Locus of Control and Cognition in Older Adults With Type I Diabetes: Evidence For Sex Differences From the Study of Longevity in Diabetes (SOLID).
CONCLUSIONS: In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition. PMID: 31633555 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans.
DISCUSSION: These findings demonstrate that SMCs are associated with lower scores on objective neuropsychological measures among older AAs. Additional work is needed to determine whether SMCs are further associated with a risk for clinical transition to mild cognitive impairment or dementia among AA older adults. PMID: 31633556 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association Between Neuropsychiatric Symptom Trajectory and Conversion to Alzheimer Disease.
DISCUSSION: On the basis of the findings, this study showed evidence that increase in NPS burden (reflected by increase in NPI) over time predicts conversion to AD, whereas stability of symptoms (reflected by stable NPI score) favors nonconversion. Further study should investigate the underlying mechanisms that drive both NPS burden and cognitive decline. PMID: 31633557 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Trends in the Use of Medications and Supplements to Treat or Prevent Dementia: A Population-based Study.
CONCLUSIONS: The use of both prescription drugs and supplements increased over time, except for decreases in ginkgo and vitamin E. Prescription drug use appeared in line with prescribing guidelines. Supplement use was associated with higher education and better self-rated health; it persists despite a lack of supportive evidence. PMID: 31633558 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Clustering and Additive Effects of Nongenetic Risk Factors in Non-Autosomal-Dominant Degenerative and Vascular Young Onset Dementia.
DISCUSSION: Results suggest that combinations of nongenetic risk factors confer more risk for young onset vascular dementia, and possibly primary degenerative YOD, than a single factor on its own. Compared with their same-age peers, some people with YOD experience a lifetime of risk exposure starting from early in life. PMID: 31633559 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

High Prevalence of Social Cognition Disorders and Mild Cognitive Impairment Long Term After Stroke.
CONCLUSIONS: The study demonstrates the high frequency of social cognition impairment 3 years after the first-ever stroke in young patients. Doctors and nurses should be sensitized to cognitive handicap after stroke because of difficulties for rehabilitation and returning to work. PMID: 31633560 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Older Adults With Subjective Cognitive Decline Worry About the Emotional Impact of Cognitive Test Results.
We report data for 393 respondents (online: n=296, primary care: n=97), mean age of 63 years, age range of 50 to 91 years, and 60% endorsing SCD. Compared with No SCD, those with SCD anticipated a higher number of worries centered disproportionately on worries of becoming depressed, ashamed or embarrassed, feeling "stupid" and unable to do things, and being put in a nursing home. We observed this SCD pattern of worries in both samples. DISCUSSION: Individuals with SCD worry about the emotional consequences of cognitive testing. This at-risk group would benefit from interventions focused on these concerns to i...
Source: Alzheimer Disease and Associated Disorders - October 3, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Virtual Support Groups for Informal Caregivers of Individuals With Dementia: A Scoping Review.
CONCLUSIONS: Clinics desiring to start virtual support groups should consider videoconferencing or telephone approaches with pretraining, technology support, and professional moderators. Clinics need adequate resources, particularly for technology, and identification of locally relevant goals and approach. PMID: 31567144 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Blood Pressure and Memory: Novel Approaches to Modeling Nonlinear Effects in Longitudinal Studies.
CONCLUSIONS: By modelling nonlinear associations, we showed that the relationship between BP and memory performance varied by baseline BP among normotensives and hypertensives. PMID: 31567145 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Symbol Comprehension in Patients With Alzheimer Disease Dementia, Mild Cognitive Impairment, and Major Depressive Disorder.
CONCLUSIONS: Our findings indicate that symbols with distracting features impede symbol comprehension in ADD and MCI. Symbols with visual cues, by contrast, facilitate symbol comprehension in ADD and may even be advantageous over standardized symbols used in public life. PMID: 31567152 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Retention of Alzheimer Disease Research Participants.
