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Drug: Polyethylene Glycol
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Total 2716 results found since Jan 2013.
Hepatic Bile Formation: Developing a New Paradigm
Pharmacol Rev. 2023 Aug 2:PHARMREV-AR-2022-000799. doi: 10.1124/pharmrev.122.000799. Online ahead of print.ABSTRACTIn 1959, Ivar Sperber contrasted bile formation with that of urine and proposed that water flow into the canalicular conduit is in response to an osmotic not a hydrostatic gradient. Early attempts to support the hypothesis using a bile acid, sodium taurocholate, and the hormone secretin to stimulate bile flow led to conflicting data and a moratorium on attempts to further develop the initial proposal. However, current data amplifiy the proposal and indicate both paracellular and transcellular water flow into h...
Source: Pharmacological Reviews - August 2, 2023 Category: Drugs & Pharmacology Authors: Norman B Javitt Source Type: research
Tuning the Solution Self-Assembly of a Peptide-PEG (Polyethylene Glycol) Conjugate with alpha-Cyclodextrin
Chembiochem. 2023 Aug 2:e202300472. doi: 10.1002/cbic.202300472. Online ahead of print.ABSTRACTCyclodextrins are saccharide ring molecules which act as host cavities that can encapsulate small guest molecules or thread polymer chains. We investigate the influence of alpha-cyclodextrin (αCD) on the aqueous solution self-assembly of a peptide-polymer conjugate YYKLVFF-PEG3K previously studied by our group [Castelletto et al., Polym. Chem., 2010, 1, 453-459]. This conjugate comprises a designed amyloid-forming peptide YYKLVFF that contains the KLVFF sequence from Amyloid β peptide, Aβ16-20, along with two aromatic tyrosine...
Source: Chembiochem - August 2, 2023 Category: Biochemistry Authors: Valeria Castelletto Radoslaw M Kowalczyk Jani Seitsonen Ian W Hamley Source Type: research
Development of an anti-infective urinary catheter composed of polyvinyl alcohol/sodium alginate/methylcellulose/polyethylene glycol by using a pressure-assisted 3D-printing technique
Int J Biol Macromol. 2023 Jul 29:126029. doi: 10.1016/j.ijbiomac.2023.126029. Online ahead of print.ABSTRACTCatheter-associated urinary tract infections (CAUTI) are a common complication associated with catheterization, leading to urosepsis, bacteriuria, and septicaemia. The present work focuses on 3D printing a urinary catheter with anti-infective properties using various concentrations of polyvinyl alcohol (PVA, e.g., 6-8 %), sodium alginate (NaAlg, e.g. 1-4 %), methylcellulose (MC, 5 %), polyethylene glycol (PEG, 5 %) impregnated with secnidazole, an antibiotic acting against Gram-negative bacteria. To produce suitable ...
Source: International Journal of Biological Macromolecules - July 31, 2023 Category: Biochemistry Authors: Menon Archana Durairajan Rubini Krishnan Priya Dharshini Bodethala Narayanan Vedha Hari Senthilganesh Jayasankari Durai Ramyadevi Weronika Gonciarz Agnieszka Doma ńska Marek Brzezi ński Paramasivam Nithyanand Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
Tailoring the release of drugs having different water solubility by hybrid polymer-lipid microparticles with a biphasic structure
Eur J Pharm Biopharm. 2023 Jul 28:S0939-6411(23)00199-6. doi: 10.1016/j.ejpb.2023.07.017. Online ahead of print.ABSTRACTThe aim of this study is to investigate the potential of hybrid polymer-lipid microparticles with a biphasic structure (b-MPs) as drug delivery system. Hybrid b-MPs of Compritol®888 ATO as main lipid constituent of the shell and polyethylene glycol 400 as core material were produced by an innovative solvent-free approach based on spray congealing. To assess the suitability of hybrid b-MPs to encapsulate various types of APIs, three model drugs (fluconazole, tolbutamide and nimesulide) with extremely diff...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 30, 2023 Category: Drugs & Pharmacology Authors: Serena Bertoni Beatrice Albertini Joanna Ronowicz-Pilarczyk Nadia Passerini Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
Adsorption of methyl orange by porous membranes prepared from deep eutectic supramolecular polymer-modified chitosan
In this study, chitosan (CS) membranes were modified with a deep eutectic supramolecular polymer (DESP), and adsorbent membranes with porous structures were prepared with polyethylene glycol (PEG). Microstructural characterization of the CS-DESP-PEG composite membranes with FT-IR, XRD and SEM showed that the membranes had amorphous crystalline structures and that hydrogen bonding interactions weakened the crystallinity and formed loose porous structures. Optimization of the chitosan to β-cyclodextrin ratio, pH, PEG proportion, MO concentration and adsorbent dose significantly improved the adsorption efficiencies of the me...
