Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition.
DISCUSSION: Cognitive complaints have robust associations with QOL. These findings have implications for AD prevention trials and management of clinical populations. PMID: 29944474 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 28, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alzheimer Disease Clinical Trial Recruitment: Does Participation in a Brief Cognitive Screen at a Community Health Fair Promote Research Engagement?
CONCLUSIONS: Completing a BCS at a community event may be an indicator of future research engagement, but for those already interested in participation, the BCS may be a poor indicator of future involvement. The BCS may also reduce anxiety and stigma around memory evaluation, which may translate into research engagement in the future. PMID: 29944475 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 28, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer's Disease: Post Hoc Analyses From a Randomized, Controlled, Clinical Trial of Patients Treated With Cholinesterase Inhibitors.
Authors: Grossberg GT, Alva G, Hendrix S, Ellison N, Kane MC, Edwards J Abstract Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus) and baseline to endpoint changes on the Severe Impairment Battery (SIB) in a 24-week, randomized trial (NCT00322153) in patients with moderate to severe Alzheimer's disease taking a cholinesterase inhibitor (ChEI). A post hoc analysis compared patients receiving memantine ER/ChEI to placebo/ChEI for time to onset of response and if the response was maintained (a...
Source: Alzheimer Disease and Associated Disorders - May 21, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Recruiting the Oldest-old for Clinical Research.
Authors: Melikyan ZA, Greenia DE, Corrada MM, Hester MM, Kawas CH, Grill JD PMID: 29734262 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 9, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Medicare Expenditures and Health Care Utilization in a Multiethnic Community-based Population With Dementia From Incidence to Death.
DISCUSSION: Health care spending for patients with dementia after diagnosis through the end-of-life is high and varies by ethnicity. PMID: 29734263 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 9, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Accuracy of INECO Frontal Screening in the Diagnosis of Executive Dysfunction in Frontotemporal Dementia and Alzheimer Disease.
CONCLUSION: The present study suggested that the IFS may be used to screen for executive dysfunction in dementia. Nonetheless, it should be used with caution in the differential diagnosis between AD and bvFTD. PMID: 29734264 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 9, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Self-awareness of Driving Ability in the Healthy Elderly and Patients With Mild Cognitive Impairment (MCI).
DISCUSSION: Our findings suggest that the ability of MCI patients to evaluate their driving performance accurately seems to be enhanced or compromised, depending on the number of cues available in their environment, suggesting that providing feedback may improve their metacognitive abilities. PMID: 29702488 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 29, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Effects of the Tailored Activity Program in Brazil (TAP-BR) for Persons With Dementia: A Randomized Pilot Trial.
The objectives of this study were to evaluate the effects of the Tailored Activity Program-Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden. MATERIALS AND METHODS: A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care. Dyads were recruited from the community of Santos City, Brazil. RESULTS: For persons with dementia, 50% were female individuals, the average age was 81.37 (&p...
Source: Alzheimer Disease and Associated Disorders - April 28, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Participant Satisfaction With Learning Alzheimer Disease Clinical Trial Results.
Authors: Pierce AL, Cox CG, Nguyen H, Hoang D, Witbracht M, Gillen DL, Grill JD PMID: 29683808 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 25, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Circadian Rhythms Disturbances in Alzheimer Disease: Current Concepts, Diagnosis, and Management
The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronounced in patients with AD. The lack of trials evaluating the management of ...
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Review Article Source Type: research

Autopsy of an Elderly Man With Incidentally Diagnosed TDP-43 Proteinopathy
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Brief Reports Source Type: research

Elevated ALS Biomarker Levels in CSF of a FTD Patient at the Presymptomatic Stage of ALS
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Brief Reports Source Type: research

