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Specialty: General Medicine
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Total 380 results found since Jan 2013.
Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner
Exp Ther Med. 2021 Nov;22(5):1275. doi: 10.3892/etm.2021.10710. Epub 2021 Sep 8.ABSTRACTOxidized low-density lipoprotein (ox-LDL) induces endothelial cell apoptosis and dysfunction. Statins are drugs that are clinically used to lower serum cholesterol levels, and they have been shown to exert vascular protective effects. In the present study, human umbilical vein endothelial cells were transfected with scramble control siRNA or siRNA specific for glutathione peroxidase (GPx)4 or cystine-glutamate antiporter (xCT). MTT, Matrigel and Transwell assays were used to evaluate cell proliferation, tube formation and migration, res...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Qing Li Chang Liu Liang Deng Enrui Xie Nishant Yadav Yuanyuan Tie Zheng Cheng Jie Deng Source Type: research
miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN
Exp Ther Med. 2021 Nov;22(5):1278. doi: 10.3892/etm.2021.10713. Epub 2021 Sep 8.ABSTRACTMicroRNAs (miRs) and inflammatory cytokines can induce acute lung injury (ALI), which can develop into acute respiratory distress syndrome in severe cases. Previous research has revealed that miR-122-5p participates in the development of ALI, and that its expression is positively associated with ALI. However, the mechanism by which miR-122-5p contributes to ALI remains to be determined. In the current study, TargetScan and dual luciferase reporter gene assays were used to confirm that IL-1 receptor antagonist (IL1RN) was a target of miR...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Jie Li Xiaoxia Zeng Weiqing Wang Source Type: research
circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis
In conclusion, findings from the present study suggested that circRNA_PTPRA may regulate HCC cell proliferation, invasion, apoptosis and migration by sponging miR-582-3p. This indicates that the circRNA_PTPRA/miR-582-3p axis may represent a potential target for HCC diagnosis and treatment.PMID:34594413 | PMC:PMC8456459 | DOI:10.3892/etm.2021.10711
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Yanlin Jin Yi Zhang Xiaoming Luo Source Type: research
Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner
Exp Ther Med. 2021 Nov;22(5):1275. doi: 10.3892/etm.2021.10710. Epub 2021 Sep 8.ABSTRACTOxidized low-density lipoprotein (ox-LDL) induces endothelial cell apoptosis and dysfunction. Statins are drugs that are clinically used to lower serum cholesterol levels, and they have been shown to exert vascular protective effects. In the present study, human umbilical vein endothelial cells were transfected with scramble control siRNA or siRNA specific for glutathione peroxidase (GPx)4 or cystine-glutamate antiporter (xCT). MTT, Matrigel and Transwell assays were used to evaluate cell proliferation, tube formation and migration, res...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Qing Li Chang Liu Liang Deng Enrui Xie Nishant Yadav Yuanyuan Tie Zheng Cheng Jie Deng Source Type: research
miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN
Exp Ther Med. 2021 Nov;22(5):1278. doi: 10.3892/etm.2021.10713. Epub 2021 Sep 8.ABSTRACTMicroRNAs (miRs) and inflammatory cytokines can induce acute lung injury (ALI), which can develop into acute respiratory distress syndrome in severe cases. Previous research has revealed that miR-122-5p participates in the development of ALI, and that its expression is positively associated with ALI. However, the mechanism by which miR-122-5p contributes to ALI remains to be determined. In the current study, TargetScan and dual luciferase reporter gene assays were used to confirm that IL-1 receptor antagonist (IL1RN) was a target of miR...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Jie Li Xiaoxia Zeng Weiqing Wang Source Type: research
circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis
In conclusion, findings from the present study suggested that circRNA_PTPRA may regulate HCC cell proliferation, invasion, apoptosis and migration by sponging miR-582-3p. This indicates that the circRNA_PTPRA/miR-582-3p axis may represent a potential target for HCC diagnosis and treatment.PMID:34594413 | PMC:PMC8456459 | DOI:10.3892/etm.2021.10711
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Yanlin Jin Yi Zhang Xiaoming Luo Source Type: research
Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner
Exp Ther Med. 2021 Nov;22(5):1275. doi: 10.3892/etm.2021.10710. Epub 2021 Sep 8.ABSTRACTOxidized low-density lipoprotein (ox-LDL) induces endothelial cell apoptosis and dysfunction. Statins are drugs that are clinically used to lower serum cholesterol levels, and they have been shown to exert vascular protective effects. In the present study, human umbilical vein endothelial cells were transfected with scramble control siRNA or siRNA specific for glutathione peroxidase (GPx)4 or cystine-glutamate antiporter (xCT). MTT, Matrigel and Transwell assays were used to evaluate cell proliferation, tube formation and migration, res...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Qing Li Chang Liu Liang Deng Enrui Xie Nishant Yadav Yuanyuan Tie Zheng Cheng Jie Deng Source Type: research
Role of miR-139-5p in ectopic endometrial stromal cells and the underlying molecular mechanism
In conclusion, the results of the present study suggested that miR-139-5p may play a key role in the progression of endometriosis by regulating the viability of ESCs and directly targeting BBC3.PMID:34539847 | PMC:PMC8438670 | DOI:10.3892/etm.2021.10686
Source: Experimental and Therapeutic Medicine - September 20, 2021 Category: General Medicine Authors: Lixia Feng Xu Chen Shenghua Zhang Yunxia Chen Yanling Yu Source Type: research