Authors: Grill JD, Kwon J, Teylan MA, Pierce A, Vidoni ED, Burns JM, Lindauer A, Quinn J, Kaye J, Gillen DL, Nan B Abstract INTRODUCTION: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research. METHODS: We surveyed representative investigators from NIH-funded Alzheimer's Disease Research Centers (ADRC), querying their use of retention tactics across 12 strategies. We compared survey results to data from the National Alzheimer's Coordinating Center for each center. We used a generalized estimating e...
Source: Alzheimer Disease and Associated Disorders - October 1, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID).
CONCLUSION: Our results suggest that sleep quality may be a modifiable risk factor for global cognitive function and executive function among elderly individuals with T1D. PMID: 31567303 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders.
CONCLUSIONS: Our results support the consensus that the R47H variant is significantly associated with AD. However, we did not find evidence for association of the R47H variant with other neurodegenerative diseases. PMID: 31513029 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 14, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Behaviors Characteristic of Autism Spectrum Disorder in a Geriatric Cohort With Mild Cognitive Impairment or Early Dementia.
DISCUSSION: Data demonstrate that ASD behaviors may seem de novo of degenerative dementia and such behaviors are more prevalent in those with early onset dementia. Further work elucidating a connection between ASD and dementia could shed light on subclinical forms of ASD, identify areas of shared neuroanatomic involvement between ASD and dementias, and provide valuable insights that might hasten the development of therapeutic strategies. PMID: 31517641 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 14, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Mortality and Associated Risk Factors in Community-Dwelling Persons With Early Dementia.
CONCLUSIONS: While newly diagnosed with early dementia, over half of our sample died in the 6-year follow-up period, with the average death occurring only 3 years after initial diagnosis. The finding of lower mortality associated with better performance on gait/balance testing indicates an important opportunity for focused interventions and early detection of gait and balance changes early during cognitive decline. PMID: 31478918 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 4, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diagnosis of Rapidly Progressive Dementia in a Referral Center in Argentina.
Authors: Acosta JN, Ricciardi ME, Alessandro L, Carnevale M, Farez MF, Nagel V, Allegri RF, Varela F Abstract INTRODUCTION: Rapidly progressive dementia (RPD) is a broadly defined clinical syndrome. Our aim was to describe clinical and ancillary study findings in patients with RPD and evaluate their diagnostic performance for the identification of nonchronic neurodegenerative rapidly progressive dementia (ncnRPD). METHODS: We reviewed clinical records and ancillary methods of patients evaluated for RPD at our institution in Buenos Aires, Argentina from 2011 to 2017. We compared findings between chronic neurodeg...
Source: Alzheimer Disease and Associated Disorders - August 31, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Frontotemporal Dementia Knowledge Scale: Development and Preliminary Psychometric Properties.
In this study, we used systematic scale development procedures to create a scale to measure knowledge of FTD based on a contemporary understanding of the disease. METHODS: Standard scale development methods were used to create items and evaluate their psychometric properties. A total of 72 health care professionals and 102 caregivers of people with FTD responded to items measuring FTD knowledge, general dementia knowledge, crystallized intelligence, experience with FTD, and demographic information. RESULTS: The Frontotemporal Dementia Knowledge Scale (FTDKS) contains 18 items that cover key, basic knowledge about F...
Source: Alzheimer Disease and Associated Disorders - August 30, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Willingness to Undergo a Risky Treatment to Improve Cognition Among Persons With Cognitive Impairment Who Received an Amyloid PET Scan.
CONCLUSIONS: Scan recipients were willing to accept a treatment with a high risk of death. Discordance was affected by scan recipient's having poorer functioning. PMID: 31414990 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 17, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia.
CONCLUSION: Increased levels of inflammatory markers were not associated with faster progression as measured by the annual change on the CDR-SB or MMSE score. PMID: 31414991 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 17, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults.
CONCLUSION: Low levels of serum BDNF and IGF-1 were associated with poorer cognition during aging. There may be differential biomarker effects by sex. PMID: 31385821 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 8, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Duration of Antipsychotic Medication Use by Aged Care Facility Residents With Dementia.
