Value of a Panel of 6 Serum Biomarkers to Differentiate between Healthy Controls and Mild Cognitive Impairment Due to Alzheimer Disease.
CONCLUSIONS: This panel of 6 markers in blood serum may indicate underlying neurodegenerative processes in patients with AD at the MCI stage. The authors assume that a deranged equilibrium of neuroprotective and inflammatory processes is an overall major cause for neurodegeneration and cognitive decline. PMID: 32649324 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship.
Authors: Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC Abstract Cancer diagnoses are associated with better long-term memory in older adults, possibly reflecting a range of social confounders that increase cancer risk but improve memory. We used spouse's memory as a negative control outcome to evaluate this possible confounding, since spouses share social characteristics and environments, and individuals' cancers are unlikely to cause better memory among their spouses. We estimated the association of an individual's incident cancer diagnosis (exposure) with...
Source: Alzheimer Disease and Associated Disorders - June 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Efficacy of Mealtime Interventions for Malnutrition and Oral Intake in Persons With Dementia: A Systematic Review.
Authors: Borders JC, Blanke S, Johnson S, Gilmore-Bykovskyi A, Rogus-Pulia N Abstract Malnutrition and weight loss are highly prevalent in persons with Alzheimer's disease and related dementias. Oral intake is an important interventional target for addressing these nutritional consequences. However, the efficacy of interventions remains poorly understood as prior syntheses have failed to examine the impact of intervention approaches on malnutrition and hypothesized mechanisms of action in persons with dementia. This review aimed to determine the efficacy of mealtime interventions to improve oral intake and nutritio...
Source: Alzheimer Disease and Associated Disorders - June 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey.
CONCLUSIONS: To distinguish between SCC, aMCI, and AD in a sample of older Turkish adults, the Qmci-TR may be preferable. In very low literacy, the choice of the instrument appears less important. PMID: 32530832 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT).
CONCLUSIONS AND RELEVANCE: Regional sex-related differences in tau PET burden may contribute to the disparities in AD prevalence between males and females. The observed decreases tau PET burden in HT users has important implications for clinical practice and trials and deserves future consideration in longitudinal studies. PMID: 32520734 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy.
Authors: Kim KH, Seo JD, Kim ES, Kim HS, Jeon S, Pak K, Lee MJ, Lee JH, Lee YM, Lee K, Shin JH, Ko JK, Jung NY, Lee JM, Yoon JA, Hwang C, Ahn JW, Sung S, Spina S, Seeley WW, Choi KU, Huh GY, Kim EJ Abstract Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between t...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning.
Authors: Stojanovic M, Jin Y, Fagan AM, Benzinger TL, Hassenstab J, Cruchaga C, Morris JC, Head D Abstract INTRODUCTION: Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Takotsubo Cardiomyopathy in an Alzheimer Disease Patient: The Potential Contribution of Antidepressant Agents.
We report the case of an 83-year-old woman with advanced Alzheimer disease who had recently used nortriptyline and sertraline and was admitted with chest pain. An electrocardiogram showed ST-elevation, and markers of myocardial necrosis were slightly increased. However, coronariography did not demonstrate stenotic lesions. Transthoracic echocardiography and ventriculography identified decreased ventricular function, apical akinesia, and compensatory hyperkinesia of other segments that were compatible with TC. The patient evolved with cardiogenic shock and died. Alzheimer patients may be more susceptible to develop TC, both...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neck Circumference and Cerebral Gray Matter Volume.
CONCLUSIONS: In men with diabetes, NC was inversely associated with cerebral gray matter volume. The link between neck anthropometry and brain aging in diabetic men warrants further consideration. PMID: 32483016 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Expanded Demographic Norms for Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set.
CONCLUSIONS: Although race-based norms represent incomplete proxies for other sociocultural variables, the appropriate application of these norms is important given the potential to improve diagnostic accuracy and to reduce misclassification bias in cognitive disorders of aging such as Alzheimer disease. PMID: 32483017 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Interactions Between Acute Infarcts and Cerebrovascular Pathology Predict Poststroke Dementia.
