. Tregs are crucial...
Source: Frontiers in Immunology - June 30, 2022 Category: Allergy & Immunology Source Type: research

Genes, Vol. 13, Pages 1179: Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core
In conclusion, functional analysis allowed us to interpret the impact of TREX1 variants on patients’ phenotypes. While the p.A136V variant is unlikely to be causative for AGS in Patient A, Patient B’s phenotype is potentially related to the p.R174G variant. Therefore, further functional investigations of TREX1 variants found in CADASIL-like patients are warranted to determine any causal link and interrogate the molecular disease mechanism(s).
Source: Genes - June 30, 2022 Category: Genetics & Stem Cells Authors: Giulia Amico Wayne O. Hemphill Mariasavina Severino Claudio Moratti Rosario Pascarella Marta Bertamino Flavia Napoli Stefano Volpi Francesca Rosamilia Sara Signa Fred Perrino Marialuisa Zedde Isabella Ceccherini on behalf of the Gaslini Stroke Study Group Tags: Article Source Type: research

CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells
Discussion CNS autoantigen-specific autoimmunity has a protective influence on primary tissue damage after experimental stroke, indicating a very early involvement of CNS antigen-specific, myeloid cell-associated anti-inflammatory immune mechanisms that mitigate ischemic injury in the acute EAE phase.
Source: Neurology Neuroimmunology and Neuroinflammation - June 8, 2022 Category: Neurology Authors: Guse, K., Hagemann, N., Thiele, L., Remlinger, J., Salmen, A., Hoepner, R., Keller, I., Meyer, P., Grandgirard, D., Leib, S. L., Vassella, E., Locatelli, G., Hermann, D. M., Chan, A. Tags: All Immunology, Multiple sclerosis, Infarction Research Article Source Type: research

Months After a Stroke, the Man Was Wasting Away. What  Was Wrong?
Swallowing food was strangely difficult, and he was getting weaker by the day.
Source: NYT Health - May 26, 2022 Category: Consumer Health News Authors: Lisa Sanders, M.D. Tags: Medicine and Health Statins (Cholesterol-Lowering Drugs) Autoimmune Diseases Source Type: news

Living on the border of the CNS: Dural immune cells in health and disease
This article will introduce in detail the composition and source of dural immune cells; as well as the changes in the dural immune landscape under various central nervous system (CNS) diseases (such as aging and neurodegeneration, autoimmune diseases, tumor, infection, stroke and migraine). Our final goal is to shed light on the immune function of the dura mater, and ultimately provide more possibilities for the diagnosis and treatment of CNS diseases from the perspective of regulating dura mater immunity.PMID:35605511 | DOI:10.1016/j.cellimm.2022.104545
Source: Cellular Immunology - May 23, 2022 Category: Allergy & Immunology Authors: Zhuangzhuang Chen Peilin Liu Xiaoshuang Xia Lin Wang Xin Li Source Type: research

Neuroimmune disorders in COVID-19
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiologic agent of the coronavirus disease 2019 (COVID-19), is now rapidly disseminating throughout the world with 147,443,848 cases reported so far. Around 30 –80% of cases (depending on COVID-19 severity) are reported to have neurological manifestations including anosmia, stroke, and encephalopathy. In addition, some patients have recognised autoimmune neurological disorders, including both central (limbic and brainstem encephalitis, acute disseminated encephalomyelitis [ADEM], and myelitis) and peripheral diseases (Guillain–Barré and Miller ...
Source: Journal of Neurology - May 20, 2022 Category: Neurology Source Type: research

Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist
Deficiency of adenosine deaminase type 2 (DADA2) was first described in 2014 as a monogenic cause of polyartertitis nodosa (PAN), early onset lacunar stroke and livedo reticularis. The clinical phenotype of DADA2 is, however, very broad and may involve several organ systems. Apart from vasculitis, children may present with i) Hematological manifestations (ii) Lymphoproliferation and iii) Immunodeficiencies. Patients with DADA2 can have variable patterns of cytopenias and bone marrow failure syndromes. Patients with DADA2 who have predominant haematological manifestations are associated with ADA2 gene variants that result i...
Source: Frontiers in Immunology - May 3, 2022 Category: Allergy & Immunology Source Type: research

Aging-Related Vascular Inflammation: Giant Cell Arteritis and Neurological Disorders
Front Aging Neurosci. 2022 Apr 12;14:843305. doi: 10.3389/fnagi.2022.843305. eCollection 2022.ABSTRACTAging is characterized by the functional decline of the immune system and constitutes the primary risk factor for infectious diseases, cardiovascular disorders, cancer, and neurodegenerative disorders. Blood vessels are immune-privileged sites and consist of endothelial cells, vascular smooth muscle cells, macrophages, dendritic cells, fibroblasts, and pericytes, among others. Aging also termed senescence inevitably affects blood vessels, making them vulnerable to inflammation. Atherosclerosis causes low-grade inflammation...
Source: Atherosclerosis - May 2, 2022 Category: Cardiology Authors: Ryu Watanabe Motomu Hashimoto Source Type: research