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Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).
DISCUSSION: The UDSNB 3.0 neuropsychological battery provides a valuable non proprietary resource for conducting research on cognitive aging and dementia. PMID: 29240561 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Occurrence of Impaired Physical Performance in Memory Clinic Patients With Cerebral Small Vessel Disease.
In this study, we investigated the cooccurrence of clinically relevant impairments in physical performance and CSVD in memory clinic patients. We included 131 patients with vascular brain injury, mild cognitive impairment or Alzheimer disease with available 3T MRI and physical performance scores. CSVD was visually rated according to 3 subtypes and as a total burden score, composed of the presence of white matter hyperintensities (WMH), lacunar infarcts (LI), and cerebral microbleeds (MB). Physical performance was assessed with the Short Physical Performance Battery (SPPB), covering gait speed, balance, and chair stand perf...
Source: Alzheimer Disease and Associated Disorders - December 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment.
CONCLUSIONS: We achieved reasonably high prediction accuracy using only clinical variables. The approach used here could be useful for study enrichment in preclinical trials where enrolling participants at risk of cognitive decline is critical for proving study efficacy, and also for developing a shorter assessment battery. PMID: 29227306 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 13, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore.
CONCLUSIONS: MTA graded on CT is a viable alternative to MRI to aid in the diagnosis of dementia in memory clinics. PMID: 29200011 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 6, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Elevated ALS Biomarker Levels in CSF of a FTD Patient at the Presymptomatic Stage of ALS.
Authors: Cognat E, De Schaepdryver M, Hugon J, Poesen K, Paquet C PMID: 29189300 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 5, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Assessing Fitness to Drive in Patients With Different Types of Dementia.
Authors: Piersma D, Fuermaier ABM, De Waard D, Davidse RJ, De Groot J, Doumen MJA, Bredewoud RA, Claesen R, Lemstra AW, Scheltens P, Vermeeren A, Ponds R, Verhey F, De Deyn PP, Brouwer WH, Tucha O Abstract Dementia is a risk factor for unsafe driving. Therefore, an assessment strategy has recently been developed for the prediction of fitness to drive in patients with the Alzheimer disease (AD). The aim of this study was to investigate whether this strategy is also predictive of fitness to drive in patients with non-AD dementia, that is, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. Pred...
Source: Alzheimer Disease and Associated Disorders - December 5, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sex Differences in Neuropsychological Test Performance in Alzheimer's Disease and the Influence of the ApoE Genotype.
CONCLUSIONS: The superiority of healthy men compared with women in tasks of object naming, constructional praxis, and visual memory seems to remain stable when people develop AD, indicating larger cognitive reserves in men. In contrast, findings that cognitively healthy women outperform men in tests of verbal memory and verbal fluency are not stable in AD. Further studies are needed to gain insight in the reasons for sex differences. PMID: 29189302 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 5, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Biomarkers of Cognitive Impairment: Brain Cortical Thickness, Volumetrics, and Cerebrospinal Fluid.
Authors: Ghazi-Saidi L, Walsh RR, Shan G, Banks SJ PMID: 29189303 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 5, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Factors Related to Different Objects of Awareness in Alzheimer Disease.
Authors: Lacerda IB, Santos RL, Neto JPS, Dourado MCN Abstract Awareness of deficits is a multidimensional phenomenon described as the ability to acknowledge difficulties and impairments. We investigated whether unawareness affects distinct domains to different degrees and identified the factors related to the awareness impairment in Alzheimer Disease (AD). Using a cross-sectional design, we assessed 89 people with AD (PwAD) and their caregivers. Awareness was evaluated by scoring discrepant responses between PwAD and their caregivers across domains including cognitive functioning and health condition, functional a...
Source: Alzheimer Disease and Associated Disorders - November 23, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

That's Inappropriate! Social Norms in an Older Population-based Cohort.
CONCLUSIONS: In population-based normative data on the SNQ22. age and sex influenced total score and over-adherence errors, which showed the expected associations with CDR and other cognitive domains. Social norms screening may be useful in the cognitive assessment of older adults. PMID: 29140857 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Computerized Cognitive Testing in Primary Care: A Qualitative Study.