DISCUSSION: Antipsychotics are often used longer than recommended. Current guidelines and restrictions may be insufficient to limit antipsychotic medication use. Further efforts are needed to ensure that antipsychotic medications are used as recommended in dementia. PMID: 31343414 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 26, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neurovascular Dysfunction in Alzheimer Disease: Assessment of Cerebral Vasoreactivity by Ultrasound Techniques and Evaluation of Circulating Progenitor Cells and Inflammatory Markers.
Authors: Cipollini V, Sette G, Bossù P, Ciaramella A, Salani F, De Carolis A, Troili F, Orzi F, Giubilei F Abstract AIMS: The aims of this study were to assess vascular dysfunction in patients with Alzheimer disease (AD) by investigating cerebral vasomotor reactivity using transcranial Doppler ultrasound (TCD) and to evaluate any correlations between cerebral vasoreactivity and endothelium dysfunction. Moreover, the frequency of circulating progenitor cells (CPCs) and the blood concentration of vascular/inflammatory markers were evaluated. MATERIALS AND METHODS: We recruited 35 AD subjects and 17 age-mat...
Source: Alzheimer Disease and Associated Disorders - July 25, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Age-related Hearing Loss and Dementia.
Authors: Chern A, Golub JS Abstract Dementia is a devastating disease and global health challenge that is highly prevalent worldwide. A growing body of research has shown an independent association between age-related hearing loss (ARHL) and dementia, identifying ARHL as a compelling potential target in preventive strategies for dementia. However, a causal linkage between ARHL and dementia needs to be investigated before making definitive clinical guidelines and treatment recommendations regarding ARHL as a modifiable risk factor. In this review, we discuss the association between ARHL and dementia, the importance ...
Source: Alzheimer Disease and Associated Disorders - July 25, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Perspectives of African American Older Adults on Brain Health: "Brains Get Tired Too".
DISCUSSION: These emic insights into perceptions of brain health may represent important foci for targeted messaging strategies to promote brain health and research engagement within the African American population. PMID: 31335456 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 25, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Differential Methylation Levels in CpGs of the BIN1 Gene in Individuals With Alzheimer Disease.
The objective of this study was to evaluate the BIN1 3' intergenic region DNA methylation patterns in a Colombian sample of LOAD patients. METHODS: A case-control study was conducted in 50 individuals with LOAD and 50 age-sex matched controls to determine associations of LOAD with DNA methylation. DNA was isolated from peripheral blood, and methylation levels of 8 CpGs were estimated by bisulfite conversion followed by Sanger sequencing with direct PCR analysis. Logistic regression models adjusted by age, sex, and APOE were used to calculate risk associations between methylation levels and LOAD. RESULTS: Overall, p...
Source: Alzheimer Disease and Associated Disorders - July 25, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Comparison of Electronic and Paper Versions of the Montreal Cognitive Assessment.
CONCLUSION: Modality of administration can affect performance on cognitive assessments. Clinicians should consider individuals' level of touchscreen experience before selecting administration modality. PMID: 31335458 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 25, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons.
Authors: Kapasi A, Yu L, Stewart CC, Schneider JA, Bennett DA, Boyle PA Abstract BACKGROUND: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging. OBJECTIVE: To test the hypothesis that TDP-43 pathology is associated with lower lite...
Source: Alzheimer Disease and Associated Disorders - July 16, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Type II Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline.
CONCLUSIONS: Participants with both diabetes and at least 1 AD risk factor (ie, Obj-SCD, APOE ε4, tau, and p-tau positivity) demonstrated faster functional decline compared with those without both risk factors (diabetes or AD). These findings have implications for early identification of, and perhaps earlier intervention for, diabetic individuals at risk for future functional difficulty. PMID: 31305320 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 16, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Identifying an Optimal Cutoff of the Montreal Cognitive Assessment to Predict Amyloid-PET Positivity in a Referral Memory Clinic.
