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Different Exposures to Risk Factors Do Not Explain the Inverse Relationship of Occurrence Between Cancer and Neurodegenerative Diseases: An Italian Nested Case-control Study.
Authors: Prinelli F, Adorni F, Leite MLC, Pettenati C, Russo A, Di Santo S, Musicco M Abstract Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed ...
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Report of p.Val717Phe Mutation in the APP Gene in a Hungarian Family With Alzheimer Disease: A Phenomenological Study.
Authors: Zádori D, Füvesi J, Timár E, Horváth E, Bencsik R, Szépfalusi N, Must A, Vécsei L, Molnár MJ, Klivényi P PMID: 28796010 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Nature and Natural History of Posterior Cortical Atrophy Syndrome: A Variant of Early-onset Alzheimer Disease.
Authors: Panegyres PK, Goh J, McCarthy M, Campbell AI Abstract A prospective longitudinal evaluation of 12 patients over a 16-year interval using clinical neurological and imaging data to determine whether posterior cortical atrophy syndrome (PCA) related to early-onset Alzheimer disease (AD) and to examine its natural history. Our 12 patients had a median age of onset of 56 years (range, 48 to 63 y) and were followed for a median of 6 years (range, 3 to 9 y). Patients either presented with complex visual phenomena or developed them with time. Six patients underwent flurodeoxyglucose and Pittsburgh investigational ...
Source: Alzheimer Disease and Associated Disorders - August 11, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Use of the Clinical Dementia Rating Scale Sum of Boxes Scores in Detecting and Staging Cognitive Impairment/Dementia in Brazilian Patients With Low Educational Attainment.
Authors: Lima APV, Castilhos R, Chaves MLF Abstract The aim of this study was to evaluate the Clinical Dementia Rating Scale sum of the boxes (CDR-SB) diagnostic validity in detecting and staging cognitive impairment/dementia in a sample of Brazilian patients with amnestic mild cognitive impairment (aMCI), Alzheimer disease (AD), and vascular dementia (VD), of low educational attainment. Data were obtained from the Dementia Clinic of Hospital de Clínicas de Porto Alegre database and included 407 participants (115 healthy elderly, 41 aMCI, 165 AD, and 86 VD). Receiver operating characteristic curves were gene...
Source: Alzheimer Disease and Associated Disorders - July 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Falls and Physical Activity in Persons With Mild to Moderate Dementia Participating in an Intensive Motor Training: Randomized Controlled Trial.
Authors: Zieschang T, Schwenk M, Becker C, Uhlmann L, Oster P, Hauer K Abstract BACKGROUND: Physical activity is beneficial in people with dementia. As physical activity increases risk exposure for falls, safety concerns arise. Prior exercise trials in people with dementia have not measured physical activity. Falls in relation to exposure time rather than person-years as outcome measure has been promoted but not investigated in people with dementia. METHODS: Patients with mild to moderate dementia (n=110) were randomized to an intensive, progressive strength and functional training intervention or to a low-inte...
Source: Alzheimer Disease and Associated Disorders - June 21, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.
This study set out to clarify the differential acute cognitive impact of lorazepam based on varying genetic risk for Alzheimer disease. METHODS: Fifty-seven cognitively unimpaired individuals aged 51 to 88, genotyped according to apolipoprotein E (APOE) and translocase of outer mitochondrial membrane (40 homolog) poly-T lengths, completed cognitive testing before, 2.5 and 5 hours after receiving a 1 mg dose of lorazepam. RESULTS: Post-lorazepam, there were significant (P
Source: Alzheimer Disease and Associated Disorders - June 6, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants.
DISCUSSION: Informant report of symptoms was associated with patients' global cognition, reflecting relatively accurate informant reports in both ethnic groups, and was stronger in Hispanics when examining memory and language. Such differences may reflect cultural caregiving practices and perceptions of dementia, having implications for diagnosis and treatment. PMID: 28557843 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 1, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Total Brain and Hippocampal Volumes and Cognition in Older American Indians: The Strong Heart Study.
