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Specialty: General Medicine
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Total 380 results found since Jan 2013.
Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat model.
Authors: Guan Y, Li L, Chen J, Lu H
Abstract
Traumatic brain injury (TBI) is one of the leading causes of mortality and permanent disabilities worldwide. Brain edema following TBI remains to be the predominant cause of mortality and disability in patients worldwide. Previous studies have reported that brain edema is closely associated with aquaporin-4 (AQP4) expression. AQP4 is a water channel protein and mediates water homeostasis in a variety of brain disorders. In the current study, a rat TBI model was established, and the features of brain edema following TBI were assessed using multimodal MRI. The results of t...
Source: Experimental and Therapeutic Medicine - February 29, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA.
CONCLUSIONS: By inhibiting DKK-1, we were able to inhibit the proliferation, invasion and pro-inflammatory cytokine secretion of FLSs derived from RA, which was mediated by the ERK or the IRAK-1 signaling pathway. These data indicate the application of DKK-1 silencing could be a potential therapeutic approach to RA.
PMID: 32068606 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - February 13, 2020 Category: General Medicine Authors: Liu YY, Wang SY, Li YN, Bian WJ, Zhang LQ, Li YH, Long L, Liu X, Zhang XW, Li ZG Tags: Chin Med J (Engl) Source Type: research
Angiotensin type 1 receptor regulates yes-associated protein in vascular endothelial cells.
Authors: Wang X, Zhang H, Ge Y, Liu J, Rong D, Cao L, He Y, Sun G, Jia S, Guo W
Abstract
Aortic dissection (AD) is one of the most lethal cardiovascular diseases. Endothelial cell (EC) dysfunction serves an important role in AD progression. Angiotensin II (Ang II) is a key effector in cardiovascular disease development that acts through binding to angiotensin type 1 receptor (AT1R). Yes-associated protein (YAP) is well-known as a key mediator of cell proliferation and apoptosis. To determine whether AT1R and YAP influence EC proliferation or injury, human aortic endothelial cells were cultured under different cultu...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
MicroRNA-1236-3p/translationally controlled tumor protein (TPT1) axis participates in congenital hypothyroidism progression by regulating neuronal apoptosis.
Authors: Meng T, Shen S, Li C, Liu X
Abstract
Congenital hypothyroidism (CH) is an endocrine disease caused by congenital thyroid hormone (TH) deficiency. MicroRNAs (miRNAs or miRs) have been reported to inhibit the progression of congenital hypothyroidism. However, the expression and role of miR-1236-3p in CH remains unclear. To address this, 12 day old Sprague-Dawley rats were divided into five groups: Control; Congenital hypothyroidism (CH), miR-1236-3p inhibitor control (inhibitor control); miR-1236-3p inhibitor (inhibitor); and miR-1236-3p inhibitor + translationally-controlled tumor protein 1 (TPT1)-small int...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition.
In conclusion, ITGB1 and EMT are involved in MAT-induced breast carcinoma cell death and the inhibition of metastasis. This may lead to the development of novel compounds for the treatment of breast cancer metastasis.
PMID: 31853313 [PubMed]
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Mechanism of IL-8-induced acute lung injury through pulmonary surfactant proteins A and B.
This study explored how interleukin-8 (IL-8) causes acute lung injury (ALI) through pulmonary surfactant protein A (SP-A) and surfactant protein B (SP-B). Serum was collected from 53 ALI patients and further 56 healthy subjects who underwent physical examination. The IL-8, SP-A, and SP-B levels were determined using enzyme-linked immunosorbent assay (ELISA). An ALI model was constructed using lipopolysaccharide (LSP)-induced normal A549 cells. siRNA was employed to interfere with the expression of IL-8, SP-A and SP-B. Western blot analysis was carried out to determine the protein levels, and MTT assay to determine the cell...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Role and mechanism of miR-144-5p in LPS-induced macrophages.
In conclusion, the data from the present study suggested that miR-144-5p overexpression reduced THP-1 macrophage cell viability and inhibited the expression of TNF-α, IL-6 and IL-8 in cells, possibly by inhibiting the expression of TLR2 and suppressing the activation of NK-κB signaling. Therefore, miR-144-5p may serve as a novel therapeutic target for the treatment of RA.
