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Specialty: General Medicine
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Total 380 results found since Jan 2013.
Role of TLR4/MyD88/NF- κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Exp Ther Med. 2020 Nov;20(5):115
Authors: Wang X, Zhou J, Yang J, Wang S, Yang L
Abstract
The aim of the present study was to explore the role of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling in the contrast-induced injury of renal tubular epithelial cells, and to investigate the potential mechanisms. HK-2 cells cultured in vitro were randomly divided into six groups as follows: i) The blank group; ii) the iohexol group; iii) the NF-κ...
Source: Experimental and Therapeutic Medicine - October 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
Roles of microRNA-186 and vascular endothelial growth factor in hepatocellular carcinoma complicated with portal vein tumor thrombus.
In conclusion, VEGF was significantly increased in tumor thrombus and blood samples from HCC patients with vein tumor thrombus, which may be associated with the downregulation of miR-186. Thus, miR-186 may promote the development and progression of vein tumor thrombus in HCC.
PMID: 32855736 [PubMed]
Source: Experimental and Therapeutic Medicine - August 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
Hydrogen peroxide induces nucleus pulposus cell apoptosis by ATF4/CHOP signaling pathway.
In this study, we found H2O2 could promote NP cell apoptosis by activating the ATF4/CHOP signaling pathway resulting in the upregulation of caspase-9. Interdict of ATF4, CHOP, or caspase-9 contributed to the reduction of apoptosis caused by H2O2.
PMID: 32855694 [PubMed]
Source: Experimental and Therapeutic Medicine - August 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
6PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.
CONCLUSIONS: Our work provides preclinical evidence that 6PGD inhibition may represent a potential therapeutic strategy to augment the efficacy of RCC standard of care drugs.
PMID: 32829780 [PubMed - in process]
Source: The American Journal of the Medical Sciences - August 26, 2020 Category: General Medicine Authors: Cao J, Sun X, Zhang X, Chen D Tags: Am J Med Sci Source Type: research
TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
CONCLUSIONS: TOSO might be involved in the pathogenesis of CLL by interacting with SYK, enhancing the BCR signaling pathway, and inducing apoptosis resistance.
PMID: 32784334 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - August 9, 2020 Category: General Medicine Authors: Zhang YR, Yu Z, Xiong WJ, Liu XX, Liu HM, Cui R, Wang Q, Chen WM, Qiu LG, Yi SH Tags: Chin Med J (Engl) Source Type: research
Activation of TGR5 receptor reduces damage of ET-1 on H9C2 cardiomyocytes by activating Nrf2.
CONCLUSIONS: Activation of TGR5 receptor may reduce the damage of ET-1 on H9C2 cardiomyocytes by activating Nrf2 and its downstream antioxidant genes HO-1, NQO-1 and Txnrd-1.
PMID: 32414227 [PubMed - as supplied by publisher]
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research
MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor- α-induced protein 8.
CONCLUSIONS: MiR-379 has a binding site with TNFAIP8 and can inhibit its activity by binding to TNFAIP8 mRNA. SiRNA-TNFAIP8 can inhibit the NF-κB signaling pathway and protect myocardial cells from AMI-induced myocardial damage by reducing the apoptosis level of myocardial cells.
PMID: 32414226 [PubMed - as supplied by publisher]
Source: Panminerva Medica - May 17, 2020 Category: General Medicine Tags: Panminerva Med Source Type: research
Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 MAPK in human coronary artery endothelial cells.
Authors: Zhang Y, Cao H
Abstract
C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the production of atherosclerosis-related factors in cultured human coronary artery endothelial cells (HCAECs). HCAECs were treated with pCRP, mCRP, p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, or transfected with p38 MAPK siRNA. Western blotting was performed to detect the expression of vascular endothelial growth factor (VEG...
Source: Bosnian Journal of Basic Medical Sciences - May 4, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
WASF3 Knockdown Sensitizes Gastric Cancer Cells to Oxaliplatin by Inhibiting ATG12-Mediated Autophagy.
CONCLUSIONS: Our analysis demonstrates WASF3 targeting is a new potential therapeutic strategy for gastric cancer.
PMID: 32359534 [PubMed - in process]
Source: The American Journal of the Medical Sciences - April 30, 2020 Category: General Medicine Authors: Nie Y, Liang X, Liu S, Guo F, Fang N, Zhou F Tags: Am J Med Sci Source Type: research
Downregulation of miRNA-663b protects against hypoxia-induced injury in cardiomyocytes by targeting BCL2L1.
In conclusion, miR-663b inhibition protected cardiomyocytes against hypoxia-induced injury by targeting BCL2L1 and may potentially be a novel target for the treatment of patients with myocardial infarction.
PMID: 32346421 [PubMed]
Source: Experimental and Therapeutic Medicine - April 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
TMEM16A regulates the cell cycle of pulmonary artery smooth muscle cells in high-flow-induced pulmonary arterial hypertension rat model.
In conclusion, TMEM16A may be involved in high pulmonary blood flow-induced PAH by regulating PASMC cell cycle progression.
PMID: 32266023 [PubMed]
Source: Experimental and Therapeutic Medicine - April 10, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
MicroRNA-490-3p suppresses hepatocellular carcinoma cell proliferation and migration by targeting the aurora kinase A gene (AURKA).
Conclusions: miR-490-3p could down-regulate the expression of AURKA, thus suppressing the proliferation and migration of HCC cells.
PMID: 32190151 [PubMed]
Source: Archives of Medical Science - March 20, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research
Long non-coding RNA PVT1 regulates the migration of hepatocellular carcinoma HepG2 cells via miR-3619-5p/MKL1 axis.
In this study, we investigated the relationship between PVT1 and MKL1 as a novel regulatory mechanism underlying HCC progression. We used HepG2 and Cos‑7 cell lines. Transfection experiments with miR-3619-5p mimics/inhibitor, PVT1, siRNA-PVT1, MKL1, or siRNA-MKL1 were performed. RNA and protein levels were analyzed by quantitative reverse transcription PCR and Western blot, respectively. Cell migration was assessed by Transwell assay. Luciferase assays, RNA-FISH, RNA immunoprecipitation, and chromatin immunoprecipitation assays were performed to confirm the interaction between PVT1, miR-3619-5p, and MKL1 in HCC cells. Ov...
Source: Bosnian Journal of Basic Medical Sciences - March 12, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model.
CONCLUSIONS: Our pangolin coronavirus GX_P2V is a workable model for 2019-nCoV research. CEP, selamectin and mefloquine hydrochloride are potential drugs for treating 2019-nCoV infection. Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted.
PMID: 32149769 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Fan HH, Wang LQ, Liu WL, An XP, Liu ZD, He XQ, Song LH, Tong YG Tags: Chin Med J (Engl) Source Type: research
Gremlin mediates the TGF- β-induced induction of profibrogenic genes in human retinal pigment epithelial cells.
Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells.
Exp Ther Med. 2020 Mar;19(3):2353-2359
Authors: Qin D, Jin X, Jiang Y
Abstract
Proliferative vitreoretinopathy (PVR) is characterised by the contraction and growth of fibrotic membranes on the retina and within the vitreous body. Retinal pigment epithelial (RPE) cells, a major cellular component of the fibrotic membrane, is one of the cell types that have been previously reported to associate with PVR pathogenesis. During PVR, RPE cells undergo increased cell proliferation, migration and the ...
Source: Experimental and Therapeutic Medicine - February 29, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
