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Specialty: General Medicine
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Total 380 results found since Jan 2013.
YY1 affects the levels and function of fibulin-5 in ox-LDL-treated vascular smooth muscle cells
Exp Ther Med. 2022 Jun;23(6):407. doi: 10.3892/etm.2022.11334. Epub 2022 Apr 21.ABSTRACTFibulin-5 is reportedly involved in the pathological process of atherosclerosis (AS) where low expression has been frequently observed in ruptured atherosclerotic plaques. The aim of the present study was to determine the effects of fibulin-5 on the responses of vascular smooth muscle cells (VSMC) to oxidized low-density lipoprotein (ox-LDL). The expression of fibulin-5 was studied in human aortic-VSMCs (HA-VSMCs) treated with ox-LDL. Fibulin-5 was first overexpressed by the transfection of Ov-Fibulin-5 plasmids in HA-VSMCs challenged w...
Source: Experimental and Therapeutic Medicine - May 27, 2022 Category: General Medicine Authors: Leijing Wang Cuiyan Li Chunli Feng Yuanbo Zang Source Type: research
mTORC1 is a key regulator that mediates OGD- and TGF β1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts
Exp Ther Med. 2022 Jun;23(6):413. doi: 10.3892/etm.2022.11340. Epub 2022 Apr 27.ABSTRACTIschemia-reperfusion infarct-derived chondroitin sulfate proteoglycans (CSPGs) are important for sustaining denervation of the infarct. Sympathetic denervation within the heart after myocardial infarction (MI) predicts the probability of a higher risk for serious ventricular arrhythmias. Chondroitin-4-sulfate (C4S) is the predominant chondroitin sulfate component in the heart. However, the mechanisms that induce CSPG expression in fibroblasts following MI remain to be elucidated. The present study found that oxygen-glucose deprivation (...
Source: Experimental and Therapeutic Medicine - May 23, 2022 Category: General Medicine Authors: Chao Li Zheng Zhang Yu Peng Yanying Zhang Wanrong Kang Yingdong Li Yang Hai Source Type: research
Injectable siRNA Approved for Lowering Cholesterol
The FDA has approved an injectable small interfering ribonucleic acid (siRNA) therapy for lowering low-density lipoprotein (LDL-C) in certain adults. It is the first siRNA in its class and one of the first developed for a nonorphan indication.
Source: JAMA - March 1, 2022 Category: General Medicine Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research