PMID: 31853295 [PubMed]
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
HIF-1 α regulates A2B adenosine receptor expression in liver cancer cells.
In conclusion, the current study indicated that A2B is induced by the HIF-1α transcriptional regulator during hypoxia, and it may be a potential pharmacologic and therapeutic target for the treatment of patients with liver cancer.
PMID: 31772626 [PubMed]
Source: Experimental and Therapeutic Medicine - November 28, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
MALAT1 inhibits the Wnt/ β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis.
MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis.
Bosn J Basic Med Sci. 2019 Nov 15;:
Authors: Zhang J, Li Q, Xue B, He R
Abstract
Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long noncoding RNA, which has been related to various pathological processes, including cancer. The role and mechanism of MALAT1 in colon cancer are not clear. We investigated MALAT1 expression in colon cancer tissues, the effect of MALAT1 on proliferation and apoptosis of SW480 cells, and the signaling pathway involved...
Source: Bosnian Journal of Basic Medical Sciences - November 19, 2019 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Newer therapeutic approaches towards the management of diabetes mellitus: an update.
This article focused on the emerging therapeutic approaches other than the conventional pharmacological therapies, which include stem cell therapy, gene therapy, siRNA, nanotechnology and theranostics.
PMID: 31663302 [PubMed - as supplied by publisher]
Source: Panminerva Medica - November 1, 2019 Category: General Medicine Tags: Panminerva Med Source Type: research
High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide-induced renal epithelial cell and cardiomyocyte apoptosis.
In conclusion, these data suggest that lncRNA MEG3 overexpression may be involved in sepsis, and the downregulation of lncRNA MEG3 may serve as a potential therapeutic target for sepsis.
PMID: 31641380 [PubMed]
Source: Experimental and Therapeutic Medicine - October 25, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1 α pathway in H9c2 cardiomyocytes.
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Exp Ther Med. 2019 Nov;18(5):3948-3958
Authors: Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY
Abstract
Hydrogen sulfide (H2S), an endogenous gasotransmitter, possesses multiple physiological and pharmacological properties including anti-apoptotic, anti-oxidative stress and cardiac protective activities in diabetic cardiomyopathy. An increasing body of evidence has suggested that signal transducer and activator of...
Source: Experimental and Therapeutic Medicine - October 18, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Downregulation of microRNA-3934-5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1.
Authors: Ye W, Liang F, Ying C, Zhang M, Feng D, Jiang X
Abstract
Neuroblastoma is the most common pediatric extracranial solid tumour in the world. miRNAs are a group of endogenous small non-coding RNAs that act on target genes to serve critical roles in many biological processes. Presently, the expression and role of miR-3934-5p in neuroblastoma remains unclear. Therefore, the aim of the present study was to investigate the expression of miR-3934-5p in neuroblastoma tissues and cell lines and to assess the role of miR-3934-5p in neuroblastoma. In the current study, the results revealed that miR-3934-5p was signif...
Source: Experimental and Therapeutic Medicine - October 18, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Platelet-derived growth factor-BB promotes proliferation and migration of retinal microvascular pericytes by up-regulating the expression of C-X-C chemokine receptor types 4.
Authors: Xiang DN, Feng YF, Wang J, Zhang X, Shen JJ, Zou R, Yuan YZ
Abstract
Stromal cell-derived growth factor (SDF)-1α acts as a ligand to C-X-C chemokine receptors 4 (CXCR4) and 7 (CXCR7), which are involved in the formation of choroidal neovascularization. Previous studies have demonstrated crosstalk between the platelet-derived growth factor (PDGF)-BB/PDGF receptor (PDGFR)-β and SDF-1α/CXCR4 axes during tumor neovascularization by increasing the recruitment of pericytes. However, the effects of interactions between these two signaling pathways in retinal microvascular pericytes remain poorly understood. We...
Source: Experimental and Therapeutic Medicine - October 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB.
Conclusions: miR-124-3p regulates the proliferation and apoptosis of BC cells by suppressing EDNRB expression.
PMID: 31572460 [PubMed]
Source: Archives of Medical Science - October 2, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research
