Filtered By:
Specialty: General Medicine
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 380 results found since Jan 2013.
LIM mineralization protein-1 inhibits IL-1 β-induced human chondrocytes injury by altering the NF-κB and MAPK/JNK pathways
Exp Ther Med. 2022 Jan;23(1):61. doi: 10.3892/etm.2021.10983. Epub 2021 Nov 21.ABSTRACTOsteoarthritis (OA) is a common degenerative disease that is associated with the degradation of articular cartilage. Accumulating evidence has confirmed that LIM mineralization protein-1 (LMP-1) is an important agent of bone formation and has been shown to be osteoinductive in various types of disease. However, the underlying mechanisms of LMP-1 in the pathogenesis of OA remain unknown. The present study aimed to evaluate the role and potential mechanism of LMP-1 in IL-1β-stimulated OA chondrocytes. CHON-001 cells were transfected with ...
Source: Experimental and Therapeutic Medicine - December 22, 2021 Category: General Medicine Authors: Dijun Ou Sheng Liu Changjun Tong Hezhong Tan Yadong Yang Chunlei He Source Type: research
High glucose induces HSP47 expression and promotes the secretion of inflammatory factors through the IRE1 α/XBP1/HIF-1α pathway in retinal Müller cells
Exp Ther Med. 2021 Dec;22(6):1411. doi: 10.3892/etm.2021.10847. Epub 2021 Oct 7.ABSTRACTDiabetic retinopathy, a common complication of diabetes, is the leading cause of blindness globally. Müller cells are key players in diabetes-associated retinal inflammation and dysfunction. However, the pathological changes of Müller cells in response to high glucose (HG) and the underlying mechanism remain unclear. The aim of the present study was to investigate the key role of heat shock protein 47 (HSP47) in HG-induced unfolded protein and inflammatory responses. Primary mouse Müller cells were starved in serum-free DMEM overnigh...
Source: Experimental and Therapeutic Medicine - October 22, 2021 Category: General Medicine Authors: Xincheng Sun Chen Chen Hu Liu Shaowen Tang Source Type: research
Insulin receptor substrate-1 and dishevelled 2 are negatively regulated by microRNA-144 and inhibit nasopharyngeal carcinoma cell malignancy
Exp Ther Med. 2021 Nov;22(5):1303. doi: 10.3892/etm.2021.10738. Epub 2021 Sep 16.ABSTRACTInsulin receptor substrate-1 (IRS-1) is reported to play a critical role in the development, progression, invasion and metastasis of several types of tumors and is abnormally expressed in nasopharyngeal carcinoma (NPC). Although IRS-1 is predicted to be targeted by microRNA (miR)-144, the biological roles and potential mechanisms of miR-144 in NPC remain unclear. In the present study, the expression levels of miR-144 and IRS-1 in several NPC cell lines were first examined, and found that they were negatively correlated. Following the i...
Source: Experimental and Therapeutic Medicine - October 11, 2021 Category: General Medicine Authors: Xuemei An Yunlan Jiang Defeng Chen Jianjun Chen Source Type: research
Autophagy is involved in neurofibromatosis type I gene-modulated osteogenic differentiation in human bone mesenchymal stem cells
In conclusion, results from the present study suggest at the involvement of autophagy in the NF1-modulated osteogenic differentiation of BMSCs. Furthermore, NF1 may partially regulate the autophagic activity of BMSCs through the PI3K/AKT/mTOR signaling pathway.PMID:34603530 | PMC:PMC8453340 | DOI:10.3892/etm.2021.10697
Source: Experimental and Therapeutic Medicine - October 4, 2021 Category: General Medicine Authors: Yiqiang Li Mingwei Zhu Xuemei Lin Jingchun Li Zhe Yuan Yanhan Liu Hongwen Xu Source Type: research
miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN
Exp Ther Med. 2021 Nov;22(5):1278. doi: 10.3892/etm.2021.10713. Epub 2021 Sep 8.ABSTRACTMicroRNAs (miRs) and inflammatory cytokines can induce acute lung injury (ALI), which can develop into acute respiratory distress syndrome in severe cases. Previous research has revealed that miR-122-5p participates in the development of ALI, and that its expression is positively associated with ALI. However, the mechanism by which miR-122-5p contributes to ALI remains to be determined. In the current study, TargetScan and dual luciferase reporter gene assays were used to confirm that IL-1 receptor antagonist (IL1RN) was a target of miR...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Jie Li Xiaoxia Zeng Weiqing Wang Source Type: research
circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis
In conclusion, findings from the present study suggested that circRNA_PTPRA may regulate HCC cell proliferation, invasion, apoptosis and migration by sponging miR-582-3p. This indicates that the circRNA_PTPRA/miR-582-3p axis may represent a potential target for HCC diagnosis and treatment.PMID:34594413 | PMC:PMC8456459 | DOI:10.3892/etm.2021.10711
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Yanlin Jin Yi Zhang Xiaoming Luo Source Type: research
