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Drug: Polyethylene Glycol
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Total 2716 results found since Jan 2013.
Titanium dioxide nanoparticles improve element uptake, antioxidant properties, and essential oil productivity of Melissa officinalis L. seedlings under in vitro drought stress
Environ Sci Pollut Res Int. 2023 Aug 21. doi: 10.1007/s11356-023-29384-x. Online ahead of print.ABSTRACTIn vitro drought stress has a considerable impact on the mass production of active compounds in medicinal plants. Nevertheless, photosynthesis, nutrient uptake, and protein synthesis may be negatively affected by drought, which results in poor growth. Titanium dioxide nanoparticles (TiO2 NPs) have recently been shown to play an important role in increasing nutrient uptake, resistance to various environmental stresses, and better plant growth. Regarding the importance of pharmaceutical metabolites of Melissa officinalis L...
Source: Environmental Science and Pollution Research International - August 21, 2023 Category: Environmental Health Authors: Roya Razavizadeh Fatemeh Adabavazeh Zahra Mosayebi Source Type: research
Poly-l-glutamic acid modification modulates the bio-nano interface of a therapeutic anti-IGF-1R antibody in prostate cancer
Biomaterials. 2023 Aug 14;301:122280. doi: 10.1016/j.biomaterials.2023.122280. Online ahead of print.ABSTRACTModifying biological agents with polymers such as polyethylene glycol (PEG) has demonstrated clinical benefits; however, post-market surveillance of PEGylated derivatives has revealed PEG-associated toxicity issues, prompting the search for alternatives. We explore how conjugating a poly-l-glutamic acid (PGA) to an anti-insulin growth factor 1 receptor antibody (AVE1642) modulates the bio-nano interface and anti-tumor activity in preclinical prostate cancer models. Native and PGA-modified AVE1642 display similar ant...
Source: Biomaterials - August 20, 2023 Category: Materials Science Authors: Sonia Vicente-Ruiz Ana Armi ñán Katia Maso Elena Gallon Oleksandr Zagorodko Julie Movellan Fernanda Rodr íguez-Otormín Maike Baues Jan-Niklas May Federica De Lorenzi Twan Lammers Mar ía J Vicent Source Type: research
Zwitterionic Polymeric Sulfur Ylides with Minimal Charge Separation Open a New Generation of Antifouling and Bactericidal Materials
Angew Chem Int Ed Engl. 2023 Aug 19:e202308971. doi: 10.1002/anie.202308971. Online ahead of print.ABSTRACTZwitterionic polymers are widely employed hydrophilic building blocks for antifouling coatings with numerous applications across a wide range of fields, including but not limited to biomedical science, drug delivery and nanotechnology. Zwitterionic polymers are considered as an attractive alternative to polyethylene glycol because of their biocompatibility and effectiveness to prevent formation of biofilms. To this end, zwitterionic polymers are classified in two categories, namely polybetaines and polyampholytes. Yet...
Source: Angewandte Chemie - August 19, 2023 Category: Chemistry Authors: Bela B Berking Georgia Poulladofonou Dimitrios Karagrigoriou Daniela A Wilson Kevin Neumann Source Type: research
pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer's disease
In this study, polyethylene glycol (PEG)-coated poly D, L-lactic-co-glycolic acid (PLGA) nanostructures were prepared, as their self-assembling ability helps to penetrate the drug at disease sites with altered pH range (5.7-6.8) due to AD. Drug and polymer interaction studies by FTIR showed no interaction among them, and the thermal properties of drugs, polymers, and nanostructures tell us about their melting behaviour, thermal degradation, and glass transition temperatures. Characterization of prepared self-assembled nanoscaffolds signifies that the acquired properties such as size, structure, surface charges, zeta-potent...
Source: Journal of Biosciences - August 18, 2023 Category: Biomedical Science Authors: Varsha Rani Rinki Verma Krishan Kumar Ruchi Chawla Source Type: research
Lysozyme-Immobilized Polyethersulfone Membranes with Satisfactory Hemocompatibility and High Enzyme Activity for Endotoxin Removal
In this study, we propose a new approach for developing the functional polyethersulfone (PES) membrane to remove endotoxins. First, the PES polymer is grafted with polyethylene glycol methyl acrylate (PEG-MA) in a homogeneous phase system via γ irradiation, and PES-g-PEG can be directly used to prepare the membrane by the phase inversion method. Then, polydopamine (PDA) is coated as an adhesive layer onto a PES-g-PEG membrane in an alkaline aqueous solution, and lysozyme (Lyz) is covalently immobilized with PDA through the Schiff base reaction. Lysozyme acts as an affinity adsorption ligand of endotoxin through charge and...
