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Drug: Melatonin
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Insomnia Management: A Review and Update
J Fam Pract. 2023 Jul;72(6 Suppl):S31-S36. doi: 10.12788/jfp.0620.ABSTRACTInsomnia is a distinct disorder that is common, yet underrecognized and undertreated in primary care. Treating insomnia has been shown to improve outcomes, including reduced risk of developing cardiovascular and mental health disorders. Insomnia is influenced by the brain's regulation of sleep and wake, which are mutually exclusive events. Insomnia should be treated as a distinct condition, even when occurring with a comorbid diagnosis such as depression or anxiety. Clinicians should implement a multimodal approach to insomnia management, including n...
Source: The Journal of Family Practice - August 7, 2023 Category: Practice Management Authors: David P Shaha Source Type: research
The cutaneous stress response system in three-spined stickleback and European flounder exposed to oxidative stress: Different mode of action
This study investigates the mode of action of CSRS in two teleost species of different biology and skin characteristics, the three-spined stickleback and the European flounder, after exposure to oxidative stress induced by a potassium dichromate solution. The cutaneous stress response system presents different ways of action in two studied species: Mel concentration increases in the skin of both species, but cortisol concentration increases in the skin only in sticklebacks. Data suggest that stickleback skin cells can produce cortisol. However, cortisol is not involved in the response to oxidative stress in flounders. In s...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - August 4, 2023 Category: Physiology Authors: Konrad Pomianowski Magdalena Gozdowska Ewa Soko łowska Ewa Kulczykowska Source Type: research
Melatonin: A look at protozoal and helminths
Biochimie. 2023 Aug 2:S0300-9084(23)00182-7. doi: 10.1016/j.biochi.2023.07.021. Online ahead of print.ABSTRACTMelatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate...
Source: Biochimie - August 4, 2023 Category: Biochemistry Authors: Pablo Igor Ribeiro Franco Jos é Rodrigues do Carmo Neto Rhanoica Oliveira Guerra Priscilla Elias Ferreira da Silva Yarlla Loyane Lira Braga Mara R úbia Nunes Celes Liliana Borges de Menezes Marina Pacheco Miguel Juliana Reis Machado Source Type: research
The cutaneous stress response system in three-spined stickleback and European flounder exposed to oxidative stress: Different mode of action
This study investigates the mode of action of CSRS in two teleost species of different biology and skin characteristics, the three-spined stickleback and the European flounder, after exposure to oxidative stress induced by a potassium dichromate solution. The cutaneous stress response system presents different ways of action in two studied species: Mel concentration increases in the skin of both species, but cortisol concentration increases in the skin only in sticklebacks. Data suggest that stickleback skin cells can produce cortisol. However, cortisol is not involved in the response to oxidative stress in flounders. In s...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - August 4, 2023 Category: Physiology Authors: Konrad Pomianowski Magdalena Gozdowska Ewa Soko łowska Ewa Kulczykowska Source Type: research
Melatonin: A look at protozoal and helminths
Biochimie. 2023 Aug 2:S0300-9084(23)00182-7. doi: 10.1016/j.biochi.2023.07.021. Online ahead of print.ABSTRACTMelatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate...
Source: Biochimie - August 4, 2023 Category: Biochemistry Authors: Pablo Igor Ribeiro Franco Jos é Rodrigues do Carmo Neto Rhanoica Oliveira Guerra Priscilla Elias Ferreira da Silva Yarlla Loyane Lira Braga Mara R úbia Nunes Celes Liliana Borges de Menezes Marina Pacheco Miguel Juliana Reis Machado Source Type: research
