Filtered By:
Drug: Melatonin
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 4647 results found since Jan 2013.
A seasonal switch hypothesis for the neuroendocrine control of aggression
Trends Endocrinol Metab. 2023 Sep 16:S1043-2760(23)00168-6. doi: 10.1016/j.tem.2023.08.015. Online ahead of print.ABSTRACTAggression is a well-studied social behavior that is universally exhibited by animals across a wide range of contexts. Prevailing knowledge suggests gonadal steroids primarily mediate aggression; however, this is based mainly on studies of male-male aggression in laboratory rodents. When males and females of other species, including humans, are examined, a positive relationship between gonadal steroids and aggression is less substantiated. For instance, hamsters housed in short 'winter-like' days show i...
Source: Trends in Endocrinology and Metabolism: TEM - September 18, 2023 Category: Endocrinology Authors: Gregory E Demas Kathleen M Munley Aaron M Jasnow Source Type: research
Melatonin as preemptive analgesic for intraoperative pain
This study evaluates the efficacy of using melatonin and ketorolac for pain prevention during open-flap debridement surgery. This prospective randomized controlled trial was performed in patients who presented with chronic periodontitis after non-surgical periodontal therapy, requiring flap surgery. Group 1: Flap surgery following non-surgical periodontal therapy after one month with no oral administration of analgesic. Group 2: Flap surgery following non-surgical periodontal therapy after one month with oral administration of Ketorolac 400mg one hour prior to the surgery. Group 3: Flap surgery following non-surgical perio...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Chanchal Katariya Sankari Malaiappan Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF- Β1/HMGB1 signaling pathway
CONCLUSIONS: The severity of fibrosis decreased with ramelteon application. These effects of ramelteon may be associated with NLRP3 inflammation cascade.PMID:37716182 | DOI:10.1016/j.advms.2023.09.004
Source: Advances in Medical Sciences - September 16, 2023 Category: Biomedical Science Authors: Pelin Aydin Zeynep B Aksakalli-Magden Maide S Civelek Sevgi Karabulut-Uzuncakmak Behzad Mokhtare Mustafa Ozkaraca Fatih Alper Zekai Halici Source Type: research
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF- Β1/HMGB1 signaling pathway
CONCLUSIONS: The severity of fibrosis decreased with ramelteon application. These effects of ramelteon may be associated with NLRP3 inflammation cascade.PMID:37716182 | DOI:10.1016/j.advms.2023.09.004
Source: Advances in Medical Sciences - September 16, 2023 Category: Biomedical Science Authors: Pelin Aydin Zeynep B Aksakalli-Magden Maide S Civelek Sevgi Karabulut-Uzuncakmak Behzad Mokhtare Mustafa Ozkaraca Fatih Alper Zekai Halici Source Type: research
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF- Β1/HMGB1 signaling pathway
CONCLUSIONS: The severity of fibrosis decreased with ramelteon application. These effects of ramelteon may be associated with NLRP3 inflammation cascade.PMID:37716182 | DOI:10.1016/j.advms.2023.09.004
Source: Advances in Medical Sciences - September 16, 2023 Category: Biomedical Science Authors: Pelin Aydin Zeynep B Aksakalli-Magden Maide S Civelek Sevgi Karabulut-Uzuncakmak Behzad Mokhtare Mustafa Ozkaraca Fatih Alper Zekai Halici Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
The effects of melatonin on the viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla
CONCLUSIONS: Melatonin treatment enhanced osteogenic/odontogenic differentiation of hSCAPs with a dose dependent effect on cell viability.PMID:37715020 | DOI:10.1007/s11033-023-08747-0
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Hamed Karkehabadi Roshanak Abbasi Rezvan Najafi Elham Khoshbin Source Type: research