Source: Environmental Research - July 30, 2023 Category: Environmental Health Authors: Yun Zhu Lei Ma Xiaoping Hai Zhi Yang Xiaofen Li Minghong Chen Mingwei Yuan Huabin Xiong Yuntao Gao Lina Wang Feng Shi Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: Molecular Medicine - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
Adsorption of methyl orange by porous membranes prepared from deep eutectic supramolecular polymer-modified chitosan
In this study, chitosan (CS) membranes were modified with a deep eutectic supramolecular polymer (DESP), and adsorbent membranes with porous structures were prepared with polyethylene glycol (PEG). Microstructural characterization of the CS-DESP-PEG composite membranes with FT-IR, XRD and SEM showed that the membranes had amorphous crystalline structures and that hydrogen bonding interactions weakened the crystallinity and formed loose porous structures. Optimization of the chitosan to β-cyclodextrin ratio, pH, PEG proportion, MO concentration and adsorbent dose significantly improved the adsorption efficiencies of the me...
Source: Environmental Research - July 30, 2023 Category: Environmental Health Authors: Yun Zhu Lei Ma Xiaoping Hai Zhi Yang Xiaofen Li Minghong Chen Mingwei Yuan Huabin Xiong Yuntao Gao Lina Wang Feng Shi Source Type: research
End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine
Int J Biol Macromol. 2023 Jul 25:125957. doi: 10.1016/j.ijbiomac.2023.125957. Online ahead of print.ABSTRACTHeparin is the most common anticoagulant used in clinical practice but shows some downsides such as short half-life (for the high molecular weight heparin) and secondary effects. On the other hand, its low molecular weight analogue cannot be neutralized with protamine, and therefore cannot be used in some treatments. To address these issues, we conjugated polyethylene glycol (PEG) to heparin reducing end (end-on) via oxime ligation and studied the interactions of the conjugate (Hep-b-PEG) with antithrombin III (AT) a...
Source: International Journal of Biological Macromolecules - July 27, 2023 Category: Biochemistry Authors: Sandra Amaral Tamara Lozano-Fern ández Juan Sabin Amanda Gallego Alain da Silva Morais Rui L Reis África González-Fernández Iva Pashkuleva Ramon Novoa Carballal Source Type: research
A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma
This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the dorsum of the tongue in white mice. The induced tumors were examined by needle biopsy. A targeted anticancer drug (Cetuximab) and [Cisplatin and 5 Fluorouracil (5-FU)] chemotherapeutic agents were loaded on polyethylene glycol-polylactide-polyethylene glycol (PEG-PLA-PEG) nanoparticles (NPs) designed for intralesional injection while systemic administration was used as control. Fourier transform infrared spectroscopy (FTIR) was performed to study NP chemical structure, a drug release profile was conducted to study ...
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Shimaa A Elsaady Moustafa N Aboushelib Essam Al-Wakeel Manal F Badawi Source Type: research
Visible Light Induced Control over Reversible Single Chain Nanoparticle Folding
Angew Chem Int Ed Engl. 2023 Jul 23:e202309259. doi: 10.1002/anie.202309259. Online ahead of print.ABSTRACTWe introduce a class of single chain nanoparticles (SCNPs) that respond to visible light (λmax = 415 nm) with complete unfolding from their compact structure into linear chain analogues. The initial folding is achieved by a simple esterification reaction of the polymer backbone constituted of acrylic acid and polyethylene glycol carrying monomer units, introducing bimane moieties, which allow for the photochemical unfolding reversing the ester-bond formation. The compaction and the light driven unfolding proceed clea...
Source: Angewandte Chemie - July 24, 2023 Category: Chemistry Authors: Patrick Maag Florian Feist Vinh Truong Hendrik Frisch Peter Roesky Christopher Barner-Kowollik Source Type: research
Efficacy and safety of 1 L polyethylene glycol plus ascorbic acid for bowel preparation in elderly: comparison with oral sulfate solution
CONCLUSIONS: The successful bowel preparation rate was > 90% in both groups without severe adverse effects and significant changes in renal function. As a new low-dose preparation regimen for colonoscopy in older adults, 1 L PEG/Asc, is as effective and safe as OSS.PMID:37482653 | DOI:10.3904/kjim.2023.030
Source: The Korean Journal of Internal Medicine - July 24, 2023 Category: Internal Medicine Authors: Ki Young Lim Kyeong Ok Kim Eun Young Kim Yoo Jin Lee Byung Ik Jang Sung Kook Kim Chang Heon Yang Crohn ’s and Colitis Association in Daegu-Gyeongbuk (CCAiD) Source Type: research
