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Drug: Melatonin
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Total 4647 results found since Jan 2013.
The effects of melatonin on the viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla
CONCLUSIONS: Melatonin treatment enhanced osteogenic/odontogenic differentiation of hSCAPs with a dose dependent effect on cell viability.PMID:37715020 | DOI:10.1007/s11033-023-08747-0
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Hamed Karkehabadi Roshanak Abbasi Rezvan Najafi Elham Khoshbin Source Type: research
Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial
CONCLUSIONS: In this double-blind placebo-controlled phase III trial, melatonin did not prevent or significantly improve fatigue and other symptoms in patients with early stage breast cancer undergoing RT. The analysis, showing little evidence of an effect, at mid-recruitment, assured early termination of the trial.PMID:37699115 | DOI:10.1093/oncolo/oyad250
Source: The Oncologist - September 12, 2023 Category: Cancer & Oncology Authors: Nitai D Mukhopadhyay Adam Khorasanchi Sudeep Pandey Srinidhi Nemani Gwendolyn Parker Xiaoyan Deng Douglas W Arthur Alfredo Urdaneta Egidio Del Fabbro Source Type: research
Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm consist with a dual oscillator hypothesis
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 11. doi: 10.1152/ajpregu.00095.2023. Online ahead of print.ABSTRACTCircadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of ca. 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch and polysomn...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research
Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial
CONCLUSIONS: Pregabalin was found better for perioperative anxiolysis, post-operative analgesia and for prolongation of duration of spinal anaesthesia when compared to melatonin.PMID:37694243 | PMC:PMC10492595 | DOI:10.4103/abr.abr_323_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Akash Mishra Vinod Kumar Srivastava Ravi Prakash Neel Kamal Mishra Jyotsna Agarwal Shruti Kabi Source Type: research
Effects of cyclic adenosine monophosphate modulating agents during oocyte pre-maturation and the role of melatonin on in vitro maturation of bovine cumulus-oocyte complexes
In conclusion, bovine COC pre-maturation with C-type natriuretic peptide and forskolin, followed by IVM with 10-8 M melatonin improves meiotic resumption rates, TZPs, mitochondrial distribution and mRNA expression for SOD and CAT.PMID:37696223 | DOI:10.1016/j.anireprosci.2023.107327
Source: Animal Reproduction Science - September 11, 2023 Category: Zoology Authors: Bianca R Silva Laryssa G Barrozo Danisv ânia R Nascimento Francisco C Costa Ven ância A N Azevedo La ís R F M Paulino Everton P F Lopes Ana L P S Batista Francisco L N Aguiar Christina A Peixoto Mariana A M Donato Ana P R Rodrigues Jos é R V Silva Source Type: research
Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm consist with a dual oscillator hypothesis
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 11. doi: 10.1152/ajpregu.00095.2023. Online ahead of print.ABSTRACTCircadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of ca. 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch and polysomn...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research
Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial
CONCLUSIONS: Pregabalin was found better for perioperative anxiolysis, post-operative analgesia and for prolongation of duration of spinal anaesthesia when compared to melatonin.PMID:37694243 | PMC:PMC10492595 | DOI:10.4103/abr.abr_323_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Akash Mishra Vinod Kumar Srivastava Ravi Prakash Neel Kamal Mishra Jyotsna Agarwal Shruti Kabi Source Type: research
Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm consist with a dual oscillator hypothesis
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 11. doi: 10.1152/ajpregu.00095.2023. Online ahead of print.ABSTRACTCircadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of ca. 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch and polysomn...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research
Unlocking Synergistic Potential: Agomelatine Enhances the Chemotherapeutic Effect of Paclitaxel in Breast Cancer Cell Through MT1 Melatonin Receptors and ER-alpha Axis
This study investigates the potential of agomelatine (AGO), a synthetic melatoninergic drug, in combination with paclitaxel (PTX) for the treatment of breast cancer. The effects of AGO, PTX and melatonin (MTN) on breast cancer cell viability were investigated, focusing on the role of MT1 receptors. Cell viability and gene expression were analyzed in MCF-7 and MDA-MB-231 breast cancer cell experiments. The results show that AGO has cytotoxic effects on breast cancer cells similar to MTN. Combining AGO and MTN with PTX showed synergistic effects in MCF-7 cells. The study also reveals differences in the molecular mechanisms o...
Source: Chemistry and Biodiversity - September 10, 2023 Category: Biochemistry Authors: Busra Dincer Gizem Yildiztekin Irfan Cinar Source Type: research