CONCLUSIONS: The risk of PSD varies depending on the presence of chronic cerebrovascular pathologies and type of acute infarcts. Clinical implications support a precision medicine approach for stratifying those at highest risk of PSD. PMID: 32483018 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study.
CONCLUSIONS: Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia. PMID: 32483019 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Physical and Vestibular Physical Therapy Referrals in People With Alzheimer Disease.
Authors: Gandhi P, Klatt BN, Agrawal Y Abstract People with Alzheimer disease (AD) are at increased risk of falls and disproportionately burdened with vestibular impairment compared with healthy older adults. Although physical therapy (PT) and vestibular physical therapy (VPT) are effective rehabilitation interventions in improving balance and fall risk, referral patterns for these services in the AD population are understudied. A retrospective chart review was conducted of patients seen for primary AD care at a tertiary AD referral center to investigate the frequency of rehabilitation referrals. Of the 801 people ...
Source: Alzheimer Disease and Associated Disorders - May 31, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association of Dementia and Vascular Risk Scores With Cortical Thickness and Cognition in Low-risk Middle-aged Adults.
CONCLUSIONS: These results indicate that the CAIDE dementia risk score is associated with cortical thickness and cognitive function at midlife in a low-risk population. These data provide insight into subclinical structural and functional changes occurring during midlife associated with future risk for the development of dementia. PMID: 32467426 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 31, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy.
CONCLUSION: Limbic-predominant age-related TDP-43 encephalopathy is uniquely associated with distinct longitudinal profiles of financial and health literacy in old age. PMID: 32452861 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 28, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults: Findings From the KHANDLE Study.
CONCLUSIONS: The association between cognitive performance and log(ECog scores) differed little across sociodemographic and psychological factors. SCD as measured by the ECog may be a valuable proxy for cognitive performance in diverse older adults. PMID: 32427599 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 21, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability.
Authors: Kitamura J, Nagai M, Ueno H, Ohshita T, Kikumoto M, Toko M, Kato M, Dote K, Yamashita H, Kario K Abstract Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus o...
Source: Alzheimer Disease and Associated Disorders - May 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons.
CONCLUSIONS: Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons. PMID: 32384286 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Vascular Dementia, Depression, and Financial Capacity Assessment.
Authors: Giannouli V, Tsolaki M Abstract We still know little about financial capacity, which consists of multiple cognitive domains as well as specific skills, and the influence of depression in patients with vascular dementia (VaD). Participants were divided into 4 groups: (1) VaD with and (2) without depressive symptoms, (3) nondemented elders with and (4) without depression. The participants were examined with the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale (GDS-15), and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS). The findings extend earlier work in othe...
Source: Alzheimer Disease and Associated Disorders - May 7, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.
CONCLUSION: Alpha-synuclein levels in the CSF can be used for the discrimination between LBD and AD, but not LBD and other neurodegenerative disorders such as dementia in PD, MSA, FTD, and PSP. PMID: 32341240 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 29, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Social Inequalities in Life Expectancy and Mortality in People With Dementia in the United Kingdom.
This study aimed to explore potential differentials in life expectancy and mortality in people with dementia according to social deprivation. METHODS: Using The Health Improvement Network (THIN) primary care database, we included people with a diagnosis of dementia in the United Kingdom in 2000 to 2016 and obtained data on age at death and mortality. Comparisons were made according to social deprivation quintiles adjusting for age at diagnosis. RESULTS: Among 166,268 people with dementia there were no differences in life expectancy and mortality in the most deprived compared with the least deprived. This pattern ha...
Source: Alzheimer Disease and Associated Disorders - April 27, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions.
