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Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells
Acta Med Okayama. 2022 Jun;76(3):281-290. doi: 10.18926/AMO/63722.ABSTRACTPeriodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of ...
Source: Acta Medica Okayama - July 5, 2022 Category: General Medicine Authors: Bo Yu Rui Wang Huikun Luo Di Yang Simo Wang Yaqiong Yu Hirohiko Okamura Lihong Qiu Source Type: research