Authors: Millett G, Naglie G, Upshur R, Jaakkimainen L, Charles J, Tierney MC Abstract Computerized cognitive assessment tools may facilitate early identification of dementia in the primary care setting. We investigated primary care physicians' (PCPs') views on advantages and disadvantages of computerized testing based on their experience with the Computer Assessment of Mild Cognitive Impairment (CAMCI). Over a 2-month period, 259 patients, 65 years and older, from the family practice of 13 PCPs completed the CAMCI. Twelve PCPs participated in an individual interview. Generally, PCPs felt that the relationship betw...
Source: Alzheimer Disease and Associated Disorders - November 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Patient and Caregiver Assessment of the Benefits From the Clinical Use of Amyloid PET Imaging.
DISCUSSION: Patients and caregivers supported the use of amyloid PET imaging in clinical practice and felt that the information would provide significant benefits particularly in terms of future planning. PMID: 29140859 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity.
Authors: West NA, Tingle JV, Simino J, Selvin E, Bressler J, Mosley TH Abstract Previous reports suggest race/ethnic and sex heterogeneity in the association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene and cognitive decline. Tests of verbal memory, processing speed, and verbal fluency and a composite global Z-score were used to assess cognitive performance longitudinally in a large (n=11,620) biracial cohort of older adults in the Atherosclerosis Risk in Communities Neurocognitive Study from midlife to older age. Linear mixed models were used to estimate as...
Source: Alzheimer Disease and Associated Disorders - November 9, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sporadic Cerebral Amyloid Angiopathy With Cortical Occipital Calcifications in the Elderly.
Authors: Nicolas G, Martinaud O PMID: 29077577 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 29, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Change in Engagement in Cognitive Activity and Risk for Mild Cognitive Impairment in a Cohort of Older Adults: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Study.
Authors: Hughes TF, Sun Z, Chang CH, Ganguli M Abstract Engagement in cognitively stimulating activities is gaining prominence as a potential strategy to maintain cognitive functioning in old age. In a population-based cohort of individuals aged 65+ years, we examined patterns of change in frequency of engagement in total cognitive activity (TCA), higher cognitive activity (HCA), and frequent cognitive activity (FCA) based on the Florida Cognitive Activities Scale over an average of 3.62 years, and whether these patterns were associated with incident mild cognitive impairment (MCI) during this same period. Among 86...
Source: Alzheimer Disease and Associated Disorders - October 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Gintonin Administration is Safe and Potentially Beneficial in Cognitively Impaired Elderly.
Authors: Moon J, Choi SH, Shim JY, Park HJ, Oh MJ, Kim M, Nah SY PMID: 29028648 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

[18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia.
CONCLUSIONS: These findings show that [F]-THK5351 retention may be detected in cortical regions correlating with svPPA pathology. PMID: 29028649 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Systemic Inflammation in Lewy Body Diseases: A Systematic Review.
Authors: King E, Thomas A Abstract Few studies have investigated the role of inflammation in Lewy body dementia (LBD) and variable results have been found. We systematically reviewed the literature for evidence of systemic inflammatory changes in dementia with Lewy bodies and Parkinson disease dementia. Owing to the low number of studies we also included Parkinson disease. Key terms were used to search the relevant databases. Titles and abstracts were screened and potentially relevant articles were reviewed in full. References of included studies and relevant reviews were searched. The database search returned 2166...
Source: Alzheimer Disease and Associated Disorders - October 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Baseline White Matter Hyperintensities and Hippocampal Volume are Associated With Conversion From Normal Cognition to Mild Cognitive Impairment in the Framingham Offspring Study.
We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain vol...
Source: Alzheimer Disease and Associated Disorders - October 7, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictors of Driving Cessation in Dementia: Baseline Characteristics and Trajectories of Disease Progression.
Authors: Connors MH, Ames D, Woodward M, Brodaty H Abstract A diagnosis of dementia implies the eventual need to relinquish driving. This is associated with significant morbidity and anticipating when it will need to occur can be important for planning. Patients, however, vary in the course of their disease. We sought to identify predictors of driving cessation in patients with dementia, including both baseline characteristics and changes in cognition and function over time as indicators of disease trajectory. A total of 779 patients with dementia were recruited from 9 memory clinics around Australia. Patients and ...
