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Specialty: General Medicine
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Total 380 results found since Jan 2013.
Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells
Acta Med Okayama. 2022 Jun;76(3):281-290. doi: 10.18926/AMO/63722.ABSTRACTPeriodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of ...
Source: Acta Medica Okayama - July 5, 2022 Category: General Medicine Authors: Bo Yu Rui Wang Huikun Luo Di Yang Simo Wang Yaqiong Yu Hirohiko Okamura Lihong Qiu Source Type: research
GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway
In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.PMID:35761807 | PMC:PMC9214606 | DOI:10.3892/etm.2022.11400
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Liang Yao Fuguo Tian Source Type: research
The X box binding protein 1/C/EBP homologous protein pathway induces apoptosis of endothelial cells under hyperglycemia
Exp Ther Med. 2022 May 18;24(1):454. doi: 10.3892/etm.2022.11381. eCollection 2022 Jul.ABSTRACTVenous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X-box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelia...
Source: Experimental and Therapeutic Medicine - June 20, 2022 Category: General Medicine Authors: Maoshun Tang Yi Zheng Jianping Li Yuanlang Hu Source Type: research
