An exaggerated epinephrine-adrenergic receptor signaling impairs uterine decidualization in mice
Publication date: Available online 11 September 2019Source: Reproductive ToxicologyAuthor(s): Jinxiang Wu, Shuangbo Kong, Chuanhui Guo, Jianqi Wang, Jinhua Lu, Ruiwei Jiang, Haibin WangAbstractOur understanding of the relationship between stress-derived epinephrine and early pregnancy failure remains incomplete. Here, we explored the effect of epinephrine exposure on early pregnancy and pseudopregnancy in mice. Increased expression of adrenergic receptors Adra1b, Adra2b and Adrb2 was observed during decidualization and post-implantation embryogenesis was delayed or survival impaired. Epinephrine treatment also impaired dec...
Source: Reproductive Toxicology - September 13, 2019 Category: Toxicology Source Type: research

Adverse effects of naphthenic acids on reproductive health: a focus on placental trophoblast cells
Publication date: Available online 11 September 2019Source: Reproductive ToxicologyAuthor(s): Sergio Raez-Villanueva, Laiba Jamshed, Geemitha Ratnayake, Lisa Cheng, Philippe J. Thomas, Alison C. HollowayABSTRACTThere is considerable concern that naphthenic acids (NA) related to oil extraction can negatively impact reproduction in mammals yet the mechanisms are unknown. Since placental dysfunction is central to many adverse pregnancy outcomes, the goal of this study was to determine the effects of NA exposure on placental trophoblast cell function. Htr8/SVneo cells were exposed to a commercial technical NA mixture (Sigma-Al...
Source: Reproductive Toxicology - September 11, 2019 Category: Toxicology Source Type: research

Effect of Chlorpyrifos on human extravillous-like trophoblast cells
Publication date: Available online 8 September 2019Source: Reproductive ToxicologyAuthor(s): Magali E. Ridano, Ana C. Racca, Jésica B. Flores-Martín, Luciana Reyna, Susana Genti-Raimondi, Graciela M. Panzetta-DutariAbstractAn increased risk of pregnancy disorders has been reported in women and animal models exposed to organophosphate pesticides. However, less information is available on impacts to human placental function. Here, we addressed the impact of chlorpyrifos (CPF) on extravillous cytotrophoblasts (evCTB) employing HTR8/SVneo cells as an in vitro model. Cell proliferation, migration and invasion were...
Source: Reproductive Toxicology - September 10, 2019 Category: Toxicology Source Type: research

Biological Interactions between Nanomaterials and Placental Development and Function Following Oral Exposure
Publication date: Available online 30 August 2019Source: Reproductive ToxicologyAuthor(s): Ninell P. Mortensen, Leah M. Johnson, Khara D. Grieger, Jeffrey L. Ambroso, Timothy R. FennellAbstractWe summarize the literature involving the deposition of nanomaterials within the placenta following oral exposure and the biological interactions between nanomaterials and placental development and function. The review focuses on the oral exposure of metal and metal oxide engineered nanomaterials (ENMs), carbon-based ENMs, and nanoplastics in animal models, with a minor discussion of intravenous injections. Although the literature su...
Source: Reproductive Toxicology - August 31, 2019 Category: Toxicology Source Type: research

Critical Review of the Association between Perineal Use of Talc Powder and Risk of Ovarian Cancer
ConclusionPerineal use of talc powder is a possible cause of human ovarian cancer. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 29, 2019 Category: Toxicology Source Type: research

Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice
This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6 J mice were intratracheally instilled with 63 µg of rutile nanosized TiO2, once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone w...
Source: Reproductive Toxicology - August 25, 2019 Category: Toxicology Source Type: research

Neural crest related gene transcript regulation by valproic acid analogues in the cardiac embryonic stem cell test
Publication date: Available online 21 August 2019Source: Reproductive ToxicologyAuthor(s): R.H. (Gina) Mennen, J.L.A. (Jeroen) Pennings, A.H. (Aldert) PiersmaAbstractIn vivo, neural crest (NC) cells contribute critically to heart formation. The embryonic stem cells in the cardiac Embryonic Stem cell Test (ESTc) differentiate into a heterogeneous cell population including non-cardiomyocyte cells. The use of molecular biomarkers from different mechanistic pathways can refine quantitative embryotoxicity assessment. Gene expression levels representing different signalling pathways that could relate to beating cardiomyocyte for...
Source: Reproductive Toxicology - August 23, 2019 Category: Toxicology Source Type: research

Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort
ConclusionHigher exposure to BPA was associated with abnormal sperm tail morphology in this prospective, pre-conception cohort. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 23, 2019 Category: Toxicology Source Type: research

BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions
Publication date: December 2019Source: Reproductive Toxicology, Volume 90Author(s): Yichang Chen, Blake Panter, Aleena Hussein, Katherine Gibbs, Daniel Ferreira, Patrick AllardAbstractBisphenol A is an endocrine disruptor associated with hormone synthesis and reproduction alterations. However, the initiating events underpinning these dysfunctions are still unclear. Here, we address the hypothesis that BPA interferes with the highly evolutionary conserved process of mitochondrial cholesterol transport, a crucial step in steroid hormone biosynthesis, by using the model organism C. elegans. We observed that embryonic lethalit...
Source: Reproductive Toxicology - August 23, 2019 Category: Toxicology Source Type: research

Alterations in oocytes and early zygotes following oral exposure to di(2-ethylhexyl) phthalate in young adult female mice
Publication date: Available online 20 August 2019Source: Reproductive ToxicologyAuthor(s): Lyda Yuliana Parra-Forero, Arlet Veloz-Contreras, Shirley Vargas-Marín, María Angelica Mojica-Villegas, Elim Alfaro-Pedraza, Mayrut Urióstegui-Acosta, Isabel Hernández-OchoaAbstractBecause di(2-ethylhexyl) phthalate (DEHP) toxicity on ovarian function is incomplete, effects of DEHP oocyte fertilization and the resulting zygotes were investigated. Further, an analysis characterizing the stage of zygote arrest was performed. Female CD1 mice were dosed orally with DEHP (0, 20, 200 and 2000 µg/kg/...
Source: Reproductive Toxicology - August 22, 2019 Category: Toxicology Source Type: research

In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer
Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloAbstractWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 1...
Source: Reproductive Toxicology - August 20, 2019 Category: Toxicology Source Type: research

Sponsors and exhibitors 2019
Publication date: Available online 19 August 2019Source: Reproductive ToxicologyAuthor(s): (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 20, 2019 Category: Toxicology Source Type: research

Congenital Heart Defects in West Virginia: Preliminary Findings from an Ecological Study of Effects of an Industrial Watershed on Increased Incidence
ConclusionThrough spatial analysis, there appears to be a direct point source exposure for observed cases of f CHD along the industrial watershed of Kanawha County, West Virginia (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research

Prenatal toxicity of the environmental pollutants on neuronal and cardiac development derived from embryonic stem cells
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Eul-Bee Ko, Kyung-A Hwang, Kyung-Chul ChoiAbstractPesticides, antibiotics, and industrial excipients are widely used in agriculture, medicine, and chemical industry, respectively. They often end up in the environment, not only being not easily decomposed but also being accumulated. Moreover, they may cause serious toxic problems such as reproductive and developmental defects, immunological toxicity, and carcinogenesis. Hence, they are called environmental pollutants. It is known that the environmental pollutants easily enter the body...
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research

Essential oils disrupt steroidogenesis in a feto-placental co-culture model
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Debbie Yancu, Thomas SandersonAbstractWe determined whether 5 common essential oils (basil, fennel seed, orange, black pepper and sage) interfered with feto-placental steroidogenesis in a co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. After a 24 h exposure, only basil and fennel seed oil significantly increased hormone concentrations of estradiol, estrone, dehydroepiandrosterone (DHEA), androstenedione, progesterone, and estriol. Basil and fennel seed oil were shown ...
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research

The Association Between Anogenital Distance, Reproductive and General Health in Adult Females- A Prospective Cohort of 17 years
ConclusionsWomen with short AGD are at increased risk for gynecological morbidities. AGD should be studied further, and may possibly be used for screening of women at risk for these conditions. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 16, 2019 Category: Toxicology Source Type: research