CONCLUSIONS: These results support further investigation into the relationship between structural Alzheimer disease biomarkers, cognition, genetics, and vascular risk factors in aging American Indians. PMID: 28538087 [PubMed - in process] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.
Authors: Koenig AM, Mechanic-Hamilton D, Xie SX, Combs MF, Cappola AR, Xie L, Detre JA, Wolk DA, Arnold SE Abstract Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the central nervous system-penetrant insulin-sensitizing medication metformin would be beneficial as a disease-modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its...
Source: Alzheimer Disease and Associated Disorders - May 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Pain, Neuropsychiatric Symptoms, and Quality of Life of Nursing Home Residents With Advanced Dementia in The Netherlands: A Cross-sectional Study.
CONCLUSIONS: Only NPS were significantly associated with QoL in nursing home residents with dementia. Further longitudinal research is needed to estimate the nature of the relationship between pain, NPS, and QoL. PMID: 28486239 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dependence Stage and Pharmacoeconomic Outcomes in Patients With Alzheimer Disease.
Authors: Michaud TL, High R, Charlton ME, Murman DL Abstract The level of assistance patients with Alzheimer disease (AD) require in their care may be an important predictor of resource use, costs of care, and quality of life. The Dependence Scale (DS), a measure of care-assistance required, was used to estimate costs of care and quality of life of patients with AD categorized into 6 dependence stages based upon the summated item scores of the DS. Data were derived from a 3-year, noninterventional study of 132 patients with probable AD (ages, 50 to 85 y) and caregiver dyads. We investigated the association between ...
Source: Alzheimer Disease and Associated Disorders - May 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups.
CONCLUSIONS: Future studies are needed to understand how immigration history, social, environmental, and genetic factors contribute to dementia risk in the growing and diverse Asian American population. PMID: 28406845 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The BIOCARD Index: A Summary Measure to Predict Onset of Mild Cognitive Impairment.
Authors: Sacktor N, Soldan A, Grega M, Farrington L, Cai Q, Wang MC, Gottesman RF, Turner RS, Albert M, BIOCARD Research Team Abstract BACKGROUND: Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. OBJECTIVE: To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. MATERIALS AND METHODS: Two hundred twenty-two participants in ...
Source: Alzheimer Disease and Associated Disorders - April 12, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia.
CONCLUSIONS AND RELEVANCE: Flortaucipir uptake distinguished individuals with PCA and amnestic AD dementia early in the symptomatic course. The posterior brain regions appear to be uniquely vulnerable to tau deposition in PCA, aligning with clinical deficits that define this disease subtype. PMID: 28394771 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 12, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Genetic Ancestry and Susceptibility to Late-Onset Alzheimer's Disease (LOAD) in the Admixed Colombian Population.
CONCLUSIONS: Our results are consistent with the presence of variants of African origin in the genome of the Colombian population and different from APOE[Latin Small Letter Open E]4 that represents a risk factor for the development of LOAD, whereas variants of Native American origin may be conferring protection. However, unknown environmental factors or epigenetic differences among continental groups could also explain the observed associations. PMID: 28369008 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 4, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Closing-in is Related to Daily Living Functioning in Patients With Mild-to-Moderate Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Validity of Death Certificate and Hospital Discharge ICD Codes for Dementia Diagnosis: The Multi-Ethnic Study of Atherosclerosis
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Sociodemographic Characteristics, Cognitive Function, and Health-related Quality of Life of Patients Referred to Memory Assessment Services in England
The objectives were to: describe the characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) of referred patients, and examine the relationships between these characteristics and cognitive function (tertiles of Mini-Mental State Examination score) and health-related quality of life (HRQL) (DEMQOL, DEMQOL-Proxy). We used multivariable regression methods to analyze data from 1420 patients from 73 MAS, and their lay carers (n=1020). The mean age of patients was 78 years; 42% had cognitive function equivalent to Mini-Mental State Examination (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia
The King-Devick (K-D) test is a 1 to 2 minute, rapid number naming test, often used to assist with detection of concussion, but also has clinical utility in other neurological conditions (eg, Parkinson disease). The K-D involves saccadic eye and other eye movements, and abnormalities thereof may be an early indicator of Alzheimer disease (AD)-associated cognitive impairment. No study has tested the utility of the K-D in AD and we sought to do so. The sample included 206 [135 controls, 39 mild cognitive impairment (MCI), and 32 AD dementia] consecutive subjects from the Boston University Alzheimer’s Disease Center reg...