Authors: Mock C, Teylan M, Beecham G, Besser L, Cairns NJ, Crary JF, Katsumata Y, Nelson PT, Kukull W Abstract The field of dementia research is rapidly evolving, especially with regards to our understanding of the diversity of neuropathologic changes that underlie cognitive decline. Definitions and criteria for known conditions are being periodically revised and refined, and new findings are being made about neuropathologic features associated with dementia status. The database maintained by the National Alzheimer's Coordinating Center (NACC) offer researchers a robust, rapid, and statistically well-powered method...
Source: Alzheimer Disease and Associated Disorders - April 19, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Clinical Presentation of Sporadic Creutzfeldt-Jakob Disease in Han-Chinese
This study retrospectively reviewed 26 cases of sCJD diagnosed in a single center in recent years. All 26 sCJD patients received brain magnetic resonance imaging scan, cerebrospinal fluid 14-3-3 protein detection, electroencephalogram, and PRNP gene screening. The codon 129 polymorphism were all homozygous MM in 26 sCJD patients. The main onset symptoms of sCJD patients were rapidly progressive dementia, visual impairment, and cerebellar ataxia. At the time of diagnosis, the incidence of myoclonus and akinetic mutism were relatively low ( (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Women and Men Presenting to a Rural and Remote Memory Clinic in Saskatchewan, Canada Show Similar Cognitive Findings for Dementia
Discussion: Within this rural and remote sample, there was equivalence between male and female level of cognitive decline, function and neuropsychiatric symptoms at initial referral. Both sexes were of similar ages at the time of initial presentation. These findings may provide reassurance to patients and their family members as it does not appear that patients of one sex were referred later than the other. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Dementia With Lewy Bodies: A Clinicopathologic Series of False-positive Cases
Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson’s disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64%) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, C...
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Factor Consistency of Neuropsychological Test Battery Versions in the NACC Uniform Data Set
The proprietary neuropsychological tests (Form C1) of the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set were replaced with nonproprietary versions (Form C2) chosen to closely model their proprietary counterparts. Correlations between analogous test pairs as measured in previous work were good (0.68-0.78), but it is unclear whether the paired tests represent the same set of common factors of cognition or if important factors specific to C1 or C2 only exist. The authors performed multiple factor analysis to analyze correlated C1 and C2 data. They included participants who completed both neuropsycholo...
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

The Past as Seen by Women and Men With Alzheimer Disease: Sex Differences in Autobiographical Memory
Discussion: AD seems to equally affect the ability of women and men with AD to construct specific autobiographical memories, to mentally travel in time to relive these memories, to construct mental visual images during memory retrieval, and to organize and monitor search processes, as the latter are mirrored by retrieval time. However, women with AD seem to attribute greater emotional value to autobiographical memories than men with AD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan
Conclusions: The 10/66 DRG tool is a valid instrument for diagnosing dementia in the Urdu-speaking population, including with low education and depression, in Pakistan. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Prevalence of Mild Cognitive Impairment in the Elderly Population in Greece: Results From the HELIAD Study
Conclusions: MCI prevalence in the elderly population in Greece is on par with previously reported rates. Prospective studies with robust methodology will enhance our understanding of the dementia continuum. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Trends in the Use of Medications and Supplements to Treat or Prevent Dementia: A Population-based Study
Conclusions: The use of both prescription drugs and supplements increased over time, except for decreases in ginkgo and vitamin E. Prescription drug use appeared in line with prescribing guidelines. Supplement use was associated with higher education and better self-rated health; it persists despite a lack of supportive evidence. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Association Between Neuropsychiatric Symptom Trajectory and Conversion to Alzheimer Disease
Discussion: On the basis of the findings, this study showed evidence that increase in NPS burden (reflected by increase in NPI) over time predicts conversion to AD, whereas stability of symptoms (reflected by stable NPI score) favors nonconversion. Further study should investigate the underlying mechanisms that drive both NPS burden and cognitive decline. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Older Adults With Subjective Cognitive Decline Worry About the Emotional Impact of Cognitive Test Results
We report data for 393 respondents (online: n=296, primary care: n=97), mean age of 63 years, age range of 50 to 91 years, and 60% endorsing SCD. Compared with No SCD, those with SCD anticipated a higher number of worries centered disproportionately on worries of becoming depressed, ashamed or embarrassed, feeling “stupid” and unable to do things, and being put in a nursing home. We observed this SCD pattern of worries in both samples. Discussion: Individuals with SCD worry about the emotional consequences of cognitive testing. This at-risk group would benefit from interventions focused on these concerns to ...
