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Drug: Polyethylene Glycol
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Total 2716 results found since Jan 2013.
PLGA and PEG based porous microparticles as vehicles for pulmonary Somatropin delivery
Eur J Pharm Biopharm. 2023 Sep 1:S0939-6411(23)00230-8. doi: 10.1016/j.ejpb.2023.08.017. Online ahead of print.ABSTRACTBreakthrough advances in protein therapeutics and sustained release systems continue to fuel innovation in novel, non-invasive polymeric platforms for delivery of biologicals. Despite the bench potential and proof-of-concept work, market analysis still shows biologicals to be predominantly injections. Characterized by insufficient secretion of growth hormone by the pituitary gland, growth hormone deficiency (GHD) is a rare disorder. Currently, chronic somatropin (r-hGH) replacement therapy is only availabl...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 3, 2023 Category: Drugs & Pharmacology Authors: Srushti Sodha Pardeep Gupta Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Enhanced persulfate activation by ethylene glycol-mediated bimetallic sulfide for imidacloprid degradation
This study not only provides a theoretical foundation for catalyst design, but also promotes the industrial application of bimetallic sulfide Fenton-like catalysts for water management.PMID:37659508 | DOI:10.1016/j.chemosphere.2023.140032
Source: Chemosphere - September 2, 2023 Category: Chemistry Authors: Mengyun Jiang Zhongjun Xu Xirong Zhang Zizhen Han Tingting Zhang Xiaochun Chen Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Enhanced persulfate activation by ethylene glycol-mediated bimetallic sulfide for imidacloprid degradation
This study not only provides a theoretical foundation for catalyst design, but also promotes the industrial application of bimetallic sulfide Fenton-like catalysts for water management.PMID:37659508 | DOI:10.1016/j.chemosphere.2023.140032
Source: Chemosphere - September 2, 2023 Category: Chemistry Authors: Mengyun Jiang Zhongjun Xu Xirong Zhang Zizhen Han Tingting Zhang Xiaochun Chen Source Type: research
Smart design of universally decorated nanoparticles for drug delivery applications driven by active transport
Eur Phys J E Soft Matter. 2023 Aug 31;46(9):74. doi: 10.1140/epje/s10189-023-00331-5.ABSTRACTTargeting the cell nucleus remains a challenge for drug delivery. Here, we present a universal platform for the smart design of nanoparticle (NP) decoration that is based on: (i) a spacer polymer, commonly biotin-polyethylene-glycol-thiol, whose grafting density and molecular weight can be tuned for optimized performance, and (ii) protein binding peptides, such as cell penetrating peptides (CPPs), cancer-targeting peptides, or nuclear localization signal (NLS) peptides, that are linked to the PEG free-end by universal chemistry. We...
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Gal Halbi Itay Fayer Dina Aranovich Shachar Gat Mariela J Pavan Dikla Nachmias Daniel Sevilla Sanchez Ashraf Brik Rony Granek Anne Bernheim-Groswasser Source Type: research
Loratadine oral bioavailability enhancement via solid dispersion loaded oro-dispersible films: Formulation, characterization and pharmacokinetics
Colloids Surf B Biointerfaces. 2023 Aug 25;230:113526. doi: 10.1016/j.colsurfb.2023.113526. Online ahead of print.ABSTRACTLoratadine (LRD) belongs to second-generation tricyclic H1 antihistamine class, known for its non-sedating properties in allergic reactions. H1 antihistamines avoid and block the responses to allergens or histamine in nose and conjunctivae, thereby abolishing itching, congestion and sneezing. LRD is a Biopharmaceutical Class System (BCS) class II drug with dissolution or solubility limited absorption which limited the oral bioavailability and therapeutic efficacy of LRD. To improve the oral bioavailabil...
Source: Colloids and Surfaces - August 30, 2023 Category: Biotechnology Authors: Nayyer Islam Naveed Ullah Khan Anam Razzaq Farid Menaa Zaheer Ullah Khan Abid Hussain Saif Ur Rehman Haroon Iqbal Jiang Ni Source Type: research
Anaphylactic shock induced by polyethylene glycol after bowel preparation for the colorectal cancer surgery: A case report
CONCLUSION: While allergic reactions to PEG are rare, they can be life-threatening. Therefore, it is crucial for clinicians to be aware of this possibility and to diagnose and resuscitate patients immediately.PMID:37637691 | PMC:PMC10450373 | DOI:10.12998/wjcc.v11.i23.5589
Source: Clinical Colorectal Cancer - August 28, 2023 Category: Cancer & Oncology Authors: Go Woon Park Nahyeon Park Jung Cheol Kuk Eung Jin Shin Dae Ro Lim Source Type: research
Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Drug Deliv Transl Res. 2023 Aug 28. doi: 10.1007/s13346-023-01421-9. Online ahead of print.ABSTRACTCelastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and systemic toxicity. Ferric oxide (Fe3O4) has a large specific surface area and can be functionalized by inorganic modification to form complex magnetic drug delivery systems. Herein, Fe3O4 was surface-modified with citric acid and polyethylene glycol (PEG) (via) the Mitsunobu reaction and then covalently bound to CST. Finally, magnetic microbubbles (MMBs) containing perfluoropropane ...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Jian Huang Zhengji Wang Zihe Chen Chunxin Huang Ying Wang Xing Li Weiyang Lv Guiqiang Qi Huilin Liu Source Type: research
Genome-wide analysis of the SMXL gene family in common bean and identification of karrikin-responsive PvSMXL2 as a negative regulator of PEG-induced drought stress
In this study, we identified nine orthologues of SMXL genes in common bean, which are located on six chromosomes and classified into four subgroups. Basic molecular properties, including theoretical isoelectric point (PI), molecular weight (MW), grand average of hydropathicity (GVIO), gene structure, and conserved motifs were characterized, and numerous cis-elements in promoters were predicted. The expression patterns of PvSMXL genes were found to be distinct under 10% polyethylene glycol (PEG)-induced drought stress and 200 μM Cu treatments. Most PvSMXLs showed reduced expression in response to Cu treatment, whereas near...
Source: Gene - August 27, 2023 Category: Genetics & Stem Cells Authors: Pingping Fang Minxuan Li Qinwei Guo Xinyang Wu Yannan Hu Yusu Cheng Pei Xu Source Type: research