That’s Inappropriate! Social Norms in an Older Population-based Cohort
Conclusions: In population-based normative data on the SNQ22. age and sex influenced total score and over-adherence errors, which showed the expected associations with CDR and other cognitive domains. Social norms screening may be useful in the cognitive assessment of older adults. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Sex Differences in Neuropsychological Test Performance in Alzheimer’s Disease and the Influence of the ApoE Genotype
Conclusions: The superiority of healthy men compared with women in tasks of object naming, constructional praxis, and visual memory seems to remain stable when people develop AD, indicating larger cognitive reserves in men. In contrast, findings that cognitively healthy women outperform men in tests of verbal memory and verbal fluency are not stable in AD. Further studies are needed to gain insight in the reasons for sex differences. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Change in Engagement in Cognitive Activity and Risk for Mild Cognitive Impairment in a Cohort of Older Adults: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Study
Engagement in cognitively stimulating activities is gaining prominence as a potential strategy to maintain cognitive functioning in old age. In a population-based cohort of individuals aged 65+ years, we examined patterns of change in frequency of engagement in total cognitive activity (TCA), higher cognitive activity (HCA), and frequent cognitive activity (FCA) based on the Florida Cognitive Activities Scale over an average of 3.62 years, and whether these patterns were associated with incident mild cognitive impairment (MCI) during this same period. Among 867 cognitively normal participants, 129 (15%) progressed to MCI. ...
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity
Previous reports suggest race/ethnic and sex heterogeneity in the association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene and cognitive decline. Tests of verbal memory, processing speed, and verbal fluency and a composite global Z-score were used to assess cognitive performance longitudinally in a large (n=11,620) biracial cohort of older adults in the Atherosclerosis Risk in Communities Neurocognitive Study from midlife to older age. Linear mixed models were used to estimate associations between the Ala12 allele and cognitive performance over 20 years of follow-up...
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Diabetic Retinopathy and Dementia in Type 1 Diabetes
Conclusions: DR was not associated with risk of dementia, suggesting that pathophysiological processes underlying dementia may be different in type 1 versus type 2 diabetes. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment
Conclusions: These data suggest that the MoCA-MIS, a recall score from items within the MoCA, is better at discriminating NCs from subjects with aMCI than the Craft Story. Word recall may be an efficient alternative to paragraph recall for diagnostic screening within clinical practice and research settings. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Computerized Cognitive Testing in Primary Care: A Qualitative Study
Computerized cognitive assessment tools may facilitate early identification of dementia in the primary care setting. We investigated primary care physicians’ (PCPs’) views on advantages and disadvantages of computerized testing based on their experience with the Computer Assessment of Mild Cognitive Impairment (CAMCI). Over a 2-month period, 259 patients, 65 years and older, from the family practice of 13 PCPs completed the CAMCI. Twelve PCPs participated in an individual interview. Generally, PCPs felt that the relationship between them and their patients helped facilitate cognitive testing; however, they thou...
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Self-awareness of Driving Ability in the Healthy Elderly and Patients With Mild Cognitive Impairment (MCI)
Discussion: Our findings suggest that the ability of MCI patients to evaluate their driving performance accurately seems to be enhanced or compromised, depending on the number of cues available in their environment, suggesting that providing feedback may improve their metacognitive abilities. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults: Role of Spatial Navigation Abilities
Conclusions: Findings suggest that cerebral amyloid deposition is associated with lower perceived ability to navigate the environment, which may lead older adults with AD pathology to limit their driving extent. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore
Conclusions: MTA graded on CT is a viable alternative to MRI to aid in the diagnosis of dementia in memory clinics. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Inferior Parietal Cortex Hypoperfusion is the Most Specific Imaging Marker for AD Patients With Positive CSF Biomarker Assays in a Memory Clinic in France
This study included 120 patients referred to a university memory clinic assessed using HMPAo SPECT, MRI, and CSF biomarkers. Three biomarker signatures suggestive of AD were analyzed (1, Aß1-42; 2, Aß1-42+t-tau and/or p-tau; 3, Aß1-42/p-tau). The clinical diagnoses were possible AD (n=29) or other causes of cognitive impairment (n=91). All CSF AD signatures were significantly (1, P=0.004; 2, P=0.017; 3, P=0.024) associated with the difference between inferior parietal perfusion and lateral dorsal frontal cortex perfusion. The hypoperfusion pattern discriminated between patients with positive CSF AD biomar...
Source: Alzheimer Disease and Associated Disorders - April 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults: Role of Spatial Navigation Abilities.
CONCLUSIONS: Findings suggest that cerebral amyloid deposition is associated with lower perceived ability to navigate the environment, which may lead older adults with AD pathology to limit their driving extent. PMID: 29578861 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 27, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years.
CONCLUSIONS: Memory impairment per se, impairment in multiple cognitive domains and severity of memory impairment were all associated with greater risk of developing AD dementia in this sample. Characterizing the severity of memory impairment may provide prognostic stratification within Petersen or Winblad taxonomies of amnestic MCI. PMID: 29561277 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 25, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Psychosis in "Cognitively Asymptomatic" Elderly Subjects is Associated With Neuritic Plaque Load, Not Neurofibrillary Tangles.
DISCUSSION: The load of NP may be an important substrate of psychosis in individuals who show no gross cognitive symptoms. PMID: 29553944 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 22, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Early Midlife Pulmonary Function and Dementia Risk.
CONCLUSIONS: In this large, diverse cohort, multiple measures of PPF in early adulthood to midlife were associated with dementia risk independent of smoking and vascular comorbidities. PMID: 29543604 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 17, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You 2017 Reviewers!
Authors: PMID: 29543605 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 17, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dementia Prevalence in Greece: The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD).
CONCLUSIONS: Our results are consistent with previous research in Southern European countries; dementia prevalence in Greece is in the lower range of what has been reported globally. PMID: 29528855 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 13, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