CONCLUSIONS: Amyloid-PET positivity is associated with lower MoCA scores. Clinical utility of amyloid-PET scan is likely to be suboptimal at the MoCA score cutoff for minimal cognitive impairment. PMID: 31305321 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 16, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

VGF in Cerebrospinal Fluid Combined With Conventional Biomarkers Enhances Prediction of Conversion From MCI to AD.
CONCLUSIONS: CSF VGF enhances the ability of conventional biomarkers to predict MCI to AD conversion. Future work will be needed to determine the specificity of VGF for AD versus other neurodegenerative diseases. PMID: 31305322 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 16, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Age-related Hearing Loss and Dementia
Dementia is a devastating disease and global health challenge that is highly prevalent worldwide. A growing body of research has shown an independent association between age-related hearing loss (ARHL) and dementia, identifying ARHL as a compelling potential target in preventive strategies for dementia. However, a causal linkage between ARHL and dementia needs to be investigated before making definitive clinical guidelines and treatment recommendations regarding ARHL as a modifiable risk factor. In this review, we discuss the association between ARHL and dementia, the importance of addressing this finding, as well as commo...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Review Article Source Type: research

Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis
The use of biomarkers has recently supported the association between Alzheimer disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir PET. A group of 10 PPA were retrospectively enrolled. Patients with logopenic variant (lvPPA) showed different levels of Aβ1-42 and p-tau compared to nonfluent/agrammatic and semantic variants (nfv/svPPA). All nfv/svPPA patients had negative amyloid PET. Among t...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Brief Reports Source Type: research

Distinguishing Dementia With Lewy Bodies From Alzheimer Disease: What is the Influence of the: GBA: Genotype in Ashkenazi Jews?
Cognitive deficits beyond memory impairment, such as those affecting language production or executive functioning, can be useful in clinically distinguishing between dementia syndromes. We tested the hypothesis that Ashkenazi Jewish (AJ) patients who have dementia with Lewy bodies (DLB) and carry glucocerebrosidase (GBA) mutations will have verbal fluency deficits different from those found in Alzheimer disease (AD), whereas AJ patients with DLB who have no GBA mutations will have similar deficits in verbal fluency to those found in AD. We compared performance in phonemic and semantic verbal fluency tasks in 44 AJ patients...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Brief Reports Source Type: research

A Comparison of Electronic and Paper Versions of the Montreal Cognitive Assessment
Conclusion: Modality of administration can affect performance on cognitive assessments. Clinicians should consider individuals’ level of touchscreen experience before selecting administration modality. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

The Relationship Between Caregiver Burden and Emotion Recognition Deficits in Persons With MCI and Early AD: The Mediating Role of Caregivers’ Subjective Evaluations
Conclusion: Caregivers’ better awareness of ER deficits in people with MCI and early AD might mitigate the deleterious consequences of caregiving for persons with cognitive deterioration and might therefore allow better chances for people with dementia to age in a homecare setting. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia
Conclusions: Changes in relationship status differed across dementia groups and were associated with empathy decline. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Perceptions of Risk Factors for Alzheimer Disease Among Community-Dwelling, Nondemented Older African Americans
This study examines perceptions of AD risk factors among nondemented older African Americans. Methods: Participants indicated how important nine factors were in increasing one’s AD risk using a Likert-type scale with endpoints 1=not at all important to 4=extremely important. We examined perceptions of AD risk factors as a function of age, education, gender, and global cognition using separate logistic regression models. Patients: Participants were from The Minority Aging Research Study (N=610) with a mean age of 74.5 years, a mean education of 14.9 years, and 24% were men. Results: Of the AD risk factors, pr...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Patient Stakeholder Versus Physician Preferences Regarding Amyloid PET Testing
Conclusions: Patients and caregivers emphasized the importance of having a dementia diagnosis and placed more value on testing and outcomes for asymptomatic populations than clinicians. This underscores the importance of research investigating the effect of amyloid PET results on asymptomatic individuals and the need for amyloid PET ordering and disclosure standards. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Health-related Quality of Life, Cognitive Performance, and Incident Dementia in a Community-based Elderly Cohort
Conclusions: These findings suggest that diminution of HRQoL precedes the onset of diagnosable dementia and may be useful in the prediction of dementia onset. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Psychiatric Symptoms in Patients With Dementia: Do Caregivers and Doctors See the Same Thing?