In Utero DDT Exposure and Breast Density in Early Menopause by Maternal History of Breast Cancer
We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p’-DDT, p,p’-DDT, and p,p’-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. We focused our analyses on o,p’-DDT exposure given our previous report of a positive association between intrauterine o,p’-DDT exposure and daughter’s breast cancer (BC) risk. Here we estimated associations of intrauterine serum DDTs with MBD in 224 daughters of women in the Child Health and Development Studies pregnancy cohort whose mothers did not develop...
Source: Reproductive Toxicology - August 16, 2019 Category: Toxicology Source Type: research

Python BMDS: A Python interface library and web application for the canonical EPA dose-response modeling software
Publication date: Available online 12 August 2019Source: Reproductive ToxicologyAuthor(s): Ly Ly Pham, Sean Watford, Katie Paul Friedman, Jessica Wignall, Andrew J. ShapiroAbstractSeveral primary sources of publicly available, quantitative dose-response data from traditional toxicology study designs relevant to predictive toxicology applications are now available, including the redeveloped U.S. Environmental Protection Agency’s Toxicity Reference Database (ToxRefDB v2.0), the Health Assessment Workspace Collaborative (HAWC), and the National Toxicology Program’s Chemical Program’s Chemical Effects in Biol...
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research

Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children
Publication date: Available online 12 August 2019Source: Reproductive ToxicologyAuthor(s): Kristin J. Marks, Zuha Jeddy, W. Dana Flanders, Kate Northstone, Abigail Fraser, Antonia M. Calafat, Kayoko Kato, Terryl J. HartmanAbstractPerfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG). We used data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children...
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research

The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis
This study shows that the levels of cAMP, progesterone, testosterone and expression of StAR decreased significantly in PFOA 50 and 100 µg/ml. PFOA affected cell populations significantly by decreasing the amount of diploid, proliferating, meiotic I and G2/M-phase cells in adult rat testis. However, PFOA did not affect fetal, proliferating or adult rat Sertoli cells but an increased tendency of apoptosis in fetal Leydig cells was observed. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research

Exposure to Low Doses of Oxybenzone During Perinatal Development Alters Mammary Gland Morphology in Male and Female Mice
Publication date: Available online 10 August 2019Source: Reproductive ToxicologyAuthor(s): Klara Matouskova, D. Joseph Jerry, Laura N. VandenbergAbstractOxybenzone (benzophenone-3) is an ultraviolet radiation filter commonly used in personal care products including sunscreens, textiles and inks, and food and beverage containers, among others. Due to its widespread use, human exposures to oxybenzone are widespread. Oxybenzone is considered an endocrine disrupting chemical due to its antiestrogenic and antiandrogenic properties. We evaluated the effects of oral exposures to oxybenzone on the growth and morphology of the mamm...
Source: Reproductive Toxicology - August 11, 2019 Category: Toxicology Source Type: research

Editorial
Publication date: Available online 6 August 2019Source: Reproductive ToxicologyAuthor(s): Nicola Powles-Glover (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 7, 2019 Category: Toxicology Source Type: research

Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application
In conclusion, the Intraperitoneal injection of Tl(I) acetate to pregnant mice induced morphological variations and a delay of the fetus ossification. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 4, 2019 Category: Toxicology Source Type: research

Developmental milestones in neonatal and juvenile C57Bl/6 mouse – indications for the design of juvenile toxicity studies
Publication date: Available online 3 August 2019Source: Reproductive ToxicologyAuthor(s): Aleksandra ZalewskaAbstractThere is a growing demand for wild type mice and mouse models of disease that may be more representative of human conditions but there is little information on neonatal and juvenile mouse anatomy. This project produces sound and comprehensive histology background data on the developing neonatal mouse at different time points from Day 0 until Day 28.The work describes optimal methods for tissue harvesting, fixation and processing from the neonatal and juvenile mice which can be used in routine toxicology stud...
Source: Reproductive Toxicology - August 4, 2019 Category: Toxicology Source Type: research

