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Drug: Melatonin
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Total 4647 results found since Jan 2013.
Effect of Melatonin on Increasing the Effectiveness of Liver Preservation Solution
CONCLUSION: When the findings were evaluated, intraperitoneal administration of melatonin, a cytoprotective antioxidant, was found to play an effective role in preserving immunohistochemical and biochemical properties of liver tissue integrity and hepatocytes in University of Wisconsin solution.PMID:37485562 | DOI:10.5152/tjg.2023.22694
Source: The Turkish Journal of Gastroenterology - July 24, 2023 Category: Gastroenterology Authors: Mehmet Mustafa Erdo ğan Mehmet Erman Erdemli Onural Özhan Zeynep Erdemli Harika G özde Gözükara Bağ Nigar Vard ı Source Type: research
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
In conclusion, agomelatine showed a nephroprotective effect against cisplatin-induced nephrotoxicity.PMID:37480488 | DOI:10.1007/s00210-023-02632-0
Source: Cancer Control - July 22, 2023 Category: Cancer & Oncology Authors: Eyup Dil Atilla Topcu Tolga Mercantepe Levent Tumkaya Kerimali Akyildiz Sinan Saral Adnan Yilmaz Source Type: research
Melatonin Promotes Mitochondrial Biogenesis and Mitochondrial Degradation in Hepatocytes During Sepsis
CONCLUSIONS: Our findings demonstrate that melatonin plays a role in regulating mitochondrial quality control in sepsis-induced hepatocytes. It achieves this result by promoting mitophagy and inducing mitochondrial biogenesis, thereby selectively eliminating dysfunctional mitochondria.PMID:37471665
Source: Alternative Therapies in Health and Medicine - July 20, 2023 Category: Complementary Medicine Authors: Bin Hu Zhijiang Chen Lili Liang Meiyu Zheng Xinxin Chen Qiyi Zeng Source Type: research
Ferroptosis-induced Cardiotoxicity and Antitumor Drugs
Curr Med Chem. 2023 Jul 19. doi: 10.2174/0929867331666230719124453. Online ahead of print.ABSTRACTThe induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) induce ferroptosis. Although this mechanism of action is interesting for fighting tumors, the clinical use of drugs that induce ferroptosis is hampered by cardiotoxicity. Besides in cancer cells, ferroptosis induced by chemotherapeutics can occur in cardiomyocytes, and this featur...
Source: Current Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Giovanni L Beretta Source Type: research
Comparative transcriptome analysis reveals the key genes and pathways involved in drought stress response of two wheat (Triticum aestivum L) varieties
In this study, we found that "Deguo 2" exhibited higher tolerance to drought than "Truman". Transcriptomics analysis enabled identification of 6084 and 7146 differentially expressed genes (DEGs), mainly mapping flavonoid biosynthesis, plant hormone, phenolamides and antioxidant pathways and revealed altered expression levels of about 700 genes. Exogenous melatonin application enhanced wheat tolerance against drought stress. Co-expression analysis showed that bHLH and bZIP transcription factors may be involved in the regulation of various pathway genes. Take together, these results provide new insights for us on exploring t...
Source: Genomics - July 20, 2023 Category: Genetics & Stem Cells Authors: Yufei Niu Jingyu Li Fanting Sun Taiyu Song Baojia Han Zijie Liu Peisen Su Source Type: research
Ferroptosis-induced Cardiotoxicity and Antitumor Drugs
Curr Med Chem. 2023 Jul 19. doi: 10.2174/0929867331666230719124453. Online ahead of print.ABSTRACTThe induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) induce ferroptosis. Although this mechanism of action is interesting for fighting tumors, the clinical use of drugs that induce ferroptosis is hampered by cardiotoxicity. Besides in cancer cells, ferroptosis induced by chemotherapeutics can occur in cardiomyocytes, and this featur...
Source: Current Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Giovanni L Beretta Source Type: research
Does exposure to moonlight affect day/night changes in melatonin and metabolic parameters in Amazonian fish?
Comp Biochem Physiol A Mol Integr Physiol. 2023 Jul 18:111489. doi: 10.1016/j.cbpa.2023.111489. Online ahead of print.ABSTRACTLunar cycle modulates the rhythmic activity patterns of many animals, including fish. The effect of the moonlight cycle on daily melatonin and metabolic parameters was evaluated in matrinxã (Brycon amazonicus) subjected to external natural lighting. Eighty juvenile were distributed in 4 tanks of 1m3 (20 fish/tank) and divided into two groups. One group was exposed to the full moon and the other group to the new moon for 30 days, which corresponds to the duration of the lunar period. At the end of t...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - July 20, 2023 Category: Physiology Authors: Ana Caroliny Cerdeira Lopes Bruno Olivetti de Mattos Jaydione Luiz Marcon Luisa Mar ía Vera Jos é Fernando López-Olmeda Francisco Javier S ánchez-Vázquez Tha ís Billalba Carvalho Source Type: research
Comparative transcriptome analysis reveals the key genes and pathways involved in drought stress response of two wheat (Triticum aestivum L) varieties
In this study, we found that "Deguo 2" exhibited higher tolerance to drought than "Truman". Transcriptomics analysis enabled identification of 6084 and 7146 differentially expressed genes (DEGs), mainly mapping flavonoid biosynthesis, plant hormone, phenolamides and antioxidant pathways and revealed altered expression levels of about 700 genes. Exogenous melatonin application enhanced wheat tolerance against drought stress. Co-expression analysis showed that bHLH and bZIP transcription factors may be involved in the regulation of various pathway genes. Take together, these results provide new insights for us on exploring t...
Source: Genomics - July 20, 2023 Category: Genetics & Stem Cells Authors: Yufei Niu Jingyu Li Fanting Sun Taiyu Song Baojia Han Zijie Liu Peisen Su Source Type: research
Does exposure to moonlight affect day/night changes in melatonin and metabolic parameters in Amazonian fish?
Comp Biochem Physiol A Mol Integr Physiol. 2023 Jul 18:111489. doi: 10.1016/j.cbpa.2023.111489. Online ahead of print.ABSTRACTLunar cycle modulates the rhythmic activity patterns of many animals, including fish. The effect of the moonlight cycle on daily melatonin and metabolic parameters was evaluated in matrinxã (Brycon amazonicus) subjected to external natural lighting. Eighty juvenile were distributed in 4 tanks of 1m3 (20 fish/tank) and divided into two groups. One group was exposed to the full moon and the other group to the new moon for 30 days, which corresponds to the duration of the lunar period. At the end of t...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - July 20, 2023 Category: Physiology Authors: Ana Caroliny Cerdeira Lopes Bruno Olivetti de Mattos Jaydione Luiz Marcon Luisa Mar ía Vera Jos é Fernando López-Olmeda Francisco Javier S ánchez-Vázquez Tha ís Billalba Carvalho Source Type: research
