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Condition: Pregnancy

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Total 418 results found since Jan 2013.

Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018Source: Pregnancy HypertensionAuthor(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian LiAbstractPreeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially me...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 5, 2018 Category: OBGYN Source Type: research

Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1
ConclusionsWe proved that PGK1 and PGK1P2 are a pair of ceRNAs against miR-330-5p and they play a vital role in human decidualization by regulating angiogenesis and glycolysis metabolism. The deficiency of PGK1 and PGK1P2 in the decidua jeopardizes the decidualization process and subsequently might lead to the occurrence of PE. These findings may help in promoting novel predictive, diagnostic and prognostic biomarkers of PE in future.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. BrenneckeAbstractDecidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research

Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018Source: Pregnancy HypertensionAuthor(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian LiAbstractPreeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially me...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research

Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption
This study suggests that avobenzone induces mitochondrial dysfunction-mediated apoptosis leading to abnormal placentation during early pregnancy.
Source: Reproductive Toxicology - July 11, 2018 Category: Toxicology Source Type: research

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target β-catenin.
Abstract Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated migration of HTR-8/SVneo trophoblastic cells has been investigated. Treatment of HTR-8/SVneo cells with HGF led to a dose-dependent increase in their migration. RT-PCR studies revealed a significant increase in the transcripts of WNT4, WNT11, ITGA2, and ITGAV, which was further confirmed at p...
Source: Molecular and Cellular Biochemistry - August 22, 2018 Category: Biochemistry Authors: Chaudhary P, Malhotra SS, Babu GS, Sobti RC, Gupta SK Tags: Mol Cell Biochem Source Type: research

Propofol Regulates Neural Stem Cell Proliferation and Differentiation via Calmodulin-Dependent Protein Kinase II/AMPK/ATF5 Signaling Axis.
CONCLUSIONS: The results from study demonstrated that propofol inhibits the proliferation, differentiation, and migration of NSCs, and these effects are partially mediated by CaMkII/pS485/AMPK/ATF5 signaling pathway. PMID: 30303867 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 9, 2018 Category: Anesthesiology Authors: Liang C, Du F, Wang J, Cang J, Xue Z Tags: Anesth Analg Source Type: research

Effect of miR-30e regulating NK cell activities on immune tolerance of maternal-fetal interface by targeting PRF1
Conclusion: Up-regulated miR-30e can reduce the cytotoxicity of PB-NK cells and D-NK cells by targeting PRF1, whereby inhibiting Th1 tolerance phenotype and inducing Th2 immunodominance. miR-30e may be contributive to creating a micro-immune tolerance environment of maternal-fetal interface.Graphical abstract
Source: Biomedicine and Pharmacotherapy - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA-TCL6 promotes early abortion and inhibits placenta implantation via the EGFR pathway.
CONCLUSIONS: Compared with normal pregnancy, lncRNA-TCL6 was highly expressed in placental tissues of threatened abortion pregnancy. Moreover, the expression of lncRNA-TCL6 in placenta tissues of spontaneous abortion pregnancy was significantly higher than induced abortion pregnancy. Knockdown of lncRNA-TCL6 promoted the proliferation of trophoblast cells and inhibited the abortion via the EGFR signaling pathway. PMID: 30468451 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Involvement of the STAT5-CyclinD/CDK4-pRb pathway in beta cell proliferation stimulated by prolactin during pregnancy.
Abstract During pregnancy, maternal pancreatic beta cells undergo a compensatory expansion in response to the state of insulin resistance, where prolactin (PRL) plays a major role. Retinoblastoma protein (Rb) has been shown to critically regulate islet proliferation and function. The aim of the study was to explore the role of Rb in beta cell mass expansion during pregnancy. During pregnancy, expression of Rb, phospho-Rb (p-Rb), p107 and E2F1 increased, while p130 decreased in maternal islets. With PRL stimulation, induction of Rb expression occurred mainly in the nucleus while p-Rb was predominantly in the cytopl...
Source: Am J Physiol Endocri... - December 4, 2018 Category: Endocrinology Authors: Zhao X, Xu Y, Wu Y, Zhang H, Shi H, Zhu H, Woo M, Wu X Tags: Am J Physiol Endocrinol Metab Source Type: research

Low-dose mifepristone increased angiogenesis in a manner involving AQP1
ConclusionsLow-dose mifepristone increased angiogenesis in a manner involving AQP1. This affords a new insight into the molecular mechanism underpinning the angiogenic effects of low-dose mifepristone.
Source: Archives of Gynecology and Obstetrics - December 19, 2018 Category: OBGYN Source Type: research

Downregulated low-density lipoprotein receptor-related protein 6 induces the maldevelopment of extravillous trophoblast via Wnt/β-catenin signaling pathway
Publication date: Available online 24 January 2019Source: Molecular and Cellular ProbesAuthor(s): Xiaoyan Yu, Yan Zhang, Ping Yang, Xueli Gao, Yuping WangAbstractPreeclampsia (PE), a special type of hypertensive disorder complicating pregnancy (HDCP), is highly associated with the migratory and invasive capacity of extravillous trophoblasts (EVTs). Here, we aimed to study the functions of low-density lipoprotein receptor-related protein 6 (LRP6) in PE pathogenesis. A comparative analysis of cellular gene expressions between placenta tissues collected from PE patients and normal pregnant women showed that the expressions of...
Source: Molecular and Cellular Probes - January 24, 2019 Category: Molecular Biology Source Type: research

HGF regulate HTR-8/SVneo trophoblastic cells migration/invasion under hypoxic conditions through increased HIF-1 α expression via MAPK and PI3K pathways.
In conclusion, HGF facilitates HTR-8/SVneo cell migration/invasion by activation of MAPK/PI3K signaling pathways and increased expression of MMPs. HIF-1α has a role in HGF-mediated increase in migration under hypoxic conditions. PMID: 30684191 [PubMed - as supplied by publisher]
Source: Journal of Cell Communication and Signaling - January 26, 2019 Category: Molecular Biology Authors: Chaudhary P, Babu GS, Sobti RC, Gupta SK Tags: J Cell Commun Signal Source Type: research

Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization
Publication date: Available online 31 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Maria M. Szwarc, Lan Hai, William E. Gibbons, Qianxing Mo, Rainer B. Lanz, Francesco J. DeMayo, John P. LydonAbstractMouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellular processes in human is unclear. Analysis of clinical samples indicate that endometrial EGR1 levels are decreased in the endometrium of...
Source: The Journal of Steroid Biochemistry and Molecular Biology - February 1, 2019 Category: Biochemistry Source Type: research