Do the Benefits of Educational Attainment for Late-life Cognition Differ by Racial/Ethnic Group?: Evidence for Heterogenous Treatment Effects in the Kaiser Healthy Aging and Diverse Life Experience (KHANDLE) Study.
DISCUSSION: With the exception of Latino performance on verbal episodic memory, more education consistently predicted better cognitive scores to a similar extent across racial/ethnic groups, despite likely heterogenous educational and social experiences. PMID: 33044303 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Model to Assess the Outcomes Associated With Dementia With Lewy Bodies.
CONCLUSIONS: This study used real-world longitudinal data to create a clinically relevant DLB disease progression model. Reducing the rate of disease progression resulted in meaningful benefits with potentially significant public health implications. PMID: 33044304 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Tailoring Research Recruitment for Acute Care Settings: Recommendations from People with Dementia and their Caregivers.
The objectives of this study were to examine views, preferences, and recommendations regarding acute care-based ADRD research recruitment among persons with dementia and their caregivers. METHODS: The authors conducted semistructured interviews with recently hospitalized persons with dementia (N=3) and family caregivers (N=28). Interviews were analyzed using thematic analysis. FINDINGS: All participants endorsed acute care as an appropriate time for recruitment into ADRD research studies and identified important elements of an appropriately tailored recruitment approach and an interpersonally effective research sta...
Source: Alzheimer Disease and Associated Disorders - October 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

An Initial Empirical Operationalization of the Earliest Stages of the Alzheimer's Continuum.
CONCLUSION: The presence of 2 of the proposed symptom classes to separate AC stage 2 from stage 1 seems to provide a good empirical balance. PMID: 33009036 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 5, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dementia Incidence in the Elderly Population of Greece: Results From the HELIAD Study.
CONCLUSIONS: The incidence rate of dementia in people 65 years and above in Greece is generally consistent with recently published rates in Europe and North America. Advancing age, baseline MCI, and APOE-ε4 homozygosity are risk factors, while higher educational attainment seems protective. PMID: 33009037 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 5, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Confluent White Matter in Progression to Alzheimer Dementia.
The objective of this study was to evaluate the role of silent CSVD in the progression from MCI to dementia and if confluent white matter hyperintensities (WMHs) pose a higher risk for progression in the clinical setting. METHODS: Patients with MCI with baseline magnetic resonance imaging and longitudinal follow-up were evaluated. WMH were quantified using visual scoring at baseline (all subjects) and at end of study period (subgroup). Influences of baseline total WMH, baseline confluent WMH, and increase of WMH on progression from MCI to dementia were analyzed. RESULTS: A total of 200 patients with a mean age of 6...
Source: Alzheimer Disease and Associated Disorders - October 5, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Biomarker Use for Dementia With Lewy Body Diagnosis: Survey of US Experts.
CONCLUSIONS AND RELEVANCE: Neuropsychological testing and MRI remain the most widely used diagnostic tests by DLB specialists. Other tests-particularly indicative biomarkers-are used only selectively. Research is needed to validate existing potential DLB biomarkers, develop new biomarkers, and investigate mechanisms to improve DLB diagnosis. PMID: 33009039 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 5, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sex Moderates the Relationship of Stress and Perceived Social Support With Neuropsychological Symptoms Among Community-dwelling Persons With Alzheimer Disease in Spain.
Authors: Gomez-Gallego M, Gallego-Mellado M, Gómez-Gallego JC, Gómez-García JG Abstract Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) patients, especially in women. Stress and stress-vulnerability factors (eg, poor social support) may trigger NPS. This cross-sectional study (n=196) aimed to examine the moderating effect of sex on the relationships between both perceived social support and salivary cortisol levels and NPS of AD patients. Only in women, greater cortisol levels were associated with higher scores in Neuropsychiatric Inventory mood, agitation, and frontal subs...
Source: Alzheimer Disease and Associated Disorders - October 5, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Exercise and the Risk of Mild Cognitive Impairment: Does the Effect Depend on Vascular Factors?