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Clustering and Additive Effects of Nongenetic Risk Factors in Non–Autosomal-Dominant Degenerative and Vascular Young Onset Dementia
Discussion: Results suggest that combinations of nongenetic risk factors confer more risk for young onset vascular dementia, and possibly primary degenerative YOD, than a single factor on its own. Compared with their same-age peers, some people with YOD experience a lifetime of risk exposure starting from early in life. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Alzheimer Disease and Cancer: A National Inpatient Sample Analysis
Discussion: This secondary data analysis further demonstrated an inverse relationship between AD and 10 cancer types, with prostate, ovarian, and lung cancers displaying the greatest inverse relationship. Pin1 underexpressing cancer types had a significantly higher likelihood of secondary diagnosis of AD than Pin1 overexpressing cancer types. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study
Conclusions: Neither a diagnosis of prostate cancer nor ADT use was associated with odds of MCI in this cross-sectional population-based study. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument
Conclusion: The AD8 is a brief and sensitive screening instrument that may facilitate earlier and more accurate AD diagnosis in a variety of care settings. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

The Utility of the National Alzheimer’s Coordinating Center’s Database for the Rapid Assessment of Evolving Neuropathologic Conditions
The field of dementia research is rapidly evolving, especially with regards to our understanding of the diversity of neuropathologic changes that underlie cognitive decline. Definitions and criteria for known conditions are being periodically revised and refined, and new findings are being made about neuropathologic features associated with dementia status. The database maintained by the National Alzheimer’s Coordinating Center (NACC) offer researchers a robust, rapid, and statistically well-powered method to evaluate the implications of newly identified neuropathologic conditions with regards to comorbidities, demog...
Source: Alzheimer Disease and Associated Disorders - April 1, 2020 Category: Geriatrics Tags: Special Article Source Type: research

Identifying Adaptive and Maladaptive Behaviors Following a Diagnosis of Mild Cognitive Impairment.
DISCUSSION: Developing strategies to circumvent the development of maladaptive behaviors could significantly reduce morbidity and mortality in MCI patients. PMID: 32218064 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 29, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Factor Consistency of Neuropsychological Test Battery Versions in the NACC Uniform Data Set.
Authors: Culhane JE, Chan KCG, Teylan MA, Chen YC, Mock C, Gauthreaux K, Kukull WA Abstract The proprietary neuropsychological tests (Form C1) of the National Alzheimer's Coordinating Center (NACC) Uniform Data Set were replaced with nonproprietary versions (Form C2) chosen to closely model their proprietary counterparts. Correlations between analogous test pairs as measured in previous work were good (0.68-0.78), but it is unclear whether the paired tests represent the same set of common factors of cognition or if important factors specific to C1 or C2 only exist. The authors performed multiple factor analysis to ...
Source: Alzheimer Disease and Associated Disorders - March 29, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

"My Parent's Body Is Sacred": Perspectives From Adult Latino Children About Brain Donation for Alzheimer Disease Research.
This study examines knowledge, attitudes, and beliefs about brain donation for research among Latinos. Latino men (N=4) and Latina women (N=11) 18 years of age or older with a parental figure age 65 years and over were invited to participate in a focus group. RESULTS: Data analyses revealed 3 themes. Two themes focused on factors influencing a family's willingness to support brain donation: (a) social and cultural contexts, and (b) lack of knowledge and information about the brain donation process. The last theme provided recommendations for engaging older Latino adults in ADRD research and brain donation. DISCUSSI...
