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Total 380 results found since Jan 2013.

< em > Ginkgo biloba < /em > leaf extract prevents diabetic nephropathy through the suppression of tissue transglutaminase
Exp Ther Med. 2021 Apr;21(4):333. doi: 10.3892/etm.2021.9764. Epub 2021 Feb 8.ABSTRACTThe present study aimed to investigate the preventive effects of Ginkgo biloba leaf extract (GBE) against extracellular matrix (ECM) accumulation in a streptozotocin (STZ)-induced rat model of diabetic nephropathy (DN), and to determine its underlying molecular mechanism. In vivo, a rat model of DN was established by intraperitoneal injection of STZ, and the rats were subsequently administered GBE. The results demonstrated that GBE significantly decreased blood glucose, the urine protein excretion rate and ECM accumulation in DN rats. In ...
Source: Experimental and Therapeutic Medicine - March 18, 2021 Category: General Medicine Authors: Xiaoyan Yu Qing Su Jianan Geng Hui Liu Yumeng Liu Jinming Liu Yan Shi Yinggang Zou Source Type: research

Integrin α7 knockdown suppresses cell proliferation, migration, invasion and EMT in hepatocellular carcinoma
In conclusion, ITGA7 knockdown suppressed HCC progression and inhibited EMT in HCC in vitro, implying that ITGA7 might be a novel treatment target for HCC.PMID:33717252 | PMC:PMC7885058 | DOI:10.3892/etm.2021.9740
Source: Experimental and Therapeutic Medicine - March 15, 2021 Category: General Medicine Authors: Zhiyong Wu Xiaoyu Kong Zhihui Wang Source Type: research

Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway.
Authors: Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY, Zhao S Abstract Schizandrin B exhibits prominent antioxidant and anti-inflammatory effects, and plays an important role in ameliorating myocardial ischemia/reperfusion injury. However, the underlying protective mechanisms remain to be elucidated. The aim of the present study was to explore the cardioprotective effects of schizandrin B against hypoxia/reoxygenation (H/R)-induced H9c2 cell injury, focusing on the role of the adenosine monophosphate-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in this process...
Source: Experimental and Therapeutic Medicine - February 20, 2021 Category: General Medicine Tags: Exp Ther Med Source Type: research

Abnormal expression of TRIAP1 and its role in gestational diabetes mellitus-related pancreatic β cells.
Authors: Li L, Yang K, Ye F, Xu Y, Cao L, Sheng J Abstract Gestational diabetes mellitus (GDM) is a disease that is typically characterized by insulin resistance and pancreatic β cell dysfunction. Currently, the role of TP53-regulated inhibitor of apoptosis 1 (TRIAP1) in the process of GDM remains to be elucidated. Therefore, the present study investigated the effects of TRIAP1 on GDM-related pancreatic β cells. Reverse transcription-quantitative PCR and western blot assays were conducted to analyze the expression levels of TRIAP1 in the peripheral blood of patients with GDM and subjects with healthy pregnancies....
Source: Experimental and Therapeutic Medicine - January 27, 2021 Category: General Medicine Tags: Exp Ther Med Source Type: research

FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPAR γ.
FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPARγ. Exp Ther Med. 2021 Mar;21(3):181 Authors: Yang XL, Mi JH, Dong Q Abstract Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen glucose deprivation/reoxygenation (OGD/R) were used to mimic ischemia-reperfusion (I/R) injury...
Source: Experimental and Therapeutic Medicine - January 27, 2021 Category: General Medicine Tags: Exp Ther Med Source Type: research

Small interfering RNAs in tendon homeostasis
AbstractBackgroundTenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing.Sources of dataA systematic search of different databases to October 2020 identified 17 suitable studies.Areas of agreementSiRNAs can be useful to study reparative processes of tendons and identify possible therapeutic targets in tendon healing.Areas of controversyMany genes and growth factors involved in the processes of tendinopathy and tendon healing can be regulated by siRNAs...
Source: British Medical Bulletin - January 18, 2021 Category: General Medicine Source Type: research

lncRNA uc.48+ regulates immune and inflammatory reactions mediated by the P2X7 receptor in type 2 diabetic mice.
In conclusion, these data suggest that uc.48+ may play an important role in the pathological changes of blood pressure, neurology and abdominal cell function in T2DM via interaction with the P2X7 receptor. PMID: 33224283 [PubMed]
Source: Experimental and Therapeutic Medicine - November 25, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis.
CONCLUSIONS: Inhibition of K17 expression by its specific siRNA significantly alleviated inflammation in mice with IMQ-induced psoriasis-like dermatitis. Thus, gene therapy targeting K17 may be a potential treatment approach for psoriasis. PMID: 33237695 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - November 20, 2020 Category: General Medicine Authors: Xiao CY, Zhu ZL, Zhang C, Fu M, Qiao HJ, Wang G, Dang EL Tags: Chin Med J (Engl) Source Type: research

MBD2 and EZH2 regulate the expression of SFRP1 without affecting its methylation status in a colorectal cancer cell line.
In conclusion, data from the present study revealed that MBD2 and EZH2 regulated SFRP1 expression without affecting the hypermethylation of SFRP1 in CRC cell lines. Instead, the regulation of SFRP1 expression may be through a distinct mechanism, which warrants further investigation. PMID: 33178340 [PubMed]
Source: Experimental and Therapeutic Medicine - November 13, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Small interfering RNA-mediated knockdown of KRT80 suppresses colorectal cancer proliferation.
In conclusion, the findings of the present study suggested that KRT80 may be overexpressed in CRC tissues. Furthermore, KRT80 may be involved in the proliferation of CRC cells, which is likely through its ability to regulate the cell cycle and DNA replication pathways, thus it may serve as a potential therapeutic target for patients with CRC. PMID: 33101466 [PubMed]
Source: Experimental and Therapeutic Medicine - October 27, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells.
CONCLUSION: Our findings suggest that estrogen induces BPH possibly by promoting AQP5 expression. Hence, AQP5 might be a novel target for modulating EMT in prostate epithelial cells. PMID: 33031138 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - October 7, 2020 Category: General Medicine Authors: Fan Y, Song TR, Wei Q, Yang L, Lin T, Feng XB, Wang XD, Huang ZL, Feng SJ Tags: Chin Med J (Engl) Source Type: research

GSK-3 β mediates the effects of HNF-1β overexpression in ovarian clear cell carcinoma.
In conclusion and to the best of our knowledge, the current study was the first to determine that GSK-3β is a target gene of HNF-1β. In addition, the results of the present study revealed the novel HNF-1β-GSK-3β-p-NFκB pathway, occurring in response to DNA damage. Targeting this pathway may therefore represent a putative, novel, anticancer strategy in patients with OCCC. PMID: 33005248 [PubMed]
Source: Experimental and Therapeutic Medicine - October 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research