Authors: Hughes TF, Liu A, Jacobsen E, Rosano C, Berman SB, Chang CH, Ganguli M Abstract INTRODUCTION: Although exercise is associated with a lower risk for mild cognitive impairment (MCI), it is unclear whether its protective effect depends on the presence or absence of vascular factors. METHODS: In an exploratory study of data from a population-based cohort, 1254 participants aged 65+ years were followed for 10 years for incident MCI. The main effect of baseline total minutes of exercise per week (0 vs. 1 to 149 vs. 150+), and its interaction with several vascular factors, on risk for incident MCI was examine...
Source: Alzheimer Disease and Associated Disorders - September 23, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alzheimer Disease Worries, Fears, and Stigma and Their Relationship to Genetic and Interventional Research Engagement.
CONCLUSIONS: Beliefs about AD genetic testing, AD worry, and AD stigma are related to research participation, but relationships vary based on the research participation investigated. Future work should identify how these findings can inform outreach and recruitment efforts. PMID: 32960855 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 23, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Androgen Deprivation Therapy Use and Risk of Mild Cognitive Impairment in Prostate Cancer Patients.
We examined the association between androgen deprivation therapy (ADT) use and the risk of mild cognitive impairment (MCI) among prostate cancer patients. METHODS: We included 241 cognitively unimpaired men, aged 70 to 90, with a history of prostate cancer before enrollment in the population-based Mayo Clinic Study of Aging. Using the Rochester Epidemiology Project medical records-linkage system, ADT use and length of exposure were abstracted. Follow-up visits occurred every 15 months and MCI diagnoses were made based on clinical consensus. Cox proportional hazards models, with age as the timescale, were used to examin...
Source: Alzheimer Disease and Associated Disorders - September 23, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Clinical Profiles of Arteriolosclerosis and Alzheimer Disease at Mild Cognitive Impairment and Mild Dementia in a National Neuropathology Cohort.
CONCLUSIONS: Differences between pARTE, pAD, and ADARTE emerge at mild dementia rather than MCI. APOE4 has varied cognitive and psychiatric impact dependent on neuropathology group and stage. PMID: 32925200 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 16, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predicting Mental Decline Rates in Mild Cognitive Impairment From Baseline MRI Volumetric Data.
This study quantitatively characterizes cognitive decline rates in MCI and tests whether volumetric data from baseline magnetic resonance imaging (MRI) can predict accelerated cognitive decline. METHODS: The authors retrospectively examined Alzheimer Disease Neuroimaging Initiative data to obtain serial Mini-Mental Status Exam (MMSE) scores, diagnoses, and the following baseline MRI volumes: total intracranial volume, whole-brain and ventricular volumes, and volumes of the hippocampus, entorhinal cortex, fusiform gyrus, and medial temporal lobe. Subjects with
Source: Alzheimer Disease and Associated Disorders - September 16, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Validity of the Mini-Mental State Examination-2 in Diagnosing Mild Cognitive Impairment and Dementia in Patients Visiting an Outpatient Clinic in the Netherlands.
This study examined the utility of the recently published MMSE-2:SV in detecting cognitive impairment. We used receiver operating characteristics to test the discriminative power of the MMSE-2:SV for distinguishing between older adults without mild cognitive impairment (MCI) or dementia (n=67) and patients with MCI (n=76) or dementia (n=79). The results show that the MMSE-2:SV had excellent discriminative ability in distinguishing older controls from patients with dementia, with cut-off scores of 26 and 27 (max=30) yielding appropriate sensitivity (0.810 and 0.924, respectively) and specificity (0.940 and 0.806). Discrimin...
Source: Alzheimer Disease and Associated Disorders - August 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dependence Clusters in Alzheimer Disease and Medicare Expenditures: A Longitudinal Analysis From the Predictors Study.
DISCUSSION: Dependence captures dementia care costs over time. Better characterization of dependence clusters has significant implications for understanding disease progression, trial design and care planning. PMID: 32826426 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cardiac and Blood Pressure Safety of Transdermal Rivastigmine in Elderly Patients With Dementia With Lewy Bodies.