When Decrease A β1-42 in CSF May Not Mean Alzheimer's Disease: Insights From Two Case Reports With Early Onset Dementia.
When Decrease Aβ1-42 in CSF May Not Mean Alzheimer's Disease: Insights From Two Case Reports With Early Onset Dementia. Alzheimer Dis Assoc Disord. 2018 Mar 09;: Authors: Ladeira F, Cação G, Correia AP, Pinto PS, Cavaco S, Melo-Pires M, Alonso I, Taipa R PMID: 29528856 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 13, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Anticholinergic Medications and Cognitive Function in Late Midlife.
Authors: Limback-Stokin MM, Krell-Roesch J, Roesler K, Hansen A, Stonnington CM, Temkit M, Caselli RJ, Geda YE PMID: 29481373 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 28, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Role of Personality in a Regular Cognitive Monitoring Program.
This study examines the role of personality in cognitive performance, adherence, and satisfaction with regular cognitive self-monitoring. MATERIALS AND METHODS: One hundred fifty-seven cognitively healthy older adults, age 55+, completed the 44-item Big-Five Inventory and were subsequently engaged in online monthly cognitive monitoring using the Cogstate Brief Battery for up to 35 months (M=14 mo, SD=7 mo). The test measures speed and accuracy in reaction time, visual learning, and working memory tasks. RESULTS: Neuroticism, although not related to cognitive performance overall (P>0.05), was relate...
Source: Alzheimer Disease and Associated Disorders - February 21, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients.
CONCLUSIONS: The present study is the first to document the factorial structure of the FTD-FRS and its convergent validity with the CDR-FTLD. These tools are key to determine dementia severity in FTD. The Brazilian FTD-FRS demonstrated adequate psychometric properties for use in Brazil. This instrument may contribute to disease staging in FTD and may help to document intervention-related changes. PMID: 29438114 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 14, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Lacosamide in the Management of Behavioral Symptoms in Frontotemporal Dementia: A 2-Case Report.
Authors: Di Lorenzo F, Motta C, Caltagirone C, Koch G, Mercuri NB, Martorana A PMID: 29389672 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 3, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Primary Angiitis of the Central Nervous System Mimicking Sporadic Creutzfeldt-Jakob Disease: A Case Study.
Authors: He D, Cai G, Li Y, Liu Q, Xiao K, Liu C, Chu L, Wu S, Liu F, You M, Jiang W PMID: 29369829 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 27, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Circadian Rhythms Disturbances in Alzheimer Disease: Current Concepts, Diagnosis, and Management.
Authors: Milán-Tomás Á, Shapiro CM Abstract The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronoun...
Source: Alzheimer Disease and Associated Disorders - January 21, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Political Ideology, Confidence in Science, and Participation in Alzheimer Disease Research Studies.
CONCLUSIONS AND RELEVANCE: Clinical studies of AD are likely biased toward participants who are more liberal and have higher confidence in science than the general population. This recruitment bias may be reduced by lowering the trust demanded of participants through measures such as returning research results to participants. PMID: 29351092 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 21, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Evidence-based Interpretation of Amyloid- β PET Results: A Clinician's Tool.
CONCLUSION: This evidence-based approach might provide guidance to clinicians and nuclear medicine physicians to interpret amyloid-β PET results for early and differential diagnosis of patients with progressive cognitive impairment. PMID: 29334498 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 17, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Function and its Risk Factors Among Older US Adults Living at Home.
Authors: Dale W, Kotwal AA, Shega JW, Schumm LP, Kern DW, Pinto JM, Pudelek KM, Waite LJ, McClintock MK Abstract BACKGROUND: The Montreal Cognitive Assessment (MoCA) has not been administered to a representative national sample, precluding comparison of patient scores to the general population and for risk factor identification. METHODS: A validated survey-based adaptation of the MoCA (MoCA-SA) was administered to a probability sample of home-dwelling US adults aged 62 to 90, using the National Social Life, Health, and Aging Project (n=3129), yielding estimates of prevalence in the United States. The associatio...
Source: Alzheimer Disease and Associated Disorders - January 17, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment.
CONCLUSIONS: These data suggest that the MoCA-MIS, a recall score from items within the MoCA, is better at discriminating NCs from subjects with aMCI than the Craft Story. Word recall may be an efficient alternative to paragraph recall for diagnostic screening within clinical practice and research settings. PMID: 29319601 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 12, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders.
Authors: Reuber M, Blackburn DJ, Elsey C, Wakefield S, Ardern KA, Harkness K, Venneri A, Jones D, Shaw C, Drew P Abstract OBJECTIVE: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD). METHODS: In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 i...
Source: Alzheimer Disease and Associated Disorders - January 12, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.
Authors: Ganguli M, Albanese E, Seshadri S, Bennett DA, Lyketsos C, Kukull WA, Skoog I, Hendrie HC Abstract Over recent decades, epidemiology has made significant contributions to our understanding of dementia, translating scientific discoveries into population health. Here, we propose reframing dementia epidemiology as "population neuroscience," blending techniques and models from contemporary neuroscience with those of epidemiology and biostatistics. On the basis of emerging evidence and newer paradigms and methods, population neuroscience will minimize the bias typical of traditional clinical research,...
Source: Alzheimer Disease and Associated Disorders - January 12, 2018 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Gintonin Administration is Safe and Potentially Beneficial in Cognitively Impaired Elderly
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Brief Reports Source Type: research