Source: Biomacromolecules - August 18, 2023 Category: Biochemistry Authors: Jingxia Wang Chaorong Peng Xijing Yang Maojun Ni Xiaobin Zhang Zhenqiang Shi Hao Chen Siyang Liu Lunqiang Jin Changsheng Zhao Source Type: research
pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer's disease
In this study, polyethylene glycol (PEG)-coated poly D, L-lactic-co-glycolic acid (PLGA) nanostructures were prepared, as their self-assembling ability helps to penetrate the drug at disease sites with altered pH range (5.7-6.8) due to AD. Drug and polymer interaction studies by FTIR showed no interaction among them, and the thermal properties of drugs, polymers, and nanostructures tell us about their melting behaviour, thermal degradation, and glass transition temperatures. Characterization of prepared self-assembled nanoscaffolds signifies that the acquired properties such as size, structure, surface charges, zeta-potent...
Source: Journal of Biosciences - August 18, 2023 Category: Biomedical Science Authors: Varsha Rani Rinki Verma Krishan Kumar Ruchi Chawla Source Type: research
Lysozyme-Immobilized Polyethersulfone Membranes with Satisfactory Hemocompatibility and High Enzyme Activity for Endotoxin Removal
In this study, we propose a new approach for developing the functional polyethersulfone (PES) membrane to remove endotoxins. First, the PES polymer is grafted with polyethylene glycol methyl acrylate (PEG-MA) in a homogeneous phase system via γ irradiation, and PES-g-PEG can be directly used to prepare the membrane by the phase inversion method. Then, polydopamine (PDA) is coated as an adhesive layer onto a PES-g-PEG membrane in an alkaline aqueous solution, and lysozyme (Lyz) is covalently immobilized with PDA through the Schiff base reaction. Lysozyme acts as an affinity adsorption ligand of endotoxin through charge and...
Source: Biomacromolecules - August 18, 2023 Category: Biochemistry Authors: Jingxia Wang Chaorong Peng Xijing Yang Maojun Ni Xiaobin Zhang Zhenqiang Shi Hao Chen Siyang Liu Lunqiang Jin Changsheng Zhao Source Type: research
pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer's disease
In this study, polyethylene glycol (PEG)-coated poly D, L-lactic-co-glycolic acid (PLGA) nanostructures were prepared, as their self-assembling ability helps to penetrate the drug at disease sites with altered pH range (5.7-6.8) due to AD. Drug and polymer interaction studies by FTIR showed no interaction among them, and the thermal properties of drugs, polymers, and nanostructures tell us about their melting behaviour, thermal degradation, and glass transition temperatures. Characterization of prepared self-assembled nanoscaffolds signifies that the acquired properties such as size, structure, surface charges, zeta-potent...
Source: Journal of Biosciences - August 18, 2023 Category: Biomedical Science Authors: Varsha Rani Rinki Verma Krishan Kumar Ruchi Chawla Source Type: research
Lysozyme-Immobilized Polyethersulfone Membranes with Satisfactory Hemocompatibility and High Enzyme Activity for Endotoxin Removal
In this study, we propose a new approach for developing the functional polyethersulfone (PES) membrane to remove endotoxins. First, the PES polymer is grafted with polyethylene glycol methyl acrylate (PEG-MA) in a homogeneous phase system via γ irradiation, and PES-g-PEG can be directly used to prepare the membrane by the phase inversion method. Then, polydopamine (PDA) is coated as an adhesive layer onto a PES-g-PEG membrane in an alkaline aqueous solution, and lysozyme (Lyz) is covalently immobilized with PDA through the Schiff base reaction. Lysozyme acts as an affinity adsorption ligand of endotoxin through charge and...
Source: Biomacromolecules - August 18, 2023 Category: Biochemistry Authors: Jingxia Wang Chaorong Peng Xijing Yang Maojun Ni Xiaobin Zhang Zhenqiang Shi Hao Chen Siyang Liu Lunqiang Jin Changsheng Zhao Source Type: research