Conclusion: NPS, though very prevalent in dementia patients, are perceived differently by caregivers and physicians. This divergence increases depending on the psychological health of caregivers. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Discriminative Ability of Montreal Cognitive Assessment Subtests and Items in Racial and Ethnic Minority Groups
Conclusions: By understanding the psychometric properties of MoCA subtests, we can focus on subtests that have higher discrimination and more diagnostic utility. Subtests should be further evaluated for use in screening of minority individuals. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Awareness in Dementia: Development and Evaluation of a Short Version of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s) in Brazil
Awareness of disease is defined as the recognition of changes caused by the deficits related to the disease process. We aimed to examine the psychometric properties of the short versions of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s), a multidimensional awareness scale. Using a cross-sectional design, we included 201 people with dementia and their family caregivers. The creation of the short versions was based on items with higher loadings on each factor, the correlations between the short versions and demographic or clinical variables and the relevance of the item to the respondent ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Neurovascular Dysfunction in Alzheimer Disease: Assessment of Cerebral Vasoreactivity by Ultrasound Techniques and Evaluation of Circulating Progenitor Cells and Inflammatory Markers
Aims: The aims of this study were to assess vascular dysfunction in patients with Alzheimer disease (AD) by investigating cerebral vasomotor reactivity using transcranial Doppler ultrasound (TCD) and to evaluate any correlations between cerebral vasoreactivity and endothelium dysfunction. Moreover, the frequency of circulating progenitor cells (CPCs) and the blood concentration of vascular/inflammatory markers were evaluated. Materials and Methods: We recruited 35 AD subjects and 17 age-matched, sex-matched, and education-matched healthy control subjects. Cerebral vasomotor reactivity was assessed by means of the TCD-...
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Automated Volumetry of Medial Temporal Lobe Subregions in Mild Cognitive Impairment and Alzheimer Disease
Conclusions: Using the combined volumes of the subiculum, entorhinal cortex, and cornu ammonis 1 may enable greater diagnostic accuracy compared with the WH volume or any single subfield in AD patients. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Stressors in Midlife and Risk of Dementia: The Role of Race and Education
Conclusion: Reporting ≥1 serious midlife stressor was associated with elevated dementia risk, especially stressors related to resources problems and for those with less than equal to high school education. Everyday stressors can impact brain health over the long term and may contribute to racial inequities in dementia rates, though education can be a mitigating factor. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Identifying an Optimal Cutoff of the Montreal Cognitive Assessment to Predict Amyloid-PET Positivity in a Referral Memory Clinic
Conclusions: Amyloid-PET positivity is associated with lower MoCA scores. Clinical utility of amyloid-PET scan is likely to be suboptimal at the MoCA score cutoff for minimal cognitive impairment. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites
Conclusions: Our study suggests that Chinese and white patients with AD, when matched demographically, are clinically and neuroanatomically similar on normalized measures of cortical atrophy and clinical severity. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Neuropsychological Test Performance and MRI Markers of Dementia Risk: Reducing Education Bias
Conclusions: Longitudinal analysis of correctly scaled neuropsychological assessments may provide unbiased proxies for MRI-based measures of dementia risk. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2019 Category: Geriatrics Tags: Original Articles Source Type: research

Neuropsychological Test Performance and MRI Markers of Dementia Risk: Reducing Education Bias.
CONCLUSIONS: Longitudinal analysis of correctly scaled neuropsychological assessments may provide unbiased proxies for MRI-based measures of dementia risk. PMID: 31206372 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 19, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comment on Andrews et al.
Authors: Royall DR PMID: 31180916 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 12, 2019 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research