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Early-Onset Dementia: Frequency, Diagnostic Procedures, and Quality Indicators in Three European Tertiary Referral Centers
Conclusions: In tertiary referral centers in Copenhagen, Stockholm, and Amsterdam, quality indicators were not always met for patients with EOD. Results partly reflect differences in referral pattern, the application of diagnostic criteria, and local best practices. Standardized international procedures for patients with EOD may reduce this variability. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer’s Disease
Effective and practical recruitment strategies are needed to ensure successful recruitment into the Alzheimer disease clinical trials. To facilitate successful recruitment for the NIH-sponsored A4 (Anti-Amyloid treatment in Asymptomatic Alzheimer’s disease, NCT02008357) trial for the secondary prevention of Alzheimer disease, we developed a small-group community information session to attract and recruit potential research participants. After a successful media campaign, 213 participants were screened through telephone for eligibility, identifying 127 potential participants. Participants were given the option of a tr...
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Willingness to Be a Brain Donor: A Survey of Research Volunteers From 4 Racial/Ethnic Groups
Discussion: The predictive factors identified in this study may be useful for researchers seeking to increase participation of diverse ethnic groups in brain donation. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Attenuation of Choroidal Thickness in Patients With Alzheimer Disease: Evidence From an Italian Prospective Study
Discussion: CT in patients with AD showed a rate of thinning greater than what could be expected during the natural course of aging. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study
Discussion: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

The BIOCARD Index: A Summary Measure to Predict Onset of Mild Cognitive Impairment
Background: Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. Objective: To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. Materials and Methods: Two hundred twenty-two participants in the BIOCARD study received a detailed history, physical examination, and neuropsychological testing annually. An index was calculated by including qu...
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study
Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the central nervous system–penetrant insulin-sensitizing medication metformin would be beneficial as a disease-modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its effects on cerebrospinal fluid (CSF), neuroimaging, and cognitive biomarkers. Twenty nondiabetic subjects with mild c...
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent. We identified 10 individuals with early-stage agrammatic variant of PPA with no prominent cortic...
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Total Brain and Hippocampal Volumes and Cognition in Older American Indians: The Strong Heart Study
Conclusions: These results support further investigation into the relationship between structural Alzheimer disease biomarkers, cognition, genetics, and vascular risk factors in aging American Indians. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia
Conclusions and Relevance: Flortaucipir uptake distinguished individuals with PCA and amnestic AD dementia early in the symptomatic course. The posterior brain regions appear to be uniquely vulnerable to tau deposition in PCA, aligning with clinical deficits that define this disease subtype. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Autoimmune Frontotemporal Dementia: A New Nosological Entity?
Authors: Borroni B, Manes MA, Alberici A, Cosseddu M, Bernasconi P, Archetti S, Pinelli L, Gasparotti R, Padovani A PMID: 28338508 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 27, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Temporal Trends and Rural-Urban Differences in Hospital Length of Stay for Alzheimer Disease and Related Disorders.
CONCLUSIONS: LOS for ADRD-related hospitalizations was found to be influenced mostly by patient-level demographic and clinical factors. Hospital-level factors were not associated with LOS. PMID: 28296666 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Functional Connectivity is Reduced in Early-Stage Primary Progressive Aphasia When Atrophy is not Prominent.
Authors: Bonakdarpour B, Rogalski EJ, Wang A, Sridhar J, Mesulam MM, Hurley RS Abstract Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent. ...
Source: Alzheimer Disease and Associated Disorders - March 15, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study.
DISCUSSION: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommo...