New Guidance for the Identification of Endocrine Disruptors in the EU for Agrochemicals (Regulation EC No 1107/2009) and Biocides (EU No 528/2012)
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Emily Richmond, Paul Parsons (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Symposium: “Digitalisation meets Pathology and Developmental Toxicology”: Invited talk: “Status and Prospect of the Virtual Embryo Program”
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Thomas B. Knudsen (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Recent updates ICH S5(R3) Guideline: Detection of toxicity to reproduction for human pharmaceuticals
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Paul C. Barrow (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Poland syndrome complicated with metabolic syndrome and gynecomastia
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Ismini Tzanaki, Zeyad Al-Jazrawi, Nicos Mantas, Elpida Niki Emmanouil-Nikoloussi (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Asb2β is essential for embryonic cardiomyocyte development and filamin B degradation in epicardium and endocardium in mice
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Seul Gi Park, Eun-Kyoung Kim, Ki-Hoan Nam, Beom Jun Lee, Young Won Yun, Sang-Yoon Nam (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Towards a mechanistic approach in toxicology – using AOP's in developmental toxicity assessment
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Aldert H. Piersma (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Teratogenicity in mammals predicted by a non-mammal test system, the zebrafish (Danio rerio) embryo
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Katharina Brotzmann, Rebecca von Hellfeld, Thomas Braunbeck (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

The retinoic acid pathway as a source of gene expression biomarkers of developmental toxicity in the zebrafish embryotoxicity assay
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Laura M.M. Samrani, Jeroen L.A. Pennings, Marc Pallardy, Helen Tinwell, Aldert H. Piersma (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Recent updates on regulatory guidances for developmental toxicity testing of chemicals - OECD 414
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): Manon Beekhuijzen (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Triclosan exposure and ovarian reserve
The objective of the current analysis was to investigate the associations of urinary triclosan concentrations with parameters of ovarian reserve.Five hundred eleven female aged 25-39 years who attended the infertility clinic for diagnostic purposes were recruited. Urinary concentrations of triclosan were measured by a validated gas chromatograohy ion-tap mass spectrometry method. Parameters of ovarian reserve were: antral follicle count (AFC), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E2) levels.Urinary concentrations of triclosan decrease antral follicle count. There were no stat...
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

Conference Programme: 47th Annual Conference of the European Teratology Society
Publication date: Available online 2 August 2019Source: Reproductive ToxicologyAuthor(s): (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 3, 2019 Category: Toxicology Source Type: research

High dose folic acid during pregnancy and the risk of autism; The birth order bias: a nested case-control study
ConclusionBirth order effects need to be accounted for in analyses aiming to decipher the associations between gestational FA use and developmental outcomes. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - July 31, 2019 Category: Toxicology Source Type: research

Prenatal exposures to bisphenol A and di (2-ethylhexyl) phthalate disrupted seminiferous tubular development in growing male rats
Publication date: Available online 29 July 2019Source: Reproductive ToxicologyAuthor(s): Fatma M Abdel-Maksoud, Fatma Abo Zakaib Ali, Benson T AkingbemiAbstractEndocrine-disrupting compounds (EDCs) are found in the environment due to their use in industrial and manufacturing activities. Exposure of the population to bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP) is significant because they are present in many consumer products. EDCs target the reproductive tract because they express high levels of steroid hormone receptors, which act as transcriptional factors to regulate reproductive development. In the present ...
Source: Reproductive Toxicology - July 30, 2019 Category: Toxicology Source Type: research

Comment on “Transcript Profiling in the Testes and Prostates of Postnatal Day 30 Sprague-Dawley Rats Exposed Prenatally and Lactationally to 2-Hydroxy-4-methoxybenzophenone”
Publication date: Available online 30 July 2019Source: Reproductive ToxicologyAuthor(s): Chen Guan, Yan Xu (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - July 30, 2019 Category: Toxicology Source Type: research