CONCLUSIONS: Transdermal rivastigmine therapy is not associated with arrhythmogenic or hypotensive effects in the elderly patients with DLB. However, when prescribing transdermal rivastigmine, physicians should pay attention to newly emerging orthostatic hypotension during the follow-up in these patients. PMID: 32809983 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 20, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

West Nile Virus Neuroinvasive Disease Accelerating Probable Dementia With Lewy Bodies.
We describe a case of dementia with Lewy bodies immediately following encephalitis due to West Nile virus (WNV). The patient had rapid eye movement-sleep behavior disorder and constipation before the onset of encephalitis, which suggests that he would have ultimately developed dementia with Lewy bodies even without WNV infection. Our case illustrates the interactions between α-synuclein and WNV, as observed in mouse models, wherein synuclein expression augments after WNV infection and protects neurons against the virus. PMID: 32809984 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 20, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Effectiveness of Community-based Outreach Events for the Promotion of African American Research Participation.
DISCUSSION: These findings have important implications for designing and implementing community events to encourage AA research participation. PMID: 32809985 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 20, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictors of Dementia in the Oldest Old: A Novel Machine Learning Approach.
CONCLUSIONS: An atheoretical machine learning method revealed several factors associated with increased probability of dementia after age 85 years in a population-based cohort. If independently validated in other cohorts, these findings could help identify the oldest-old at the highest risk of dementia. PMID: 32701513 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Staging of Dementia Severity With the Hong Kong Version of the Montreal Cognitive Assessment (HK-MoCA)'s.
This study aimed to determine the cut-off score ranges for mild, moderate, and severe AD. METHODS: The HK-MoCA score was matched against the Clinical Dementia Rating on 155 patients with AD. Investigators performing the HK-MoCA and Clinical Dementia Rating were blinded to each other. Receiver-operating characteristic analysis was used to determine the cut-off scores between different stages of AD (mild, moderate, and severe stage). A secondary analysis with adjustments for age and education received were also performed. RESULT: The cut-off score in HK-MoCA was ≤4 for those with severe AD (sensitivity 84.4%, spec...
Source: Alzheimer Disease and Associated Disorders - July 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Value of a Panel of 6 Serum Biomarkers to Differentiate between Healthy Controls and Mild Cognitive Impairment Due to Alzheimer Disease.
CONCLUSIONS: This panel of 6 markers in blood serum may indicate underlying neurodegenerative processes in patients with AD at the MCI stage. The authors assume that a deranged equilibrium of neuroprotective and inflammatory processes is an overall major cause for neurodegeneration and cognitive decline. PMID: 32649324 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability
Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the p...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Review Article Source Type: research

Validity of the Mini-Mental State Examination-2 in Diagnosing Mild Cognitive Impairment and Dementia in Patients Visiting an Outpatient Clinic in the Netherlands
This study examined the utility of the recently published MMSE-2:SV in detecting cognitive impairment. We used receiver operating characteristics to test the discriminative power of the MMSE-2:SV for distinguishing between older adults without mild cognitive impairment (MCI) or dementia (n=67) and patients with MCI (n=76) or dementia (n=79). The results show that the MMSE-2:SV had excellent discriminative ability in distinguishing older controls from patients with dementia, with cut-off scores of 26 and 27 (max=30) yielding appropriate sensitivity (0.810 and 0.924, respectively) and specificity (0.940 and 0.806). Discrimin...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy
Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers. We conducted a comparison of CSF Aβ1-42 level, amyloid PET, and autopsy findings in a case with progressive supranuclear palsy in which biomarker acquisition and postmortem pathologic...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study
Conclusions: Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Brief Reports Source Type: research

Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons
Conclusions: Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Identifying Adaptive and Maladaptive Behaviors Following a Diagnosis of Mild Cognitive Impairment
Discussion: Developing strategies to circumvent the development of maladaptive behaviors could significantly reduce morbidity and mortality in MCI patients. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Social Inequalities in Life Expectancy and Mortality in People With Dementia in the United Kingdom
