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Total 380 results found since Jan 2013.
SPTBN2 regulates endometroid ovarian cancer cell proliferation, invasion and migration via ITGB4 ‑mediated focal adhesion and ECM receptor signalling pathway
Exp Ther Med. 2023 Apr 24;25(6):277. doi: 10.3892/etm.2023.11977. eCollection 2023 Jun.ABSTRACTOvarian cancer is as a major contributor to gynaecologic death globally. The present study aimed to investigate the regulatory role of spectrin β non-erythrocytic 2 gene (SPTBN2) in endometroid ovarian cancer and its mechanism of action. According to the Gene Expression Profiling Interactive Analysis (GEPIA) database, SPTBN2 expression is elevated in ovarian cancer tissues and higher SPTBN2 expression indicated a worse prognosis. The present study assessed SPTBN2 mRNA and protein expression levels by reverse transcription-quanti...
Source: Experimental and Therapeutic Medicine - May 19, 2023 Category: General Medicine Authors: La Yang Yuanyuan Gu Source Type: research
CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
ConclusionCCT6A facilitates ESCC malignant activities by activating the TGF- β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.
Source: Irish Journal of Medical Science - April 5, 2023 Category: General Medicine Source Type: research
Dual specificity phosphatase 22 suppresses mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK signaling pathway in diabetic nephropathy
In conclusion, DUSP22 suppresses HG-induced mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK pathway, implying its potency in DN treatment.PMID:36561966 | PMC:PMC9748649 | DOI:10.3892/etm.2022.11680
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Na Ren Shanshan Shi Na Zhao Lingyan Zhang Source Type: research
SIRT3 expression alleviates microglia activation ‑induced dopaminergic neuron injury through the mitochondrial pathway
In conclusion, these results indicated that SIRT3 expression attenuated cell damage caused by microglia activation through the mitochondrial apoptosis pathway in DACs. The mitophagy-NLRP3 inflammasome pathway may also be associated with this neuroprotection. These findings may provide new intervention targets for the survival of dopaminergic neurons and the prevention and treatment of Parkinson's disease.PMID:36168411 | PMC:PMC9475350 | DOI:10.3892/etm.2022.11598
Source: Experimental and Therapeutic Medicine - September 28, 2022 Category: General Medicine Authors: De-Qi Jiang Qing-Min Zang Li-Lin Jiang Cheng-Shu Lu Shi-Hua Zhao Lan-Cheng Xu Source Type: research
Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells
Acta Med Okayama. 2022 Jun;76(3):281-290. doi: 10.18926/AMO/63722.ABSTRACTPeriodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of ...
Source: Acta Medica Okayama - July 5, 2022 Category: General Medicine Authors: Bo Yu Rui Wang Huikun Luo Di Yang Simo Wang Yaqiong Yu Hirohiko Okamura Lihong Qiu Source Type: research