Reproductive and Developmental Toxicity Assessment of Palbociclib, a CDK4/6 Inhibitor, in Sprague-Dawley Rats and New Zealand White Rabbits
Publication date: Available online 27 July 2019Source: Reproductive ToxicologyAuthor(s): N.R. Catlin, C.J. Bowman, S.M. Engel, A. Sacaan, S. Thibault, E.M. Lewis, G.D. CapponAbstractPalbociclib is a selective inhibitor of the cyclin-dependent kinase (CDK) 4/6, approved for the treatment of breast cancer. We assessed the potential effects of oral administration of palbociclib on reproduction and development. There were no effects on female or male fertility indices; however, in the male there was seminiferous tubule degeneration in the testes and secondary findings in the epididymides, lower testicular and epididymal weight...
Source: Reproductive Toxicology - July 28, 2019 Category: Toxicology Source Type: research

Assembling Systems Biology, Embryo Development and Teratogenesis: what do we know so far and where to go next?
Publication date: Available online 27 July 2019Source: Reproductive ToxicologyAuthor(s): Thayne Woycinck Kowalski, Ágata de Vargas Dupont, Bruna Duarte Rengel, Eduarda Sgarioni, Julia do Amaral Gomes, Lucas Rosa Fraga, Lavínia Schuler-Faccini, Fernanda Sales Luiz ViannaAbstractThe recognition of molecular mechanisms of a teratogen can provide insights to understand its embryopathy, and later to plan strategies for the prevention of new exposures. In this context, experimental research is the most invested approach. Despite its relevance, these assays require financial and time investment. Hence, the evaluatio...
Source: Reproductive Toxicology - July 28, 2019 Category: Toxicology Source Type: research

Secondary sex ratio and trends in the associated gender-specific births near nuclear facilities in France and Germany: update of birth counts
Publication date: Available online 25 July 2019Source: Reproductive ToxicologyAuthor(s): Hagen Scherb, Ralf Kusmierz, Kristina VoigtAbstractIncreases in childhood cancer near nuclear facilities in France and in Germany as well as elevated human birth sex ratios after the atmospheric atomic bomb tests and after Chernobyl motivated the inspection of the secondary sex ratio and the corresponding gender-specific birth counts in the vicinity of nuclear facilities. Focus is on which changes in the birth counts go along with significant changes in the sex ratios. Official municipality-specific annual birth counts by sex for all o...
Source: Reproductive Toxicology - July 25, 2019 Category: Toxicology Source Type: research

A critical evaluation of thyroid hormone measurements in OECD test guideline studies: Is there any added value?
In conclusion, the current testing approach is not providing specific information needed to assess endocrine disruption, as too often a statistical significant finding is noted and as down-stream adverse effects are not evaluated. Therefore, major modifications are urgently needed. Instead of extending the in vivo experiments, it should be investigated if in vitro assessments will provide more relevant information on human endocrine disruptor potential. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - July 25, 2019 Category: Toxicology Source Type: research

ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses
Publication date: Available online 21 July 2019Source: Reproductive ToxicologyAuthor(s): Sean Watford, Ly Ly Pham, Jessica Wignall, Robert Shin, Matthew T. Martin, Katie Paul FriedmanAbstractThe Toxicity Reference Database (ToxRefDB) structures information from over 5000 in vivo toxicity studies, conducted largely to guidelines or specifications from the US Environmental Protection Agency and the National Toxicology Program, into a public resource for training and validation of predictive models. Herein, ToxRefDB version 2.0 (ToxRefDBv2) development is described. Endpoints were annotated (e.g. required, not required) accor...
Source: Reproductive Toxicology - July 22, 2019 Category: Toxicology Source Type: research

Rebuttal to the comments by Dr. Yan Xu on the article “Transcript Profiling in the Testes and Prostates of Postnatal Day 30 Sprague-Dawley Rats Exposed Prenatally and Lactationally to 2-Hydroxy-4-methoxybenzophenone”
Publication date: Available online 22 July 2019Source: Reproductive ToxicologyAuthor(s): Noriko Nakamura (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - July 22, 2019 Category: Toxicology Source Type: research

