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Drug: Melatonin
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"Tell Me More About Your Child's Sleep": A Qualitative Investigation Of Sleep Problems In Children With ADHD
CONCLUSIONS: Sleep problems in children with ADHD were perceived as important issues by parents. Equipping parents with evidence-based strategies for the management of their children's sleep may lead to benefits for the children, parents and wider household.PMID:37665076 | DOI:10.1080/15402002.2023.2253947
Source: Behavioral Sleep Medicine - September 4, 2023 Category: Sleep Medicine Authors: Upasana Bondopadhyay Jane McGrath Andrew N Coogan Source Type: research
Active coatings based on oxidized chitin nanocrystals and silk fibroins for the control of anthracnose in 'Hass' avocados
Int J Biol Macromol. 2023 Sep 1:126673. doi: 10.1016/j.ijbiomac.2023.126673. Online ahead of print.ABSTRACTPostharvest avocado losses are mainly due to anthracnose disease caused by Colletotrichum gloeosporioides. Chemical fungicides are effective, but their negative effects on health and the environment have led to the search for sustainable alternatives such as biopolymer-based coatings and natural compounds. Therefore, chitin nanocrystals (NCChit) were extracted using a sustainable deep eutectic solvent (DES) and chemically modified into oxidized chitin nanocrystals (O-NCChit) or deacetylated chitin nanocrystals (D-NCCh...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Catalina Ferreira Funes Alejandra Larach Ximena Besoain Daniela Duarte Serrano Caroline Hadad Romina Pedreschi Albert Nguyen Van Nhien Claudia Fuentealba Source Type: research
Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice
CONCLUSION AND IMPLICATIONS: Melatonin attenuated CIH-induced intestinal barrier dysfunction by regulating gut flora dysbiosis, mucosal epithelium integrity, and Th17 polarization via STAT3 signalling.PMID:37659335 | DOI:10.1016/j.micres.2023.127480
Source: Cell Research - September 2, 2023 Category: Cytology Authors: Xinyi Li Fan Wang Zhenfei Gao Weijun Huang Xiaoman Zhang Feng Liu Hongliang Yi Jian Guan Xiaolin Wu Huajun Xu Shankai Yin Source Type: research
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro
This study is the first to reveal the interplay between mitophagy and ferroptosis in kidney stone models and establish the protective role of melatonin in restoring mitophagy to inhibit ferroptosis.PMID:37651854 | DOI:10.1016/j.intimp.2023.110801
Source: International Immunopharmacology - August 31, 2023 Category: Allergy & Immunology Authors: Jiawei Zhou Lingchao Meng Ziqi He Qianlin Song Junwei Liu Xiaozhe Su Chuan Wang Hu Ke Caitao Dong Wenbiao Liao Sixing Yang Source Type: research
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation
Autophagy. 2023 Aug 31:1-15. doi: 10.1080/15548627.2023.2252265. Online ahead of print.ABSTRACTAKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A,...
Source: Autophagy - August 31, 2023 Category: Cytology Authors: Zhiya Deng Man He Hongbin Hu Wenqian Zhang Yaoyuan Zhang Yue Ge Tongtong Ma Jie Wu Lulan Li Maomao Sun Sheng An Jiaxin Li Qiaobing Huang Shenhai Gong Jiaxing Zhang Zhongqing Chen Zhenhua Zeng Source Type: research
Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research
Melatonin Supplementation Reduces Nighttime Blood Pressure But Does Not Affect Blood Pressure Reactivity in Normotensive Adults on a High Sodium Diet
In conclusion, melatonin supplementation did not alter BP reactivity to the perturbations tested on a HSD but may be beneficial in lowering BP in young healthy normotensive adults.PMID:37642281 | DOI:10.1152/ajpregu.00101.2023
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 29, 2023 Category: Physiology Authors: Macarena Ramos Gonzalez Michael R Axler Kathryn E Kaseman Andrea J Lobene William B Farquhar Melissa A Witman Danielle L Kirkman Shannon L Lennon Source Type: research
Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research
Melatonin Supplementation Reduces Nighttime Blood Pressure But Does Not Affect Blood Pressure Reactivity in Normotensive Adults on a High Sodium Diet
In conclusion, melatonin supplementation did not alter BP reactivity to the perturbations tested on a HSD but may be beneficial in lowering BP in young healthy normotensive adults.PMID:37642281 | DOI:10.1152/ajpregu.00101.2023
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 29, 2023 Category: Physiology Authors: Macarena Ramos Gonzalez Michael R Axler Kathryn E Kaseman Andrea J Lobene William B Farquhar Melissa A Witman Danielle L Kirkman Shannon L Lennon Source Type: research
Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research
Melatonin Supplementation Reduces Nighttime Blood Pressure But Does Not Affect Blood Pressure Reactivity in Normotensive Adults on a High Sodium Diet
In conclusion, melatonin supplementation did not alter BP reactivity to the perturbations tested on a HSD but may be beneficial in lowering BP in young healthy normotensive adults.PMID:37642281 | DOI:10.1152/ajpregu.00101.2023
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 29, 2023 Category: Physiology Authors: Macarena Ramos Gonzalez Michael R Axler Kathryn E Kaseman Andrea J Lobene William B Farquhar Melissa A Witman Danielle L Kirkman Shannon L Lennon Source Type: research
