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Total 380 results found since Jan 2013.
Insulin growth factor-1 promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells through the Wnt/ β-catenin pathway
Exp Ther Med. 2021 Aug;22(2):891. doi: 10.3892/etm.2021.10323. Epub 2021 Jun 17.ABSTRACTBone marrow mesenchymal stem cells (BMSCs) are stem cells that exist in bone marrow tissue and have osteogenic differentiation potential. Insulin growth factor-1 (IGF-1) plays a key role in the proliferation and osteogenic differentiation of BMSCs. However, the specific mechanism of IGF-1 in cell proliferation and osteogenic differentiation remains unclear. In the present study, BMSCs were transfected with lentivirus carrying the siRNA-Wnt3a gene, and the Wnt3a level in BMSCs was revealed to be reduced by western blotting, real-time qua...
Source: Experimental and Therapeutic Medicine - July 1, 2021 Category: General Medicine Authors: Jing Feng Zhiqiang Meng Source Type: research
Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy
Exp Ther Med. 2021 Aug;22(2):814. doi: 10.3892/etm.2021.10246. Epub 2021 May 28.ABSTRACTRenal tubular interstitial injury plays a key role in the progression of diabetic nephropathy (DN) and, thus, the study of renal tubular injury in DN is important. The aim of the present study was to elucidate the role of the NLR family CARD domain containing 4 (NLRC4) inflammasome in renal tubular epithelial cell (RTEC) injury in DN. Human kidney biopsy tissues were obtained from patients with DN, and normal kidney tissues were obtained from nephrectomies performed for renal hamartoma. Human RTECs (HK2 cells) were divided into normal g...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Yulin Wang Rong Gou Lu Yu Liuwei Wang Zijun Yang Yanhong Guo Lin Tang Source Type: research
Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma
Exp Ther Med. 2021 Aug;22(2):817. doi: 10.3892/etm.2021.10249. Epub 2021 Jun 2.ABSTRACTThe incidence of rectal carcinoma (RC) is increasing and the age at onset of the disease is reducing. Therefore, elucidating the pathogenesis of RC is beneficial for early diagnosis and improving the prognosis. Aminoacylase-1 (ACY-1) is abnormally expressed in various malignant tumor tissues. Furthermore, the human epidermal growth factor receptor-2 (HER2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell apoptosis. The aim of the present study was ...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Zizhong Xu Yating Hu Zhaohui Yu Source Type: research
Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy
Exp Ther Med. 2021 Aug;22(2):814. doi: 10.3892/etm.2021.10246. Epub 2021 May 28.ABSTRACTRenal tubular interstitial injury plays a key role in the progression of diabetic nephropathy (DN) and, thus, the study of renal tubular injury in DN is important. The aim of the present study was to elucidate the role of the NLR family CARD domain containing 4 (NLRC4) inflammasome in renal tubular epithelial cell (RTEC) injury in DN. Human kidney biopsy tissues were obtained from patients with DN, and normal kidney tissues were obtained from nephrectomies performed for renal hamartoma. Human RTECs (HK2 cells) were divided into normal g...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Yulin Wang Rong Gou Lu Yu Liuwei Wang Zijun Yang Yanhong Guo Lin Tang Source Type: research
Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma
Exp Ther Med. 2021 Aug;22(2):817. doi: 10.3892/etm.2021.10249. Epub 2021 Jun 2.ABSTRACTThe incidence of rectal carcinoma (RC) is increasing and the age at onset of the disease is reducing. Therefore, elucidating the pathogenesis of RC is beneficial for early diagnosis and improving the prognosis. Aminoacylase-1 (ACY-1) is abnormally expressed in various malignant tumor tissues. Furthermore, the human epidermal growth factor receptor-2 (HER2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell apoptosis. The aim of the present study was ...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Zizhong Xu Yating Hu Zhaohui Yu Source Type: research
Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy
Exp Ther Med. 2021 Aug;22(2):814. doi: 10.3892/etm.2021.10246. Epub 2021 May 28.ABSTRACTRenal tubular interstitial injury plays a key role in the progression of diabetic nephropathy (DN) and, thus, the study of renal tubular injury in DN is important. The aim of the present study was to elucidate the role of the NLR family CARD domain containing 4 (NLRC4) inflammasome in renal tubular epithelial cell (RTEC) injury in DN. Human kidney biopsy tissues were obtained from patients with DN, and normal kidney tissues were obtained from nephrectomies performed for renal hamartoma. Human RTECs (HK2 cells) were divided into normal g...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Yulin Wang Rong Gou Lu Yu Liuwei Wang Zijun Yang Yanhong Guo Lin Tang Source Type: research
Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma
Exp Ther Med. 2021 Aug;22(2):817. doi: 10.3892/etm.2021.10249. Epub 2021 Jun 2.ABSTRACTThe incidence of rectal carcinoma (RC) is increasing and the age at onset of the disease is reducing. Therefore, elucidating the pathogenesis of RC is beneficial for early diagnosis and improving the prognosis. Aminoacylase-1 (ACY-1) is abnormally expressed in various malignant tumor tissues. Furthermore, the human epidermal growth factor receptor-2 (HER2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell apoptosis. The aim of the present study was ...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Zizhong Xu Yating Hu Zhaohui Yu Source Type: research
Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy
Exp Ther Med. 2021 Aug;22(2):814. doi: 10.3892/etm.2021.10246. Epub 2021 May 28.ABSTRACTRenal tubular interstitial injury plays a key role in the progression of diabetic nephropathy (DN) and, thus, the study of renal tubular injury in DN is important. The aim of the present study was to elucidate the role of the NLR family CARD domain containing 4 (NLRC4) inflammasome in renal tubular epithelial cell (RTEC) injury in DN. Human kidney biopsy tissues were obtained from patients with DN, and normal kidney tissues were obtained from nephrectomies performed for renal hamartoma. Human RTECs (HK2 cells) were divided into normal g...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Yulin Wang Rong Gou Lu Yu Liuwei Wang Zijun Yang Yanhong Guo Lin Tang Source Type: research
lncRNA WT1-AS is upregulated in osteoporosis and regulates the apoptosis of osteoblasts by interacting with p53
Exp Ther Med. 2021 Jul;22(1):734. doi: 10.3892/etm.2021.10166. Epub 2021 May 9.ABSTRACTIn cervical cancer, cellular tumor antigen p53 (p53) interacts with long non-coding WT1 antisense RNA (WT1-AS) and this protein serves an important role in osteoporosis. The present study aimed to investigate the role of WT1-AS in osteoporosis. WT1-AS was upregulated in the plasma of patients with osteoporosis and was positively correlated with p53 expression. Altered expression of WT1-AS and p53 separated patients with osteoporosis from healthy controls. Expression levels of WT1-AS and p53 decreased with prolonged treatment. In osteobla...
Source: Experimental and Therapeutic Medicine - May 31, 2021 Category: General Medicine Authors: Chaoqun Wang Quan Xie Wen Sun Ying Zhou Yu Liu Source Type: research
miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression
In conclusion, miR-770-5p was highly expressed in the serum of patients with T2DM compared with healthy volunteers. In UA-treated pancreatic β-cells, compared with the inhibitor control group, miR-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting BAG5. Therefore, the present study suggested that miR-770-5p inhibitor may serve a protective role in T2DM.PMID:33986829 | PMC:PMC8112148 | DOI:10.3892/etm.2021.10096
Source: Experimental and Therapeutic Medicine - May 14, 2021 Category: General Medicine Authors: Min Wang Jilou Wei Ting Ji Kui Zang Source Type: research