Source: Alzheimer Disease and Associated Disorders - March 7, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Change in Health-related Quality of Life After Referral to Memory Assessment Services.
Authors: Park MH, Smith SC, Chrysanthaki T, Neuburger J, Ritchie CW, Hendriks AA, Black N Abstract Despite strong support for the provision of memory assessment services (MASs) in England and other countries, their effectiveness in improving patient outcomes is uncertain. We aimed to describe change in patients' health-related quality of life (HRQL) 6 months after referral to MASs and to examine associations with patient characteristics and use of postdiagnostic interventions. Data from 883 patients referred to 69 MASs and their informal caregivers (n=569) were collected at referral and 6 months later. Multivariabl...
Source: Alzheimer Disease and Associated Disorders - March 3, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study.
Authors: Marden JR, Mayeda ER, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM Abstract BACKGROUND: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. MATERIALS AND METHODS: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician's diagnosis of diabetes was self-reported in the same year. Composite memory (z scored) was assesse...
Source: Alzheimer Disease and Associated Disorders - February 24, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Time, Sex, Gender, History, and Dementia.
Authors: Rocca WA Abstract A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type. Third, I suggest some areas of future research...
Source: Alzheimer Disease and Associated Disorders - February 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Chorein Deficiency and Alzheimer Disease: An Intriguing, Yet Premature Speculation.
Authors: Velayos-Baeza A, Danek A PMID: 28121633 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Correlation of Histopathology and MRI in Prion Disease.
This study includes 11 cases of definite prion disease in which FDG-PET scans were obtained. There were 8 sporadic CJD cases, 2 genetic CJD cases, and 1 fatal familial insomnia case. Automated FDG-PET analysis revealed parietal region hypometabolism in all cases. Surprisingly, limbic and mesolimbic hypermetabolism were also present in the majority of cases. When FDG-PET hypometabolism was compared with neuropathologic changes (neuronal loss, astrocytosis, spongiosis), hypometabolism was predictive of neuropathology in 80.6% of cortical regions versus 17.6% of subcortical regions. The odds of neuropathologic changes were 2....
Source: Alzheimer Disease and Associated Disorders - January 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Heterozygous Deletion of Chorein Exons 70-73 and GNA14 Exons 3-7 in a Brazilian Patient Presenting With Probable Tau-Negative Early-Onset Alzheimer Disease.
Authors: Lazarczyk MJ, Haller S, Savioz A, Gimelli S, Bena F, Giannakopoulos P PMID: 28079535 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You to Our Reviewers in 2016!
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Guest Reviewers Acknowledgement Source Type: research

Heterozygous Deletion of Chorein Exons 70-73 and GNA14 Exons 3-7 in a Brazilian Patient Presenting With Probable Tau-Negative Early-Onset Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Chorein Deficiency and Alzheimer Disease: An Intriguing, Yet Premature Speculation
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Time, Sex, Gender, History, and Dementia
A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type. Third, I suggest some areas of future research to further elucidate the trends. T...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Review Article Source Type: research

Low-dose Lithium Treatment for Agitation and Psychosis in Alzheimer Disease and Frontotemporal Dementia: A Case Series
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals
We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/A&beta...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

The Effects of Computerized Cognitive Testing of Older Patients on Primary Care Physicians’ Approaches to Care: A Canadian Study
Conclusions: Our findings indicate that PCPs documented more care approaches in patients with greater cognitive impairment based on the CAMCI results and this was independent of their, the patients’, or families’ prior concerns about their patients’ cognition. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia
Conclusions: Specific functional deficits increased dementia risk and, with age and global cognition, constituted a validated clinical algorithm to estimate dementia risk. Clinicians can use this clinically important algorithm to personalize decision-making about further investigation and identify high-risk patients for early treatment or inclusion in clinical trials. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study
Background: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. Materials and Methods: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician’s diagnosis of diabetes was self-reported in the same year. Composite memory (z scored) was assessed biennially through 2012 using immediate and delayed word list recall or the Informant Q...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology. Diabetes [odds ratio (OR)=0.94; 95% conf...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research