Source: Alzheimer Disease and Associated Disorders - October 7, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Machine-learning Support to Individual Diagnosis of Mild Cognitive Impairment Using Multimodal MRI and Cognitive Assessments.
CONCLUSION: Feature selection was profoundly driven by statistical independence. Some features showed no between-group differences, or showed a trend in either direction. This indicates that clinically relevant brain alterations typical of MCI might be subtle and not inferable from group analysis. PMID: 28891818 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 13, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Factors Influencing Successful Lumbar Puncture in Alzheimer Research.
CONCLUSIONS: LP in Alzheimer disease research is generally safe and well tolerated. Factors influencing LP agreement potentially could be studied to advance participant acceptance of the procedure. PMID: 28891819 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 13, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Different Exposures to Risk Factors Do Not Explain the Inverse Relationship of Occurrence Between Cancer and Neurodegenerative Diseases: An Italian Nested Case-control Study.
Authors: Prinelli F, Adorni F, Leite MLC, Pettenati C, Russo A, Di Santo S, Musicco M Abstract Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed ...
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Report of p.Val717Phe Mutation in the APP Gene in a Hungarian Family With Alzheimer Disease: A Phenomenological Study.
Authors: Zádori D, Füvesi J, Timár E, Horváth E, Bencsik R, Szépfalusi N, Must A, Vécsei L, Molnár MJ, Klivényi P PMID: 28796010 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Nature and Natural History of Posterior Cortical Atrophy Syndrome: A Variant of Early-onset Alzheimer Disease.
Authors: Panegyres PK, Goh J, McCarthy M, Campbell AI Abstract A prospective longitudinal evaluation of 12 patients over a 16-year interval using clinical neurological and imaging data to determine whether posterior cortical atrophy syndrome (PCA) related to early-onset Alzheimer disease (AD) and to examine its natural history. Our 12 patients had a median age of onset of 56 years (range, 48 to 63 y) and were followed for a median of 6 years (range, 3 to 9 y). Patients either presented with complex visual phenomena or developed them with time. Six patients underwent flurodeoxyglucose and Pittsburgh investigational ...
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Use of the Clinical Dementia Rating Scale Sum of Boxes Scores in Detecting and Staging Cognitive Impairment/Dementia in Brazilian Patients With Low Educational Attainment.
Authors: Lima APV, Castilhos R, Chaves MLF Abstract The aim of this study was to evaluate the Clinical Dementia Rating Scale sum of the boxes (CDR-SB) diagnostic validity in detecting and staging cognitive impairment/dementia in a sample of Brazilian patients with amnestic mild cognitive impairment (aMCI), Alzheimer disease (AD), and vascular dementia (VD), of low educational attainment. Data were obtained from the Dementia Clinic of Hospital de Clínicas de Porto Alegre database and included 407 participants (115 healthy elderly, 41 aMCI, 165 AD, and 86 VD). Receiver operating characteristic curves were gene...
Source: Alzheimer Disease and Associated Disorders - July 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

WeCareAdvisor™: The Development of a Caregiver-focused, Web-based Program to Assess and Manage Behavioral and Psychological Symptoms of Dementia
Conclusions: The WeCareAdvisor was designed with input on functionality and content by end-users, family caregivers. The randomized controlled trial of WeCareAdvisor will test whether the tool improves outcomes including caregiver upset and burden and frequency and severity of BPSD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Article Source Type: research

Autoimmune Frontotemporal Dementia: A New Nosological Entity?
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Sarcopenia is Associated With Impairment of Activities of Daily Living in Japanese Patients With Early-Stage Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Repressive Coping Does Not Contribute to Anosognosia in First-Diagnosis Patients With Alzheimer Disease
Anosognosia is common in patients with Alzheimer disease (AD) even in early stages. Although neural correlates and the impact of cognitive dysfunctions have been described, possible psychodynamic processes such as a repressive coping style as described in other illnesses, have not been examined. Our study aimed to examine possible psychological influence factors on illness perception embracing a repressive coping style and cognitive functions in AD patients in the diagnostic process. Fifty-four subjects with mild AD diagnosed in our memory clinic were enrolled. Anosognosia was evaluated using a patient-caregiver discrepanc...
