The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.01. Epub 2024 Apr 3.ABSTRACTIn this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agen...
Source: J Physiol Pharmacol - April 7, 2024 Category: Drugs & Pharmacology Authors: L Romano L Napolitano F Crocetto C Sciorio K Priadko M Fonticelli A Federico M Romano A G Gravina Source Type: research
The role of the orexin (hypocretin) system in controlling energy homeostasis, endocrine system, and reproduction in pigs and other living organisms
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.01. Epub 2024 Feb 7.ABSTRACTOrexins A (OXA) and B (OXB) (hypocretin 1 and 2) are neuropeptides produced in the brain and peripheral tissues. Biological activities of orexins are mediated through activation of two G-protein coupled receptors termed as orexin 1 receptor (OX1R) and orexin 2 receptor (OX1R). Orexin system (OXA, OXB, OX1R, OX2R) was implicated in controlling sleep, energy expenditure, appetite, reproduction as well as metabolism and energy homeostasis. In this review, we summarize the current knowledge regarding the role of the orexin system in contr...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: T Wojciechowicz M Rybska N Smolinska T Kaminski A Rak J Wlodarek K W Nowak M Skrzypski Source Type: research
Radial artery spasms impair invasive cardiological procedures' performance: a pharmacological approach to prevention and treatment
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.02. Epub 2024 Feb 7.ABSTRACTThe radial artery (RA) access is currently the gold standard to perform cardiovascular interventions. One of the more common limitations is radial artery spasm which is an often complication interrupting the procedure. Common risk factors associated with spasm include female gender, periprocedural anxiety, multiple puncture attempts, distal radial access, diabetes, hypertension, and smoking. The mechanism of spasm is complex and includes calmodulin and rho-kinase pathways leading to the smooth muscle contraction. Proper hydration, anx...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: M Chyrchel J Roczniak A Surdacki Source Type: research
Transcriptional cofactor dyxin mediates hypertrophic response in the heart during angiotensin II-induced hypertension
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.03. Epub 2024 Feb 7.ABSTRACTDyxin is a LIM-domain containing transcriptional regulator protein shown to play a role in a hypertrophic response in the heart. Here, the effect of adenoviral dyxin overexpression was studied on cardiac function and gene expression in the normal heart and in angiotensin II (Ang II)-induced hypertension in rats. The adenovirus-mediated intramyocardial gene transfer of dyxin (1.5x109 infectious units/animal) was performed into the left ventricle (LV) of Sprague-Dawley rats with and without the Ang II (33 μg/kg/h) infusion, administere...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: H Sakkinen H Luosujarvi T Karvonen E Mustonen A-M Moilanen J Aro J Napankangas H Ruskoaho J Rysa Source Type: research
Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.04. Epub 2024 Feb 7.ABSTRACTWe explored the involvement of orphan nuclear receptor 4 A1 (NR4A1) in myocardial fibrosis mediated by transforming growth factor-beta1 (TGF-β1) and its response to cytosporone B (Csn-B). We developed a diabetic cardiomyopathy mouse model by administering a high-fat diet in conjunction with a low-dose streptozotocin injection. Our analysis involved monitoring alterations in blood glucose and lipid levels, cardiac function and structure, as well as profibrotic factors such as α smooth muscle actin (α-SMA), collagen I, collagen III, ...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: M-F Ma Z-Y Chen L-J Wang N Li B-Y Guo Source Type: research
Significance of multiple myeloma oncogene 1 immunohistochemistry in chronic endometritis detection in patients with recurrent pregnancy losses: an observational study
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.05. Epub 2024 Feb 7.ABSTRACTThe most reliable chronic endometritis diagnosis is based on immunohistochemistry plasma cell identification in endometrial samples. Our study aimed to compare multiple myeloma oncogene 1 (MUM1) and syndecan-1/CD138 immunohistochemistry staining for chronic endometritis diagnosis among patients with recurrent pregnancy loss. We evaluated the presence of endometrial stromal changes. Fifty-four patients with a history of at least two intrauterine pregnancy losses underwent diagnostic hysteroscopy in the follicular phase of the cycle wit...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: K Klimaszyk K Bednarek-Rajewska H Svarrre Nielsen E Wender Ozegowska M Kedzia Source Type: research
Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway
The objective of this study is to investigate the influence mechanism of paeonol on the proliferatory and apoptotic activities of ovarian cancer (OC) cells by modulating the transforming growth factor beta (TGF-β)/Smad3 pathway. The SKOV3 cells were pretreated with various concentrations of paeonol (0, 25, 50, 100, 200, 400 μg/mL) for 48 hours to determine the optimal experimental concentration of paeonol. Following this, the TGF-β overexpression vector was constructed and transfected into the SKOV3 cells. The assessment of cell proliferation, invasion, and migration was conducted through MTT, colony formation, flow cyt...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: X M Chen C L Jia Z Y Zhu Source Type: research
The effect of curcumin on on intravitreal proinflammatory cytokines, oxidative stress markers, and vascular endothelial growth factor in an experimental model of diabetic retinopathy
This study aimed to investigate the impact of CUR on pro-inflammatory cytokines, oxidative stress markers, and vascular endothelial growth factor (VEGF) in an experimental model of DR. The study used Spontaneously Diabetic Torii (SDT) rats and divided them into groups to receive various CUR doses (10, 50, 100 mg/kg/day) or distilled water for four weeks. Non-diabetic Sprague-Dawley (SD) rats were used as a control group. Pro-inflammatory cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ)) (by ELISA), oxidative stress markers (superoxide dismutase (SOD), malondialdehyde (MDA...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: B Yao Z K Xin D Wang Source Type: research
