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Drug: Melatonin
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Total 4647 results found since Jan 2013.
Melatonin as a potential treatment for septic cardiomyopathy
Biomed Pharmacother. 2023 Aug 22;166:115305. doi: 10.1016/j.biopha.2023.115305. Online ahead of print.ABSTRACTSeptic cardiomyopathy (SCM) is a common complication of sepsis contributing to high mortality rates. Its pathophysiology involves complex factors, including inflammatory cytokines, mitochondrial dysfunction, oxidative stress, and immune dysregulation. Despite extensive research, no effective pharmacological agent has been established for sepsis-induced cardiomyopathy. Melatonin, a hormone with diverse functions in the body, has emerged as a potential agent for SCM through its anti-oxidant, anti-inflammatory, anti-a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Amira Mohamed Taha Abdelrahman Mohamed Mahmoud Mohamed M Ghonaim Ateeba Kamran Jehad Feras AlSamhori Majd M AlBarakat Abhigan Babu Shrestha Vikash Jaiswal Russel J Reiter Source Type: research
Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus)
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Aug 21:109731. doi: 10.1016/j.cbpc.2023.109731. Online ahead of print.ABSTRACTIn photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process. The beneficial effects of MT in delaying the progress of ageing have been reported in laboratory mice and rats. However, little is known about MT in wild mammals. In the current study, we investigated energy metabolism, microbial community structure and colon homeostasis in ageing Mongolian gerbils (Meriones unguiculatus) through exogenous su...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 23, 2023 Category: Biochemistry Authors: Wen-Ting Gao Jin-Xiu Liu De-Hua Wang Hai-Ji Sun Xue-Ying Zhang Source Type: research
Differentiation of T cells producing interleukin-17 (Th17) against the background of exogenous melatonin during pregnancy
J Pineal Res. 2023 Aug 21:e12904. doi: 10.1111/jpi.12904. Online ahead of print.ABSTRACTThe population of T lymphocytes producing IL-17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation of Th17 cells of pregnant women in vitro. The stimulatory effects of melatonin were limited to in the first trimester of pregnancy and were ...
Source: Cell Research - August 21, 2023 Category: Cytology Authors: Natalya Sergeevna Glebezdina Irina Valerievna Nekrasova Anna Alexandrovna Olina Gulnara Kamilyevna Sadykova Elena Michajlovna Kuklina Source Type: research
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Arch Toxicol. 2023 Aug 19. doi: 10.1007/s00204-023-03562-9. Online ahead of print.ABSTRACTA physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor ...
Source: Archives of Toxicology - August 19, 2023 Category: Toxicology Authors: Klaudia Jomova Renata Raptova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults
CONCLUSIONS: This systematic review found that blue-light filtering spectacle lenses may not attenuate symptoms of eye strain with computer use, over a short-term follow-up period, compared to non-blue-light filtering lenses. Further, this review found no clinically meaningful difference in changes to CFF with blue-light filtering lenses compared to non-blue-light filtering lenses. Based on the current best available evidence, there is probably little or no effect of blue-light filtering lenses on BCVA compared with non-blue-light filtering lenses. Potential effects on sleep quality were also indeterminate, with included t...
Source: Cochrane Database of Systematic Reviews - August 18, 2023 Category: General Medicine Authors: Sumeer Singh Peter R Keller Ljoudmila Busija Patrick McMillan Eve Makrai John G Lawrenson Christopher C Hull Laura E Downie Source Type: research
Melatonin associated with a high-fat diet during pregnancy and lactation prevents liver changes in the offspring
In conclusion, melatonin combined with a high-fat diet preserves the liver architecture and function in the offspring.PMID:37586542 | DOI:10.1016/j.ygcen.2023.114357
Source: General and Comparative Endocrinology - August 16, 2023 Category: Endocrinology Authors: Clovis J C Lapa Neto Ismaela M F de Melo Paloma K B M Alpiovezza Yuri M L de Albuquerque An ísio Francisco Soares Álvaro A C Teixeira Val éria Wanderley-Teixeira Source Type: research
The Efficacy of Ramelteon to Prevent Postoperative Delirium After General Anesthesia in the Elderly: A Double-Blind, Randomized, Placebo-Controlled Trial
CONCLUSION: There was no significant difference in the incidence of postoperative delirium between ramelteon and placebo after general anesthesia in elderly patients.PMID:37567839 | DOI:10.1016/j.jagp.2023.07.011
Source: Am J Geriatr Psychia... - August 11, 2023 Category: Geriatrics Authors: Mariko Kinouchi Takahiro Mihara Masataka Taguri Makoto Ogura Source Type: research