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Temporal Trends and Rural-Urban Differences in Hospital Length of Stay for Alzheimer Disease and Related Disorders
Conclusions: LOS for ADRD-related hospitalizations was found to be influenced mostly by patient-level demographic and clinical factors. Hospital-level factors were not associated with LOS. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Rapidly Progressive Dementia: Prevalence and Causes in a Neurologic Unit of a Tertiary Hospital in Brazil
Conclusions: Immune-mediated diseases were the most common cause of RPD in this series. Timely evaluation and diagnosis along with institution of appropriate therapy are required in RPD, especially in view of potentially reversible causes. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology
Conclusions: These findings potentially explain some of the variation in whether a person with AD neuropathology expresses symptoms. Understanding why some people remain cognitively normal despite having AD neuropathology could identify pathways to disease heterogeneity and guide treatment trials. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Genetic Ancestry and Susceptibility to Late-Onset Alzheimer Disease (LOAD) in the Admixed Colombian Population
Conclusions: Our results are consistent with the presence of variants of African origin in the genome of the Colombian population and different from APOE[Latin Small Letter Open E]4 that represents a risk factor for the development of LOAD, whereas variants of Native American origin may be conferring protection. However, unknown environmental factors or epigenetic differences among continental groups could also explain the observed associations. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Modeling Alzheimer Disease Through Functional Independence and Participation
This study aimed at investigating such relationships along AD evolution by means of the Disability Assessment for Dementia (DAD). Methods: Consecutive pairs of AD outpatients and their primary informal caregivers were enrolled. Patients were evaluated by means of the Mini Mental State Examination and neuropsychological tests. A clinician completed the Clinical Dementia Rating Scale to stage dementia severity and interviewed the caregivers to complete the Neuropsychiatric Inventory to assess behavioral disturbances and the DAD to evaluate patients’ functional competence. Results: A total of 158 dyads were enrolled; ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Dependence Stage and Pharmacoeconomic Outcomes in Patients With Alzheimer Disease
The level of assistance patients with Alzheimer disease (AD) require in their care may be an important predictor of resource use, costs of care, and quality of life. The Dependence Scale (DS), a measure of care-assistance required, was used to estimate costs of care and quality of life of patients with AD categorized into 6 dependence stages based upon the summated item scores of the DS. Data were derived from a 3-year, noninterventional study of 132 patients with probable AD (ages, 50 to 85 y) and caregiver dyads. We investigated the association between DS scores and health care costs, health-related quality of life (HRQo...
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Pneumonia, Intake Problems, and Survival Among Nursing Home Residents With Variable Stages of Dementia in the Netherlands: Results From a Prospective Observational Study
Discussion: Developing pneumonia and intake problems affects survival, and this is not limited to advanced dementia. The occurrence of pneumonia and intake problems are important signals to consider a palliative care approach in nursing home residents with dementia, and an active focus on advance care planning is needed. Future studies should investigate whether this is also relevant for patients in primary care. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Change in Health-related Quality of Life After Referral to Memory Assessment Services
Despite strong support for the provision of memory assessment services (MASs) in England and other countries, their effectiveness in improving patient outcomes is uncertain. We aimed to describe change in patients’ health-related quality of life (HRQL) 6 months after referral to MASs and to examine associations with patient characteristics and use of postdiagnostic interventions. Data from 883 patients referred to 69 MASs and their informal caregivers (n=569) were collected at referral and 6 months later. Multivariable linear regression was used to examine associations of change in HRQL (DEMQOL, DEMQOL-Proxy) with pa...
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Neuropsychological Testing in Pathologically Verified Alzheimer Disease and Frontotemporal Dementia: How Well Do the Uniform Data Set Measures Differentiate Between Diseases?
Conclusions: Other than memory, numerical scores of neurocognitive performance on the UDS are of limited value in differentiating FTLD from AD at the initial visit. These results highlight the difficulty of obtaining an accurate early diagnosis of FTLD and argue for adding supplemental tests to those included in the UDS to assess cognition in FTD and AD patients. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups
Conclusions: Future studies are needed to understand how immigration history, social, environmental, and genetic factors contribute to dementia risk in the growing and diverse Asian American population. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Falls and Physical Activity in Persons With Mild to Moderate Dementia Participating in an Intensive Motor Training: Randomized Controlled Trial.
