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Drug: Melatonin
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Ferroptosis-induced Cardiotoxicity and Antitumor Drugs
Curr Med Chem. 2023 Jul 19. doi: 10.2174/0929867331666230719124453. Online ahead of print.ABSTRACTThe induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) induce ferroptosis. Although this mechanism of action is interesting for fighting tumors, the clinical use of drugs that induce ferroptosis is hampered by cardiotoxicity. Besides in cancer cells, ferroptosis induced by chemotherapeutics can occur in cardiomyocytes, and this featur...
Source: Current Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Giovanni L Beretta Source Type: research
Comparative transcriptome analysis reveals the key genes and pathways involved in drought stress response of two wheat (Triticum aestivum L) varieties
In this study, we found that "Deguo 2" exhibited higher tolerance to drought than "Truman". Transcriptomics analysis enabled identification of 6084 and 7146 differentially expressed genes (DEGs), mainly mapping flavonoid biosynthesis, plant hormone, phenolamides and antioxidant pathways and revealed altered expression levels of about 700 genes. Exogenous melatonin application enhanced wheat tolerance against drought stress. Co-expression analysis showed that bHLH and bZIP transcription factors may be involved in the regulation of various pathway genes. Take together, these results provide new insights for us on exploring t...
Source: Genomics - July 20, 2023 Category: Genetics & Stem Cells Authors: Yufei Niu Jingyu Li Fanting Sun Taiyu Song Baojia Han Zijie Liu Peisen Su Source Type: research
Melatonin for migraine prevention in children and adolescents: A randomized, double-blind, placebo-controlled trial after single-blind placebo lead-in
CONCLUSIONS: When compared to recall at enrollment, headache days decreased across the single-blind placebo phase and the double-blind phase. There was no suggestion of superiority of melatonin; however, given the substantial portion of missing data, numerically higher in the placebo arm, and underpowering, this should not be interpreted as proof of inefficacy. Melatonin was generally well tolerated with no serious adverse events. Future migraine preventive trials in this age group may find this trial helpful for anticipating enrollment needs if using a single-blind placebo run-in. Enriching for those already on a migraine...
Source: Headache - July 19, 2023 Category: Neurology Authors: Amy A Gelfand I Elaine Allen Barbara Grimes Samantha Irwin William Qubty Kaitlin Greene Maggie Waung Scott W Powers Christina L Szperka Source Type: research
Chrono-modulated effects of external stressors on oxidative stress and damage in humans: A scoping review on night shift work
DISCUSSION: The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in ...
Source: Environment International - July 18, 2023 Category: Environmental Health Authors: Konstantinos C Makris Behzad Heibati Shan Zienolddiny Narui Source Type: research
Melatonin ameliorates high glucose-induced autophagy in Schwann cells
In conclusion, melatonin alleviates high glucose-induced autophagy in Schwann cells through PERK-eIF2α-ATF4-CHOP signaling pathways.PMID:37456910 | PMC:PMC10349298
Source: Mol Biol Cell - July 17, 2023 Category: Molecular Biology Authors: Hagar Mohamed Ahmed Salem Kian Chung Chok Rhun Yian Koh Pei Ying Ng Yee Lian Tiong Soi Moi Chye Source Type: research
