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Drug: Polyethylene Glycol
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Total 2716 results found since Jan 2013.
Preparation of an ophthalmic formulation of TPGS-modified insulin-loaded liposomes and its < em > in vitro < /em > corneal permeation and pharmacokinetics in rabbit eyes
CONCLUSION: The prepared T-LPs/INS shows an improved corneal permeability, ocular surface retention capacity and eye tissue concentration of insulin in rabbits.PMID:37313826 | PMC:PMC10267244 | DOI:10.12122/j.issn.1673-4254.2023.05.20
Source: Journal of Southern Medical University - June 14, 2023 Category: Universities & Medical Training Authors: D Zhang Z DU Source Type: research
Clinical and cost outcomes of a polyethylene glycol (PEG)-coated patch versus drainage after axillary lymph node dissection in breast cancer: results from a multicentre randomized clinical trial
CONCLUSION: Compared with patients who received drainage after axillary lymph node dissection, the use of a polyethylene glycol-coated patch resulted in a higher rate of seroma, but a lower number of postoperative outpatient or emergency department visits and thus a reduction in overall costs.PMID:37311694 | DOI:10.1093/bjs/znad150
Source: The British Journal of Surgery - June 13, 2023 Category: Surgery Authors: Elvira Buch-Villa Carlos Casta ñer-Puga Silvia Delgado-Garcia Carlos Fuster-Diana Beatriz Vidal-Herrador Francisco Ripoll-Orts Tania Galeote-Quecedo Antonio Prat Myrian Andr és-Matias Jaime Jimeno-Fraile Ernesto Mu ñoz-Sorsona Giovani Vento Ver ónica Source Type: research
Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery
Biomacromolecules. 2023 Jun 12. doi: 10.1021/acs.biomac.3c00265. Online ahead of print.ABSTRACTProtease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are readily dispensable through 27G needles. The effects of exposure to matrix metalloproteinase 9 (MMP-9) on the microparticles were eval...
Source: Biomacromolecules - June 12, 2023 Category: Biochemistry Authors: Heidi K Noddeland Marianne Lind Karsten Petersson Frank Caruso Martin Malmsten Andrea Heinz Source Type: research
Effects of N-succinyl-chitosan coating on properties of astaxanthin-loaded PEG-liposomes: Environmental stability, antioxidant/antibacterial activities, and in vitro release
In this study, N-succinyl-chitosan (NSC)-coated AST polyethylene glycol (PEG)-liposomes were constructed to enhance the biocompatibility, stability, and intestinal-targeted migration of AST. The AST NSC/PEG-liposomes were uniform in size, had larger particles, greater encapsulation efficiency, and better storage, pH, and temperature stability than the AST PEG-liposomes. AST NSC/PEG-liposomes exerted stronger antibacterial and antioxidant activities against Escherichia coli and Staphylococcus aureus than AST PEG-liposomes. The NSC coating not only protects AST PEG-liposomes from gastric acid but also prolongs the retention ...
Source: International Journal of Biological Macromolecules - June 11, 2023 Category: Biochemistry Authors: Aiyang Liu Xiuhang Chai Shuang Zhu Ping-Tan Chin Mengxue He Yong-Jiang Xu Yuanfa Liu Source Type: research
A novel combination therapy of arginine deiminase and an arginase inhibitor targeting arginine metabolism in the tumor and immune microenvironment
This study implied the possibility of L-Norvaline as a modulator of the immune response in cancer and provided a new potential therapy combined with ADI-PEG 20.PMID:37293150 | PMC:PMC10244097
Source: Cell Research - June 9, 2023 Category: Cytology Authors: Pei-Hsuan Ye Chung-Yen Li Hao-Yu Cheng Gangga Anuraga Chih-Yang Wang Feng-Wei Chen Shiang-Jie Yang Kuo-Ting Lee Kwang-Yu Chang Ming-Derg Lai Source Type: research
Delivery mechanism of doxorubicin by PEG-DPPE micelles on membrane invasion by dynamic simulations
This study provides new theoretical insights into the mechanism of PEG-DPPE micelles in delivering drugs through membranes, which is of benefit for further optimization of PEGylated delivery systems.PMID:37278335 | DOI:10.1039/d2cp05946k
Source: Health Physics - June 6, 2023 Category: Physics Authors: Lina Zhao Meina Ren Yanjiao Wang Hailong An Fude Sun Source Type: research