This study aimed to explore potential differentials in life expectancy and mortality in people with dementia according to social deprivation. Methods: Using The Health Improvement Network (THIN) primary care database, we included people with a diagnosis of dementia in the United Kingdom in 2000 to 2016 and obtained data on age at death and mortality. Comparisons were made according to social deprivation quintiles adjusting for age at diagnosis. Results: Among 166,268 people with dementia there were no differences in life expectancy and mortality in the most deprived compared with the least deprived. This pattern has ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Impact of the Prevalence of Cognitive Impairment on the Accuracy of the Montreal Cognitive Assessment: The Advantage of Using two MoCA Thresholds to Identify Error-prone Test Scores
Conclusion: In comparison to a dichotomous threshold, considering the most error-prone test scores as uncertain enables a classification that offers adequate classification accuracies in a larger number of clinical settings. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders
Conclusions: Although our findings were inconclusive, the earlier age of onset observed among neurodegenerative disease patients carrying the CCR5-delta32 allele suggests that the deletion may have a detrimental effect in the context of neurodegeneration. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Anticholinergic Use Among the Elderly With Alzheimer Disease in South Korea: A Population-based Study
Conclusions: Heavy use of strong ACs was more prevalent in patients with AD than in non-AD elderly. Multiple ACs for treating multimorbidities in AD were mainly attributable to their heavy use. In patients with AD, the integrated management of medications for reducing the preventable heavy use of these drugs should be reinforced. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Association Between Gait, Cognition, and Gray Matter Volumes in Mild Cognitive Impairment and Healthy Controls
Aims: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between gait and gray matter volumes. Materials and Methods: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). Participants underwent comprehensive neuropsychological assessment. Gait speed, cadence, and stride length, were assessed with the BTS FREEMG 300 device. Three-dimensional (3D) T1-weighted MR images were acquired u...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Conversion of Mild Cognitive Impairment to Alzheimer Disease in Monolingual and Bilingual Patients
Discussion: The findings suggest that greater cognitive reserve as measured by language status leads to faster conversion between MCI and AD, all else being equal. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis
Conclusion: Alpha-synuclein levels in the CSF can be used for the discrimination between LBD and AD, but not LBD and other neurodegenerative disorders such as dementia in PD, MSA, FTD, and PSP. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning
Introduction: Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects of exercise on longitudinal changes. Methods: Clinically normal individuals completed a questionnaire on phys...
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Interactions Between Acute Infarcts and Cerebrovascular Pathology Predict Poststroke Dementia
Conclusions: The risk of PSD varies depending on the presence of chronic cerebrovascular pathologies and type of acute infarcts. Clinical implications support a precision medicine approach for stratifying those at highest risk of PSD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults: Findings From the KHANDLE Study
Conclusions: The association between cognitive performance and log(ECog scores) differed little across sociodemographic and psychological factors. SCD as measured by the ECog may be a valuable proxy for cognitive performance in diverse older adults. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

Expanded Demographic Norms for Version 3 of the Alzheimer Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set
Conclusions: Although race-based norms represent incomplete proxies for other sociocultural variables, the appropriate application of these norms is important given the potential to improve diagnostic accuracy and to reduce misclassification bias in cognitive disorders of aging such as Alzheimer disease. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2020 Category: Geriatrics Tags: Original Articles Source Type: research

The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship.
Authors: Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC Abstract Cancer diagnoses are associated with better long-term memory in older adults, possibly reflecting a range of social confounders that increase cancer risk but improve memory. We used spouse's memory as a negative control outcome to evaluate this possible confounding, since spouses share social characteristics and environments, and individuals' cancers are unlikely to cause better memory among their spouses. We estimated the association of an individual's incident cancer diagnosis (exposure) with...
Source: Alzheimer Disease and Associated Disorders - June 24, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Efficacy of Mealtime Interventions for Malnutrition and Oral Intake in Persons With Dementia: A Systematic Review.