In Utero Exposure to Poly and Perfluoroalkyl Substances (PFASs) and Subsequent Breast Cancer
Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloABSTRACTWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9,300 daughters born 1959-1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 da...
Source: Reproductive Toxicology - July 18, 2019 Category: Toxicology Source Type: research

Mitochondria as a target of organophosphate and carbamate pesticides: revisiting common mechanisms of action with new approach methodologies
Publication date: Available online 14 July 2019Source: Reproductive ToxicologyAuthor(s): Maxwell C.K. Leung, Joel N. MeyerAbstractMitochondrial toxicity has been proposed as a potential cause of developmental defects in humans. We evaluated 51 organophosphate and carbamate pesticides using the U.S. EPA ToxCast and Tox21 databases. Only a small number of them bind directly to cholinesterases in the parent form. The hydrophobicity of organophosphate pesticides is correlated significantly to TSPO binding affinity, mitochondrial membrane potential reduction in HepG2 cells, and developmental toxicity in Caenorhabditis elegans and Danio rerio (p
Source: Reproductive Toxicology - July 15, 2019 Category: Toxicology Source Type: research

Maternal and fetal outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKAGFP
Publication date: Available online 13 July 2019Source: Reproductive ToxicologyAuthor(s): Ana Cláudia Boareto, Caroline Gomes, Juliane Centeno Müller, Jonas Golart da Silva, Fernanda Vergara, Noruê Salum, Rafaela Maristany Sargaço, Rosângela Ribeiro de Carvalho, José Ederaldo Queiroz Telles, Cláudio Romero Farias Marinho, Francisco José Roma Paumgartten, Paulo Roberto DalsenterAbstractMalaria in pregnant women is associated with risk of maternal and perinatal morbidity and mortality, and there are few antimalarial drugs considered safe to treat them, so it is necessary to ...
Source: Reproductive Toxicology - July 15, 2019 Category: Toxicology Source Type: research

Arsenic exposure during prepuberty alters prostate maturation in pubescent rats
This study evaluated prostate morphophysiology after sodium arsenite exposure during prepubertal period in rats. Male Wistar rats at PND23 were randomly distributed into three experimental groups (n = 10/group). The Ctrl group (filtered drinking water); As1 group (0.01 mg/L of NaAsO2); As2 group (10.0 mg/L of NaAsO2) that received the diluted solution in drinking water from PND23 to PND53. Histological and molecular analyzes showed developmental delay in the As1 group and important morphophysiological alterations in As2 group. The results showed that exposure to NaAsO2 during prepuberty compromi...
Source: Reproductive Toxicology - July 15, 2019 Category: Toxicology Source Type: research

Associations between ambient air pollution and pregnancy rate in women who underwent in vitro fertilization in Shenyang, China
Publication date: Available online 12 July 2019Source: Reproductive ToxicologyAuthor(s): Jiahui Qiu, Jichun TanAbstractTo assess the associations between air pollution and the pregnancy rate of IVF, we performed a retrospective cohort study on 1455 women who underwent the first fresh IVF cycle at a fertility center from January 2014 to April 2018 and lived in Shenyang during treatment. Binary logistic regression models were used to evaluate the effect of an interquartile range increase in each pollutant on the intrauterine pregnancy rate. Both average chronic and daily acute exposure to air pollution were considered. Incre...
Source: Reproductive Toxicology - July 13, 2019 Category: Toxicology Source Type: research

Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators
Publication date: Available online 12 July 2019Source: Reproductive ToxicologyAuthor(s): Arnon Gal, Kristene Gedye, Zelieann R. Craig, Ayelet Ziv-GalAbstractPropylparaben is prevalently used in cosmetics, pharmaceuticals, and foods; yet, its direct effects on the mammalian ovary are unknown. We investigated the direct effects of propylparaben on the growth and steroidogenic function of mouse antral follicles. Antral follicles were isolated from the ovaries of Swiss mice (age: 32-42 days) and cultured in media with dimethylsulfoxide vehicle control or propylparaben (0.01-100 μg/mL) for 24-72 hours. Follicle...
Source: Reproductive Toxicology - July 13, 2019 Category: Toxicology Source Type: research