Source: Alzheimer Disease and Associated Disorders - March 29, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Conversion of Mild Cognitive Impairment to Alzheimer Disease in Monolingual and Bilingual Patients.
DISCUSSION: The findings suggest that greater cognitive reserve as measured by language status leads to faster conversion between MCI and AD, all else being equal. PMID: 32049674 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alzheimer Disease and Cancer: A National Inpatient Sample Analysis.
DISCUSSION: This secondary data analysis further demonstrated an inverse relationship between AD and 10 cancer types, with prostate, ovarian, and lung cancers displaying the greatest inverse relationship. Pin1 underexpressing cancer types had a significantly higher likelihood of secondary diagnosis of AD than Pin1 overexpressing cancer types. PMID: 31990712 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 29, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association Between Gait, Cognition, and Gray Matter Volumes in Mild Cognitive Impairment and Healthy Controls.
Authors: Cosentino E, Palmer K, Della Pietà C, Mitolo M, Meneghello F, Levedianos G, Iaia V, Venneri A Abstract AIMS: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between gait and gray matter volumes. MATERIALS AND METHODS: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). Participants underwent comprehensive neuropsychological assessment. Gait speed, cadence,...
Source: Alzheimer Disease and Associated Disorders - January 26, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.
CONCLUSIONS: Although our findings were inconclusive, the earlier age of onset observed among neurodegenerative disease patients carrying the CCR5-delta32 allele suggests that the deletion may have a detrimental effect in the context of neurodegeneration. PMID: 31972607 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 25, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Impact of the Prevalence of Cognitive Impairment on the Accuracy of the Montreal Cognitive Assessment: The Advantage of Using two MoCA Thresholds to Identify Error-prone Test Scores.
CONCLUSION: In comparison to a dichotomous threshold, considering the most error-prone test scores as uncertain enables a classification that offers adequate classification accuracies in a larger number of clinical settings. PMID: 31934880 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 16, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Capgras Syndrome in the Young: Schizophrenia or Alzheimer Disease?
Authors: Ng KP, Wong B, Xie W, Kandiah N Abstract This is a case report of an atypical presentation of early onset Alzheimer disease (EOAD) in a young patient with Capgras syndrome and cognitive impairment. The concurrent onset of psychiatric and cognitive symptoms prompted a detailed evaluation for a neurodegenerative disease. A 50-year-old male lawyer presented with low mood, apathy, delusions, and auditory hallucinations over 18 months. He considered his wife as an imposter and would require her text message to confirm her identity. He became more forgetful and had to give up his law practice. His neuropsycholog...
Source: Alzheimer Disease and Associated Disorders - January 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Prevalence of Mild Cognitive Impairment in the Elderly Population in Greece: Results From the HELIAD Study.
CONCLUSIONS: MCI prevalence in the elderly population in Greece is on par with previously reported rates. Prospective studies with robust methodology will enhance our understanding of the dementia continuum. PMID: 31913961 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Past as Seen by Women and Men With Alzheimer Disease: Sex Differences in Autobiographical Memory.
DISCUSSION: AD seems to equally affect the ability of women and men with AD to construct specific autobiographical memories, to mentally travel in time to relive these memories, to construct mental visual images during memory retrieval, and to organize and monitor search processes, as the latter are mirrored by retrieval time. However, women with AD seem to attribute greater emotional value to autobiographical memories than men with AD. PMID: 31913962 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Anticholinergic Use Among the Elderly With Alzheimer Disease in South Korea: A Population-based Study.
CONCLUSIONS: Heavy use of strong ACs was more prevalent in patients with AD than in non-AD elderly. Multiple ACs for treating multimorbidities in AD were mainly attributable to their heavy use. In patients with AD, the integrated management of medications for reducing the preventable heavy use of these drugs should be reinforced. PMID: 31913963 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 9, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You to Our Reviewers in 2019!
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2020 Category: Geriatrics Tags: Guest Reviewers Acknowledgement Source Type: research