Authors: Borders JC, Blanke S, Johnson S, Gilmore-Bykovskyi A, Rogus-Pulia N Abstract Malnutrition and weight loss are highly prevalent in persons with Alzheimer's disease and related dementias. Oral intake is an important interventional target for addressing these nutritional consequences. However, the efficacy of interventions remains poorly understood as prior syntheses have failed to examine the impact of intervention approaches on malnutrition and hypothesized mechanisms of action in persons with dementia. This review aimed to determine the efficacy of mealtime interventions to improve oral intake and nutritio...
Source: Alzheimer Disease and Associated Disorders - June 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey.
CONCLUSIONS: To distinguish between SCC, aMCI, and AD in a sample of older Turkish adults, the Qmci-TR may be preferable. In very low literacy, the choice of the instrument appears less important. PMID: 32530832 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 14, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT).
CONCLUSIONS AND RELEVANCE: Regional sex-related differences in tau PET burden may contribute to the disparities in AD prevalence between males and females. The observed decreases tau PET burden in HT users has important implications for clinical practice and trials and deserves future consideration in longitudinal studies. PMID: 32520734 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy.
Authors: Kim KH, Seo JD, Kim ES, Kim HS, Jeon S, Pak K, Lee MJ, Lee JH, Lee YM, Lee K, Shin JH, Ko JK, Jung NY, Lee JM, Yoon JA, Hwang C, Ahn JW, Sung S, Spina S, Seeley WW, Choi KU, Huh GY, Kim EJ Abstract Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between t...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning.
Authors: Stojanovic M, Jin Y, Fagan AM, Benzinger TL, Hassenstab J, Cruchaga C, Morris JC, Head D Abstract INTRODUCTION: Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Takotsubo Cardiomyopathy in an Alzheimer Disease Patient: The Potential Contribution of Antidepressant Agents.
We report the case of an 83-year-old woman with advanced Alzheimer disease who had recently used nortriptyline and sertraline and was admitted with chest pain. An electrocardiogram showed ST-elevation, and markers of myocardial necrosis were slightly increased. However, coronariography did not demonstrate stenotic lesions. Transthoracic echocardiography and ventriculography identified decreased ventricular function, apical akinesia, and compensatory hyperkinesia of other segments that were compatible with TC. The patient evolved with cardiogenic shock and died. Alzheimer patients may be more susceptible to develop TC, both...
Source: Alzheimer Disease and Associated Disorders - June 11, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neck Circumference and Cerebral Gray Matter Volume.
CONCLUSIONS: In men with diabetes, NC was inversely associated with cerebral gray matter volume. The link between neck anthropometry and brain aging in diabetic men warrants further consideration. PMID: 32483016 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Expanded Demographic Norms for Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set.
CONCLUSIONS: Although race-based norms represent incomplete proxies for other sociocultural variables, the appropriate application of these norms is important given the potential to improve diagnostic accuracy and to reduce misclassification bias in cognitive disorders of aging such as Alzheimer disease. PMID: 32483017 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Interactions Between Acute Infarcts and Cerebrovascular Pathology Predict Poststroke Dementia.
CONCLUSIONS: The risk of PSD varies depending on the presence of chronic cerebrovascular pathologies and type of acute infarcts. Clinical implications support a precision medicine approach for stratifying those at highest risk of PSD. PMID: 32483018 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study.
CONCLUSIONS: Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia. PMID: 32483019 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 4, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Physical and Vestibular Physical Therapy Referrals in People With Alzheimer Disease.
Authors: Gandhi P, Klatt BN, Agrawal Y Abstract People with Alzheimer disease (AD) are at increased risk of falls and disproportionately burdened with vestibular impairment compared with healthy older adults. Although physical therapy (PT) and vestibular physical therapy (VPT) are effective rehabilitation interventions in improving balance and fall risk, referral patterns for these services in the AD population are understudied. A retrospective chart review was conducted of patients seen for primary AD care at a tertiary AD referral center to investigate the frequency of rehabilitation referrals. Of the 801 people ...
Source: Alzheimer Disease and Associated Disorders - May 31, 2020 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research