Sporadic Cerebral Amyloid Angiopathy With Cortical Occipital Calcifications in the Elderly
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Brief Reports Source Type: research

Different Exposures to Risk Factors Do Not Explain the Inverse Relationship of Occurrence Between Cancer and Neurodegenerative Diseases: An Italian Nested Case-control Study
Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed to determine the odds ratios (OR) and 95% confidence intervals (CI) of AD/PD in subjects with and witho...
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Assessing Fitness to Drive in Patients With Different Types of Dementia
Dementia is a risk factor for unsafe driving. Therefore, an assessment strategy has recently been developed for the prediction of fitness to drive in patients with the Alzheimer disease (AD). The aim of this study was to investigate whether this strategy is also predictive of fitness to drive in patients with non-AD dementia, that is, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. Predictors were derived from 3 types of assessment: clinical interviews, neuropsychological tests, and driving simulator rides. The criterion was the pass-fail outcome of an official on-road driving assessment. About h...
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

[18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia
Conclusions: These findings show that [18F]-THK5351 retention may be detected in cortical regions correlating with svPPA pathology. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Predictors of Driving Cessation in Dementia: Baseline Characteristics and Trajectories of Disease Progression
A diagnosis of dementia implies the eventual need to relinquish driving. This is associated with significant morbidity and anticipating when it will need to occur can be important for planning. Patients, however, vary in the course of their disease. We sought to identify predictors of driving cessation in patients with dementia, including both baseline characteristics and changes in cognition and function over time as indicators of disease trajectory. A total of 779 patients with dementia were recruited from 9 memory clinics around Australia. Patients and their carers reported their driving status and completed measures of...
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Baseline White Matter Hyperintensities and Hippocampal Volume are Associated With Conversion From Normal Cognition to Mild Cognitive Impairment in the Framingham Offspring Study
We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. Methods: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain volu...
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research

Brain Volumes and Longitudinal Cognitive Change: A Population-based Study
Objective: To investigate the association of brain volumes, white matter lesion (WML) volumes, and lacunes, with cognitive decline in a population-based cohort of nondemented persons. Methods: Within the Rotterdam Study, 3624 participants underwent brain magnetic resonance imaging. Cognition was evaluated at baseline (2005 to 2009) and at the follow-up visit (2011 to 2013). We used a test battery that tapped into domains of executive function, information processing speed, motor speed, and memory. The volumetric measures assessed were total brain volume, lobar (gray matter and white matter) volumes, and hippocampal vo...
Source: Alzheimer Disease and Associated Disorders - January 1, 2018 Category: Geriatrics Tags: Original Articles Source Type: research