Authors: Zieschang T, Schwenk M, Becker C, Uhlmann L, Oster P, Hauer K Abstract BACKGROUND: Physical activity is beneficial in people with dementia. As physical activity increases risk exposure for falls, safety concerns arise. Prior exercise trials in people with dementia have not measured physical activity. Falls in relation to exposure time rather than person-years as outcome measure has been promoted but not investigated in people with dementia. METHODS: Patients with mild to moderate dementia (n=110) were randomized to an intensive, progressive strength and functional training intervention or to a low-inte...
Source: Alzheimer Disease and Associated Disorders - June 21, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.
This study set out to clarify the differential acute cognitive impact of lorazepam based on varying genetic risk for Alzheimer disease. METHODS: Fifty-seven cognitively unimpaired individuals aged 51 to 88, genotyped according to apolipoprotein E (APOE) and translocase of outer mitochondrial membrane (40 homolog) poly-T lengths, completed cognitive testing before, 2.5 and 5 hours after receiving a 1 mg dose of lorazepam. RESULTS: Post-lorazepam, there were significant (P
Source: Alzheimer Disease and Associated Disorders - June 6, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants.
DISCUSSION: Informant report of symptoms was associated with patients' global cognition, reflecting relatively accurate informant reports in both ethnic groups, and was stronger in Hispanics when examining memory and language. Such differences may reflect cultural caregiving practices and perceptions of dementia, having implications for diagnosis and treatment. PMID: 28557843 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 1, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Total Brain and Hippocampal Volumes and Cognition in Older American Indians: The Strong Heart Study.
CONCLUSIONS: These results support further investigation into the relationship between structural Alzheimer disease biomarkers, cognition, genetics, and vascular risk factors in aging American Indians. PMID: 28538087 [PubMed - in process] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.
Authors: Koenig AM, Mechanic-Hamilton D, Xie SX, Combs MF, Cappola AR, Xie L, Detre JA, Wolk DA, Arnold SE Abstract Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the central nervous system-penetrant insulin-sensitizing medication metformin would be beneficial as a disease-modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its...
Source: Alzheimer Disease and Associated Disorders - May 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Pain, Neuropsychiatric Symptoms, and Quality of Life of Nursing Home Residents With Advanced Dementia in The Netherlands: A Cross-sectional Study.
CONCLUSIONS: Only NPS were significantly associated with QoL in nursing home residents with dementia. Further longitudinal research is needed to estimate the nature of the relationship between pain, NPS, and QoL. PMID: 28486239 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dependence Stage and Pharmacoeconomic Outcomes in Patients With Alzheimer Disease.
Authors: Michaud TL, High R, Charlton ME, Murman DL Abstract The level of assistance patients with Alzheimer disease (AD) require in their care may be an important predictor of resource use, costs of care, and quality of life. The Dependence Scale (DS), a measure of care-assistance required, was used to estimate costs of care and quality of life of patients with AD categorized into 6 dependence stages based upon the summated item scores of the DS. Data were derived from a 3-year, noninterventional study of 132 patients with probable AD (ages, 50 to 85 y) and caregiver dyads. We investigated the association between ...
Source: Alzheimer Disease and Associated Disorders - May 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups.
CONCLUSIONS: Future studies are needed to understand how immigration history, social, environmental, and genetic factors contribute to dementia risk in the growing and diverse Asian American population. PMID: 28406845 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The BIOCARD Index: A Summary Measure to Predict Onset of Mild Cognitive Impairment.
Authors: Sacktor N, Soldan A, Grega M, Farrington L, Cai Q, Wang MC, Gottesman RF, Turner RS, Albert M, BIOCARD Research Team Abstract BACKGROUND: Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. OBJECTIVE: To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. MATERIALS AND METHODS: Two hundred twenty-two participants in ...
Source: Alzheimer Disease and Associated Disorders - April 12, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia.
CONCLUSIONS AND RELEVANCE: Flortaucipir uptake distinguished individuals with PCA and amnestic AD dementia early in the symptomatic course. The posterior brain regions appear to be uniquely vulnerable to tau deposition in PCA, aligning with clinical deficits that define this disease subtype. PMID: 28394771 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 12, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research