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Total 380 results found since Jan 2013.

Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research

Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research

Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research

Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research