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Drug: Melatonin
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Potential therapeutic role of melatonin in hepatobiliary diseases: current evidence and clinical observations
J Physiol Pharmacol. 2023 Apr;74(2). doi: 10.26402/jpp.2023.2.01. Epub 2023 Jul 10.ABSTRACTMelatonin (MEL) is produced and secreted by the pineal gland as well as the small intestine, liver, retina, lymphocytes, and melanocytes in the skin in both experimental animals as well as in humans. While pineal and retinas MEL is closely related to the light/dark cycle, the production of MEL by other so called extrapineal tissues is independent of such circadian rhythm. Among the primary mechanisms of action of MEL in humans, the most important are interaction of MEL with specific receptors (M1, M2, M3) and the MEL 'scavenging' act...
Source: J Physiol Pharmacol - July 15, 2023 Category: Drugs & Pharmacology Authors: M Gonciarz I Lombard L Konecki P Gietka R Pajdo T Brzozowski Source Type: research
